WO2006090073A3 - Procede et dispositif pour separer des cibles moleculaires dans un melange complexe - Google Patents

Procede et dispositif pour separer des cibles moleculaires dans un melange complexe Download PDF

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Publication number
WO2006090073A3
WO2006090073A3 PCT/FR2006/000428 FR2006000428W WO2006090073A3 WO 2006090073 A3 WO2006090073 A3 WO 2006090073A3 FR 2006000428 W FR2006000428 W FR 2006000428W WO 2006090073 A3 WO2006090073 A3 WO 2006090073A3
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WO
WIPO (PCT)
Prior art keywords
molecular targets
primary probes
primary
array
molecular
Prior art date
Application number
PCT/FR2006/000428
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English (en)
Other versions
WO2006090073A2 (fr
Inventor
Nicolas Ugolin
Sylvie Chevillard
Alexandre Coutant
Jerome Lebeau
Original Assignee
Commissariat Energie Atomique
Nicolas Ugolin
Sylvie Chevillard
Alexandre Coutant
Jerome Lebeau
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0501962A external-priority patent/FR2882563B1/fr
Priority claimed from FR0502027A external-priority patent/FR2882564B3/fr
Application filed by Commissariat Energie Atomique, Nicolas Ugolin, Sylvie Chevillard, Alexandre Coutant, Jerome Lebeau filed Critical Commissariat Energie Atomique
Priority to JP2007556637A priority Critical patent/JP2008532003A/ja
Priority to EP06709377.3A priority patent/EP1851331B1/fr
Priority to CA002598508A priority patent/CA2598508A1/fr
Publication of WO2006090073A2 publication Critical patent/WO2006090073A2/fr
Publication of WO2006090073A3 publication Critical patent/WO2006090073A3/fr
Priority to US11/892,672 priority patent/US8241893B2/en
Priority to US13/465,636 priority patent/US20130012400A1/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00653—Making arrays on substantially continuous surfaces the compounds being bound to electrodes embedded in or on the solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00729—Peptide nucleic acids [PNA]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0822—Slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension

Abstract

L'invention a pour objet un procédé d'analyse de cibles moléculaires contenues dans un mélange complexe comprenant : a) la mise en contact du mélange de cibles moléculaires à analyser avec un jeu de sondes primaires de types différents, chaque type de sonde primaire composant le jeu étant susceptible de se lier par liaison spécifique à un type de cible parmi les cibles moléculaires, dans des conditions permettant la liaison spécifique entre lesdites cibles moléculaires et lesdites sondes primaires, b) éventuellement l'élimination des sondes primaires non spécifiquement liées avec une cible moléculaire, c) la séparation des cibles moléculaires et des sondes primaires liées par liaison spécifique dans un complexe sonde-cible, de façon à récupérer le jeu de sondes primaires représentant une empreinte des cibles moléculaires à analyser, d) l'analyse quantitative des sondes primaires éluées à l'étape c.
PCT/FR2006/000428 2005-02-25 2006-02-24 Procede et dispositif pour separer des cibles moleculaires dans un melange complexe WO2006090073A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2007556637A JP2008532003A (ja) 2005-02-25 2006-02-24 複合混合物中の分子標的を分離するための方法及びデバイス
EP06709377.3A EP1851331B1 (fr) 2005-02-25 2006-02-24 Procede et dispositif pour separer des cibles moleculaires dans un melange complexe
CA002598508A CA2598508A1 (fr) 2005-02-25 2006-02-24 Procede et dispositif pour separer des cibles moleculaires dans un melange complexe
US11/892,672 US8241893B2 (en) 2005-02-25 2007-08-24 Method and device for separating molecular targets in a complex mixture
US13/465,636 US20130012400A1 (en) 2005-02-25 2012-05-07 Method and device for separating molecular targets in a complex mixture

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR0501962 2005-02-25
FR0501962A FR2882563B1 (fr) 2005-02-25 2005-02-25 Procede et dispositif pour separer des cibles moleculaires dans un melange complexe
FR0502027 2005-02-28
FR0502027A FR2882564B3 (fr) 2005-02-28 2005-02-28 Procede et dispositif pour separer des cibles moleculaires dans un melange complexe

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/892,672 Continuation US8241893B2 (en) 2005-02-25 2007-08-24 Method and device for separating molecular targets in a complex mixture

Publications (2)

Publication Number Publication Date
WO2006090073A2 WO2006090073A2 (fr) 2006-08-31
WO2006090073A3 true WO2006090073A3 (fr) 2007-03-22

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2006/000428 WO2006090073A2 (fr) 2005-02-25 2006-02-24 Procede et dispositif pour separer des cibles moleculaires dans un melange complexe

Country Status (5)

Country Link
US (2) US8241893B2 (fr)
EP (1) EP1851331B1 (fr)
JP (1) JP2008532003A (fr)
CA (1) CA2598508A1 (fr)
WO (1) WO2006090073A2 (fr)

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EP1972375A1 (fr) * 2007-03-23 2008-09-24 Koninklijke Philips Electronics N.V. Dispositif micro-fluidique basé selon les principes de matrice active
JP2009145196A (ja) * 2007-12-14 2009-07-02 Lintec Corp ペプチド低吸着領域を有する改質基板及びその製造方法
WO2009100201A2 (fr) * 2008-02-07 2009-08-13 Lawrence Livermore National Security, Llc Plateforme fonctionnalisée pour puces permettant la détection optique de cibles, et puces, procédés et systèmes associés
US8906610B2 (en) * 2010-02-08 2014-12-09 The Regents Of The University Of California Using phylogenetic probes for quantification of stable isotope labeling and microbial community analysis
FR2958645B1 (fr) 2010-04-09 2012-08-31 Commissariat Energie Atomique Hemi-anticorps a auto-assemblage
BR112012027151A8 (pt) * 2010-04-23 2018-06-26 Genomic Vision método para detectar ou identificar uma sequência de polinucleotídeo viral infeccioso ou genômico em uma célula de mamífero, tecido ou fluido biológico, método para detectar ou seguir a presença viral, replicação viral ou rearranjos genômicos virais em uma célula de mamífero, método para avaliação da eficácia de um tratamento antiviral, conjunto de sondas, kit para realizar molelular combing e materiais biológicos.
JP5494396B2 (ja) * 2010-09-28 2014-05-14 大日本印刷株式会社 バイオセンサ
JP5527139B2 (ja) * 2010-09-28 2014-06-18 大日本印刷株式会社 バイオセンサを用いる測定方法およびバイオセンサ
JP5488372B2 (ja) * 2010-09-28 2014-05-14 大日本印刷株式会社 バイオセンサ
JP5531886B2 (ja) * 2010-09-29 2014-06-25 大日本印刷株式会社 バイオセンサシステム
US8399262B2 (en) 2011-03-23 2013-03-19 Darrel A. Mazzari Biosensor
KR101860973B1 (ko) * 2011-05-25 2018-05-24 오스람 옵토 세미컨덕터스 게엠베하 광전 반도체 칩
WO2014004852A2 (fr) * 2012-06-29 2014-01-03 General Electric Company Kit pour l'amplification d'adn isotherme à partir d'une matrice d'arn
RU2582500C2 (ru) * 2014-05-14 2016-04-27 Нокиа Текнолоджиз Ой Информация о погодных условиях на основе магнитометров
US9909167B2 (en) 2014-06-23 2018-03-06 The Board Of Trustees Of The Leland Stanford Junior University On-slide staining by primer extension
US20160291002A1 (en) * 2015-03-12 2016-10-06 Pathogen Systems, Inc. dba Crystal Diagnostics Ltd Sample Preparation and Specific Capture for Multiplex Detection of Target Analytes (i.e., Bacteria, Viruses, Etc.)
EP3490616B1 (fr) 2016-07-27 2022-09-28 The Board of Trustees of the Leland Stanford Junior University Imagerie fluorescente hautement multiplexée
US11360016B2 (en) * 2019-06-13 2022-06-14 The Regents Of The University Of California Plasmofluidic microlenses for label-free optical sorting of bioparticles
CN111537422B (zh) * 2020-06-10 2022-09-23 兰州大学 表征及调控包晶合金定向凝固时糊状区内渗透率的方法

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US5846708A (en) * 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
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Also Published As

Publication number Publication date
EP1851331A2 (fr) 2007-11-07
WO2006090073A2 (fr) 2006-08-31
JP2008532003A (ja) 2008-08-14
US20130012400A1 (en) 2013-01-10
US20080182758A1 (en) 2008-07-31
US8241893B2 (en) 2012-08-14
CA2598508A1 (fr) 2006-08-31
EP1851331B1 (fr) 2016-02-24

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