WO2006091223A3 - Multimodal method for identifying hazardous agents - Google Patents

Multimodal method for identifying hazardous agents Download PDF

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Publication number
WO2006091223A3
WO2006091223A3 PCT/US2005/023705 US2005023705W WO2006091223A3 WO 2006091223 A3 WO2006091223 A3 WO 2006091223A3 US 2005023705 W US2005023705 W US 2005023705W WO 2006091223 A3 WO2006091223 A3 WO 2006091223A3
Authority
WO
WIPO (PCT)
Prior art keywords
sample
methods
hazardous agents
identifying hazardous
multimodal method
Prior art date
Application number
PCT/US2005/023705
Other languages
French (fr)
Other versions
WO2006091223A2 (en
Inventor
Jason Neiss
Matthew P Nelson
Patrick Treado
Robert Schweitzer
Original Assignee
Chemimage Corp
Jason Neiss
Matthew P Nelson
Patrick Treado
Robert Schweitzer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/882,082 external-priority patent/US7046359B2/en
Priority claimed from US11/000,841 external-priority patent/US7532320B2/en
Application filed by Chemimage Corp, Jason Neiss, Matthew P Nelson, Patrick Treado, Robert Schweitzer filed Critical Chemimage Corp
Priority to EP05857503A priority Critical patent/EP1766351A4/en
Priority to CA002571932A priority patent/CA2571932A1/en
Publication of WO2006091223A2 publication Critical patent/WO2006091223A2/en
Publication of WO2006091223A3 publication Critical patent/WO2006091223A3/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28Investigating the spectrum
    • G01J3/44Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02Details
    • G01J3/10Arrangements of light sources specially adapted for spectrometry or colorimetry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28Investigating the spectrum
    • G01J3/30Measuring the intensity of spectral lines directly on the spectrum itself
    • G01J3/32Investigating bands of a spectrum in sequence by a single detector
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/21Polarisation-affecting properties
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/6456Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458Fluorescence microscopy
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65Raman scattering
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N2021/6417Spectrofluorimetric devices
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N2021/6484Optical fibres
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65Raman scattering
    • G01N2021/653Coherent methods [CARS]
    • G01N2021/656Raman microprobe

Abstract

The invention relates to apparatus and methods for assessing occurrence of a hazardous agent in a sample by performing multimodal spectral analysis of the sample. Methods of employing Raman spectroscopy for entities in a sample which exhibit one or more optical properties characteristic of a hazardous agent are disclosed. Devices and systems suitable for performing such methods are also disclosed.
PCT/US2005/023705 2004-06-30 2005-06-30 Multimodal method for identifying hazardous agents WO2006091223A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP05857503A EP1766351A4 (en) 2004-06-30 2005-06-30 Multimodal method for identifying hazardous agents
CA002571932A CA2571932A1 (en) 2004-06-30 2005-06-30 Multimodal method for identifying hazardous agents

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US58471904P 2004-06-30 2004-06-30
US10/882,082 2004-06-30
US60/584,719 2004-06-30
US10/882,082 US7046359B2 (en) 2004-06-30 2004-06-30 System and method for dynamic chemical imaging
US11/000,841 US7532320B2 (en) 2004-06-30 2004-11-30 Multimodal method for identifying hazardous agents
US11/000,841 2004-11-30

Publications (2)

Publication Number Publication Date
WO2006091223A2 WO2006091223A2 (en) 2006-08-31
WO2006091223A3 true WO2006091223A3 (en) 2007-03-22

Family

ID=36927863

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/023705 WO2006091223A2 (en) 2004-06-30 2005-06-30 Multimodal method for identifying hazardous agents

Country Status (3)

Country Link
EP (1) EP1766351A4 (en)
CA (1) CA2571932A1 (en)
WO (1) WO2006091223A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0606891D0 (en) 2006-04-05 2006-05-17 Council Cent Lab Res Councils Raman Analysis Of Pharmaceutical Tablets
DE102006053540B3 (en) * 2006-11-14 2008-01-31 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Optospectroscopic analysis of biological sample in fluid, comprises: fixing the biological sample in a sample holding unit, categorizing particles in biological sample based on an analysis of the image data and analyzing biological sample
WO2008147227A1 (en) * 2007-05-31 2008-12-04 Veritide Limited Method for spore detection
DE102007062067A1 (en) * 2007-12-21 2009-07-02 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Method for characterizing particles, involves irradiating particles with visible light, detecting light reflected or radiated by particles, and irradiating particles with ultraviolet light
EP2405256B1 (en) * 2010-07-09 2019-01-09 SoftScan HealthCare Group Quantitative in vivo lifetime imaging using a time-domain platform with a supercontinuum tunable laser for extended spectral coverage
WO2012012258A2 (en) 2010-07-21 2012-01-26 First Solar, Inc. Temperature-adjusted spectrometer
GB201111560D0 (en) * 2011-07-06 2011-08-24 Micromass Ltd Photo-dissociation of proteins and peptides in a mass spectrometer
FR2998967A1 (en) * 2012-12-03 2014-06-06 Univ Lorraine Spectroscopy apparatus i.e. spectroscope, for spectroscopy of door sample for study of e.g. Raman diffusion, has adjusting unit regulating position of sample support according to three translation axes and fulcrum pin
EP3293510B1 (en) * 2014-01-21 2020-05-27 Molecular Devices, LLC Fluorescent microscopy system
DE102015001033A1 (en) 2015-01-27 2016-07-28 Leibniz-Institut für Photonische Technologien e. V. High-throughput screening system for performing optical measurements

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5442438A (en) * 1988-12-22 1995-08-15 Renishaw Plc Spectroscopic apparatus and methods
US5638166A (en) * 1995-05-18 1997-06-10 The Regents Of The University Of California Apparatus and method for rapid detection of explosives residue from the deflagration signature thereof
US5759859A (en) * 1996-07-15 1998-06-02 United States Of America As Represented By The Secretary Of The Army Sensor and method for detecting trace underground energetic materials
US5866430A (en) * 1996-06-13 1999-02-02 Grow; Ann E. Raman optrode processes and devices for detection of chemicals and microorganisms

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6765668B2 (en) * 2002-01-10 2004-07-20 Chemimage, Inc. Method for detection of pathogenic microorganisms
US20040068193A1 (en) * 2002-08-02 2004-04-08 Barnes Russell H. Optical devices for medical diagnostics

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5442438A (en) * 1988-12-22 1995-08-15 Renishaw Plc Spectroscopic apparatus and methods
US5638166A (en) * 1995-05-18 1997-06-10 The Regents Of The University Of California Apparatus and method for rapid detection of explosives residue from the deflagration signature thereof
US5866430A (en) * 1996-06-13 1999-02-02 Grow; Ann E. Raman optrode processes and devices for detection of chemicals and microorganisms
US5759859A (en) * 1996-07-15 1998-06-02 United States Of America As Represented By The Secretary Of The Army Sensor and method for detecting trace underground energetic materials

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1766351A4 *

Also Published As

Publication number Publication date
WO2006091223A2 (en) 2006-08-31
CA2571932A1 (en) 2006-08-31
EP1766351A2 (en) 2007-03-28
EP1766351A4 (en) 2009-12-02

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