WO2006093655B1 - Tethered capsule endoscope for barrett's esophagus screening - Google Patents

Tethered capsule endoscope for barrett's esophagus screening

Info

Publication number
WO2006093655B1
WO2006093655B1 PCT/US2006/004828 US2006004828W WO2006093655B1 WO 2006093655 B1 WO2006093655 B1 WO 2006093655B1 US 2006004828 W US2006004828 W US 2006004828W WO 2006093655 B1 WO2006093655 B1 WO 2006093655B1
Authority
WO
WIPO (PCT)
Prior art keywords
lumen
capsule
tether
light
scanner
Prior art date
Application number
PCT/US2006/004828
Other languages
French (fr)
Other versions
WO2006093655A2 (en
WO2006093655A3 (en
Inventor
Eric Seibel
Michael Kimmey
Richard Johnston
Original Assignee
Univ Washington
Eric Seibel
Michael Kimmey
Richard Johnston
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington, Eric Seibel, Michael Kimmey, Richard Johnston filed Critical Univ Washington
Priority to EP06734808A priority Critical patent/EP1855581A4/en
Priority to JP2007558034A priority patent/JP2008531193A/en
Publication of WO2006093655A2 publication Critical patent/WO2006093655A2/en
Publication of WO2006093655A3 publication Critical patent/WO2006093655A3/en
Publication of WO2006093655B1 publication Critical patent/WO2006093655B1/en

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Classifications

    • A—HUMAN NECESSITIES
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    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00147—Holding or positioning arrangements
    • A61B1/00148—Holding or positioning arrangements using anchoring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00002—Operational features of endoscopes
    • A61B1/00004—Operational features of endoscopes characterised by electronic signal processing
    • A61B1/00009—Operational features of endoscopes characterised by electronic signal processing of image signals during a use of endoscope
    • A61B1/000094—Operational features of endoscopes characterised by electronic signal processing of image signals during a use of endoscope extracting biological structures
    • A—HUMAN NECESSITIES
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    • A61B1/00002—Operational features of endoscopes
    • A61B1/00043—Operational features of endoscopes provided with output arrangements
    • A61B1/00055—Operational features of endoscopes provided with output arrangements for alerting the user
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00064—Constructional details of the endoscope body
    • A61B1/00071—Insertion part of the endoscope body
    • A61B1/0008—Insertion part of the endoscope body characterised by distal tip features
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B1/00087—Tools
    • A—HUMAN NECESSITIES
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    • A61B1/00163—Optical arrangements
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    • A61B1/012—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor characterised by internal passages or accessories therefor
    • A61B1/015—Control of fluid supply or evacuation
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    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/041—Capsule endoscopes for imaging
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    • A61B1/0638—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements providing two or more wavelengths
    • A—HUMAN NECESSITIES
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    • A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/0661—Endoscope light sources
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    • A61B1/07—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
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    • A61B1/273—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the upper alimentary canal, e.g. oesophagoscopes, gastroscopes
    • A61B1/2733—Oesophagoscopes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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    • A61B5/42—Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
    • A61B5/4222—Evaluating particular parts, e.g. particular organs
    • A61B5/4233—Evaluating particular parts, e.g. particular organs oesophagus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A61N5/0603—Apparatus for use inside the body for treatment of body cavities
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
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    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00064—Constructional details of the endoscope body
    • A61B1/00071—Insertion part of the endoscope body
    • A61B1/0008—Insertion part of the endoscope body characterised by distal tip features
    • A61B1/00097—Sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A61B5/0068—Confocal scanning
    • A—HUMAN NECESSITIES
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    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
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    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14556—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases by fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
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    • A61N5/0601—Apparatus for use inside the body
    • A61N5/0603—Apparatus for use inside the body for treatment of body cavities
    • A61N2005/0609—Stomach and/or esophagus

Abstract

Capsule (20) is coupled to a tether (22) that is manipulated to position the capsule and a scanner (26) included within the capsule at desired location within a lumen in a patient's body. Images produced by scanner can be used to detect Barrett's Esophagus (BE) and early (asymptomatic) esophageal cancer after capsule is swallowed and positioned with the tether to enable the scanner in the capsule to scan a region of the esophagus above the stomach to detect a characteristic dark pink color indicative of BE. The scanner moves in a desired pattern to illuminate a portion of the inner surface. Light from the inner surface is then received by detectors in the capsule, or conveyed externally through a waveguide to external detectors. Electrical signals are applied to energize an actuator (28) that moves the scanner. The capsule can also be used for diagnostic and/or therapeutic purposes in other lumens.

Claims

45AMENDED CLAIMS received by the International Bureau on 06 August 2007 (06.08.2007)The invention in which an exclusive right is claimed is defined by the following:
1. Apparatus for imaging an inner surface of a lumen in a patient's body, comprising:
(a) a capsule housing that is sized to readily pass through the lumen, the capsule housing having at least an imaging portion that is optically transparent;
(b) a light source;
(c) a scanner disposed within the capsule housing and coupled to the light source, the scanner having an actuator that drives the scanner to scan an inner surface of a lumen in a patient's body in a desired scanning pattern with a beam of light from the scanner;
(d) at least one light sensor that responds to light that has been reflected from an inner surface of a lumen, producing an electrical signal that is indicative of an intensity of the light;
(e) an optical system that focuses the light emitted from the scanner onto a portion of an inner surface of a lumen in a patient's body; and
(f) a flexible tether that is connected to the capsule housing and which extends proximally through a lumen to enable a force to be applied to the capsule housing to control a movement of the capsule housing, wherein the flexible tether is of sufficient strength to retract the capsule housing from the lumen but is too flexible to force the capsule housing distally through the lumen.
2. The apparatus of Claim 1, wherein the at least one light sensor is disposed external to the capsule housing, the light reflected from an inner surface of a lumen being conveyed through an optically transmissive channel included within the tether to the at least one light sensor.
3. The apparatus of Claim 2, wherein the optically transmissive channel comprises one of:
(a) a core of an optical fiber that comprises the tether;
(b) a core of an optical fiber that also conveys light from the light source through the tether and into the capsule housing; and
(c) a cladding of an optical fiber that comprises the tether. 46
4. The apparatus of Claim 1, wherein the at least one light sensor is disposed within the capsule housing, the light reflected from an inner surface of a lumen being received by the at least one light sensor, causing a corresponding electrical signal to be produced.
5. The apparatus of Claim 4, wherein the tether includes at least one electrical lead that is coupled to the light sensor and conveys the electrical signal from the at least one light sensor to a location that is outside of a lumen in a patient's body.
6. The apparatus of Claim 1, wherein the scanner includes a scanning mirror that is driven by the actuator to reflect the light produced by the light source, in the desired scanning pattern.
7. The apparatus of Claim 1, wherein the scanner comprises a waveguide that is driven to move by the actuator, so that the waveguide emits light from a distal end of the waveguide, to scan in the desired pattern.
8. The apparatus of Claim 1, further comprising a pressure sensor disposed on the capsule housing for monitoring a pressure applied to the capsule, the pressure sensor producing a pressure signal indicative of the pressure applied to the capsule housing.
9. The apparatus of Claim 1, further comprising a location sensor for monitoring a location of the capsule housing within a lumen relative to a reference point.
10. The apparatus of Claim 1, further comprising a chemical sensor for monitoring at least one chemical parameter from within a lumen of a patient's body.
11. The apparatus of Claim 1 , further comprising means for performing a biopsy to take a tissue sample at a desired site within a lumen of a patient's body. 47
12. The apparatus of Claim 1, further comprising at least one electrical contact disposed on an exterior of the capsule housing, to stimulate a muscle in a wall of a lumen of a patient's body in which the capsule housing is disposed, to promote peristalsis that moves the capsule housing through a lumen.
13. The apparatus of Claim 1, wherein the tether includes a plurality of scale markings that serve to enable a user to measure a distance traveled by the capsule housing into a lumen of a patient's body.
14. The apparatus of Claim 1, further comprising a rotary component engaged by the tether that is rotated as the capsule housing moves through a lumen of a patient's body, the rotary component being used to provide an indication of a distance traveled by the capsule housing into a lumen.
15. The apparatus of Claim 14, wherein a lumen comprises an esophagus of a patient's body, further comprising a bite bar that is adapted to be disposed in a mouth of a patient to support the rotary component, so as to ensure a reproducible tracking of the distance through which the capsule housing moves within an esophagus.
16. The apparatus of Claim 14, further comprising a selectively releasable joint for connecting to the tether and disposed at least at one of:
(a) adjacent to the capsule housing; and
(b) adjacent to the bite bar.
17. The apparatus of Claim 1, wherein the optics system includes at least one reflective surface for directing the light emitted from the scanner laterally to a side of the capsule housing.
18. The apparatus of Claim 1, wherein the optical system includes at least one lens disposed between the scanner and the imaging portion of the capsule.
19. The apparatus of Claim 1, wherein the imaging portion of the capsule is disposed at a distal end of the capsule housing, the tether being connected to a proximal end of the capsule housing.
20. The apparatus of Claim 1, wherein the optical system includes at least one filter that is disposed so as to filter light that is one of:
(a) produced by the scanner and directed to an internal surface of a lumen; and
(b) reflected from an internal surface of a lumen before the light is sensed by the at least one light sensor.
21. The apparatus of Claim 1 , wherein the scanner comprises one of:
(a) a single mode optical fiber;
(b) a dual cladding optical fiber;
(c) a single mode optical fiber used for conveying light from the light source, and at least one multimode collection optical fiber for conveying light reflected from an inner surface of a lumen to the at least one light sensor; and
(d) a waveguide comprising a microelectromechanical system (MEMS) device.
22. The apparatus of Claim 1, wherein the scanner comprises one of a waveguide and an optical fiber that is driven by the actuator to move at about a resonant frequency when scanning in the desired pattern.
23. The apparatus of Claim 22, further comprising a feedback sensor for controlling a movement of said one of the waveguide and the optical fiber, so as to substantially reduce any distortion in an image produced by scanning with the light beam produced by said one of the waveguide and the optical fiber.
24. The apparatus of Claim 1, wherein the actuator comprises an electromechanical actuator that produces a driving force in a plurality of orthogonal directions, to achieve the desired pattern for scanning an internal surface of a lumen in a patient's body. 49
25. The apparatus of Claim 1, wherein the at least one light sensor comprises a plurality of light sensors, including light sensors that are responsive to at least one of:
(a) light of different spectral wavebands; and
(b) polarized light.
26. The apparatus of Claim 1, wherein the optical system directs the light emitted by the scanner through the imaging portion of the capsule housing, so that the desired scanning pattern illuminates an interior surface of a lumen over substantially an entire 360 degree arc.
27. The apparatus of Claim 1, further comprising a plurality of scanners disposed within the capsule housing, each scanner including a separate actuator and being configured to scan a different part of an inner surface of a lumen in a patient's body.
28. The apparatus of Claim 27, wherein the plurality of scanners are configured to at least:
(a) increase a field of view compared to a field of view provided by a single scanner;
(b) scan an inner surface of a lumen from opposite ends of the capsule housing;
(c) provide a stereo scan image of an inner surface of a lumen;
(d) perform a diagnostic scan of an inner surface of a lumen using light of a predefined waveband;
(e) provide a therapeutic scan of an inner surface of a lumen using light from at least one of the plurality of scanners;
(f) monitor a state of therapy being applied within a lumen; and
(g) provide illumination used to measure distance between one scanner and an inner surface of a lumen. 50
29. The apparatus of Claim 27, wherein the plurality of scanners are spaced apart in an array within the capsule housing, and wherein the optical system directs the light emitted from each scanner to different parts of an inner surface of a lumen.
30. The apparatus of Claim 1, wherein the capsule housing is sized and configured to be swallowed by a patient with the tether connected thereto.
31. The apparatus of Claim 1, further comprising a data recording medium that receives an electrical signal from the at least one light sensor and stores data corresponding to the electrical signal produced by the at least one light sensor.
32. The apparatus of Claim 31, wherein the data represent a plurality of image frames that are readily combined to provide at least one continuous two- dimensional image of an inner surface of a lumen in a patient's body.
33. The apparatus of Claim 1, further comprising a spectral analyzer that analyzes an electrical signal produced by the at least one light sensor in a desired range that is selected from a waveband range extending from an ultraviolet to an infrared waveband.
51
34. The apparatus of Claim 1, further comprising an inflatable balloon coupled to the capsule, the balloon being inflated to at least one of:
(a) enable peristaltic advancement of the balloon with the capsule through a lumen in a patient's body by forces applied by a lumen on the balloon;
(b) convey a fluid pressure from a wall of a lumen in which the balloon is disposed, to a pressure sensor that enables a pressure exerted thereby on the balloon to be monitored;
(c) to enlarge a cross-sectional size of the balloon and the capsule housing in combination, thereby preventing further movement of the capsule housing through a cross-sectional passage in a patient's body that is smaller than a cross-sectional size of the balloon when the balloon is at least partially inflated; and
(d) generally center the capsule housing within a lumen of a patient's body.
35. The apparatus of Claim 1, further comprising a disconnect that is selectively actuatable to release the capsule housing from the tether.
36. A capsular system for scanning an inner surface of a lumen in a patient's body, comprising:
(a) a housing defining a capsule that is sized to fit within a lumen in a patient's body and to be readily advanced therethrough;
(b) a flexible tether connected to the capsule and having a length sufficient to extend proximally external of a lumen in which the housing is disposed, wherein the flexible tether is of sufficient strength to retract the capsule from the lumen but is too flexible to force the capsule distally through the lumen;
(c) a light source that produces light for illuminating an inner surface of a lumen in which the housing is disposed;
(d) a scanner having an actuator that drives the scanner to scan an inner surface of a lumen in a patient's body in a desired scanning pattern with a beam of light from the scanner; and
(e) a light sensor that receives light reflected from a region of an inner surface of a lumen, producing a signal indicative of an intensity thereof. 52
37. The capsular system of Claim 36, wherein the housing is shaped to facilitate swallowing by a patient down an esophagus, the scanner being used to scan an inner surface of an esophagus to detect a visual change associated with Barrett's Esophagus.
38. The capsular system of Claim 36, further comprising a location sensor disposed within the housing to determine a relative position of the housing within a lumen of a patient's body, including a distance along a lumen traversed by the housing relative to a reference point.
39. The capsular system of Claim 36, wherein the scanner comprises one of a waveguide and an optical fiber, a distal end of the waveguide being driven by the actuator to move and emit a beam of light in the desired pattern.
40. The capsular system of Claim 36, wherein the scanner further includes an optical system having at least one lens disposed within the housing to modify the light emitted from the distal end of the waveguide so as to facilitate scanning a desired region of an inner surface of a lumen in which the housing is disposed.
41. The capsular system of Claim 40, further comprising a plurality of scanners disposed within the housing, each scanner being directed to scan a different portion of an inner surface of a lumen in which the housing is disposed.
42. The capsular system of Claim 36, wherein the light sensor is responsive to at least one of:
(a) white light;
(b) visible light within a specific waveband;
(c) non-visible light within a specific waveband; and
(d) polarized light. 53
43. A method for scanning an inner surface of a lumen in a patient's body, comprising the steps of:
(a) introducing a capsule that includes a scanner into the lumen, the capsule further including a tether coupled to the capsule;
(b) enabling the capsule to advance through the lumen, with a proximal end of the tether remaining outside the lumen;
(c) controlling a disposition of the capsule within the lumen by exerting a force on the tether;
(d) producing an image of the inner surface of the lumen with the scanner; and
(e) reproducibly tracking a distance through which the capsule moves within the lumen.
44. The method of Claim 43, wherein the step of controlling a disposition comprises the step of using the tether to position the capsule to scan a desired region in the lumen with the scanner.
45. The method of Claim 43, wherein the step of enabling the capsule to advance comprises the step of enabling a peristaltic movement of muscle tissue comprising walls of the lumen to move the capsule through the lumen.
46. The method of Claim 45, wherein the step of enabling the capsule to advance further comprises the step of inflating a balloon around the capsule so that the muscle tissue interacts with the balloon to advance the capsule through the lumen.
54
47. The method of Claim 43, further comprising the step of exciting the muscle tissue with an electrical current applied through a conductor disposed on at least one of the capsule and the tether, the electrical current causing a peristaltic movement of muscle tissue so as to at least one of:
(a) advance the capsule through the lumen;
(b) change a portion of the inner surface of the lumen that is imaged with the scanner by causing relative movement between the capsule and the inner surface; and
(c) diagnose an abnormal medical condition of the inner surface of the lumen by detecting a portion of the inner surface that is substantially less contractile in response to the electrical current, compared to normal tissue comprising the inner surface.
48. The method of Claim 43, wherein the lumen comprises an esophagus of a patient, and wherein the step of introducing the capsule comprises the step of enabling the patient to swallow the capsule with a liquid.
49. The method of Claim 43, further comprising the step of analyzing the image with a spectral analyzer that responds to a range of wavelengths from an ultraviolet waveband to an infrared waveband.
50. The method of Claim 43, further comprising the step of determining a position of the capsule within the lumen by at least one of:
(a) sensing a signal indicative of the position of the capsule within the lumen;
(b) measuring a length of the tether that has been advanced into the lumen; and
(c) determining the position based upon a content of the image that is produced that indicates one of an anatomical feature and a medical condition within the lumen.
51. The method of Claim 43, further comprising the step of administering a therapy to the lumen using the capsule. 55
52. The method of Claim 43, further comprising the steps of:
(a) producing a plurality of overlapping images with the scanner; and
(b) combining the plurality of overlapping images to produce a composite image of a substantially larger area than is encompassed by a single image.
53. The method of Claim 43, further comprising the step of employing a plurality of scanners disposed in the capsule to achieve at least one of the following results:
(a) scanning different regions of the lumen with each of the plurality of scanners;
(b) producing a stereoscopic view of an inner surface of the lumen;
(c) implementing a diagnostic function by detecting light hi different wavebands received from the inner surface of the lumen;
(d) rendering a therapeutic function;
(e) monitoring the lumen for at least one of controlling a therapy being rendered, and assessing a condition of the lumen after the therapy has been administered; and
(f) providing additional illumination for imaging the interior surface of the lumen.
54. The method of Claim 43, further comprising the step of employing a sensor associated with the capsule for monitoring a parameter related to the lumen.
55. The method of Claim 54, wherein the parameter comprises one of:
(a) a chemical level;
(b) a pressure exerted by walls of the lumen; and
(c) a temperature. 56
56. The method of Claim 43, further comprising the step of enabling a user to enable the capsule to pass through the lumen without further constraint from the tether by one of the steps of:
(a) releasing a proximal end of the tether so that the tether and the capsule move through the lumen; and
(b) releasing the capsule from the tether so that the capsule can move through the lumen.
57. The method of Claim 43, further comprising the step of retrieving the capsule by one of the steps of:
(a) enabling the capsule to pass through the lumen and be expelled from the patient's body; and
(b) withdrawing the capsule from the lumen by applying force to the tether.
58. The method of Claim 43, further comprising the step of enabling a user to rotate the capsule by rotating the tether connected thereto.
59. An imaging probe system for producing images of a surface within a body lumen, comprising:
(a) a capsule disposed at a distal end of the imaging probe system, said capsule being sized to enable the capsule to be readily introduced into a body lumen and including an imaging device for producing a signal that is usable to display an image of an inner surface within a body lumen; and
(b) a tether having a proximal end, and a distal end that is coupled to the capsule, said tether being flexible and substantially smaller in diameter than the capsule and being employed for moving the capsule and for conveying signals produced by the imaging device for use in displaying an image of an inner surface of a body lumen.
60. The imaging probe of Claim 59, wherein the tether conveys at least one signal from the capsule toward the proximal end of the tether, wherein the at least one signal is selected from the group consisting of an electrical signal, and an optical signal. 57
61. The imaging probe of Claim 59, wherein the tether conveys at least one signal from the proximal end of the tether to the capsule, wherein the at least one signal is selected from the group consisting of an electrical signal, and an optical signal.
62. The imaging probe of Claim 59, wherein the capsule is sized and configured to enable it to be readily swallowed down an esophagus of a patient, to enable imaging of a wall of an esophagus.
63. The imaging probe of Claim 62, wherein the tether is sufficiently small in cross-sectional size and sufficiently flexible to enable it to readily follow the capsule down an esophagus of a patient when the capsule is swallowed.
64. The imaging probe of Claim 59, further comprising means for monitoring a position of the capsule within a body lumen.
65. The imaging probe of Claim 59, wherein the signal produced by the imaging device in the capsule that enables display of an image of an inner surface of a body lumen is one of an electrical signal conveyed by a conductor disposed in the tether and an optical signal that is conveyed through an optical fiber in the tether, for use in externally displaying the image.
66. The method of Claim 43, wherein the step of reproducibly tracking the distance further comprises the step of providing a rotary component for monitoring a relative position of the capsule within the body lumen, so as to ensure the reproducible tracking of the distance.
PCT/US2006/004828 2005-02-28 2006-02-09 Tethered capsule endoscope for barrett's esophagus screening WO2006093655A2 (en)

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Families Citing this family (329)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8636648B2 (en) 1999-03-01 2014-01-28 West View Research, Llc Endoscopic smart probe
US10973397B2 (en) 1999-03-01 2021-04-13 West View Research, Llc Computerized information collection and processing apparatus
US7134557B2 (en) * 2000-02-04 2006-11-14 Bratten Jack R Lift station and method
US7555333B2 (en) 2000-06-19 2009-06-30 University Of Washington Integrated optical scanning image acquisition and display
ATE454845T1 (en) 2000-10-30 2010-01-15 Gen Hospital Corp OPTICAL SYSTEMS FOR TISSUE ANALYSIS
US9295391B1 (en) 2000-11-10 2016-03-29 The General Hospital Corporation Spectrally encoded miniature endoscopic imaging probe
WO2002088705A2 (en) 2001-05-01 2002-11-07 The General Hospital Corporation Method and apparatus for determination of atherosclerotic plaque type by measurement of tissue optical properties
US9113846B2 (en) 2001-07-26 2015-08-25 Given Imaging Ltd. In-vivo imaging device providing data compression
US7347817B2 (en) * 2001-08-02 2008-03-25 Given Imaging Ltd. Polarized in vivo imaging device, system and method
US7355716B2 (en) 2002-01-24 2008-04-08 The General Hospital Corporation Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
WO2004045374A2 (en) * 2002-11-14 2004-06-03 Ethicon Endo-Surgery, Inc. Methods and devices for detecting tissue cells
US8054468B2 (en) 2003-01-24 2011-11-08 The General Hospital Corporation Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
US7761139B2 (en) * 2003-01-24 2010-07-20 The General Hospital Corporation System and method for identifying tissue using low-coherence interferometry
JP4805142B2 (en) 2003-03-31 2011-11-02 ザ ジェネラル ホスピタル コーポレイション Speckle reduction in optically interfering tomography by combining light of different angles with varying path length
KR20130138867A (en) 2003-06-06 2013-12-19 더 제너럴 하스피탈 코포레이션 Process and apparatus for a wavelength tunning source
KR101321413B1 (en) 2003-10-27 2013-10-22 더 제너럴 하스피탈 코포레이션 Method and apparatus for performing optical imaging using frequency-domain interferometry
US7901348B2 (en) 2003-12-12 2011-03-08 University Of Washington Catheterscope 3D guidance and interface system
AU2004320269B2 (en) * 2004-05-29 2011-07-21 The General Hospital Corporation Process, system and software arrangement for a chromatic dispersion compensation using reflective layers in optical coherence tomography (OCT) imaging
WO2005120325A2 (en) * 2004-06-07 2005-12-22 Given Imaging Ltd Method, system and device for suction biopsy
JP4995720B2 (en) 2004-07-02 2012-08-08 ザ ジェネラル ホスピタル コーポレイション Endoscopic imaging probe with double clad fiber
US8081316B2 (en) 2004-08-06 2011-12-20 The General Hospital Corporation Process, system and software arrangement for determining at least one location in a sample using an optical coherence tomography
EP2272420B1 (en) * 2004-08-24 2013-06-19 The General Hospital Corporation Apparatus for imaging of vessel segments
WO2006024014A2 (en) 2004-08-24 2006-03-02 The General Hospital Corporation Process, system and software arrangement for measuring a mechanical strain and elastic properties of a sample
JP5215664B2 (en) 2004-09-10 2013-06-19 ザ ジェネラル ホスピタル コーポレイション System and method for optical coherence imaging
EP1804638B1 (en) 2004-09-29 2012-12-19 The General Hospital Corporation System and method for optical coherence imaging
EP2278266A3 (en) 2004-11-24 2011-06-29 The General Hospital Corporation Common-Path Interferometer for Endoscopic OCT
JP2008521516A (en) 2004-11-29 2008-06-26 ザ ジェネラル ホスピタル コーポレイション Configuration, apparatus, endoscope, catheter, and method for performing optical image generation by simultaneously illuminating and detecting multiple points on a sample
US7909756B2 (en) * 2005-01-26 2011-03-22 Karl Storz Imaging, Inc. Illumination system for variable direction of view instruments
US7530948B2 (en) 2005-02-28 2009-05-12 University Of Washington Tethered capsule endoscope for Barrett's Esophagus screening
US8761865B2 (en) * 2005-03-10 2014-06-24 Anatoly Babchenko Optical sensor and a method of its use
DE102005013042A1 (en) * 2005-03-18 2006-09-28 Siemens Ag Three-dimensional fluorescence/luminescence scanner for detection of e.g. breast cancer, computes three-dimensional position information of surface points of scanned body based on projection and recording angles of optical pattern
JP4700390B2 (en) * 2005-04-05 2011-06-15 オリンパスメディカルシステムズ株式会社 Intra-subject introduction device
ES2337497T3 (en) * 2005-04-28 2010-04-26 The General Hospital Corporation EVALUATION OF CHARACTERISTICS OF THE IMAGE OF AN ANATOMICAL STRUCTURE IN IMAGES OF TOMOGRAPHY OF OPTICAL COHERENCE.
JP5702049B2 (en) 2005-06-01 2015-04-15 ザ ジェネラル ホスピタル コーポレイション Apparatus, method and system for performing phase resolved optical frequency domain imaging
US7783337B2 (en) 2005-06-06 2010-08-24 Board Of Regents, The University Of Texas System OCT using spectrally resolved bandwidth
DE102005032369A1 (en) * 2005-07-08 2007-01-11 Siemens Ag endoscopy capsule
CN101217909B (en) * 2005-07-08 2010-05-19 奥林巴斯株式会社 Device and system for acquiring information in living body
CN101238347B (en) 2005-08-09 2011-05-25 通用医疗公司 Apparatus, methods and storage medium for performing polarization-based quadrature demodulation in optical coherence tomography
CN101360447B (en) 2005-09-29 2012-12-05 通用医疗公司 Method and apparatus for optical imaging via spectral encoding
US7414729B2 (en) * 2005-10-13 2008-08-19 President And Fellows Of Harvard College System and method for coherent anti-Stokes Raman scattering endoscopy
WO2007047690A1 (en) 2005-10-14 2007-04-26 The General Hospital Corporation Spectral- and frequency- encoded fluorescence imaging
EP1954193B1 (en) 2005-11-23 2013-03-06 University of Washington Scanning beam with variable sequential framing using interrupted scanning resonance
JP5680826B2 (en) 2006-01-10 2015-03-04 ザ ジェネラル ホスピタル コーポレイション Data generation system using endoscopic technology for encoding one or more spectra
WO2007084849A1 (en) * 2006-01-18 2007-07-26 The General Hospital Corporation System and methods for generating data using one or more endoscopic microscopy techniques
WO2007084995A2 (en) 2006-01-19 2007-07-26 The General Hospital Corporation Methods and systems for optical imaging of epithelial luminal organs by beam scanning thereof
WO2007084903A2 (en) 2006-01-19 2007-07-26 The General Hospital Corporation Apparatus for obtaining information for a structure using spectrally-encoded endoscopy techniques and method for producing one or more optical arrangements
US9186066B2 (en) 2006-02-01 2015-11-17 The General Hospital Corporation Apparatus for applying a plurality of electro-magnetic radiations to a sample
EP1983921B1 (en) 2006-02-01 2016-05-25 The General Hospital Corporation Systems for providing electromagnetic radiation to at least one portion of a sample using conformal laser therapy procedures
EP1988825B1 (en) 2006-02-08 2016-12-21 The General Hospital Corporation Arrangements and systems for obtaining information associated with an anatomical sample using optical microscopy
US20080015413A1 (en) * 2006-02-22 2008-01-17 Olympus Medical Systems Corporation Capsule endoscope system and medical procedure
EP2982929A1 (en) 2006-02-24 2016-02-10 The General Hospital Corporation Methods and systems for performing angle-resolved fourier-domain optical coherence tomography
US7935050B2 (en) * 2006-02-27 2011-05-03 Microvision, Inc. Endoscope tips, scanned beam endoscopes using same, and methods of use
WO2007106075A2 (en) 2006-03-03 2007-09-20 University Of Washington Multi-cladding optical fiber scanner
DE102006014885A1 (en) * 2006-03-30 2007-10-18 Siemens Ag Endoscopic device with biochip sensor
US7476197B2 (en) * 2006-04-17 2009-01-13 Microvision, Inc. Scanned beam imagers and endoscopes utilizing multiple light collectors
JP2009536740A (en) 2006-05-10 2009-10-15 ザ ジェネラル ホスピタル コーポレイション Process, configuration and system for providing frequency domain imaging of samples
JP4979271B2 (en) * 2006-05-29 2012-07-18 オリンパス株式会社 ENDOSCOPE SYSTEM AND ENDOSCOPE OPERATING METHOD
EP2046188B1 (en) 2006-07-24 2019-03-27 Philips Intellectual Property & Standards GmbH Capsule camera with variable illumination of the surrounding tissue
US8540393B2 (en) * 2006-08-09 2013-09-24 Olympus Medical Systems Corp. First and second light-emitting elements having identical peak emission intensities
US20080058629A1 (en) * 2006-08-21 2008-03-06 University Of Washington Optical fiber scope with both non-resonant illumination and resonant collection/imaging for multiple modes of operation
US7920271B2 (en) 2006-08-25 2011-04-05 The General Hospital Corporation Apparatus and methods for enhancing optical coherence tomography imaging using volumetric filtering techniques
US7680373B2 (en) * 2006-09-13 2010-03-16 University Of Washington Temperature adjustment in scanning beam devices
US7796870B2 (en) * 2007-01-16 2010-09-14 Capso Vision, Inc. Lighting control for in vivo capsule camera
US9079762B2 (en) * 2006-09-22 2015-07-14 Ethicon Endo-Surgery, Inc. Micro-electromechanical device
US8838213B2 (en) 2006-10-19 2014-09-16 The General Hospital Corporation Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample, and effecting such portion(s)
US20080132834A1 (en) * 2006-12-04 2008-06-05 University Of Washington Flexible endoscope tip bending mechanism using optical fibers as tension members
KR100853655B1 (en) * 2006-12-15 2008-08-25 한국전기연구원 Apparatus, light source system and method for photo-diagnosis and phototherapy of skin disease
US7447415B2 (en) * 2006-12-15 2008-11-04 University Of Washington Attaching optical fibers to actuator tubes with beads acting as spacers and adhesives
US7738762B2 (en) * 2006-12-15 2010-06-15 University Of Washington Attaching optical fibers to actuator tubes with beads acting as spacers and adhesives
US7713265B2 (en) 2006-12-22 2010-05-11 Ethicon Endo-Surgery, Inc. Apparatus and method for medically treating a tattoo
KR20080060058A (en) * 2006-12-26 2008-07-01 전자부품연구원 Capsule type endoscope with an induction hose
US8405711B2 (en) * 2007-01-09 2013-03-26 Capso Vision, Inc. Methods to compensate manufacturing variations and design imperfections in a capsule camera
US10499029B2 (en) 2007-01-09 2019-12-03 Capso Vision Inc Methods to compensate manufacturing variations and design imperfections in a display device
US8801606B2 (en) * 2007-01-09 2014-08-12 Ethicon Endo-Surgery, Inc. Method of in vivo monitoring using an imaging system including scanned beam imaging unit
US9007478B2 (en) * 2007-01-09 2015-04-14 Capso Vision, Inc. Methods to compensate manufacturing variations and design imperfections in a capsule camera
US8273015B2 (en) * 2007-01-09 2012-09-25 Ethicon Endo-Surgery, Inc. Methods for imaging the anatomy with an anatomically secured scanner assembly
US8305432B2 (en) * 2007-01-10 2012-11-06 University Of Washington Scanning beam device calibration
JP2010517080A (en) 2007-01-19 2010-05-20 ザ ジェネラル ホスピタル コーポレイション Rotating disk reflection for fast wavelength scanning of dispersive broadband light
JP5507258B2 (en) * 2007-01-19 2014-05-28 ザ ジェネラル ホスピタル コーポレイション Apparatus and method for controlling measurement depth in optical frequency domain imaging
EP2111148B1 (en) * 2007-01-19 2015-08-12 Given Imaging (Los Angeles) LLC Micro-remote gastrointestinal physiological measurement device
US8396539B2 (en) * 2007-02-16 2013-03-12 Medtronic, Inc. Implantable medical device having optical fiber for sensing electrical activity
US20080221388A1 (en) * 2007-03-09 2008-09-11 University Of Washington Side viewing optical fiber endoscope
EP2120719A4 (en) * 2007-03-09 2011-07-06 Univ Washington Side viewing optical fiber endoscope
US20080226029A1 (en) 2007-03-12 2008-09-18 Weir Michael P Medical device including scanned beam unit for imaging and therapy
US8216214B2 (en) * 2007-03-12 2012-07-10 Ethicon Endo-Surgery, Inc. Power modulation of a scanning beam for imaging, therapy, and/or diagnosis
JP5558839B2 (en) 2007-03-23 2014-07-23 ザ ジェネラル ホスピタル コーポレイション Method, arrangement and apparatus for utilizing a wavelength swept laser using angular scanning and dispersion procedures
US20080242967A1 (en) * 2007-03-27 2008-10-02 Ethicon Endo-Surgery, Inc. Medical imaging and therapy utilizing a scanned beam system operating at multiple wavelengths
WO2008121844A1 (en) 2007-03-30 2008-10-09 The General Hospital Corporation System and method providing intracoronary laser speckle imaging for the detection of vulnerable plaque
US8840566B2 (en) * 2007-04-02 2014-09-23 University Of Washington Catheter with imaging capability acts as guidewire for cannula tools
WO2008121143A1 (en) * 2007-04-02 2008-10-09 University Of Washington Catheter with imaging capability acts as guidewire for cannula tools
US7583872B2 (en) * 2007-04-05 2009-09-01 University Of Washington Compact scanning fiber device
US8626271B2 (en) * 2007-04-13 2014-01-07 Ethicon Endo-Surgery, Inc. System and method using fluorescence to examine within a patient's anatomy
US7995045B2 (en) * 2007-04-13 2011-08-09 Ethicon Endo-Surgery, Inc. Combined SBI and conventional image processor
US8045177B2 (en) 2007-04-17 2011-10-25 The General Hospital Corporation Apparatus and methods for measuring vibrations using spectrally-encoded endoscopy
US7608842B2 (en) * 2007-04-26 2009-10-27 University Of Washington Driving scanning fiber devices with variable frequency drive signals
US20080275305A1 (en) * 2007-05-01 2008-11-06 Ethicon Endo-Surgery, Inc. Medical scanned beam imager and components associated therewith
WO2008137710A1 (en) * 2007-05-03 2008-11-13 University Of Washington High resolution optical coherence tomography based imaging for intraluminal and interstitial use implemented with a reduced form factor
US20080281159A1 (en) * 2007-05-08 2008-11-13 University Of Washington Coordinating image acquisition among multiple endoscopes
US20080281207A1 (en) * 2007-05-08 2008-11-13 University Of Washington Image acquisition through filtering in multiple endoscope systems
US8212884B2 (en) * 2007-05-22 2012-07-03 University Of Washington Scanning beam device having different image acquisition modes
US8160678B2 (en) * 2007-06-18 2012-04-17 Ethicon Endo-Surgery, Inc. Methods and devices for repairing damaged or diseased tissue using a scanning beam assembly
US7558455B2 (en) 2007-06-29 2009-07-07 Ethicon Endo-Surgery, Inc Receiver aperture broadening for scanned beam imaging
US20090010507A1 (en) * 2007-07-02 2009-01-08 Zheng Jason Geng System and method for generating a 3d model of anatomical structure using a plurality of 2d images
US7982776B2 (en) 2007-07-13 2011-07-19 Ethicon Endo-Surgery, Inc. SBI motion artifact removal apparatus and method
US8437587B2 (en) * 2007-07-25 2013-05-07 University Of Washington Actuating an optical fiber with a piezoelectric actuator and detecting voltages generated by the piezoelectric actuator
US9125552B2 (en) * 2007-07-31 2015-09-08 Ethicon Endo-Surgery, Inc. Optical scanning module and means for attaching the module to medical instruments for introducing the module into the anatomy
EP2173254A2 (en) 2007-07-31 2010-04-14 The General Hospital Corporation Systems and methods for providing beam scan patterns for high speed doppler optical frequency domain imaging
US7983739B2 (en) * 2007-08-27 2011-07-19 Ethicon Endo-Surgery, Inc. Position tracking and control for a scanning assembly
US7925333B2 (en) * 2007-08-28 2011-04-12 Ethicon Endo-Surgery, Inc. Medical device including scanned beam unit with operational control features
US20090060381A1 (en) * 2007-08-31 2009-03-05 Ethicon Endo-Surgery, Inc. Dynamic range and amplitude control for imaging
US7522813B1 (en) * 2007-10-04 2009-04-21 University Of Washington Reducing distortion in scanning fiber devices
EP2207469A4 (en) * 2007-10-12 2012-07-11 Gen Hospital Corp Systems and processes for optical imaging of luminal anatomic structures
WO2009059034A1 (en) 2007-10-30 2009-05-07 The General Hospital Corporation System and method for cladding mode detection
US9017248B2 (en) * 2007-11-08 2015-04-28 Olympus Medical Systems Corp. Capsule blood detection system and method
US8411922B2 (en) 2007-11-30 2013-04-02 University Of Washington Reducing noise in images acquired with a scanning beam device
US8529441B2 (en) * 2008-02-12 2013-09-10 Innurvation, Inc. Ingestible endoscopic optical scanning device
EP3300652A1 (en) * 2008-02-12 2018-04-04 Innurvation, Inc. Radial scanner imaging system
US20100016662A1 (en) * 2008-02-21 2010-01-21 Innurvation, Inc. Radial Scanner Imaging System
CN104799904B (en) * 2008-02-28 2017-10-27 史密夫和内修有限公司 System and method for recognizing mark
US9220514B2 (en) * 2008-02-28 2015-12-29 Smith & Nephew, Inc. System and method for identifying a landmark
WO2009120694A2 (en) * 2008-03-24 2009-10-01 The Regents Of The University Of Michigan Office Of Technology Transfer Non-contact infrared fiber-optic device for monitoring esophageal temperature to prevent thermal injury during radiofrequency catheter ablation or cryoablation
US8050520B2 (en) 2008-03-27 2011-11-01 Ethicon Endo-Surgery, Inc. Method for creating a pixel image from sampled data of a scanned beam imager
US9125562B2 (en) 2009-07-01 2015-09-08 Avinger, Inc. Catheter-based off-axis optical coherence tomography imaging system
US8548571B2 (en) 2009-12-08 2013-10-01 Avinger, Inc. Devices and methods for predicting and preventing restenosis
US8062316B2 (en) 2008-04-23 2011-11-22 Avinger, Inc. Catheter system and method for boring through blocked vascular passages
US8332014B2 (en) 2008-04-25 2012-12-11 Ethicon Endo-Surgery, Inc. Scanned beam device and method using same which measures the reflectance of patient tissue
US7898656B2 (en) 2008-04-30 2011-03-01 The General Hospital Corporation Apparatus and method for cross axis parallel spectroscopy
US8593619B2 (en) 2008-05-07 2013-11-26 The General Hospital Corporation System, method and computer-accessible medium for tracking vessel motion during three-dimensional coronary artery microscopy
JP5281826B2 (en) * 2008-06-05 2013-09-04 オリンパス株式会社 Image processing apparatus, image processing program, and image processing method
EP2288948A4 (en) 2008-06-20 2011-12-28 Gen Hospital Corp Fused fiber optic coupler arrangement and method for use thereof
US9254089B2 (en) 2008-07-14 2016-02-09 The General Hospital Corporation Apparatus and methods for facilitating at least partial overlap of dispersed ration on at least one sample
US8264524B1 (en) * 2008-09-17 2012-09-11 Grandeye Limited System for streaming multiple regions deriving from a wide-angle camera
JP5467756B2 (en) * 2008-11-14 2014-04-09 Ｈｏｙａ株式会社 Endoscope device
US9459415B2 (en) * 2008-11-18 2016-10-04 Stryker Corporation Endoscopic LED light source having a feedback control system
US9621825B2 (en) * 2008-11-25 2017-04-11 Capsovision Inc Camera system with multiple pixel arrays on a chip
ES2957932T3 (en) 2008-12-10 2024-01-30 Massachusetts Gen Hospital Systems, apparatus and procedures for extending the image depth range of optical coherence tomography using optical subsampling
JP5424634B2 (en) * 2008-12-19 2014-02-26 Ｈｏｙａ株式会社 Optical scanning endoscope processor and optical scanning endoscope apparatus
JP5342869B2 (en) * 2008-12-22 2013-11-13 Ｈｏｙａ株式会社 Endoscope apparatus, endoscope illumination apparatus, image forming apparatus, operation method of endoscope illumination apparatus, and operation method of image formation apparatus
EP2389093A4 (en) 2009-01-20 2013-07-31 Gen Hospital Corp Endoscopic biopsy apparatus, system and method
US8097864B2 (en) 2009-01-26 2012-01-17 The General Hospital Corporation System, method and computer-accessible medium for providing wide-field superresolution microscopy
CA2749670A1 (en) * 2009-02-04 2010-08-12 The General Hospital Corporation Apparatus and method for utilization of a high-speed optical wavelength tuning source
JP2010253155A (en) * 2009-04-28 2010-11-11 Fujifilm Corp Endoscope system, endoscope, and endoscope driving method
JP2010253156A (en) * 2009-04-28 2010-11-11 Fujifilm Corp Endoscope system, endoscope, and endoscope driving method
WO2010129075A1 (en) 2009-04-28 2010-11-11 Avinger, Inc. Guidewire support catheter
US20120101331A1 (en) * 2009-05-28 2012-04-26 Zvika Gilad Apparatus for delivery of autonomous in-vivo capsules
JP6101078B2 (en) 2009-05-28 2017-03-29 アビンガー・インコーポレイテッドＡｖｉｎｇｅｒ， Ｉｎｃ． Optical coherence tomography for bioimaging
US8834513B2 (en) 2009-06-05 2014-09-16 Entellus Medical, Inc. Method and articles for treating the sinus system
US8282667B2 (en) 2009-06-05 2012-10-09 Entellus Medical, Inc. Sinus dilation catheter
JP5498728B2 (en) * 2009-06-09 2014-05-21 Ｈｏｙａ株式会社 Medical observation system
JP2010284369A (en) * 2009-06-12 2010-12-24 Fujifilm Corp Endoscope system, endoscope, and endoscope driving method
US9713417B2 (en) 2009-06-18 2017-07-25 Endochoice, Inc. Image capture assembly for use in a multi-viewing elements endoscope
US8926502B2 (en) 2011-03-07 2015-01-06 Endochoice, Inc. Multi camera endoscope having a side service channel
US9492063B2 (en) 2009-06-18 2016-11-15 Endochoice Innovation Center Ltd. Multi-viewing element endoscope
US11547275B2 (en) 2009-06-18 2023-01-10 Endochoice, Inc. Compact multi-viewing element endoscope system
US10165929B2 (en) 2009-06-18 2019-01-01 Endochoice, Inc. Compact multi-viewing element endoscope system
EP2865322B1 (en) 2009-06-18 2020-07-22 EndoChoice, Inc. Multi-camera endoscope
US9474440B2 (en) * 2009-06-18 2016-10-25 Endochoice, Inc. Endoscope tip position visual indicator and heat management system
US11864734B2 (en) 2009-06-18 2024-01-09 Endochoice, Inc. Multi-camera endoscope
US9402533B2 (en) 2011-03-07 2016-08-02 Endochoice Innovation Center Ltd. Endoscope circuit board assembly
US9872609B2 (en) 2009-06-18 2018-01-23 Endochoice Innovation Center Ltd. Multi-camera endoscope
US9901244B2 (en) 2009-06-18 2018-02-27 Endochoice, Inc. Circuit board assembly of a multiple viewing elements endoscope
US9101287B2 (en) 2011-03-07 2015-08-11 Endochoice Innovation Center Ltd. Multi camera endoscope assembly having multiple working channels
US9642513B2 (en) 2009-06-18 2017-05-09 Endochoice Inc. Compact multi-viewing element endoscope system
US9706903B2 (en) 2009-06-18 2017-07-18 Endochoice, Inc. Multiple viewing elements endoscope system with modular imaging units
US11278190B2 (en) 2009-06-18 2022-03-22 Endochoice, Inc. Multi-viewing element endoscope
WO2012077116A1 (en) 2010-12-09 2012-06-14 Peermedical Ltd. Flexible electronic circuit board for a multi-camera endoscope
US9101268B2 (en) 2009-06-18 2015-08-11 Endochoice Innovation Center Ltd. Multi-camera endoscope
EP2448502B1 (en) 2009-07-01 2022-04-06 Avinger, Inc. Atherectomy catheter with laterally-displaceable tip
US11490826B2 (en) 2009-07-14 2022-11-08 The General Hospital Corporation Apparatus, systems and methods for measuring flow and pressure within a vessel
JP2011043793A (en) * 2009-07-23 2011-03-03 Hoya Corp Scanning objective lens, scanning probe and scanning endoscope
US8911360B2 (en) 2009-11-20 2014-12-16 Given Imaging Ltd. System and method for controlling power consumption of an in vivo device
US8363887B2 (en) * 2010-02-03 2013-01-29 Chemspectra, Inc. Variable fan for portable explosive or drug detection system
HUE052561T2 (en) 2010-03-05 2021-05-28 Massachusetts Gen Hospital Apparatus for providing electro-magnetic radiation to a sample
US9069130B2 (en) 2010-05-03 2015-06-30 The General Hospital Corporation Apparatus, method and system for generating optical radiation from biological gain media
EP2575597B1 (en) 2010-05-25 2022-05-04 The General Hospital Corporation Apparatus for providing optical imaging of structures and compositions
JP5778762B2 (en) 2010-05-25 2015-09-16 ザ ジェネラル ホスピタル コーポレイション Apparatus and method for spectral analysis of optical coherence tomography images
US10285568B2 (en) 2010-06-03 2019-05-14 The General Hospital Corporation Apparatus and method for devices for imaging structures in or at one or more luminal organs
WO2011160062A2 (en) 2010-06-17 2011-12-22 The Usa As Represented By The Secretary, National Institutes Of Health Compositions and methods for treating inflammatory conditions
JP2013531542A (en) 2010-07-01 2013-08-08 アビンガー・インコーポレイテッド An atherectomy catheter having a longitudinally movable drive shaft
US11382653B2 (en) 2010-07-01 2022-07-12 Avinger, Inc. Atherectomy catheter
WO2014039096A1 (en) 2012-09-06 2014-03-13 Avinger, Inc. Re-entry stylet for catheter
US9560953B2 (en) 2010-09-20 2017-02-07 Endochoice, Inc. Operational interface in a multi-viewing element endoscope
EP3718466B1 (en) 2010-09-20 2023-06-07 EndoChoice, Inc. Endoscope distal section comprising a unitary fluid channeling component
WO2012058381A2 (en) 2010-10-27 2012-05-03 The General Hospital Corporation Apparatus, systems and methods for measuring blood pressure within at least one vessel
JP5944912B2 (en) 2010-10-28 2016-07-05 エンドチョイス イノベーション センター リミテッド Optical system for multi-sensor endoscope
US20140031642A1 (en) * 2010-10-29 2014-01-30 Check-Cap Ltd. Intra body capsule motion sensing and position determination systems and methods
JP5292379B2 (en) * 2010-11-09 2013-09-18 富士フイルム株式会社 Endoscope device
AU2011332014B2 (en) 2010-11-27 2016-12-22 Securus Medical Group, Inc. Ablation and temperature measurement devices
US11889986B2 (en) 2010-12-09 2024-02-06 Endochoice, Inc. Flexible electronic circuit board for a multi-camera endoscope
EP2648602B1 (en) 2010-12-09 2018-07-18 EndoChoice Innovation Center Ltd. Flexible electronic circuit board multi-camera endoscope
WO2012100030A2 (en) * 2011-01-19 2012-07-26 Duke University Imaging and visualization systems, instruments, and methods using optical coherence tomography
CN103491854B (en) 2011-02-07 2016-08-24 恩多卓斯创新中心有限公司 Multicomponent cover for many cameras endoscope
EP2686067B1 (en) 2011-03-17 2016-05-18 Photopill Medical Ltd. Capsule phototherapy
WO2012145133A2 (en) 2011-03-28 2012-10-26 Avinger, Inc. Occlusion-crossing devices, imaging, and atherectomy devices
US9949754B2 (en) 2011-03-28 2018-04-24 Avinger, Inc. Occlusion-crossing devices
EP2659827B1 (en) * 2011-03-31 2015-09-23 Olympus Medical Systems Corp. Endoscope apparatus, endoscope cap, and analysis method
EP2653091B1 (en) * 2011-03-31 2015-06-10 Olympus Medical Systems Corp. Scanning endoscope device
US9757038B2 (en) 2011-05-31 2017-09-12 Vanderbilt University Optical coherence tomography probe
US8655431B2 (en) 2011-05-31 2014-02-18 Vanderbilt University Apparatus and method for real-time imaging and monitoring of an electrosurgical procedure
JP2014523536A (en) 2011-07-19 2014-09-11 ザ ジェネラル ホスピタル コーポレイション System, method, apparatus and computer-accessible medium for providing polarization mode dispersion compensation in optical coherence tomography
US9155677B2 (en) * 2011-08-09 2015-10-13 Franklin R. Lacy System for gastrointestinal and vascular atrophy engineering to restore normal youthful bodily functions
US8599009B2 (en) 2011-08-16 2013-12-03 Elwha Llc Systematic distillation of status data relating to regimen compliance
EP2748587B1 (en) 2011-08-25 2021-01-13 The General Hospital Corporation Methods and arrangements for providing micro-optical coherence tomography procedures
JP6356604B2 (en) 2011-10-17 2018-07-11 アビンガー・インコーポレイテッドＡｖｉｎｇｅｒ， Ｉｎｃ． Atherotomy catheters and non-contact actuation mechanisms for catheters
US9341783B2 (en) 2011-10-18 2016-05-17 The General Hospital Corporation Apparatus and methods for producing and/or providing recirculating optical delay(s)
US20130116552A1 (en) * 2011-10-20 2013-05-09 Air Liquide Implantable imaging arrangement and method for using the same
US20130123648A1 (en) * 2011-11-11 2013-05-16 Leontios Stampoulidis Medical diagnosis and treatment using multi-core optical fibers
US9345406B2 (en) 2011-11-11 2016-05-24 Avinger, Inc. Occlusion-crossing devices, atherectomy devices, and imaging
EP2604172B1 (en) 2011-12-13 2015-08-12 EndoChoice Innovation Center Ltd. Rotatable connector for an endoscope
CA2798716A1 (en) 2011-12-13 2013-06-13 Peermedical Ltd. Removable tip endoscope
JP6033000B2 (en) * 2011-12-20 2016-11-30 オリンパス株式会社 Scanning endoscope
WO2013148306A1 (en) 2012-03-30 2013-10-03 The General Hospital Corporation Imaging system, method and distal attachment for multidirectional field of view endoscopy
EP2849660B1 (en) 2012-05-14 2021-08-25 Avinger, Inc. Atherectomy catheter drive assemblies
WO2013172970A1 (en) 2012-05-14 2013-11-21 Avinger, Inc. Atherectomy catheters with imaging
US9557156B2 (en) 2012-05-14 2017-01-31 Avinger, Inc. Optical coherence tomography with graded index fiber for biological imaging
US11490797B2 (en) 2012-05-21 2022-11-08 The General Hospital Corporation Apparatus, device and method for capsule microscopy
JP2017000838A (en) * 2012-06-01 2017-01-05 ソニー株式会社 Medical device and control method
US9560954B2 (en) 2012-07-24 2017-02-07 Endochoice, Inc. Connector for use with endoscope
WO2014024529A1 (en) * 2012-08-07 2014-02-13 オリンパスメディカルシステムズ株式会社 Scanning endoscope device
US10110785B2 (en) * 2012-08-10 2018-10-23 Karl Storz Imaging, Inc. Deployable imaging system equipped with solid state imager
US9415550B2 (en) 2012-08-22 2016-08-16 The General Hospital Corporation System, method, and computer-accessible medium for fabrication miniature endoscope using soft lithography
WO2015120146A1 (en) 2014-02-06 2015-08-13 Avinger, Inc. Atherectomy catheters and occlusion crossing devices
US11284916B2 (en) 2012-09-06 2022-03-29 Avinger, Inc. Atherectomy catheters and occlusion crossing devices
US9498247B2 (en) 2014-02-06 2016-11-22 Avinger, Inc. Atherectomy catheters and occlusion crossing devices
EP2892448B1 (en) 2012-09-06 2020-07-15 Avinger, Inc. Balloon atherectomy catheters with imaging
IN2015DN02774A (en) * 2012-09-07 2015-09-04 Check Cap Ltd
JP2014104138A (en) * 2012-11-27 2014-06-09 Olympus Corp Endoscope and endoscope system
US20140187999A1 (en) * 2012-12-20 2014-07-03 The General Hospital Corporation Apparatus, system and method for providing image-guided in-vivo biopsy with at least one capsule
EP2948758B1 (en) 2013-01-28 2024-03-13 The General Hospital Corporation Apparatus for providing diffuse spectroscopy co-registered with optical frequency domain imaging
WO2014120791A1 (en) 2013-01-29 2014-08-07 The General Hospital Corporation Apparatus, systems and methods for providing information regarding the aortic valve
WO2014121082A1 (en) * 2013-02-01 2014-08-07 The General Hospital Corporation Objective lens arrangement for confocal endomicroscopy
KR102119534B1 (en) * 2013-03-13 2020-06-05 삼성전자주식회사 Surgical robot and method for controlling the same
WO2014144709A2 (en) 2013-03-15 2014-09-18 The General Hospital Corporation Methods and systems for characterizing an object
US10932670B2 (en) 2013-03-15 2021-03-02 Avinger, Inc. Optical pressure sensor assembly
EP2967507B1 (en) 2013-03-15 2018-09-05 Avinger, Inc. Tissue collection device for catheter
EP2967299B1 (en) 2013-03-15 2022-11-30 Stryker Corporation Endoscopic light source and imaging system
US9854979B2 (en) 2013-03-15 2018-01-02 Avinger, Inc. Chronic total occlusion crossing devices with imaging
EP4079242A1 (en) 2013-03-19 2022-10-26 Surgisense Corporation Apparatus, systems and methods for determining tissue oxygenation
US9993142B2 (en) 2013-03-28 2018-06-12 Endochoice, Inc. Fluid distribution device for a multiple viewing elements endoscope
US9986899B2 (en) 2013-03-28 2018-06-05 Endochoice, Inc. Manifold for a multiple viewing elements endoscope
US9107578B2 (en) * 2013-03-31 2015-08-18 Gyrus Acmi, Inc. Panoramic organ imaging
US10499794B2 (en) 2013-05-09 2019-12-10 Endochoice, Inc. Operational interface in a multi-viewing element endoscope
WO2014186353A1 (en) 2013-05-13 2014-11-20 The General Hospital Corporation Detecting self-interefering fluorescence phase and amplitude
US9683928B2 (en) 2013-06-23 2017-06-20 Eric Swanson Integrated optical system and components utilizing tunable optical sources and coherent detection and phased array for imaging, ranging, sensing, communications and other applications
US9464883B2 (en) 2013-06-23 2016-10-11 Eric Swanson Integrated optical coherence tomography systems and methods
WO2014210226A1 (en) 2013-06-25 2014-12-31 Public Service Solutions, Inc. Side-scan infrared imaging devices
US10130386B2 (en) 2013-07-08 2018-11-20 Avinger, Inc. Identification of elastic lamina to guide interventional therapy
US10413359B2 (en) * 2013-07-18 2019-09-17 International Business Machines Corporation Laser-assisted transdermal delivery of nanoparticulates and hydrogels
EP3692887B1 (en) 2013-07-19 2024-03-06 The General Hospital Corporation Imaging apparatus which utilizes multidirectional field of view endoscopy
WO2015010133A1 (en) 2013-07-19 2015-01-22 The General Hospital Corporation Determining eye motion by imaging retina. with feedback
ES2893237T3 (en) 2013-07-26 2022-02-08 Massachusetts Gen Hospital Apparatus with a laser arrangement using optical scattering for applications in optical coherence tomography in the Fourier domain
US10345903B2 (en) * 2013-07-30 2019-07-09 Microsoft Technology Licensing, Llc Feedback for optic positioning in display devices
ITFI20130182A1 (en) * 2013-08-01 2015-02-02 El En Spa "DEVICE FOR THE TREATMENT OF THE VAGINAL CHANNEL OR OTHER NATURAL ORIFICES OR SURGICAL-FINAL, AND ITS APPARATUS"
US9196056B2 (en) * 2013-08-19 2015-11-24 Manufacturing Techniques, Inc. Electro-optical system and method for analyzing images of a scene to identify the presence of a target color
WO2015054243A1 (en) * 2013-10-07 2015-04-16 Van Dam, Jacques Integrated ultrasound, oct, pa and/or florescence imaging endoscope for diagnosing cancers in gastrointestinal, respiratory, and urogenital tracts
WO2015061588A1 (en) * 2013-10-23 2015-04-30 The Trustees Of Dartmouth College Surgical vision augmentation system
KR101524723B1 (en) * 2013-10-31 2015-06-02 주식회사 옵티메드 Inspection system capable of laser treatment
WO2016018463A2 (en) * 2013-12-23 2016-02-04 Jason Case Methods and systems using led sources to create contrast agents for mid-infrared imaging of blood vessels
WO2015105870A1 (en) 2014-01-08 2015-07-16 The General Hospital Corporation Method and apparatus for microscopic imaging
JP6238751B2 (en) * 2014-01-09 2017-11-29 オリンパス株式会社 Scanning observation device
US20160345809A1 (en) * 2014-01-28 2016-12-01 The General Hospital Corporation Apparatus, systems and methods which controls and facilitates information gathering using a tethered capsule catheter
JP6049209B2 (en) * 2014-01-28 2016-12-21 富士フイルム株式会社 Photoacoustic measurement probe and photoacoustic measurement apparatus including the same
WO2015116986A2 (en) 2014-01-31 2015-08-06 The General Hospital Corporation System and method for facilitating manual and/or automatic volumetric imaging with real-time tension or force feedback using a tethered imaging device
JP6345946B2 (en) * 2014-02-26 2018-06-20 オリンパス株式会社 Optical fiber scanner, illumination device and observation device
US10228556B2 (en) 2014-04-04 2019-03-12 The General Hospital Corporation Apparatus and method for controlling propagation and/or transmission of electromagnetic radiation in flexible waveguide(s)
CN107072505B (en) * 2014-04-05 2021-03-12 手术感应设备公司 Devices, systems, and methods for mapping of tissue oxygenation
WO2015157727A2 (en) * 2014-04-10 2015-10-15 Avendo Imaging Systems Tethered endoscope
JP6253491B2 (en) * 2014-04-17 2017-12-27 オリンパス株式会社 Scanner unit, optical fiber scanner, illumination device and observation device
KR101609365B1 (en) * 2014-05-27 2016-04-21 주식회사 고영테크놀러지 Removable optical coherence tomography apparatus
WO2015182860A1 (en) * 2014-05-30 2015-12-03 한국기계연구원 Laser induced breakdown spectroscopy device and medical diagnostic device using same
US10054286B2 (en) * 2014-07-04 2018-08-21 The United States Of America, As Represented By The Secretary Of Commerce, The National Insitute Of Standards And Technology Optical transformer, process for making and use of same
US10379222B2 (en) * 2014-07-04 2019-08-13 Z-Senz Llc Systems, devices, and/or methods for resonant light ranging and distance sensing
CN107106190B (en) 2014-07-08 2020-02-28 阿维格公司 High-speed chronic full-closure crossing device
KR102513779B1 (en) 2014-07-25 2023-03-24 더 제너럴 하스피탈 코포레이션 Apparatus, devices and methods for in vivo imaging and diagnosis
CN107072464B (en) * 2014-10-28 2018-10-23 奥林巴斯株式会社 Optical scanning-type endoscope apparatus
JP6432770B2 (en) 2014-11-12 2018-12-05 ソニー株式会社 Image processing apparatus, image processing method, and program
AU2015346153B2 (en) * 2014-11-14 2019-12-12 Boston Scientific Scimed, Inc. Surgical laser systems and laser devices
US20180263574A1 (en) * 2014-12-10 2018-09-20 Sparkbio S.R.L. System for the capture and combined display of video and analog signals coming from electromedical instruments and equipment
US10835119B2 (en) 2015-02-05 2020-11-17 Duke University Compact telescope configurations for light scanning systems and methods of using the same
WO2016127088A1 (en) 2015-02-06 2016-08-11 Duke University Stereoscopic display systems and methods for displaying surgical data and information in a surgical microscope
US11786111B2 (en) 2015-03-06 2023-10-17 Imperial College Innovations Limited Probe deployment device
US20160357007A1 (en) 2015-05-05 2016-12-08 Eric Swanson Fixed distal optics endoscope employing multicore fiber
CA2992272A1 (en) 2015-07-13 2017-01-19 Avinger, Inc. Micro-molded anamorphic reflector lens for image guided therapeutic/diagnostic catheters
US11147503B2 (en) 2015-09-30 2021-10-19 The General Hospital Corporation Systems and methods for an actively controlled optical imaging device
CN108289596B (en) * 2015-09-30 2021-02-26 通用医疗公司 System and method for actively controlled optical imaging device
US10799129B2 (en) * 2016-01-07 2020-10-13 Panasonic Intellectual Property Management Co., Ltd. Biological information measuring device including light source, light detector, and control circuit
EP3407777B1 (en) 2016-01-25 2020-12-30 Avinger, Inc. Oct imaging catheter with lag correction
WO2017173370A1 (en) 2016-04-01 2017-10-05 Avinger, Inc. Atherectomy catheter with serrated cutter
US10690904B2 (en) 2016-04-12 2020-06-23 Stryker Corporation Multiple imaging modality light source
US10498940B2 (en) * 2016-04-29 2019-12-03 Deuk Soo Jang Endoscope
US10694939B2 (en) 2016-04-29 2020-06-30 Duke University Whole eye optical coherence tomography(OCT) imaging systems and related methods
WO2017200885A1 (en) * 2016-05-18 2017-11-23 Stuart Bradley Systems and methods for observing and analyzing swallowing
US10969571B2 (en) 2016-05-30 2021-04-06 Eric Swanson Few-mode fiber endoscope
CN109475368A (en) 2016-06-03 2019-03-15 阿维格公司 Conduit device with detachable distal end
US10120214B2 (en) * 2016-06-24 2018-11-06 Qualcomm Incorporated Systems and methods for light beam position detection
CN109414273B (en) 2016-06-30 2023-02-17 阿维格公司 Atherectomy catheter with shapeable distal tip
WO2018008098A1 (en) * 2016-07-06 2018-01-11 株式会社日立製作所 Information display terminal
JP7031118B2 (en) * 2016-12-09 2022-03-08 ソニーグループ株式会社 Image processing device and image processing method
JP7036825B2 (en) * 2016-12-22 2022-03-15 マジック リープ， インコーポレイテッド Methods and systems for the fabrication of molded fiber elements for scanning fiber displays
US10041163B1 (en) 2017-02-03 2018-08-07 Ge-Hitachi Nuclear Energy Americas Llc Plasma spray coating for sealing a defect area in a workpiece
DE102017104617A1 (en) 2017-03-06 2018-09-06 Grintech Gmbh Optical probe and method for operating the optical probe
CN110381805B (en) * 2017-03-16 2022-10-11 基文影像公司 System and method for position detection of in-vivo device
EP3606346B1 (en) 2017-04-07 2023-08-30 The Trustees of Columbia University in the City of New York Oral antimicrobial or antiseptic rinse for use in treating or preventing barrett's oesophagus
WO2018204674A1 (en) * 2017-05-04 2018-11-08 Massachusetts Institute Of Technology Scanning optical imaging device
JP2020520691A (en) * 2017-05-12 2020-07-16 オーリス ヘルス インコーポレイテッド Biopsy devices and systems
WO2019140174A2 (en) 2018-01-11 2019-07-18 The General Hospital Corporation Devices, systems, and methods for advancing and positioning tethered capsule microendoscopes
JP2019185002A (en) * 2018-04-11 2019-10-24 ソニー株式会社 Microscope system and medical light source device
WO2019213594A1 (en) * 2018-05-03 2019-11-07 The General Hospital Corporation Systems, methods, and media for capsule-based multimode endoscopy
US10848753B1 (en) * 2018-05-31 2020-11-24 Facebook Technologies, Llc Eye-tracking system using a scanning laser assembly
CN109924937B (en) * 2018-08-03 2024-04-12 上海安翰医疗技术有限公司 Endoscope device and endoscopic detection method
EP3667299B1 (en) * 2018-12-13 2022-11-09 Imec VZW Multimodal imaging system
US20200305999A1 (en) * 2019-04-01 2020-10-01 West Virginia University Surgical devices and methods for bariatric and gastroesophageal surgery
US11786114B2 (en) 2019-04-09 2023-10-17 AnX Robotica Corp Systems and methods for liquid biopsy and drug delivery
KR102273928B1 (en) * 2019-05-15 2021-07-14 연세대학교 산학협력단 Light radiation device that secures light transmission depth by focused ultrasonic wave guidance and method of controlling light output by feedback control of ultrasonic wave
US11700995B2 (en) * 2019-06-20 2023-07-18 Cilag Gmbh International Speckle removal in a pulsed fluorescence imaging system
CN112147774B (en) * 2019-06-28 2022-07-19 成都理想境界科技有限公司 Scanning actuator and optical fiber scanner
CN114746033A (en) 2019-10-18 2022-07-12 阿维格公司 Obstruction crossing device
US11219358B2 (en) * 2020-03-02 2022-01-11 Capso Vision Inc. Method and apparatus for detecting missed areas during endoscopy
US11681093B2 (en) 2020-05-04 2023-06-20 Eric Swanson Multicore fiber with distal motor
US11802759B2 (en) 2020-05-13 2023-10-31 Eric Swanson Integrated photonic chip with coherent receiver and variable optical delay for imaging, sensing, and ranging applications
US20220013223A1 (en) * 2020-05-22 2022-01-13 Jack Wade Virtual pointer for real-time endoscopic video using gesture and voice commands and video architecture and framework for collecting surgical video at scale
CN111808916A (en) 2020-07-24 2020-10-23 上海安翰医疗技术有限公司 Trypsin detection film, preparation method and application thereof and trypsin detection kit
US20220044428A1 (en) * 2020-08-06 2022-02-10 Canon U.S.A., Inc. Methods and systems for image synchronization
US20220061644A1 (en) * 2020-08-27 2022-03-03 Nokia Technologies Oy Holographic endoscope
GB2603789A (en) * 2021-02-12 2022-08-17 Creo Medical Ltd Raman spectroscopy probe, Raman spectroscopy apparatus including the Raman spectroscopy probe and elongate assembly
US20230138742A1 (en) * 2021-11-04 2023-05-04 Lumicell, Inc. Sterile barrier for medical imaging device
WO2023205631A2 (en) * 2022-04-18 2023-10-26 The General Hospital Corporation Multimodal capsule-based light delivery, collection, and detection systems and methods
CN115399713B (en) * 2022-05-24 2023-03-07 北京大学第一医院 Magnetic control capsule endoscope traction cap and kit with spraying function
CN117338427B (en) * 2023-12-05 2024-02-27 四川大学华西医院 Photodynamic intervention type catheter end positioning system and method

Family Cites Families (269)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5215190A (en) * 1975-07-28 1977-02-04 Olympus Optical Co Endscope
US4118270A (en) 1976-02-18 1978-10-03 Harris Corporation Micro lens formation at optical fiber ends
US4085745A (en) 1977-02-14 1978-04-25 Alenares Santiago S Elastic support for the veins of the foot
US4234788A (en) 1979-04-06 1980-11-18 General Dynamics Corporation, Pomona Division Electrostatic fiber optic scanning device
US4265699A (en) 1979-05-04 1981-05-05 Rca Corporation Etching of optical fibers
DE2936463A1 (en) 1979-09-10 1981-03-19 Siemens AG, 1000 Berlin und 8000 München DEVICE FOR GENERATING MOVING LIGHT BEAMS
US4454547A (en) 1982-07-02 1984-06-12 Xerox Corporation Raster output scanner having a full width electro-mechanical modulator
JPS597919A (en) * 1982-07-06 1984-01-17 Olympus Optical Co Ltd Positioning device of endoscope
AU583786B2 (en) * 1982-12-13 1989-05-11 Sumitomo Electric Industries, Ltd. Endoscope
US4758222A (en) 1985-05-03 1988-07-19 Mccoy William C Steerable and aimable catheter
NL8403931A (en) 1984-12-24 1986-07-16 Philips Nv MONOMODE OPTICAL TRANSMISSION FIBER WITH A TAPER END SECTION LENS AND METHOD FOR MANUFACTURING THAT.
DE3447721A1 (en) 1984-12-21 1986-06-26 Messerschmitt-Bölkow-Blohm GmbH, 8012 Ottobrunn DEVICE FOR PROVIDING A STORAGE AND / OR PRESENCE SIGNAL FOR A SATELLITE TO BE ALIGNED TO EARTH
US4695163A (en) 1985-06-17 1987-09-22 Schachar Ronald A Method and apparatus for determining surface shapes using reflected laser light
JP2554465B2 (en) * 1985-08-09 1996-11-13 株式会社 エスジー Absolute position detection device
US4686963A (en) 1986-03-05 1987-08-18 Circon Corporation Torsion resistant vertebrated probe of simple construction
JPS62247232A (en) 1986-04-21 1987-10-28 Agency Of Ind Science & Technol Fluorescence measuring apparatus
US4688555A (en) 1986-04-25 1987-08-25 Circon Corporation Endoscope with cable compensating mechanism
US4804395A (en) 1987-01-13 1989-02-14 Itt Corporation Electrode arrangement for lensing method
US4743283A (en) 1987-01-13 1988-05-10 Itt Corporation Alternating current arc for lensing system and method of using same
US4782228A (en) 1987-01-16 1988-11-01 Honeywell Inc. High efficiency optical scanner with multiplexing means
US4762118A (en) 1987-07-28 1988-08-09 Welch Allyn, Inc. Self-adjusting steering mechanism for borescope, endoscope, or guide tube
US4850364A (en) 1987-11-12 1989-07-25 Hewlett-Packard Company Medical ultrasound imaging system with velocity-dependent rejection filtering
US4928316A (en) 1988-02-04 1990-05-22 Bell Communications Research, Inc. Optical systems and methods based upon temporal stretching, modulation and recompression of ultrashort pulses
US4979496A (en) 1988-04-05 1990-12-25 Fuji Photo Optical Co., Ltd. Endoscope for bile duct and pancreatic duct
US5172685A (en) 1988-05-27 1992-12-22 The University Of Connecticut Endoscope and video laser camera system therefor
JP2981556B2 (en) * 1989-02-28 1999-11-22 旭光学工業株式会社 Endoscope tip
US5074642A (en) 1989-11-14 1991-12-24 Hicks John W Multifiber endoscope with fibers having different indices of refraction
US5103497A (en) 1989-11-14 1992-04-07 Hicks John W Flying spot endoscope
JP2858261B2 (en) * 1989-11-21 1999-02-17 科学技術振興事業団 Endoscope observation device
US4983165A (en) 1990-01-23 1991-01-08 Loiterman David A Guidance system for vascular catheter or the like
US5037174A (en) 1990-01-31 1991-08-06 E. I. Du Pont De Nemours And Company Optical fiber having an aspherical lens thereon and method of making same
IL94308A0 (en) 1990-05-07 1991-03-10 Scitex Corp Ltd Laser scanning apparatus
US5231286A (en) 1990-08-31 1993-07-27 Olympus Optical Co., Ltd. Scanning probe microscope utilizing an optical element in a waveguide for dividing the center part of the laser beam perpendicular to the waveguide
US5305759A (en) 1990-09-26 1994-04-26 Olympus Optical Co., Ltd. Examined body interior information observing apparatus by using photo-pulses controlling gains for depths
US5209117A (en) 1990-10-22 1993-05-11 Motorola, Inc. Tapered cantilever beam for sensors
US5286970A (en) 1990-11-19 1994-02-15 At&T Bell Laboratories Near field optical microscopic examination of a biological specimen
US5272330A (en) 1990-11-19 1993-12-21 At&T Bell Laboratories Near field scanning optical microscope having a tapered waveguide
JP3063784B2 (en) * 1991-03-26 2000-07-12 オリンパス光学工業株式会社 Endoscope device
US6564087B1 (en) 1991-04-29 2003-05-13 Massachusetts Institute Of Technology Fiber optic needle probes for optical coherence tomography imaging
US6485413B1 (en) 1991-04-29 2002-11-26 The General Hospital Corporation Methods and apparatus for forward-directed optical scanning instruments
EP0581871B2 (en) 1991-04-29 2009-08-12 Massachusetts Institute Of Technology Apparatus for optical imaging and measurement
US6134003A (en) * 1991-04-29 2000-10-17 Massachusetts Institute Of Technology Method and apparatus for performing optical measurements using a fiber optic imaging guidewire, catheter or endoscope
US5177631A (en) 1991-06-28 1993-01-05 Eastman Kodak Company Magnetic position sensor
US5446556A (en) 1991-11-07 1995-08-29 Nikon Corporation Video clock signal generator in an optical scanner in which a mask including a linear scale provides timing for controlling the amplitude of a vibrating mirror
JPH05154154A (en) 1991-12-06 1993-06-22 Tosoh Corp Optical ct device using wavelength variable laser
WO1993013704A1 (en) 1992-01-09 1993-07-22 Endomedix Corporation Bi-directional miniscope
US5360968A (en) 1992-01-17 1994-11-01 Eastman Kodak Company "Consensus sync" data-sampling systems and methods
JP2746790B2 (en) 1992-03-02 1998-05-06 富士写真フイルム株式会社 Stereoscopic image recording method and stereoscopic image recording apparatus
US5396880A (en) 1992-04-08 1995-03-14 Danek Medical, Inc. Endoscope for direct visualization of the spine and epidural space
FR2690066B1 (en) * 1992-04-21 1998-08-07 Jean Marc Inglese IMAGE ACQUISITION DEVICE USING A SEMICONDUCTOR LIGHT SOURCE
US5643175A (en) * 1992-09-01 1997-07-01 Adair; Edwin L. Sterilizable endoscope with separable disposable tube assembly
US5361314A (en) 1992-09-04 1994-11-01 The Regents Of The University Of Michigan Micro optical fiber light source and sensor and method of fabrication thereof
JPH06114036A (en) 1992-10-05 1994-04-26 Olympus Optical Co Ltd Capsule for medical treatment
JPH06114037A (en) * 1992-10-05 1994-04-26 Olympus Optical Co Ltd Capsule device for medical treatment
US5549542A (en) 1992-11-17 1996-08-27 Life Medical Technologies, Inc. Deflectable endoscope
US5368564A (en) 1992-12-23 1994-11-29 Angeion Corporation Steerable catheter
US5459803A (en) 1993-02-18 1995-10-17 The Furukawa Electric Co., Ltd. Quartz-based optical fiber with a lens and its manufacturing method
US5405337A (en) 1993-02-24 1995-04-11 The Board Of Trustees Of The Leland Stanford Junior University Spatially distributed SMA actuator film providing unrestricted movement in three dimensional space
US6081605A (en) 1993-03-08 2000-06-27 The United States Of America As Represented By The Secretary Of The Navy Clutter rejection through edge integration
US5570441A (en) 1993-07-15 1996-10-29 At&T Corp. Cylindrical fiber probes and methods of making them
US5531343A (en) 1993-07-15 1996-07-02 At&T Corp. Cylindrical fiber probe devices and methods of making them
US5425123A (en) 1993-07-20 1995-06-13 Hicks; John W. Multifiber endoscope with multiple viewing modes to produce an image free of fixed pattern noise
DE69431206T2 (en) 1993-09-20 2003-04-17 Boston Scient Corp DEVICE FOR REPEATING SAMPLING
US5480046A (en) 1993-12-22 1996-01-02 At&T Corp. Fiber probe fabrication having a tip with concave sidewalls
US5394500A (en) 1993-12-22 1995-02-28 At&T Corp. Fiber probe device having multiple diameters
JPH0843647A (en) 1994-05-23 1996-02-16 Nec Corp Sphering method of optical fiber end and device therefor
WO1996002184A1 (en) 1994-07-14 1996-02-01 Washington Research Foundation Method and apparatus for detecting barrett's metaplasia of the esophagus
DE4428967C1 (en) 1994-08-16 1995-12-21 Jochen Dr Ing Liebetruth Medical catheter for guiding laser fibre
US5727098A (en) 1994-09-07 1998-03-10 Jacobson; Joseph M. Oscillating fiber optic display and imager
US5765561A (en) 1994-10-07 1998-06-16 Medical Media Systems Video-based surgical targeting system
US5512035A (en) 1994-10-27 1996-04-30 Circon Corporation, A Delaware Corporation Cable compensating mechanism for an endoscope
US5649897A (en) 1994-11-02 1997-07-22 Terumo Kabushiki Kaisha Endoscope apparatus for compensating for change in polarization state during image transmission
US5535759A (en) 1994-11-02 1996-07-16 Wilk; Peter J. Endoscopic method of cleaning and operating on a site within a patient
US6690963B2 (en) 1995-01-24 2004-02-10 Biosense, Inc. System for determining the location and orientation of an invasive medical instrument
JP3487944B2 (en) * 1995-02-24 2004-01-19 オリンパス株式会社 Endoscope device
US5728044A (en) * 1995-03-10 1998-03-17 Shan; Yansong Sensor device for spacial imaging of endoscopes
BR9608503A (en) 1995-05-12 1999-07-06 Novarts Ag Novarits Sa Novarit Sensor platform and method for the parallel detection of a plurality of analytes using evanescently excited luminescence
US5814052A (en) 1995-06-29 1998-09-29 Nakao; Naomi L. Surgical cauterization snare with ligating suture
US5776050A (en) 1995-07-24 1998-07-07 Medical Media Systems Anatomical visualization system
US5716321A (en) * 1995-10-10 1998-02-10 Conceptus, Inc. Method for maintaining separation between a falloposcope and a tubal wall
US5724169A (en) 1996-02-27 1998-03-03 The Boeing Company Phase-modulated fiber optic communication link with carrier signal filtering
JP3290586B2 (en) 1996-03-13 2002-06-10 セイコーインスツルメンツ株式会社 Scanning near-field optical microscope
US5762613A (en) 1996-05-07 1998-06-09 Spectrascience, Inc. Optical biopsy forceps
US6167296A (en) 1996-06-28 2000-12-26 The Board Of Trustees Of The Leland Stanford Junior University Method for volumetric image navigation
US5715337A (en) 1996-09-19 1998-02-03 The Mirco Optical Corporation Compact display system
US5991697A (en) 1996-12-31 1999-11-23 The Regents Of The University Of California Method and apparatus for optical Doppler tomographic imaging of fluid flow velocity in highly scattering media
WO1998030266A1 (en) * 1997-01-09 1998-07-16 Endosonics Corporation Device for withdrawing a catheter
US6466687B1 (en) 1997-02-12 2002-10-15 The University Of Iowa Research Foundation Method and apparatus for analyzing CT images to determine the presence of pulmonary tissue pathology
EP0971626A1 (en) 1997-03-06 2000-01-19 Massachusetts Institute Of Technology Instrument for optically scanning of living tissue
WO1998043530A1 (en) 1997-03-31 1998-10-08 Biosense Inc. Deflectable catheter
JP3417795B2 (en) 1997-04-30 2003-06-16 ペンタックス株式会社 Fluorescence diagnostic equipment
US6046720A (en) 1997-05-07 2000-04-04 University Of Washington Point source scanning apparatus and method
EP1007901B1 (en) 1997-06-02 2009-04-29 Joseph A. Izatt Doppler flow imaging using optical coherence tomography
US5939709A (en) 1997-06-19 1999-08-17 Ghislain; Lucien P. Scanning probe optical microscope using a solid immersion lens
US6501542B2 (en) 1998-06-30 2002-12-31 Lj Laboratories, Llc Apparatus and method for measuring optical characteristics of an object
AUPO790197A0 (en) 1997-07-16 1997-08-07 Optiscan Pty Limited Scanning microscope with miniature head
US6185443B1 (en) 1997-09-29 2001-02-06 Boston Scientific Corporation Visible display for an interventional device
US6324418B1 (en) * 1997-09-29 2001-11-27 Boston Scientific Corporation Portable tissue spectroscopy apparatus and method
US5924976A (en) 1997-08-21 1999-07-20 Stelzer; Paul Minimally invasive surgery device
US6069698A (en) 1997-08-28 2000-05-30 Olympus Optical Co., Ltd. Optical imaging apparatus which radiates a low coherence light beam onto a test object, receives optical information from light scattered by the object, and constructs therefrom a cross-sectional image of the object
JPH1172431A (en) * 1997-08-28 1999-03-16 Olympus Optical Co Ltd Optical tomographic imaging apparatus
US6327493B1 (en) 1997-08-28 2001-12-04 Olympus Optical Co., Ltd. Light scanning devices of a water-tight structure to be inserted into a body cavity to obtain optical information on inside of a biological tissue
US6148095A (en) 1997-09-08 2000-11-14 University Of Iowa Research Foundation Apparatus and method for determining three-dimensional representations of tortuous vessels
US6211904B1 (en) 1997-09-11 2001-04-03 Edwin L. Adair Surgical devices incorporating reduced area imaging devices
US5947905A (en) 1997-10-15 1999-09-07 Advanced Coronary Intervention, Inc. Ultrasound transducer array probe for intraluminal imaging catheter
US6240312B1 (en) * 1997-10-23 2001-05-29 Robert R. Alfano Remote-controllable, micro-scale device for use in in vivo medical diagnosis and/or treatment
BR9813935A (en) 1997-11-07 2000-09-19 Salviac Ltd Vascular filtration devices for removing embolic material from body fluids
FR2772209B1 (en) 1997-12-05 2000-02-25 Centre Nat Rech Scient ELECTROSTATIC MICROACTUATORS, ACTIVE THREE-DIMENSIONAL MICROCATHETERS OPERATING THEREOF AND MANUFACTURING METHOD
US6096054A (en) 1998-03-05 2000-08-01 Scimed Life Systems, Inc. Expandable atherectomy burr and method of ablating an occlusion from a patient's blood vessel
RU2148378C1 (en) 1998-03-06 2000-05-10 Геликонов Валентин Михайлович Device for performing optic coherent tomography, optic fiber scanning device and method for diagnosing biological tissue in vivo
US6066102A (en) 1998-03-09 2000-05-23 Spectrascience, Inc. Optical biopsy forceps system and method of diagnosing tissue
IL123646A (en) * 1998-03-11 2010-05-31 Refael Beyar Remote control catheterization
WO1999047041A1 (en) 1998-03-19 1999-09-23 Board Of Regents, The University Of Texas System Fiber-optic confocal imaging apparatus and methods of use
US5984860A (en) 1998-03-25 1999-11-16 Shan; Yansong Pass-through duodenal enteroscopic device
US6807328B2 (en) 1998-04-17 2004-10-19 John Farah Polished polyimide substrate
US6563998B1 (en) 1999-04-15 2003-05-13 John Farah Polished polymide substrate
EP1080361A4 (en) 1998-05-19 2005-08-10 Spectrx Inc Apparatus and method for determining tissue characteristics
US6091067A (en) 1998-06-02 2000-07-18 Science Applications International Corporation Scanning device using fiber optic bimorph
US6549801B1 (en) 1998-06-11 2003-04-15 The Regents Of The University Of California Phase-resolved optical coherence tomography and optical doppler tomography for imaging fluid flow in tissue with fast scanning speed and high velocity sensitivity
US6097528A (en) 1998-07-20 2000-08-01 Motorola, Inc. Microscanner for portable laser diode displays
US6169281B1 (en) 1998-07-29 2001-01-02 International Business Machines Corporation Apparatus and method for determining side wall profiles using a scanning probe microscope having a probe dithered in lateral directions
EP1100373B1 (en) 1998-08-02 2008-09-03 Super Dimension Ltd. Intrabody navigation system for medical applications
US6381490B1 (en) * 1999-08-18 2002-04-30 Scimed Life Systems, Inc. Optical scanning and imaging system and method
US6511417B1 (en) 1998-09-03 2003-01-28 Olympus Optical Co., Ltd. System for detecting the shape of an endoscope using source coils and sense coils
US6261304B1 (en) 1998-09-10 2001-07-17 Percardia, Inc. Delivery methods for left ventricular conduit
US7180600B2 (en) 1998-09-21 2007-02-20 Olympus Corporation Optical imaging apparatus
US5919200A (en) 1998-10-09 1999-07-06 Hearten Medical, Inc. Balloon catheter for abrading a patent foramen ovale and method of using the balloon catheter
DE19847135B4 (en) 1998-10-13 2007-10-31 Texas Instruments Deutschland Gmbh Method for reading the data stored in a transponder and transponder system for carrying out the method
US6441359B1 (en) 1998-10-20 2002-08-27 The Board Of Trustees Of The Leland Stanford Junior University Near field optical scanning system employing microfabricated solid immersion lens
US6678541B1 (en) 1998-10-28 2004-01-13 The Governmemt Of The United States Of America Optical fiber probe and methods for measuring optical properties
US6191862B1 (en) 1999-01-20 2001-02-20 Lightlab Imaging, Llc Methods and apparatus for high speed longitudinal scanning in imaging systems
US6615072B1 (en) 1999-02-04 2003-09-02 Olympus Optical Co., Ltd. Optical imaging device
US6902528B1 (en) 1999-04-14 2005-06-07 Stereotaxis, Inc. Method and apparatus for magnetically controlling endoscopes in body lumens and cavities
US6294775B1 (en) * 1999-06-08 2001-09-25 University Of Washington Miniature image acquistion system using a scanning resonant waveguide
US6563105B2 (en) 1999-06-08 2003-05-13 University Of Washington Image acquisition with depth enhancement
US6882429B1 (en) 1999-07-20 2005-04-19 California Institute Of Technology Transverse optical fiber devices for optical sensing
CA2380149A1 (en) 1999-07-20 2001-01-25 Konstantin B. Shelimov Near-field scanning optical microscoe with a high q-factor piezoelectric sensing elment
US6525310B2 (en) 1999-08-05 2003-02-25 Microvision, Inc. Frequency tunable resonant scanner
US6515781B2 (en) 1999-08-05 2003-02-04 Microvision, Inc. Scanned imaging apparatus with switched feeds
US6246914B1 (en) 1999-08-12 2001-06-12 Irvine Biomedical, Inc. High torque catheter and methods thereof
US6687010B1 (en) 1999-09-09 2004-02-03 Olympus Corporation Rapid depth scanning optical imaging device
US6443894B1 (en) 1999-09-29 2002-09-03 Acuson Corporation Medical diagnostic ultrasound system and method for mapping surface data for three dimensional imaging
US6546271B1 (en) 1999-10-01 2003-04-08 Bioscience, Inc. Vascular reconstruction
JP2001174744A (en) 1999-10-06 2001-06-29 Olympus Optical Co Ltd Optical scanning probe device
JP4472069B2 (en) * 1999-11-10 2010-06-02 オリンパス株式会社 Medical capsule endoscope
US6545260B1 (en) 1999-11-19 2003-04-08 Olympus Optical Co., Ltd. Light scanning optical device which acquires a high resolution two-dimensional image without employing a charge-coupled device
US20010030744A1 (en) 1999-12-27 2001-10-18 Og Technologies, Inc. Method of simultaneously applying multiple illumination schemes for simultaneous image acquisition in an imaging system
US20020071625A1 (en) 1999-12-30 2002-06-13 Bartholomew Dwight Urban Wave-guided miniature spectrophotometer transducer
US7747312B2 (en) 2000-01-04 2010-06-29 George Mason Intellectual Properties, Inc. System and method for automatic shape registration and instrument tracking
IL134017A (en) 2000-01-13 2008-04-13 Capsule View Inc Camera for viewing inside intestines
EP1259163A4 (en) 2000-02-08 2006-05-03 Cornell Res Foundation Inc Multiphoton excitation through optical fibers for fluorescence spectroscopy
US6858005B2 (en) 2000-04-03 2005-02-22 Neo Guide Systems, Inc. Tendon-driven endoscope and methods of insertion
US6610007B2 (en) * 2000-04-03 2003-08-26 Neoguide Systems, Inc. Steerable segmented endoscope and method of insertion
EP1662972A4 (en) 2000-04-03 2010-08-25 Intuitive Surgical Inc Activated polymer articulated instruments and methods of insertion
CA2403925C (en) 2000-04-05 2008-09-16 Stx Medical, Inc. Intralumenal material removal systems and methods
JP2003535622A (en) 2000-05-09 2003-12-02 ユナイテッド ステーツ エンドスコピー グループ インコーポレイテッド Barrett's esophageal cytology device
DE10025285A1 (en) 2000-05-22 2001-12-06 Siemens Ag Fully automatic, robot-assisted camera guidance using position sensors for laparoscopic interventions
US6468204B2 (en) * 2000-05-25 2002-10-22 Fuji Photo Film Co., Ltd. Fluorescent endoscope apparatus
US6975898B2 (en) 2000-06-19 2005-12-13 University Of Washington Medical imaging, diagnosis, and therapy using a scanning single optical fiber system
US7555333B2 (en) 2000-06-19 2009-06-30 University Of Washington Integrated optical scanning image acquisition and display
US6836560B2 (en) 2000-11-13 2004-12-28 Kla - Tencor Technologies Corporation Advanced phase shift inspection method
JP2002153419A (en) * 2000-11-22 2002-05-28 Sanguroo:Kk Endoscope
US6845190B1 (en) 2000-11-27 2005-01-18 University Of Washington Control of an optical fiber scanner
US6856712B2 (en) 2000-11-27 2005-02-15 University Of Washington Micro-fabricated optical waveguide for use in scanning fiber displays and scanned fiber image acquisition
WO2002045598A2 (en) 2000-12-05 2002-06-13 Lumend, Inc. Catheter system for vascular re-entry from a sub-intimal space
US7179220B2 (en) 2001-02-07 2007-02-20 Siemens Corporate Research, Inc. Method for guiding flexible instrument procedures
US20020140942A1 (en) 2001-02-17 2002-10-03 Fee Michale Sean Acousto-optic monitoring and imaging in a depth sensitive manner
US6872433B2 (en) 2001-03-27 2005-03-29 The Regents Of The University Of California Shape memory alloy/shape memory polymer tools
US6785571B2 (en) 2001-03-30 2004-08-31 Neil David Glossop Device and method for registering a position sensor in an anatomical body
US7766856B2 (en) * 2001-05-06 2010-08-03 Stereotaxis, Inc. System and methods for advancing a catheter
US7108661B2 (en) 2001-05-07 2006-09-19 United States Endoscopy Group, Inc. Method and collection device for Barrett's esophagus cells
US7349098B2 (en) 2001-05-07 2008-03-25 University Of Washington Simultaneous beam-focus and coherence-gate tracking for real-time optical coherence tomography
US7616986B2 (en) 2001-05-07 2009-11-10 University Of Washington Optical fiber scanner for performing multimodal optical imaging
JP2003028791A (en) 2001-05-09 2003-01-29 Olympus Optical Co Ltd Optical imaging device
US6846286B2 (en) * 2001-05-22 2005-01-25 Pentax Corporation Endoscope system
JP2002360508A (en) * 2001-06-08 2002-12-17 Olympus Optical Co Ltd Canal alimenta'rius inspection device
US6689064B2 (en) 2001-06-22 2004-02-10 Koninklijke Philips Electronics N.V. Ultrasound clutter filter
JP2003135387A (en) * 2001-10-30 2003-05-13 Olympus Optical Co Ltd Capsule type medical apparatus
JP4754743B2 (en) 2001-09-18 2011-08-24 オリンパス株式会社 Endoscope device
JP4643089B2 (en) * 2001-09-27 2011-03-02 オリンパス株式会社 Capsule medical device
WO2003038410A1 (en) 2001-10-31 2003-05-08 Olympus Corporation Optical scanning type observation device
US20030125788A1 (en) * 2001-11-09 2003-07-03 Long Gary L. Self-propelled, intraluminal device with electrode configuration and method of use
US20030093031A1 (en) 2001-11-09 2003-05-15 Long Gary L. Self-propelled, intraluminal device with medical agent applicator and method of use
US6866626B2 (en) * 2001-11-09 2005-03-15 Ethicon-Endo Surgery, Inc. Self-propelled, intraluminal device with working channel and method of use
AU2002357155A1 (en) 2001-12-10 2003-06-23 Carnegie Mellon University Endoscopic imaging system
JP3943927B2 (en) 2001-12-25 2007-07-11 オリンパス株式会社 Optical scanning observation system
WO2003062799A2 (en) 2002-01-18 2003-07-31 Newton Laboratories, Inc. Spectroscopic diagnostic methods and system
JP3957272B2 (en) * 2002-01-22 2007-08-15 オリンパス株式会社 Capsule medical device
ATE415853T1 (en) 2002-02-05 2008-12-15 Kersten Zaar ENDOSCOPE WITH SIDE LOOK OPTICS
DE10207186C1 (en) 2002-02-21 2003-04-17 Alexander Knuettel Low coherence interferometry device for object scanning has variable wavelength selection device used for varying selected wavelengths of detection beam dependent on scanning position
JP3600228B2 (en) 2002-03-01 2004-12-15 株式会社リコー Optical scanning device and image forming apparatus
US6550918B1 (en) 2002-03-19 2003-04-22 Eastman Kodak Company Monocentric autostereoscopic viewing apparatus using resonant fiber-optic image generation
JP3869291B2 (en) * 2002-03-25 2007-01-17 オリンパス株式会社 Capsule medical device
US20040039242A1 (en) * 2002-04-02 2004-02-26 Seedling Enterprises, Llc Apparatus and methods using visible light for debilitating and/or killing microorganisms within the body
US7016048B2 (en) 2002-04-09 2006-03-21 The Regents Of The University Of California Phase-resolved functional optical coherence tomography: simultaneous imaging of the stokes vectors, structure, blood flow velocity, standard deviation and birefringence in biological samples
EP1499235B1 (en) 2002-04-17 2016-08-17 Covidien LP Endoscope structures and techniques for navigating to a target in branched structure
EP1503669A1 (en) * 2002-05-02 2005-02-09 Medigus Ltd Entry port for endoscopes and laparoscopes
RU2242710C2 (en) 2002-06-07 2004-12-20 Геликонов Григорий Валентинович Method and device for building object image and device for delivering low coherence optical radiation
US20040243227A1 (en) 2002-06-13 2004-12-02 Guided Delivery Systems, Inc. Delivery devices and methods for heart valve repair
US6932829B2 (en) 2002-06-24 2005-08-23 Cordis Corporation Centering catheter
US6779892B2 (en) 2002-07-26 2004-08-24 Eastman Kodak Company Monocentric autostereoscopic optical display having an expanded color gamut
EP1526802A2 (en) * 2002-07-29 2005-05-04 GI View Ltd. Self-propelled imaging system
CN100364479C (en) 2002-07-31 2008-01-30 奥林巴斯株式会社 Endoscope
US6892090B2 (en) 2002-08-19 2005-05-10 Surgical Navigation Technologies, Inc. Method and apparatus for virtual endoscopy
AU2002951841A0 (en) 2002-09-30 2002-10-24 Swinburne University Of Technology Apparatus
US20040068190A1 (en) * 2002-10-04 2004-04-08 Cespedes Eduardo Ignacio Imaging catheter with indicia and methods of use
AU2003269460A1 (en) 2002-10-18 2004-05-04 Arieh Sher Atherectomy system with imaging guidewire
US7599730B2 (en) 2002-11-19 2009-10-06 Medtronic Navigation, Inc. Navigation system for cardiac therapies
US7226410B2 (en) * 2002-12-05 2007-06-05 Ethicon-Endo Surgery, Inc. Locally-propelled, intraluminal device with cable loop track and method of use
US20040186349A1 (en) 2002-12-24 2004-09-23 Usgi Medical Corp. Apparatus and methods for achieving endoluminal access
ATE338507T1 (en) 2003-01-03 2006-09-15 Juergen Kress HYGIENE PROTECTION FOR ENDOSCOPES
JP2004298560A (en) * 2003-04-01 2004-10-28 Olympus Corp Capsule endoscope system
US6889175B2 (en) 2003-01-13 2005-05-03 Trimble Navigation Limited Tunable filter device for spatial positioning systems
US7075658B2 (en) 2003-01-24 2006-07-11 Duke University Method for optical coherence tomography imaging with molecular contrast
US7013169B2 (en) 2003-01-27 2006-03-14 Cardiac Pacemakers, Inc. Dual steer preshaped catheter
US20040176683A1 (en) 2003-03-07 2004-09-09 Katherine Whitin Method and apparatus for tracking insertion depth
US7038191B2 (en) 2003-03-13 2006-05-02 The Boeing Company Remote sensing apparatus and method
US6826342B1 (en) 2003-03-13 2004-11-30 Fitel U.S.A. Corp. Temperature tuning of dispersion in photonic band gap fiber
US6755532B1 (en) 2003-03-20 2004-06-29 Eastman Kodak Company Method and apparatus for monocentric projection of an image
US20040199052A1 (en) 2003-04-01 2004-10-07 Scimed Life Systems, Inc. Endoscopic imaging system
JP4418173B2 (en) 2003-06-03 2010-02-17 オリンパス株式会社 Optical imaging device
US7431694B2 (en) 2003-05-16 2008-10-07 Ethicon Endo-Surgery, Inc. Method of guiding medical devices
US20040260199A1 (en) 2003-06-19 2004-12-23 Wilson-Cook Medical, Inc. Cytology collection device
US7448995B2 (en) 2003-06-23 2008-11-11 Microvision, Inc. Scanning endoscope
US20050054931A1 (en) 2003-09-09 2005-03-10 Clark David W. Tracking clutter filter for spectral & audio doppler
DE10343808B4 (en) * 2003-09-22 2017-06-01 Siemens Healthcare Gmbh Medical examination and / or treatment system
US8354837B2 (en) 2003-09-24 2013-01-15 Ge Medical Systems Global Technology Company Llc System and method for electromagnetic tracking operable with multiple coil architectures
JP3993550B2 (en) * 2003-09-30 2007-10-17 オリンパス株式会社 Gastrointestinal inspection device
US7460250B2 (en) 2003-10-24 2008-12-02 3Dm Devices Inc. Laser triangulation system
WO2005044094A1 (en) * 2003-11-11 2005-05-19 Olympus Corporation Capsule type medical device system and capsule type medical device
US7359062B2 (en) 2003-12-09 2008-04-15 The Regents Of The University Of California High speed spectral domain functional optical coherence tomography and optical doppler tomography for in vivo blood flow dynamics and tissue structure
US7901348B2 (en) 2003-12-12 2011-03-08 University Of Washington Catheterscope 3D guidance and interface system
US8082024B2 (en) * 2004-01-16 2011-12-20 Alfano Robert R Micro-scale compact device for in vivo medical diagnosis combining optical imaging and point fluorescence spectroscopy
JP4352916B2 (en) 2004-02-04 2009-10-28 ソニー株式会社 Imaging apparatus and imaging method
US7922654B2 (en) 2004-08-09 2011-04-12 Boston Scientific Scimed, Inc. Fiber optic imaging catheter
US7261687B2 (en) 2004-03-23 2007-08-28 California Institute Of Technology Forward scanning imaging optical fiber probe
AU2005228956B2 (en) 2004-03-23 2011-08-18 Boston Scientific Limited In-vivo visualization system
JP4698966B2 (en) 2004-03-29 2011-06-08 オリンパス株式会社 Procedure support system
US7507205B2 (en) 2004-04-07 2009-03-24 St. Jude Medical, Atrial Fibrillation Division, Inc. Steerable ultrasound catheter
US8517921B2 (en) 2004-04-16 2013-08-27 Gyrus Acmi, Inc. Endoscopic instrument having reduced diameter flexible shaft
US20050245788A1 (en) * 2004-04-28 2005-11-03 Medtronic, Inc. Esophageal delivery system and method with position indexing
JP4995720B2 (en) 2004-07-02 2012-08-08 ザ ジェネラル ホスピタル コーポレイション Endoscopic imaging probe with double clad fiber
US20060009679A1 (en) * 2004-07-08 2006-01-12 Pentax Corporation Electronic endoscope system capable of detecting inserted length
EP1804638B1 (en) 2004-09-29 2012-12-19 The General Hospital Corporation System and method for optical coherence imaging
JP4471163B2 (en) 2004-09-30 2010-06-02 富士フイルム株式会社 Optical tomographic image acquisition device
US7611474B2 (en) 2004-12-29 2009-11-03 Ethicon Endo-Surgery, Inc. Core sampling biopsy device with short coupled MRI-compatible driver
DE102005002461B3 (en) * 2005-01-18 2006-07-06 Martin Dr. Neumann Drive for an endoscope
US7884945B2 (en) 2005-01-21 2011-02-08 Massachusetts Institute Of Technology Methods and apparatus for optical coherence tomography scanning
US7189961B2 (en) 2005-02-23 2007-03-13 University Of Washington Scanning beam device with detector assembly
US7530948B2 (en) 2005-02-28 2009-05-12 University Of Washington Tethered capsule endoscope for Barrett's Esophagus screening
US7321114B2 (en) 2005-03-10 2008-01-22 Hitachi Via Mechanics, Ltd. Apparatus and method for beam drift compensation
US20060252993A1 (en) 2005-03-23 2006-11-09 Freed David I Medical devices and systems
JP4875315B2 (en) 2005-04-05 2012-02-15 オリンパスメディカルシステムズ株式会社 Intra-subject introduction device
JP4700390B2 (en) 2005-04-05 2011-06-15 オリンパスメディカルシステムズ株式会社 Intra-subject introduction device
JP2006280859A (en) 2005-04-05 2006-10-19 Olympus Medical Systems Corp In-vivo introduction device
US7576865B2 (en) 2005-04-18 2009-08-18 Zhongping Chen Optical coherent tomographic (OCT) imaging apparatus and method using a fiber bundle
US7783337B2 (en) 2005-06-06 2010-08-24 Board Of Regents, The University Of Texas System OCT using spectrally resolved bandwidth
CN101217909B (en) 2005-07-08 2010-05-19 奥林巴斯株式会社 Device and system for acquiring information in living body
DE102005045373A1 (en) 2005-09-22 2007-04-05 Siemens Ag catheter device
US7414729B2 (en) 2005-10-13 2008-08-19 President And Fellows Of Harvard College System and method for coherent anti-Stokes Raman scattering endoscopy
WO2007050683A2 (en) 2005-10-24 2007-05-03 Spectrascience, Inc. System and method for non-endoscopic optical biopsy detection of diseased tissue
US20070106114A1 (en) * 2005-11-09 2007-05-10 Pentax Corporation Endoscope-shape monitoring system
US20070213618A1 (en) 2006-01-17 2007-09-13 University Of Washington Scanning fiber-optic nonlinear optical imaging and spectroscopy endoscope
US8568299B2 (en) 2006-05-19 2013-10-29 Intuitive Surgical Operations, Inc. Methods and apparatus for displaying three-dimensional orientation of a steerable distal tip of an endoscope
JP4979271B2 (en) * 2006-05-29 2012-07-18 オリンパス株式会社 ENDOSCOPE SYSTEM AND ENDOSCOPE OPERATING METHOD
US20080004491A1 (en) 2006-06-28 2008-01-03 University Of Washington Method for fabricating optical fiber
US7582055B2 (en) * 2006-08-09 2009-09-01 Olympus Medical Systems Corp. Endoscope system
US20080221388A1 (en) 2007-03-09 2008-09-11 University Of Washington Side viewing optical fiber endoscope
WO2009032016A1 (en) 2007-09-07 2009-03-12 University Of Washington Monitoring disposition of tethered capsule endoscope in esophagus

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WO2006093655A2 (en) 2006-09-08
US20060195014A1 (en) 2006-08-31
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US9161684B2 (en) 2015-10-20
US20070299309A1 (en) 2007-12-27
US20160000312A1 (en) 2016-01-07
WO2006093655A3 (en) 2007-08-09
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US9872613B2 (en) 2018-01-23
US7530948B2 (en) 2009-05-12

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