WO2006105414A3 - Apparatus and method for detecting microscopic organisms using microphage - Google Patents

Apparatus and method for detecting microscopic organisms using microphage Download PDF

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Publication number
WO2006105414A3
WO2006105414A3 PCT/US2006/011955 US2006011955W WO2006105414A3 WO 2006105414 A3 WO2006105414 A3 WO 2006105414A3 US 2006011955 W US2006011955 W US 2006011955W WO 2006105414 A3 WO2006105414 A3 WO 2006105414A3
Authority
WO
WIPO (PCT)
Prior art keywords
phage
microorganisms
target
microphage
signal
Prior art date
Application number
PCT/US2006/011955
Other languages
French (fr)
Other versions
WO2006105414A2 (en
Inventor
Kent J Vorhees
Jon Rees
Original Assignee
Colorado School Of Mines
Kent J Vorhees
Jon Rees
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Colorado School Of Mines, Kent J Vorhees, Jon Rees filed Critical Colorado School Of Mines
Publication of WO2006105414A2 publication Critical patent/WO2006105414A2/en
Publication of WO2006105414A3 publication Critical patent/WO2006105414A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • G01N33/54387—Immunochromatographic test strips
    • G01N33/54388—Immunochromatographic test strips based on lateral flow
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria

Abstract

Methods and apparatus are provided for detection of microorganisms in a sample. Methods and apparatus of the invention are based on the specificity that phage, for example bacteriophage, have for target microorganisms, for example bacterium. Typically, phage adsorption to target microorganisms act as signal, or a signal target, for the presence of the target microorganism. Typically, the phage are labeled with a detectable signal. Apparatus of the invention are directed toward concentrating the phage adsorbed microorganisms at a predetermined site for flag dependent observation.
PCT/US2006/011955 2005-03-31 2006-03-31 Apparatus and method for detecting microscopic organisms using microphage WO2006105414A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66729105P 2005-03-31 2005-03-31
US60/667,291 2005-03-31

Publications (2)

Publication Number Publication Date
WO2006105414A2 WO2006105414A2 (en) 2006-10-05
WO2006105414A3 true WO2006105414A3 (en) 2007-05-10

Family

ID=36764372

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2006/012371 WO2006105504A1 (en) 2005-03-31 2006-03-31 Apparatus and method for detecting microorganisms using flagged bacteriophage
PCT/US2006/011955 WO2006105414A2 (en) 2005-03-31 2006-03-31 Apparatus and method for detecting microscopic organisms using microphage

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2006/012371 WO2006105504A1 (en) 2005-03-31 2006-03-31 Apparatus and method for detecting microorganisms using flagged bacteriophage

Country Status (2)

Country Link
US (1) US8092990B2 (en)
WO (2) WO2006105504A1 (en)

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US8216780B2 (en) 2002-04-12 2012-07-10 Microphage (Tm) Incorporated Method for enhanced sensitivity in bacteriophage-based diagnostic assays
ES2346424T3 (en) * 2002-04-12 2010-10-15 Colorado School Of Mines PROCEDURE FOR DETECTION OF LOW CONCENTRATIONS OF A DIANA BACTERIA THAT USES PHAGOS TO INFECT BACTERIAL CELLS DIANA.
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US8697434B2 (en) * 2008-01-11 2014-04-15 Colorado School Of Mines Detection of phage amplification by SERS nanoparticles
US9441204B2 (en) 2008-04-03 2016-09-13 Colorado School Of Mines Compositions and methods for detecting Yersinia pestis bacteria
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EP3562953A1 (en) 2016-12-30 2019-11-06 Quidel Corporation Phage-mediated immunoassay and methods for determining susceptibility of bacteria to antibiotic or probiotic agents
US10768177B2 (en) 2018-08-29 2020-09-08 The United States Of America, As Represented By The Secretary Of Agriculture Bacteriophage-based electrochemical biosensor
FR3110703A1 (en) * 2020-05-20 2021-11-26 Vetophage DEVICE FOR DETECTION OF BACTERIA OF INTEREST
IT202100005363A1 (en) * 2021-03-08 2022-09-08 Inova Biomedical Tech S R L METHOD FOR DETERMINING THE PRESENCE OF A TARGET MICROORGANISM IN A BIOLOGICAL SAMPLE
CN113308484B (en) * 2021-05-08 2023-09-22 扬州大学 M13 phage nano-probe and preparation method thereof

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Also Published As

Publication number Publication date
WO2006105414A2 (en) 2006-10-05
US8092990B2 (en) 2012-01-10
WO2006105504A1 (en) 2006-10-05
US20070059725A1 (en) 2007-03-15

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