WO2006086159A3 - Method for monitoring early treatment response - Google Patents

Method for monitoring early treatment response Download PDF

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Publication number
WO2006086159A3
WO2006086159A3 PCT/US2006/002675 US2006002675W WO2006086159A3 WO 2006086159 A3 WO2006086159 A3 WO 2006086159A3 US 2006002675 W US2006002675 W US 2006002675W WO 2006086159 A3 WO2006086159 A3 WO 2006086159A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
monitoring early
angiogenesis
inhibitor
early treatment
Prior art date
Application number
PCT/US2006/002675
Other languages
French (fr)
Other versions
WO2006086159A2 (en
Inventor
Joseph F Norfray
Original Assignee
Receptomon Llc
Joseph F Norfray
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Receptomon Llc, Joseph F Norfray filed Critical Receptomon Llc
Priority to EP06733897A priority Critical patent/EP1845848A4/en
Publication of WO2006086159A2 publication Critical patent/WO2006086159A2/en
Publication of WO2006086159A3 publication Critical patent/WO2006086159A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations

Abstract

Disclosed is a method for monitoring early treatment response of a cancer treatment comprising measuring by magnetic resonance spectroscopy (MRS), before and after treatment; the treatment comprises administration of an angiogenesis inhibitor, for example, a VEGF inhibitor, whereby a decrease in the amount of Choline after treatment is indicative of a positive response. Disclosed also is a method for determining effectiveness of an angiogenesis inhibitor in the treatment of cancer. Also disclosed are methods of monitoring early treatment response in diseases where an angiogenesis effector, i.e., an inhibitor or promoter of angiogenesis, is employed.
PCT/US2006/002675 2005-02-08 2006-01-26 Method for monitoring early treatment response WO2006086159A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06733897A EP1845848A4 (en) 2005-02-08 2006-01-26 Method for monitoring early treatment response

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11/053,059 US7622102B2 (en) 2005-02-08 2005-02-08 Method for monitoring early treatment response
US11/053,059 2005-02-08
US11/193,037 US20060177378A1 (en) 2005-02-08 2005-07-29 Method for monitoring early treatment response
US11/193,037 2005-07-29

Publications (2)

Publication Number Publication Date
WO2006086159A2 WO2006086159A2 (en) 2006-08-17
WO2006086159A3 true WO2006086159A3 (en) 2006-12-07

Family

ID=36780160

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/002675 WO2006086159A2 (en) 2005-02-08 2006-01-26 Method for monitoring early treatment response

Country Status (3)

Country Link
US (3) US7622102B2 (en)
EP (1) EP1845848A4 (en)
WO (1) WO2006086159A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7289840B2 (en) * 2004-09-22 2007-10-30 Receptomon, Llc Method for monitoring early treatment response
US7622102B2 (en) * 2005-02-08 2009-11-24 Receptomon, Llc Method for monitoring early treatment response
EP1865840A4 (en) * 2005-04-05 2009-10-21 Receptomon Llc Method for monitoring early treatment response
CA2663933A1 (en) * 2006-10-03 2008-05-22 Oklahoma Medical Research Foundation Metabolite detection using magnetic resonance
US9198597B2 (en) * 2008-05-22 2015-12-01 Christopher Duma Leading-edge cancer treatment
EP2508894A1 (en) * 2011-04-05 2012-10-10 Receptomon LLC Method for monitoring gene expression of translation and Integral/Secretory protein synthesis by magnetic resonance spectroscopy (MRS)
GB2493746A (en) * 2011-08-17 2013-02-20 Schlumberger Holdings NMR Flow meter with superconducting polariser
CN111444613B (en) * 2020-03-26 2023-09-08 云南电网有限责任公司电力科学研究院 Harmonic analysis method, device and storage medium based on improved EMD (electromagnetic radiation) power system

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EP1865840A4 (en) 2005-04-05 2009-10-21 Receptomon Llc Method for monitoring early treatment response

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* Cited by examiner, † Cited by third party
Title
DALY P.F. ET AL.: "Phospholipid Metabolism in Cancer Cells Monitored by 31P NMR Spectroscopy", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 262, no. 31, November 1987 (1987-11-01), pages 14875 - 14878, XP003004437 *
See also references of EP1845848A4 *

Also Published As

Publication number Publication date
US7771706B2 (en) 2010-08-10
US20070128114A1 (en) 2007-06-07
US20060177378A1 (en) 2006-08-10
EP1845848A2 (en) 2007-10-24
WO2006086159A2 (en) 2006-08-17
US20060177377A1 (en) 2006-08-10
US7622102B2 (en) 2009-11-24
EP1845848A4 (en) 2009-03-25

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