WO2006083911A3 - Method and apparatus for phase contrast quadrature interferometric detection of an immunoassay - Google Patents

Method and apparatus for phase contrast quadrature interferometric detection of an immunoassay Download PDF

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Publication number
WO2006083911A3
WO2006083911A3 PCT/US2006/003470 US2006003470W WO2006083911A3 WO 2006083911 A3 WO2006083911 A3 WO 2006083911A3 US 2006003470 W US2006003470 W US 2006003470W WO 2006083911 A3 WO2006083911 A3 WO 2006083911A3
Authority
WO
WIPO (PCT)
Prior art keywords
region
phase contrast
immunoassay
target analyte
quadrature
Prior art date
Application number
PCT/US2006/003470
Other languages
French (fr)
Other versions
WO2006083911A2 (en
Inventor
David Nolte
Leilei Peng
Fred E Regnier
Ming Zhao
Original Assignee
Purdue Research Foundation
David Nolte
Leilei Peng
Fred E Regnier
Ming Zhao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation, David Nolte, Leilei Peng, Fred E Regnier, Ming Zhao filed Critical Purdue Research Foundation
Priority to JP2007553367A priority Critical patent/JP2008529013A/en
Priority to EP06720028A priority patent/EP1856692A4/en
Publication of WO2006083911A2 publication Critical patent/WO2006083911A2/en
Publication of WO2006083911A3 publication Critical patent/WO2006083911A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
    • G01N21/45—Refractivity; Phase-affecting properties, e.g. optical path length using interferometric methods; using Schlieren methods

Abstract

A phase contrast quadrature interferometric method and apparatus for determining the presence or absence of a target analyte in a sample, comprising using a laser beam having a wavelength h and a waist w, to probe at least a portion of a substrate having a reflecting surface that has been exposed to the sample. The reflecting surface includes at least a first region having a layer of recognition molecules specific to the target analyte and a second region that does not include a layer of recognition molecules specific to the target analyte. The method further comprises measuring a time dependent intensity on a photodetector of a substantiall only first quadrature at one of a pair of quadrature angles, of a reflected diffraction signal of the probe beam while probing the first region and the second region.
PCT/US2006/003470 2005-02-01 2006-02-01 Method and apparatus for phase contrast quadrature interferometric detection of an immunoassay WO2006083911A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2007553367A JP2008529013A (en) 2005-02-01 2006-02-01 Method and apparatus for quadrature phase difference interference detection of an immunoassay
EP06720028A EP1856692A4 (en) 2005-02-01 2006-02-01 Method and apparatus for phase contrast quadrature interferometric detection of an immunoassay

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US64907005P 2005-02-01 2005-02-01
US60/649,070 2005-02-01
US75517705P 2005-12-30 2005-12-30
US60/755,177 2005-12-30

Publications (2)

Publication Number Publication Date
WO2006083911A2 WO2006083911A2 (en) 2006-08-10
WO2006083911A3 true WO2006083911A3 (en) 2007-10-11

Family

ID=36777851

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/003470 WO2006083911A2 (en) 2005-02-01 2006-02-01 Method and apparatus for phase contrast quadrature interferometric detection of an immunoassay

Country Status (3)

Country Link
EP (1) EP1856692A4 (en)
JP (1) JP2008529013A (en)
WO (1) WO2006083911A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5361268B2 (en) * 2008-07-18 2013-12-04 株式会社ミツトヨ Oblique incidence interferometer

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4741620A (en) * 1982-10-08 1988-05-03 National Research Development Corporation Irradiative probe system
USRE33581E (en) * 1984-06-25 1991-04-30 Immunoassay using optical interference detection
US5581345A (en) * 1990-12-03 1996-12-03 Nikon Corporation Confocal laser scanning mode interference contrast microscope, and method of measuring minute step height and apparatus with said microscope
US20030026735A1 (en) * 2001-06-22 2003-02-06 Nolte David D. Bio-optical compact disk system

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4741620A (en) * 1982-10-08 1988-05-03 National Research Development Corporation Irradiative probe system
USRE33581E (en) * 1984-06-25 1991-04-30 Immunoassay using optical interference detection
US5581345A (en) * 1990-12-03 1996-12-03 Nikon Corporation Confocal laser scanning mode interference contrast microscope, and method of measuring minute step height and apparatus with said microscope
US20030026735A1 (en) * 2001-06-22 2003-02-06 Nolte David D. Bio-optical compact disk system

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of EP1856692A4 *
VARMA ET AL.: "High-speed label-free detection by spinning-disk mirror-inferometry", BIOSENSORS AND BIOELECTRONICS, vol. 19, 2004, pages 1371 - 1376, XP003016970 *

Also Published As

Publication number Publication date
EP1856692A4 (en) 2009-12-09
JP2008529013A (en) 2008-07-31
EP1856692A2 (en) 2007-11-21
WO2006083911A2 (en) 2006-08-10

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