WO2006091727A3 - Single branch heparin-binding growth factor analogs - Google Patents

Single branch heparin-binding growth factor analogs Download PDF

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Publication number
WO2006091727A3
WO2006091727A3 PCT/US2006/006397 US2006006397W WO2006091727A3 WO 2006091727 A3 WO2006091727 A3 WO 2006091727A3 US 2006006397 W US2006006397 W US 2006006397W WO 2006091727 A3 WO2006091727 A3 WO 2006091727A3
Authority
WO
WIPO (PCT)
Prior art keywords
hbgf
growth factor
analog
binding growth
heparin
Prior art date
Application number
PCT/US2006/006397
Other languages
French (fr)
Other versions
WO2006091727A2 (en
Inventor
Kazuyuki Takahashi
Paul O Zamora
Original Assignee
Biosurface Eng Tech Inc
Kazuyuki Takahashi
Paul O Zamora
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosurface Eng Tech Inc, Kazuyuki Takahashi, Paul O Zamora filed Critical Biosurface Eng Tech Inc
Priority to AU2006216676A priority Critical patent/AU2006216676A1/en
Priority to EP06735882A priority patent/EP1855706A4/en
Priority to CA002598688A priority patent/CA2598688A1/en
Priority to JP2007556427A priority patent/JP4897708B2/en
Publication of WO2006091727A2 publication Critical patent/WO2006091727A2/en
Publication of WO2006091727A3 publication Critical patent/WO2006091727A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/522—Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/49—Platelet-derived growth factor [PDGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

A heparin-binding growth factor (HBGF) analog having two substantially similar sequences (homodimeric sequences) branched from a single amino acid residue, where the sequences are analogs of a particular HBGF that binds to a heparin-binding growth factor receptor (HBGFR), or alternatively that bind to a HBGFR without being an analog of any particular HBGF. The homodimeric sequences may be derived from any portion of a HBGF. The synthetic HBGF analog may be an analog of a hormone, a cytokine, a lymphokine, a chemokine or an interleukin, and may bind to any HBGFR. Further provided are preparations for medical devices, pharmaceutical compositions and methods of using the same.
PCT/US2006/006397 2005-02-22 2006-02-22 Single branch heparin-binding growth factor analogs WO2006091727A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2006216676A AU2006216676A1 (en) 2005-02-22 2006-02-22 Single branch heparin-binding growth factor analogs
EP06735882A EP1855706A4 (en) 2005-02-22 2006-02-22 Single branch heparin-binding growth factor analogs
CA002598688A CA2598688A1 (en) 2005-02-22 2006-02-22 Single branch heparin-binding growth factor analogs
JP2007556427A JP4897708B2 (en) 2005-02-22 2006-02-22 Single-branched heparin-binding growth factor analog

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US65557005P 2005-02-22 2005-02-22
US60/655,570 2005-02-22
US11/359,173 2006-02-21
US11/359,173 US20080227696A1 (en) 2005-02-22 2006-02-21 Single branch heparin-binding growth factor analogs

Publications (2)

Publication Number Publication Date
WO2006091727A2 WO2006091727A2 (en) 2006-08-31
WO2006091727A3 true WO2006091727A3 (en) 2007-03-01

Family

ID=36928004

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/006397 WO2006091727A2 (en) 2005-02-22 2006-02-22 Single branch heparin-binding growth factor analogs

Country Status (6)

Country Link
US (2) US20080227696A1 (en)
EP (1) EP1855706A4 (en)
JP (1) JP4897708B2 (en)
AU (1) AU2006216676A1 (en)
CA (1) CA2598688A1 (en)
WO (1) WO2006091727A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8227411B2 (en) * 2002-08-20 2012-07-24 BioSurface Engineering Technologies, Incle FGF growth factor analogs
US7598224B2 (en) 2002-08-20 2009-10-06 Biosurface Engineering Technologies, Inc. Dual chain synthetic heparin-binding growth factor analogs
US7166574B2 (en) * 2002-08-20 2007-01-23 Biosurface Engineering Technologies, Inc. Synthetic heparin-binding growth factor analogs
US7981862B2 (en) 2003-08-19 2011-07-19 Biosurface Engineering Technologies, Inc. Composition comprising BMP-2 amplifier/co-activator for enhancement of osteogenesis
US7482427B2 (en) * 2002-08-20 2009-01-27 Biosurface Engineering Technologies, Inc. Positive modulator of bone morphogenic protein-2
US20080227696A1 (en) 2005-02-22 2008-09-18 Biosurface Engineering Technologies, Inc. Single branch heparin-binding growth factor analogs
AU2013201291B2 (en) * 2005-08-05 2015-08-13 Araim Pharmaceuticals, Inc. Tissue protective peptides and uses thereof
KR20180067735A (en) 2005-08-05 2018-06-20 아라임 파마슈티칼즈, 인크. Tissue protective peptides and uses thereof
US7820172B1 (en) * 2006-06-01 2010-10-26 Biosurface Engineering Technologies, Inc. Laminin-derived multi-domain peptides
US9187517B2 (en) * 2006-11-13 2015-11-17 The Brigham And Women's Hospital, Inc. Methods of promoting cardiac repair using growth factors fused to heparin binding sequences
NZ587105A (en) 2008-01-22 2012-09-28 Araim Pharmaceuticals Inc Tissue protective peptides and peptide analogs for preventing and treating diseases and disorders associated with tissue damage
CN111936157A (en) * 2018-02-13 2020-11-13 佛罗里达大学研究基金会 Fibroblast growth factor analogs and uses thereof
CN111303271B (en) * 2020-02-19 2022-02-01 西安交通大学医学院第一附属医院 Platelet-derived growth factor recombinant vaccine for treating pulmonary fibrosis and application thereof
WO2022204331A1 (en) * 2021-03-24 2022-09-29 Combangio, Inc. Compositions comprising branched kgf-2 derived peptides and methods for use in ocular treatment
WO2024050602A1 (en) * 2022-09-09 2024-03-14 The University Of Sydney Novel platelet derived growth factor peptide mimetic

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040038348A1 (en) * 2002-08-20 2004-02-26 Pena Louis A. Synthetic heparin-binding growth factor analogs

Family Cites Families (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3272204A (en) * 1965-09-22 1966-09-13 Ethicon Inc Absorbable collagen prosthetic implant with non-absorbable reinforcing strands
US4172128A (en) 1975-03-26 1979-10-23 Erhard Thiele Process of degrading and regenerating bone and tooth material and products
GB1537448A (en) * 1976-08-20 1978-12-29 Sumitomo Electric Industries Vascular prostheses and process for production thereof
US5197977A (en) * 1984-01-30 1993-03-30 Meadox Medicals, Inc. Drug delivery collagen-impregnated synthetic vascular graft
US4842575A (en) * 1984-01-30 1989-06-27 Meadox Medicals, Inc. Method for forming impregnated synthetic vascular grafts
US4563350A (en) * 1984-10-24 1986-01-07 Collagen Corporation Inductive collagen based bone repair preparations
GB8430265D0 (en) * 1984-11-30 1985-01-09 Vascutek Ltd Vascular graft
US5859208A (en) * 1988-07-06 1999-01-12 Fiddes; John C. Human basic fibroblast growth factor analog
US5658894A (en) * 1989-04-23 1997-08-19 The Trustees Of The University Of Pennsylvania Compositions for inhibiting restenosis
US6018026A (en) 1988-01-22 2000-01-25 Zymogenetics, Inc. Biologically active dimerized and multimerized polypeptide fusions
FI890312A (en) * 1988-01-25 1989-07-26 Oncogen AMFIREGULIN: ETT NOWT BIFUNKTIONELLT TILLVAEXT MODULERANDE GLYKOPROTEIN.
US6919308B2 (en) 1988-04-08 2005-07-19 Stryker Corporation Osteogenic devices
US5202311A (en) * 1988-08-19 1993-04-13 Children's Medical Center Corporation Stabilized fgf composition
US5108436A (en) * 1988-09-29 1992-04-28 Collagen Corporation Implant fixation
US5510418A (en) * 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
US5576288A (en) 1989-04-27 1996-11-19 The Salk Institute For Biological Studies Fibroblast growth factor conjugates
US5759515A (en) * 1989-08-09 1998-06-02 Rhomed Incorporated Polyvalent peptide pharmaceutical applications
US5380536A (en) * 1990-10-15 1995-01-10 The Board Of Regents, The University Of Texas System Biocompatible microcapsules
US5270197A (en) * 1990-12-20 1993-12-14 The Children's Medical Center Corporation Cells expressing a substantial number of surface high affinity HBGF receptors but relatively few low affinity HBGF binding sites and system for assaying binding to HBGF receptor
GB9101645D0 (en) * 1991-01-25 1991-03-06 British Bio Technology Compounds
US5728802A (en) * 1992-05-06 1998-03-17 Affymax Technologies N.V. Peptides and compounds that bind selectins including endothelium leukocyte adhesion molecule 1 (ELAM-1)
US5648458A (en) * 1992-05-06 1997-07-15 Affymax Technologies N.V. Peptides and compounds that bind to ELAM-1
US5643873A (en) * 1992-05-06 1997-07-01 Affymax Technologies N.V. Peptides and compounds that bind selectins including endothelial leukocyte adhesion molecule 1
US5326695A (en) * 1992-05-15 1994-07-05 Ludwig Institute For Cancer Research Platelet derived growth factor agonists
DE69333950T2 (en) * 1992-05-18 2006-08-17 Genentech, Inc., South San Francisco Activation of receptors capable of oligomerization by use of fused receptor ligands
US5763584A (en) 1992-05-18 1998-06-09 Genentech, Inc. Receptor activation with hepatocyte growth factor agonists
US5643756A (en) * 1992-08-28 1997-07-01 The Public Health Research Institute Of The City Of New York, Inc. Fusion glycoproteins
US5679673A (en) 1992-09-24 1997-10-21 The United States Of America, Represented By The Department Of Health And Human Services Aralkyl bridged diazabicycloalkane derivatives for CNS disorders
US6057133A (en) * 1992-11-24 2000-05-02 G. D. Searle Multivariant human IL-3 fusion proteins and their recombinant production
US5674977A (en) 1993-02-05 1997-10-07 The Ontario Cancer Institute Branched synthetic peptide conjugate
US6174530B1 (en) * 1993-05-05 2001-01-16 Gryphon Sciences Homogeneous polyoxime compositions and their preparation by parallel assembly
US6001364A (en) 1993-05-05 1999-12-14 Gryphon Sciences Hetero-polyoxime compounds and their preparation by parallel assembly
US5563046A (en) 1993-08-02 1996-10-08 Celtrix Pharmaceuticals, Inc. Fusion polypeptides and proteins
US6284503B1 (en) * 1993-08-20 2001-09-04 University Of Utah Research Foundation Composition and method for regulating the adhesion of cells and biomolecules to hydrophobic surfaces
US5952304A (en) * 1993-10-22 1999-09-14 Trigen Limited Platelet-derived growth factor analogues
US5830851A (en) 1993-11-19 1998-11-03 Affymax Technologies N.V. Methods of administering peptides that bind to the erythropoietin receptor
US5773569A (en) * 1993-11-19 1998-06-30 Affymax Technologies N.V. Compounds and peptides that bind to the erythropoietin receptor
US5861476A (en) * 1994-02-02 1999-01-19 Affymax Technologies N.V. Peptides and compounds that bind to the IL-1 receptor
US5608035A (en) * 1994-02-02 1997-03-04 Affymax Technologies N.V. Peptides and compounds that bind to the IL-1 receptor
US5880096A (en) * 1994-02-02 1999-03-09 Affymax Technologies N.V. Peptides and compounds that bind to the IL-1 receptor
US5786331A (en) * 1994-02-02 1998-07-28 Affymax Technologies N.V. Peptides and compounds that bind to the IL-1 receptor
US5635599A (en) * 1994-04-08 1997-06-03 The United States Of America As Represented By The Department Of Health And Human Services Fusion proteins comprising circularly permuted ligands
US5635597A (en) * 1994-05-27 1997-06-03 Affymax Technologies, N.V. Peptides that bind IL-2 receptors
US5589359A (en) * 1994-08-05 1996-12-31 Chiron Corporation Chimeric proteins
US5665114A (en) * 1994-08-12 1997-09-09 Meadox Medicals, Inc. Tubular expanded polytetrafluoroethylene implantable prostheses
US5650234A (en) * 1994-09-09 1997-07-22 Surface Engineering Technologies, Division Of Innerdyne, Inc. Electrophilic polyethylene oxides for the modification of polysaccharides, polypeptides (proteins) and surfaces
US5509899A (en) * 1994-09-22 1996-04-23 Boston Scientific Corp. Medical device with lubricious coating
US5932462A (en) * 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
US5919570A (en) * 1995-02-01 1999-07-06 Schneider Inc. Slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with a poly(N-vinylpyrrolidone) polymer hydrogel, coated polymer and metal substrate materials, and coated medical devices
US6231600B1 (en) * 1995-02-22 2001-05-15 Scimed Life Systems, Inc. Stents with hybrid coating for medical devices
US6099562A (en) * 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
US6251864B1 (en) * 1995-06-07 2001-06-26 Glaxo Group Limited Peptides and compounds that bind to a receptor
US5869451A (en) * 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
US5654276A (en) * 1995-06-07 1997-08-05 Affymax Technologies N.V. Peptides and compounds that bind to the IL-5 receptor
US5668110A (en) * 1995-06-07 1997-09-16 Affymax Technologies N.V. Peptides and compounds that bind to the IL-5 receptor
US6491965B1 (en) * 1995-11-30 2002-12-10 Hamilton Civic Hospitals Research Development, Inc. Medical device comprising glycosaminoglycan-antithrombin III/heparin cofactor II conjugates
US6048964A (en) 1995-12-12 2000-04-11 Stryker Corporation Compositions and therapeutic methods using morphogenic proteins and stimulatory factors
ATE330644T1 (en) * 1995-12-18 2006-07-15 Angiotech Biomaterials Corp CROSS-LINKED POLYMER MATERIALS AND METHODS FOR USE THEREOF
US6458889B1 (en) * 1995-12-18 2002-10-01 Cohesion Technologies, Inc. Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
GB9608882D0 (en) * 1996-04-30 1996-07-03 Luthra Ajay K Non-thrombogenic and anti-thrombogenic polymers
US5811151A (en) * 1996-05-31 1998-09-22 Medtronic, Inc. Method of modifying the surface of a medical device
US5916585A (en) * 1996-06-03 1999-06-29 Gore Enterprise Holdings, Inc. Materials and method for the immobilization of bioactive species onto biodegradable polymers
US5965532A (en) 1996-06-28 1999-10-12 Trustees Of Tufts College Multivalent compounds for crosslinking receptors and uses thereof
US6060534A (en) * 1996-07-11 2000-05-09 Scimed Life Systems, Inc. Medical devices comprising ionically and non-ionically crosslinked polymer hydrogels having improved mechanical properties
US6306165B1 (en) * 1996-09-13 2001-10-23 Meadox Medicals ePTFE small caliber vascular grafts with significant patency enhancement via a surface coating which contains covalently bonded heparin
IL129379A (en) 1996-10-16 2008-12-29 Zymogenetics Inc Fibroblast growth factor homologs
US5994104A (en) 1996-11-08 1999-11-30 Royal Free Hospital School Of Medicine Interleukin-12 fusion protein
US6214795B1 (en) * 1996-11-12 2001-04-10 Praecis Pharmaceuticals, Inc. Peptide compounds useful for modulating FGF receptor activity
JP4388602B2 (en) * 1997-02-07 2009-12-24 ストライカー コーポレイション Bone-forming device not containing matrix, graft, and method of use thereof
US7041641B2 (en) * 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
ATE285415T1 (en) 1997-06-13 2005-01-15 Gryphon Therapeutics Inc SOLID PHASE NATIVE CHEMICAL LIGATION OF UNPROTECTED OR N-CYSTEINE PROTECTED PEPTIDES IN AQUEOUS SOLUTIONS
US6168784B1 (en) * 1997-09-03 2001-01-02 Gryphon Sciences N-terminal modifications of RANTES and methods of use
US5945457A (en) * 1997-10-01 1999-08-31 A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Science Process for preparing biologically compatible polymers and their use in medical devices
US5955588A (en) * 1997-12-22 1999-09-21 Innerdyne, Inc. Non-thrombogenic coating composition and methods for using same
US6410044B1 (en) * 1998-03-19 2002-06-25 Surmodics, Inc. Crosslinkable macromers
US6121236A (en) * 1998-03-24 2000-09-19 The Children's Medical Center Corporation Multivalent ligands which modulate angiogenesis
DE19814057B4 (en) * 1998-03-30 2009-01-02 Carl Zeiss Meditec Ag Arrangement for optical coherence tomography and coherence topography
US6258371B1 (en) * 1998-04-03 2001-07-10 Medtronic Inc Method for making biocompatible medical article
US6248057B1 (en) * 1998-07-28 2001-06-19 Innerdyne, Inc. Absorbable brachytherapy and chemotherapy delivery devices and methods
US6514534B1 (en) * 1998-08-14 2003-02-04 Incept Llc Methods for forming regional tissue adherent barriers and drug delivery systems
US6818018B1 (en) * 1998-08-14 2004-11-16 Incept Llc In situ polymerizable hydrogels
ATE332306T1 (en) * 1998-08-31 2006-07-15 Gryphon Therapeutics Inc CHEMICAL CONNECTION INVOLVING A LIPID MATRIX AND PRODUCTION OF MEMBRANE POLYPEPTIDES
US6596699B2 (en) * 1998-09-22 2003-07-22 Biosurface Engineering Technologies, Inc. Nucleic acid coating compositions and methods
US6921811B2 (en) * 1998-09-22 2005-07-26 Biosurface Engineering Technologies, Inc. Bioactive coating composition and methods
US6342591B1 (en) * 1998-09-22 2002-01-29 Biosurface Engineering Technologies, Inc. Amphipathic coating for modulating cellular adhesion composition and methods
US6548634B1 (en) * 1998-09-30 2003-04-15 Chiron Corporation Synthetic peptides having FGF receptor affinity
ATE269114T1 (en) * 1998-11-20 2004-07-15 Univ Connecticut METHOD AND DEVICE FOR CONTROLLING TISSUE IMPLANT INTERACTIONS
US6368347B1 (en) * 1999-04-23 2002-04-09 Sulzer Vascutek Ltd. Expanded polytetrafluoroethylene vascular graft with coating
US6309660B1 (en) * 1999-07-28 2001-10-30 Edwards Lifesciences Corp. Universal biocompatible coating platform for medical devices
US6458162B1 (en) * 1999-08-13 2002-10-01 Vita Special Purpose Corporation Composite shaped bodies and methods for their production and use
AU2432501A (en) * 1999-12-28 2001-07-09 Osteotech, Inc. Calcium phosphate bone graft material and osteoimplant fabricated therefrom
US6585765B1 (en) * 2000-06-29 2003-07-01 Advanced Cardiovascular Systems, Inc. Implantable device having substances impregnated therein and a method of impregnating the same
US6949251B2 (en) * 2001-03-02 2005-09-27 Stryker Corporation Porous β-tricalcium phosphate granules for regeneration of bone tissue
US6984393B2 (en) * 2001-05-07 2006-01-10 Queen's University At Kingston Biodegradable elastomer and method of preparing same
US7297343B2 (en) * 2001-07-31 2007-11-20 Biosurface Engineering Technologies, Inc. Bioactive medical films
US7981862B2 (en) * 2003-08-19 2011-07-19 Biosurface Engineering Technologies, Inc. Composition comprising BMP-2 amplifier/co-activator for enhancement of osteogenesis
US7482427B2 (en) * 2002-08-20 2009-01-27 Biosurface Engineering Technologies, Inc. Positive modulator of bone morphogenic protein-2
US7598224B2 (en) 2002-08-20 2009-10-06 Biosurface Engineering Technologies, Inc. Dual chain synthetic heparin-binding growth factor analogs
US8227411B2 (en) * 2002-08-20 2012-07-24 BioSurface Engineering Technologies, Incle FGF growth factor analogs
US7135027B2 (en) * 2002-10-04 2006-11-14 Baxter International, Inc. Devices and methods for mixing and extruding medically useful compositions
US7468210B1 (en) * 2002-12-10 2008-12-23 Biosurface Engineering Technologies, Inc. Cross-linked heparin coatings and methods
WO2005046746A2 (en) * 2003-11-10 2005-05-26 Angiotech International Ag Medical implants and fibrosis-inducing agents
US7234787B2 (en) * 2004-01-08 2007-06-26 Eastman Kodak Company Liquid level detection method and apparatus
US7414028B1 (en) * 2004-02-04 2008-08-19 Biosurface Engineering Technologies, Inc. Growth factor analogs
US20080227696A1 (en) 2005-02-22 2008-09-18 Biosurface Engineering Technologies, Inc. Single branch heparin-binding growth factor analogs
US20060024347A1 (en) * 2004-02-10 2006-02-02 Biosurface Engineering Technologies, Inc. Bioactive peptide coatings
US7528105B1 (en) * 2004-02-10 2009-05-05 Biosurface Engineering Technologies Heterodimeric chain synthetic heparin-binding growth factor analogs
US7671012B2 (en) * 2004-02-10 2010-03-02 Biosurface Engineering Technologies, Inc. Formulations and methods for delivery of growth factor analogs
DE102004045176B4 (en) * 2004-09-17 2011-07-21 Adidas International Marketing B.V. bladder
US20090111743A1 (en) * 2005-02-25 2009-04-30 Biosurface Engineering Technologies, Inc. Cysteine-branched heparin-binding growth factor analogs

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040038348A1 (en) * 2002-08-20 2004-02-26 Pena Louis A. Synthetic heparin-binding growth factor analogs

Also Published As

Publication number Publication date
US20100298218A1 (en) 2010-11-25
JP2008531505A (en) 2008-08-14
US8101570B2 (en) 2012-01-24
CA2598688A1 (en) 2006-08-31
EP1855706A4 (en) 2012-03-28
US20080227696A1 (en) 2008-09-18
WO2006091727A2 (en) 2006-08-31
EP1855706A2 (en) 2007-11-21
AU2006216676A1 (en) 2006-08-31
JP4897708B2 (en) 2012-03-14

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