WO2006098744A3 - Ifbm’s to promote attachment of target analytes - Google Patents

Ifbm’s to promote attachment of target analytes Download PDF

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Publication number
WO2006098744A3
WO2006098744A3 PCT/US2005/021270 US2005021270W WO2006098744A3 WO 2006098744 A3 WO2006098744 A3 WO 2006098744A3 US 2005021270 W US2005021270 W US 2005021270W WO 2006098744 A3 WO2006098744 A3 WO 2006098744A3
Authority
WO
WIPO (PCT)
Prior art keywords
ifbm
implant
module
coating
target analytes
Prior art date
Application number
PCT/US2005/021270
Other languages
French (fr)
Other versions
WO2006098744A2 (en
Inventor
Paul T Hamilton
Mark W Grinstaff
Daniel J Kenan
Dale J Christensen
Wayne Fl Beyer Jr
Robin Hyde-Deruyscher
Ray Edward Benson
Original Assignee
Affinergy Inc
Paul T Hamilton
Mark W Grinstaff
Daniel J Kenan
Dale J Christensen
Wayne Fl Beyer Jr
Robin Hyde-Deruyscher
Ray Edward Benson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affinergy Inc, Paul T Hamilton, Mark W Grinstaff, Daniel J Kenan, Dale J Christensen, Wayne Fl Beyer Jr, Robin Hyde-Deruyscher, Ray Edward Benson filed Critical Affinergy Inc
Priority to EP05857694A priority Critical patent/EP1793875B9/en
Priority to DE602005020320T priority patent/DE602005020320D1/en
Priority to AT05857694T priority patent/ATE462451T1/en
Priority to JP2007516728A priority patent/JP2008504850A/en
Priority to CA002569864A priority patent/CA2569864A1/en
Publication of WO2006098744A2 publication Critical patent/WO2006098744A2/en
Publication of WO2006098744A3 publication Critical patent/WO2006098744A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings

Abstract

The present invention provides an improved coating for surfaces of medical implants. The coating comprises at least one interfacial biomaterial (IFBM) which is comprised of at least one binding module that binds to the surface of an implant or implant-related material (“implant module”) and at least one binding module that selectively binds to a target analyte or that is designed to have a desired effect (“analyte module”). The modules are connected by a linker. In some embodiments, the IFBM coating acts to promote the recognition and attachment of target analytes to surface of the device. The IFBM coating improves the performance of implanted medical devices, for example, by promoting osteointegration of the implant.
PCT/US2005/021270 2004-06-16 2005-06-15 Ifbm’s to promote attachment of target analytes WO2006098744A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP05857694A EP1793875B9 (en) 2004-06-16 2005-06-15 Ifbm's to promote attachment of target analytes
DE602005020320T DE602005020320D1 (en) 2004-06-16 2005-06-15 BORDER BIOMATERIALS FOR PROMOTING THE ATTACHMENT OF TARGET ANALYTES
AT05857694T ATE462451T1 (en) 2004-06-16 2005-06-15 INTERFACE BIOMATERIALS TO PROMOTE ADHESION OF TARGET ANALYTES
JP2007516728A JP2008504850A (en) 2004-06-16 2005-06-15 IFBM for promoting specific adhesion of a target analyte to the surface of an orthopedic implant
CA002569864A CA2569864A1 (en) 2004-06-16 2005-06-15 Ifbm's to promote attachment of target analytes

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US58001904P 2004-06-16 2004-06-16
US60/580,019 2004-06-16
US65133805P 2005-02-09 2005-02-09
US60/651,338 2005-02-09
US65174705P 2005-02-10 2005-02-10
US60/651,747 2005-02-10

Publications (2)

Publication Number Publication Date
WO2006098744A2 WO2006098744A2 (en) 2006-09-21
WO2006098744A3 true WO2006098744A3 (en) 2006-11-30

Family

ID=35784316

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2005/021147 WO2006007368A2 (en) 2004-06-16 2005-06-15 Biofunctional coatings
PCT/US2005/021270 WO2006098744A2 (en) 2004-06-16 2005-06-15 Ifbm’s to promote attachment of target analytes

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2005/021147 WO2006007368A2 (en) 2004-06-16 2005-06-15 Biofunctional coatings

Country Status (8)

Country Link
US (15) US7572766B2 (en)
EP (4) EP2255832A3 (en)
JP (1) JP2008504850A (en)
AT (1) ATE462451T1 (en)
CA (1) CA2569864A1 (en)
DE (1) DE602005020320D1 (en)
ES (1) ES2342551T3 (en)
WO (2) WO2006007368A2 (en)

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