WO2006110761A3 - A variant form of urate oxidase and use thereof - Google Patents
A variant form of urate oxidase and use thereof Download PDFInfo
- Publication number
- WO2006110761A3 WO2006110761A3 PCT/US2006/013502 US2006013502W WO2006110761A3 WO 2006110761 A3 WO2006110761 A3 WO 2006110761A3 US 2006013502 W US2006013502 W US 2006013502W WO 2006110761 A3 WO2006110761 A3 WO 2006110761A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- variant form
- urate oxidase
- proteins
- relates
- urate oxidases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0044—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7)
- C12N9/0046—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7) with oxygen as acceptor (1.7.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y107/00—Oxidoreductases acting on other nitrogenous compounds as donors (1.7)
- C12Y107/03—Oxidoreductases acting on other nitrogenous compounds as donors (1.7) with oxygen as acceptor (1.7.3)
- C12Y107/03003—Factor-independent urate hydroxylase (1.7.3.3), i.e. uricase
Abstract
Priority Applications (24)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NZ562291A NZ562291A (en) | 2005-04-11 | 2006-04-11 | A variant form of urate oxidase and use thereof |
EP06740863A EP1871877A2 (en) | 2005-04-11 | 2006-04-11 | A variant form of urate oxidase and use thereof |
MX2007012548A MX2007012548A (en) | 2005-04-11 | 2006-04-11 | A variant form of urate oxidase and use thereof. |
BRPI0612942-0A BRPI0612942A2 (en) | 2005-04-11 | 2006-04-11 | variant form of urate oxidase and its use |
JP2008505656A JP2008535499A (en) | 2005-04-11 | 2006-04-11 | Mutant urate oxidase and use thereof |
AU2006235437A AU2006235437B2 (en) | 2005-04-11 | 2006-04-11 | A variant form of urate oxidase and use thereof |
US11/918,296 US7811800B2 (en) | 2005-04-11 | 2006-04-11 | Variant form of urate oxidase and use thereof |
CN2006800206898A CN101194016B (en) | 2005-04-11 | 2006-04-11 | A variant form of urate oxidase and use thereof |
HU0700729A HU229626B1 (en) | 2005-04-11 | 2006-04-11 | A variant form of urate oxidase and use thereof |
KR1020077026114A KR101304289B1 (en) | 2005-04-11 | 2006-04-11 | A variant form of urate oxidase and use thereof |
CA002604545A CA2604545A1 (en) | 2005-04-11 | 2006-04-11 | A variant form of urate oxidase and use thereof |
US11/539,475 US8148123B2 (en) | 2005-04-11 | 2006-10-06 | Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase |
US11/899,688 US20080159976A1 (en) | 2005-04-11 | 2007-09-07 | Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase |
IL186511A IL186511A (en) | 2005-04-11 | 2007-10-09 | Variant form of urate oxidase and use thereof |
US12/879,084 US7964381B2 (en) | 2005-04-11 | 2010-09-10 | Variant form of urate oxidase and use thereof |
IL208643A IL208643A0 (en) | 2005-04-11 | 2010-10-12 | A variant form of urate oxidase and use thereof |
US13/107,498 US8034594B2 (en) | 2005-04-11 | 2011-05-13 | Variant form of urate oxidase and use thereof |
US13/226,891 US8178334B2 (en) | 2005-04-11 | 2011-09-07 | Variant form of urate oxidase and use thereof |
US13/452,151 US8293228B2 (en) | 2005-04-11 | 2012-04-20 | Variant form of urate oxidase and use thereof |
US13/623,512 US8465735B2 (en) | 2005-04-11 | 2012-09-20 | Variant form of urate oxidase and use thereof |
IL223476A IL223476A (en) | 2005-04-11 | 2012-12-06 | Method of preparing isolated modified uricase |
IL223477A IL223477A (en) | 2005-04-11 | 2012-12-06 | Pharmaceutical composition comprising modified uricase |
IL256157A IL256157B (en) | 2005-04-11 | 2017-12-06 | Method of preparing isolated modified uricase |
IL281228A IL281228A (en) | 2005-04-11 | 2021-03-03 | A variant form of urate oxidase and use thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67054105P | 2005-04-11 | 2005-04-11 | |
US60/670,541 | 2005-04-11 |
Related Child Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/013660 Continuation-In-Part WO2006110819A2 (en) | 2005-04-11 | 2006-04-11 | Variant forms of urate oxidase and use thereof |
US11/918,296 A-371-Of-International US7811800B2 (en) | 2005-04-11 | 2006-04-11 | Variant form of urate oxidase and use thereof |
US11/539,475 Continuation-In-Part US8148123B2 (en) | 2005-04-11 | 2006-10-06 | Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase |
US12/879,084 Division US7964381B2 (en) | 2005-04-11 | 2010-09-10 | Variant form of urate oxidase and use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006110761A2 WO2006110761A2 (en) | 2006-10-19 |
WO2006110761A3 true WO2006110761A3 (en) | 2007-03-08 |
Family
ID=37087650
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/013502 WO2006110761A2 (en) | 2005-04-11 | 2006-04-11 | A variant form of urate oxidase and use thereof |
Country Status (18)
Country | Link |
---|---|
US (6) | US7811800B2 (en) |
EP (2) | EP1871877A2 (en) |
JP (3) | JP2008535499A (en) |
KR (1) | KR101304289B1 (en) |
CN (2) | CN101194016B (en) |
AU (1) | AU2006235437B2 (en) |
BR (1) | BRPI0612942A2 (en) |
CA (1) | CA2604545A1 (en) |
CZ (1) | CZ2007700A3 (en) |
HU (1) | HU229626B1 (en) |
IL (6) | IL186511A (en) |
MX (1) | MX2007012548A (en) |
NZ (1) | NZ562291A (en) |
PL (1) | PL215157B1 (en) |
RU (1) | RU2435847C2 (en) |
SG (3) | SG2014009484A (en) |
TW (1) | TW200716751A (en) |
WO (1) | WO2006110761A2 (en) |
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JP2008535500A (en) | 2005-04-11 | 2008-09-04 | サビエント ファーマセウティカルズ インク. | Mutant urate oxidase and use thereof |
US20080159976A1 (en) * | 2005-04-11 | 2008-07-03 | Jacob Hartman | Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase |
US8148123B2 (en) * | 2005-04-11 | 2012-04-03 | Savient Pharmaceuticals, Inc. | Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase |
CN101622270B (en) * | 2006-04-12 | 2014-01-01 | 萨文特医药公司 | Method for purification of proteins with cationic surfactant |
JP4890133B2 (en) * | 2006-07-20 | 2012-03-07 | 東洋紡績株式会社 | Stable uric acid measurement reagent |
JP4890132B2 (en) * | 2006-07-20 | 2012-03-07 | 東洋紡績株式会社 | Method for improving specific activity of uricase and modified uricase with improved specific activity |
JP4890134B2 (en) * | 2006-07-20 | 2012-03-07 | 東洋紡績株式会社 | Method for improving the stability of uricase, and modified uricase with improved stability |
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CN102051348B (en) | 2009-10-27 | 2012-10-03 | 重庆富进生物医药有限公司 | Humanized recombinant uricase and mutant thereof |
WO2011127393A2 (en) | 2010-04-08 | 2011-10-13 | Georgia Tech Research Corporation | Variants of ancestral uricases and uses thereof |
CN102634492B (en) | 2011-02-14 | 2015-06-10 | 重庆富进生物医药有限公司 | Polyethylene glycol dog source urate oxidase analogue, and preparation method and applications thereof |
CN102827073A (en) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | Therapeutically active compositions and application methods thereof |
US9474779B2 (en) | 2012-01-19 | 2016-10-25 | Agios Pharmaceuticals, Inc. | Therapeutically active compositions and their methods of use |
WO2014170916A2 (en) | 2013-04-17 | 2014-10-23 | Council Of Scientific & Industrial Research | Novel uricase mutants |
JP6529492B2 (en) | 2013-07-11 | 2019-06-12 | アジオス ファーマシューティカルズ, インコーポレイテッド | 2,4- or 4,6-Diaminopyrimidine Compounds as IDH2 Mutant Inhibitors for the Treatment of Cancer |
WO2015003360A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
WO2015003355A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
US9579324B2 (en) | 2013-07-11 | 2017-02-28 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
US20150031627A1 (en) | 2013-07-25 | 2015-01-29 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
AU2015229214B2 (en) | 2014-03-14 | 2019-07-11 | Les Laboratoires Servier | Pharmaceutical compositions of therapeutically active compounds |
AU2016265677B2 (en) * | 2015-05-15 | 2021-12-09 | Medimmune, Llc | Improved uricase sequences and methods of treatment |
CN106554948B (en) * | 2015-09-29 | 2019-06-25 | 上海生物制品研究所有限责任公司 | Saltant type uricase, the saltant type uricase of PEG modification and its application |
BR112018007656A2 (en) | 2015-10-15 | 2018-11-06 | Agios Pharmaceuticals Inc | combination therapy for treatment of malignant diseases |
CA3216701A1 (en) | 2015-10-15 | 2017-04-20 | Les Laboratoires Servier | Combination therapy for treating malignancies |
CN116637177A (en) | 2016-11-11 | 2023-08-25 | 好利恩治疗美国公司 | Combination therapy of prednisone and uricase molecules and uses thereof |
US10980788B2 (en) | 2018-06-08 | 2021-04-20 | Agios Pharmaceuticals, Inc. | Therapy for treating malignancies |
CN109207479A (en) * | 2018-09-07 | 2019-01-15 | 大连大学 | Marine low temperature urate oxidase promoter and terminator |
CN111088268B (en) * | 2019-03-05 | 2022-08-02 | 北京锦篮基因科技有限公司 | Gene therapy medicine for hyperuricemia |
CN113244412B (en) * | 2021-06-25 | 2021-10-26 | 深圳市瑞吉生物科技有限公司 | Medicine for treating hyperuricemia or gout based on mRNA dosage form and preparation method thereof |
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