WO2006103666A3 - Isolated bid polypeptides, polynucleotides encoding same and antibodies directed thereagainst and methods of using same for inducing cell cycle arrest or apoptosis - Google Patents

Isolated bid polypeptides, polynucleotides encoding same and antibodies directed thereagainst and methods of using same for inducing cell cycle arrest or apoptosis Download PDF

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Publication number
WO2006103666A3
WO2006103666A3 PCT/IL2006/000393 IL2006000393W WO2006103666A3 WO 2006103666 A3 WO2006103666 A3 WO 2006103666A3 IL 2006000393 W IL2006000393 W IL 2006000393W WO 2006103666 A3 WO2006103666 A3 WO 2006103666A3
Authority
WO
WIPO (PCT)
Prior art keywords
same
cell cycle
cycle arrest
bid
apoptosis
Prior art date
Application number
PCT/IL2006/000393
Other languages
French (fr)
Other versions
WO2006103666A2 (en
Inventor
Atan Gross
Rachel Sarig
Iris Kamer
Original Assignee
Yeda Res & Dev
Atan Gross
Rachel Sarig
Iris Kamer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev, Atan Gross, Rachel Sarig, Iris Kamer filed Critical Yeda Res & Dev
Publication of WO2006103666A2 publication Critical patent/WO2006103666A2/en
Publication of WO2006103666A3 publication Critical patent/WO2006103666A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans

Abstract

The present invention relates to a PIKK-phosphorylated BID polypeptide which can be used to induce cell cycle arrest. Specifically, the present invention provides isolated polypeptides comprising a BID amino acid sequence which can be used to induce cell cycle arrest and treat diseases associated with genomic instability. Alternatively, the present invention provides isolated polypeptides comprising a BID amino acid sequence capable of inhibiting the PIKK-mediated phosphorylation of endogenous BID which can be used to induce apoptosis and treat cancer.
PCT/IL2006/000393 2005-03-28 2006-03-29 Isolated bid polypeptides, polynucleotides encoding same and antibodies directed thereagainst and methods of using same for inducing cell cycle arrest or apoptosis WO2006103666A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66538305P 2005-03-28 2005-03-28
US60/665,383 2005-03-28

Publications (2)

Publication Number Publication Date
WO2006103666A2 WO2006103666A2 (en) 2006-10-05
WO2006103666A3 true WO2006103666A3 (en) 2007-03-08

Family

ID=37053783

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2006/000393 WO2006103666A2 (en) 2005-03-28 2006-03-29 Isolated bid polypeptides, polynucleotides encoding same and antibodies directed thereagainst and methods of using same for inducing cell cycle arrest or apoptosis

Country Status (1)

Country Link
WO (1) WO2006103666A2 (en)

Cited By (7)

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Publication number Priority date Publication date Assignee Title
US8859723B2 (en) 2010-08-13 2014-10-14 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US8889632B2 (en) 2007-01-31 2014-11-18 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
US8927500B2 (en) 2012-02-15 2015-01-06 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US8987414B2 (en) 2012-02-15 2015-03-24 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
US9273099B2 (en) 2003-11-05 2016-03-01 President And Fellows Of Harvard College Stabilized alpha helical peptides and uses thereof
US9394336B2 (en) 2008-09-22 2016-07-19 Aileron Therapeutics, Inc. Methods for preparing purified polypeptide compositions
US9522947B2 (en) 2011-10-18 2016-12-20 Aileron Therapeutics, Inc. Peptidomimetic macrocycles

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US7192713B1 (en) 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
KR101623985B1 (en) 2007-03-28 2016-05-25 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 Stitched polypeptides
EP2152294B1 (en) 2007-05-02 2017-07-26 Dana-Farber Cancer Institute, Inc. A bad bh3 domain peptide for use in treating or delaying the onset of diabetes.
EP2242503A4 (en) 2008-02-08 2012-04-25 Aileron Therapeutics Inc Therapeutic peptidomimetic macrocycles
EP2356139A4 (en) 2008-07-23 2013-01-09 Harvard College Ligation of stapled polypeptides
AU2009294877C1 (en) 2008-09-22 2015-05-07 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
EP2352507A4 (en) 2008-11-24 2012-04-25 Aileron Therapeutics Inc Peptidomimetic macrocycles with improved properties
BRPI1006139A2 (en) 2009-01-14 2017-05-30 Aileron Therapeutics Inc peptidomimetic macrocycles
WO2010116375A1 (en) * 2009-04-08 2010-10-14 Yeda Research And Development Co. Ltd. Isolated peptides for regulating apoptosis
US9163330B2 (en) 2009-07-13 2015-10-20 President And Fellows Of Harvard College Bifunctional stapled polypeptides and uses thereof
CA2774973A1 (en) 2009-09-22 2011-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
WO2012040459A2 (en) 2010-09-22 2012-03-29 President And Fellows Of Harvard College Beta-catenin targeting peptides and uses thereof
WO2012174423A1 (en) 2011-06-17 2012-12-20 President And Fellows Of Harvard College Stabilized polypeptides as regulators of rab gtpase function
CA3113959A1 (en) 2012-09-26 2014-04-03 President And Fellows Of Harvard College Proline-locked stapled peptides and uses thereof
MX2015005244A (en) 2012-11-01 2015-07-14 Aileron Therapeutics Inc Disubstituted amino acids and methods of preparation and use thereof.
EP2991665A4 (en) 2013-03-13 2016-11-09 Harvard College Stapled and stitched polypeptides and uses thereof
KR20160019547A (en) 2013-06-14 2016-02-19 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 Stabilized polypeptide insulin receptor modulators
JP6759109B2 (en) 2014-05-21 2020-09-23 プレジデント アンド フェローズ オブ ハーバード カレッジ RAS inhibitory peptides and their use
WO2016049359A1 (en) 2014-09-24 2016-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
MX2017003819A (en) 2014-09-24 2017-06-15 Aileron Therapeutics Inc Peptidomimetic macrocycles and formulations thereof.
WO2016154058A1 (en) 2015-03-20 2016-09-29 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
CN108368161A (en) 2015-09-10 2018-08-03 艾瑞朗医疗公司 Peptidomimetic macrocyclic compound as MCL-1 conditioning agents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KAMER ET AL.: "Proapoptotic BID is an ATM effector in the DNA-Damage Response", CELL, vol. 122, 25 August 2005 (2005-08-25), pages 593 - 603, XP003002484 *
ZINKEL ET AL.: "A role for proapoptotic BID in the DNA-Damage response", CELL, vol. 122, 26 August 2005 (2005-08-26), pages 579 - 591, XP003002485 *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9273099B2 (en) 2003-11-05 2016-03-01 President And Fellows Of Harvard College Stabilized alpha helical peptides and uses thereof
US9464115B2 (en) 2003-11-05 2016-10-11 Dana-Farber Cancer Institute, Inc. Stabilized alpha helical peptides and uses thereof
US8889632B2 (en) 2007-01-31 2014-11-18 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
US9527896B2 (en) 2007-01-31 2016-12-27 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
US9394336B2 (en) 2008-09-22 2016-07-19 Aileron Therapeutics, Inc. Methods for preparing purified polypeptide compositions
US8859723B2 (en) 2010-08-13 2014-10-14 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US9522947B2 (en) 2011-10-18 2016-12-20 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US8927500B2 (en) 2012-02-15 2015-01-06 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US8987414B2 (en) 2012-02-15 2015-03-24 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
US9505804B2 (en) 2012-02-15 2016-11-29 Aileron Therapeutics, Inc. Peptidomimetic macrocycles

Also Published As

Publication number Publication date
WO2006103666A2 (en) 2006-10-05

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