WO2006093892A3 - Compositions and methods of detecting an analyte by using a nucleic acid hybridization switch probe - Google Patents

Compositions and methods of detecting an analyte by using a nucleic acid hybridization switch probe Download PDF

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Publication number
WO2006093892A3
WO2006093892A3 PCT/US2006/006895 US2006006895W WO2006093892A3 WO 2006093892 A3 WO2006093892 A3 WO 2006093892A3 US 2006006895 W US2006006895 W US 2006006895W WO 2006093892 A3 WO2006093892 A3 WO 2006093892A3
Authority
WO
WIPO (PCT)
Prior art keywords
analyte
probe
detecting
conformation
compositions
Prior art date
Application number
PCT/US2006/006895
Other languages
French (fr)
Other versions
WO2006093892A2 (en
Inventor
Lyle J Arnold Jr
Lizhong Dai
Steven T Brentano
James Russell
Original Assignee
Gen Probe Inc
Lyle J Arnold Jr
Lizhong Dai
Steven T Brentano
James Russell
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Probe Inc, Lyle J Arnold Jr, Lizhong Dai, Steven T Brentano, James Russell filed Critical Gen Probe Inc
Priority to CA002599013A priority Critical patent/CA2599013A1/en
Priority to EP06736254A priority patent/EP1853732A2/en
Priority to AU2006218794A priority patent/AU2006218794A1/en
Priority to JP2007558110A priority patent/JP2008531052A/en
Publication of WO2006093892A2 publication Critical patent/WO2006093892A2/en
Publication of WO2006093892A3 publication Critical patent/WO2006093892A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means

Abstract

Compositions are described for detecting binding of an analyte to a binding partner attached to a nucleic acid hybridization switch probe that includes first and second arm sequences and a support sequence that is at least partially complementary to both arm sequences, allowing the probe under hybridization conditions to form a first conformation in the absence of the analyte and to form a second conformation in the presence of the analyte, and a label associated with the probe that produces a signal that indicates the conformation of the probe. Methods are described for detecting an analyte that forms a specific binding pair with the binding partner attached to the hybridization switch probe, thereby changing the probe from a first to a second conformation that results in a detectable signal that indicates the presence of the analyte in the sample.
PCT/US2006/006895 2005-02-28 2006-02-28 Compositions and methods of detecting an analyte by using a nucleic acid hybridization switch probe WO2006093892A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002599013A CA2599013A1 (en) 2005-02-28 2006-02-28 Compositions and methods of detecting an analyte by using a nucleic acid hybridization switch probe
EP06736254A EP1853732A2 (en) 2005-02-28 2006-02-28 Compositions and methods of detecting an analyte by using a nucleic acid hybridization switch probe
AU2006218794A AU2006218794A1 (en) 2005-02-28 2006-02-28 Compositions and methods of detecting an analyte by using a nucleic acid hybridization switch probe
JP2007558110A JP2008531052A (en) 2005-02-28 2006-02-28 Composition and method for detecting an analyte using a nucleic acid hybridization switch probe

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65752305P 2005-02-28 2005-02-28
US60/657,523 2005-02-28

Publications (2)

Publication Number Publication Date
WO2006093892A2 WO2006093892A2 (en) 2006-09-08
WO2006093892A3 true WO2006093892A3 (en) 2006-12-14

Family

ID=36926791

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/006895 WO2006093892A2 (en) 2005-02-28 2006-02-28 Compositions and methods of detecting an analyte by using a nucleic acid hybridization switch probe

Country Status (6)

Country Link
US (1) US20060194240A1 (en)
EP (1) EP1853732A2 (en)
JP (1) JP2008531052A (en)
AU (1) AU2006218794A1 (en)
CA (1) CA2599013A1 (en)
WO (1) WO2006093892A2 (en)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1937847A2 (en) 2005-10-17 2008-07-02 Gen-Probe Incorporated Compositions and methods to detect legionella pneumophila nucleic acid
ATE514794T1 (en) * 2006-05-12 2011-07-15 Gen Probe Inc COMPOSITIONS AND METHODS FOR THE DETECTION OF ENTEROCOCCAL NUCLEIC ACIDS
EP2121956B1 (en) 2006-12-21 2016-08-17 Gen-Probe Incorporated Methods and compositions for nucleic acid amplification
JP5223237B2 (en) * 2007-05-14 2013-06-26 ソニー株式会社 Method for detecting binding or interaction between nucleic acid strand for detection and substance
WO2009085704A2 (en) 2007-12-26 2009-07-09 Gen-Probe Incorporated Compositions and methods to detect candida albicans nucleic acid
JP5463621B2 (en) * 2008-02-27 2014-04-09 ソニー株式会社 Target substance quantification method
WO2010011884A2 (en) * 2008-07-25 2010-01-28 University Of Florida Research Foundation, Inc. Novel nucleic acid-based molecular probes
US20110200529A1 (en) * 2008-09-17 2011-08-18 Stanford University Activatable bioluminescent probe system and method of use thereof
EP2446057B1 (en) 2009-06-23 2014-11-19 Gen-Probe Incorporated Compositions and methods for detecting nucleic acid from mollicutes
US9169512B2 (en) 2009-07-01 2015-10-27 Gen-Probe Incorporated Methods and compositions for nucleic acid amplification
US20110151439A1 (en) * 2009-12-18 2011-06-23 United States Government As Represented By The Secretary Of The Army System and method for the rapid identification of biological and chemical analytes
WO2011103274A1 (en) 2010-02-17 2011-08-25 Gen-Probe Incorporated Compositions and methods to detect atopobium vaginae nucleic acid
CN103108952A (en) * 2010-09-01 2013-05-15 日本电气株式会社 Method for detecting target substance, aptamer set used therefor, sensor, and device
EP2683833B1 (en) 2011-03-10 2018-09-26 Gen-Probe Incorporated Methods for the selection and optimization of oligonucleotide tag sequences
EP3272886B1 (en) 2011-04-25 2019-09-25 Gen-Probe Incorporated Compositions and methods for detecting bv-associated bacterial nucleic acid
CA2835942C (en) 2011-05-19 2019-01-22 Sequenom, Inc. Products and processes for multiplex nucleic acid identification
US9663829B2 (en) 2011-09-08 2017-05-30 Gen-Probe Incorporated Compositions and methods for detecting BV-associated bacterial nucleic acid
EP2758547B1 (en) 2011-09-21 2015-09-16 Gen-Probe Incorporated Methods for amplifying nucleic acid using tag-mediated displacement
ES2761920T3 (en) 2012-08-30 2020-05-21 Gen Probe Inc Multiphasic nucleic acid amplification
AU2013205122B2 (en) 2012-10-11 2016-11-10 Gen-Probe Incorporated Compositions and Methods for Detecting Human Papillomavirus Nucleic Acid
WO2015023892A1 (en) 2013-08-14 2015-02-19 Gen-Probe Incorporated Compositions and methods for detecting hev nucleic acid
GB2559919B (en) 2014-02-28 2018-11-14 Gen Probe Inc Method of isolating nucleic acid from specimens in liquid-based cytology preservatives containing formaldehyde
USRE48665E1 (en) 2014-02-28 2021-08-03 Gen-Probe Incorporated Method of isolating nucleic acid from specimens in liquid-based cytology preservatives containing formaldehyde
DE102015220401B4 (en) 2014-10-20 2022-12-29 Gen-Probe Incorporated Erythrocyte Lysis Solution
WO2016112252A1 (en) 2015-01-09 2016-07-14 Gen-Probe Incorporated Methods and compositions for diagnosing bacterial vaginosis
US10550438B2 (en) 2015-03-16 2020-02-04 Gen-Probe Incorporated Methods and compositions for detecting bacterial nucleic acid
CN107787371B (en) 2015-04-24 2022-02-01 基纳生物技术有限公司 Parallel method for detecting and quantifying minor variants
AU2016250841A1 (en) 2015-04-24 2017-11-02 Agena Bioscience, Inc. Multiplexed method for the identification and quantitation of minor alleles and polymorphisms
AU2017205399C1 (en) 2016-01-04 2023-06-15 Gen-Probe Incorporated Methods and compositions for detecting Candida species
WO2017139409A1 (en) * 2016-02-09 2017-08-17 Children's Medical Center Corporation Method for detection of analytes via polymer complexes
AU2017257978B2 (en) 2016-04-27 2022-12-22 Gen-Probe Incorporated Blood cell lysis reagent
AU2017278065B2 (en) 2016-06-10 2020-09-10 Gen-Probe Incorporated Compositions and methods for detecting Zika virus nucleic acid
CA3040907A1 (en) 2016-10-19 2018-04-26 Gen-Probe Incorporated Compositions and methods for detecting or quantifying hepatitis c virus
JP7125395B2 (en) 2016-11-21 2022-08-24 ジェン－プローブ・インコーポレーテッド Compositions and methods for detecting or quantifying hepatitis B virus
WO2018175883A1 (en) 2017-03-24 2018-09-27 Gen-Probe Incorporated Compositions and methods for detecting or quantifying parainfluenza virus
WO2018183124A1 (en) 2017-03-25 2018-10-04 Gen-Probe Incorporated Compositions, methods and kits to detect adenovirus, metapneumovirus and/or rhinovirus nucleic acids
WO2018226798A1 (en) 2017-06-07 2018-12-13 Gen-Probe Incorporated Detecting babesia species nucleic acid in a sample
WO2019032809A1 (en) 2017-08-11 2019-02-14 Gen-Probe Incorporated Compositions and methods for detecting staphylococcus aureus
CA3082909C (en) 2017-11-17 2023-07-25 Gen-Probe Incorporated Compositions and methods for detecting c1orf43 nucleic acid
US20200318171A1 (en) 2017-12-15 2020-10-08 Gen-Probe Incorporated Compositions and Methods for Detecting Toxigenic Clostridium Difficile
GB2597567B (en) 2018-06-13 2022-11-23 Gen Probe Inc Compositions and methods for detecting group B streptococcus nucleic acid
EP3830302B1 (en) 2018-08-01 2022-10-05 Gen-Probe Incorporated Compositions and methods for detecting nucleic acids of epstein-barr virus
AU2019326462A1 (en) 2018-08-21 2021-03-25 Gen-Probe Incorporated Compositions and methods for amplifying, detecting or quantifying human cytomegalovirus
CA3108906A1 (en) 2018-08-24 2020-02-27 Gen-Probe Incorporated Compositions and methods for detecting bacterial nucleic acid and diagnosing bacterial vaginosis
WO2020069085A2 (en) 2018-09-27 2020-04-02 Gen-Probe Incorporated Compositions and methods for detecting bordetella pertussis and bordetella parapertussis nucleic acid
JP2022508954A (en) 2018-10-22 2022-01-19 ジェン－プローブ・インコーポレーテッド Compositions and Methods for Amplifying, Detecting or Quantifying Human Polyomavirus BK Virus
TW202030333A (en) 2018-12-20 2020-08-16 美商簡 探針公司 Compositions and methods for detecting plasmodium species nucleic acid
EP3914732A1 (en) 2019-01-25 2021-12-01 Gen-Probe Incorporated Detection of drug-resistant mycoplasma genitalium
US20220098647A1 (en) 2019-03-22 2022-03-31 Gen-Probe Incorporated Compositions and Methods for Detecting Group A Streptococcus
CN114096683A (en) 2019-07-03 2022-02-25 简·探针公司 Oligonucleotides for determining the presence of Trichomonas vaginalis in a sample
WO2021178644A1 (en) 2020-03-04 2021-09-10 Gen-Probe Incorporated Compositions and methods for detecting sars-cov-2 nucleic acid
US20230220499A1 (en) 2020-05-07 2023-07-13 Grifols Diagnostic Solutions Inc. Methods and compositions for detecting sars-cov-2 nucleic acid
AU2022273052A1 (en) 2021-05-14 2023-11-30 Gen-Probe Incorporated Compositions and methods for detecting human adenovirus nucleic acid
AU2022304654A1 (en) 2021-07-01 2023-12-14 Gen-Probe Incorporated Enzyme formulations and reaction mixtures for nucleic acid amplification
AU2022319876A1 (en) 2021-07-27 2024-01-18 Gen-Probe Incorporated Compositions and methods for detecting gastrointestinal pathogens
WO2024054924A1 (en) 2022-09-08 2024-03-14 Gen-Probe Incorporated Method of detecting nucleic acid analytes using dual-specificity primers
WO2024081776A1 (en) 2022-10-13 2024-04-18 Gen-Probe Incorporated Cellularity control for nucleic acid assays

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150097A (en) * 1996-04-12 2000-11-21 The Public Health Research Institute Of The City Of New York, Inc. Nucleic acid detection probes having non-FRET fluorescence quenching and kits and assays including such probes
US6361945B1 (en) * 1998-07-02 2002-03-26 Gen-Probe Incorporated Molecular torches
US6399302B1 (en) * 1998-08-21 2002-06-04 University Of Virginia Patent Foundation Signal generating oligonucleotide-based biosensor
WO2004033476A1 (en) * 2002-10-11 2004-04-22 Ahram Biosystems Inc. Target detection system having a conformationally sensitive probe comprising a nucleic acid based signal transducer

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5283174A (en) * 1987-09-21 1994-02-01 Gen-Probe, Incorporated Homogenous protection assay
US5118801A (en) * 1988-09-30 1992-06-02 The Public Health Research Institute Nucleic acid process containing improved molecular switch
CA2020958C (en) * 1989-07-11 2005-01-11 Daniel L. Kacian Nucleic acid sequence amplification methods
US5215899A (en) * 1989-11-09 1993-06-01 Miles Inc. Nucleic acid amplification employing ligatable hairpin probe and transcription
EP0601889A2 (en) * 1992-12-10 1994-06-15 Maine Medical Center Research Institute Nucleic acid probes
US5925517A (en) * 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5538848A (en) * 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US5556752A (en) * 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
WO1996034983A1 (en) * 1995-05-05 1996-11-07 The Perkin-Elmer Corporation Methods and reagents for combined pcr amplification and hybridization probing assay
US6361940B1 (en) * 1996-09-24 2002-03-26 Qiagen Genomics, Inc. Compositions and methods for enhancing hybridization and priming specificity
US5989823A (en) * 1998-09-18 1999-11-23 Nexstar Pharmaceuticals, Inc. Homogeneous detection of a target through nucleic acid ligand-ligand beacon interaction
US6261783B1 (en) * 1997-12-15 2001-07-17 Gilead Sciences, Inc. Homogeneous detection of a target through nucleic acid ligand-ligand beacon interaction
DE1075328T1 (en) * 1998-05-01 2001-10-11 Ammann Kelly G AUTOMATIC DIAGNOSTIC ANALYSIS DEVICE AND METHOD
WO2000024941A1 (en) * 1998-10-27 2000-05-04 Clinical Micro Sensors, Inc. Detection of target analytes using particles and electrodes
ATE439452T1 (en) * 1999-05-07 2009-08-15 Life Technologies Corp METHOD FOR DETECTING ANALYTES USING SEMICONDUCTOR NANOCRYSTALS
US6350580B1 (en) * 2000-10-11 2002-02-26 Stratagene Methods for detection of a target nucleic acid using a probe comprising secondary structure
WO2004098386A2 (en) * 2003-05-01 2004-11-18 Gen-Probe Incorporated Oligonucleotides comprising a molecular switch

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150097A (en) * 1996-04-12 2000-11-21 The Public Health Research Institute Of The City Of New York, Inc. Nucleic acid detection probes having non-FRET fluorescence quenching and kits and assays including such probes
US6361945B1 (en) * 1998-07-02 2002-03-26 Gen-Probe Incorporated Molecular torches
US6399302B1 (en) * 1998-08-21 2002-06-04 University Of Virginia Patent Foundation Signal generating oligonucleotide-based biosensor
WO2004033476A1 (en) * 2002-10-11 2004-04-22 Ahram Biosystems Inc. Target detection system having a conformationally sensitive probe comprising a nucleic acid based signal transducer

Also Published As

Publication number Publication date
JP2008531052A (en) 2008-08-14
US20060194240A1 (en) 2006-08-31
CA2599013A1 (en) 2006-09-08
WO2006093892A2 (en) 2006-09-08
EP1853732A2 (en) 2007-11-14
AU2006218794A1 (en) 2006-09-08

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