WO2006083260A3 - Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use - Google Patents

Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use Download PDF

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Publication number
WO2006083260A3
WO2006083260A3 PCT/US2005/014906 US2005014906W WO2006083260A3 WO 2006083260 A3 WO2006083260 A3 WO 2006083260A3 US 2005014906 W US2005014906 W US 2005014906W WO 2006083260 A3 WO2006083260 A3 WO 2006083260A3
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WO
WIPO (PCT)
Prior art keywords
compositions
groups
preparation
systems
associated methods
Prior art date
Application number
PCT/US2005/014906
Other languages
French (fr)
Other versions
WO2006083260A2 (en
Inventor
George Y Daniloff
Louis C Sehl
Olof Mikael Trollsas
Jacqueline Schroeder
David M Gravett
Philip M Toleikis
Original Assignee
Angiotech Biomaterials Corp
George Y Daniloff
Louis C Sehl
Olof Mikael Trollsas
Jacqueline Schroeder
David M Gravett
Philip M Toleikis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angiotech Biomaterials Corp, George Y Daniloff, Louis C Sehl, Olof Mikael Trollsas, Jacqueline Schroeder, David M Gravett, Philip M Toleikis filed Critical Angiotech Biomaterials Corp
Priority to NZ550964A priority Critical patent/NZ550964A/en
Priority to KR1020067025027A priority patent/KR100974733B1/en
Priority to KR1020107011113A priority patent/KR101148445B1/en
Priority to BRPI0510477-7A priority patent/BRPI0510477B1/en
Publication of WO2006083260A2 publication Critical patent/WO2006083260A2/en
Publication of WO2006083260A3 publication Critical patent/WO2006083260A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/041—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/043—Mixtures of macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Crosslinkable compositions are provided that readily crosslink in situ to provide crosslinked biomaterials. The composition contains at least two biocompatible, non-immunogenic components having reactive groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i.e., crosslinking. In one embodiment, a first component has nucleophilic groups and a second component has electrophilic groups. Additional components may have nucleophilic or electrophilic groups. Methods for preparing and using the compositions are also provided as are kits for delivery of the compositions. Exemplary uses for the crosslinked compositions include tissue augmentation, biologically active agent delivery, bioadhesion, and prevention of adhesions following surgery or injury.
PCT/US2005/014906 2004-04-28 2005-04-28 Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use WO2006083260A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
NZ550964A NZ550964A (en) 2004-04-28 2005-04-28 Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
KR1020067025027A KR100974733B1 (en) 2004-04-28 2005-04-28 Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
KR1020107011113A KR101148445B1 (en) 2004-04-28 2005-04-28 Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
BRPI0510477-7A BRPI0510477B1 (en) 2004-04-28 2005-04-28 METHOD FOR FORMING A GEL AND DEVICE FOR USE IN MEDICAL APPLICATIONS

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56656904P 2004-04-28 2004-04-28
US60/566,569 2004-04-28

Publications (2)

Publication Number Publication Date
WO2006083260A2 WO2006083260A2 (en) 2006-08-10
WO2006083260A3 true WO2006083260A3 (en) 2009-02-26

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2005/015036 WO2006078282A2 (en) 2004-04-28 2005-04-28 Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
PCT/US2005/014906 WO2006083260A2 (en) 2004-04-28 2005-04-28 Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2005/015036 WO2006078282A2 (en) 2004-04-28 2005-04-28 Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use

Country Status (7)

Country Link
US (3) US8067031B2 (en)
KR (2) KR101148445B1 (en)
CN (2) CN104174071A (en)
BR (1) BRPI0510477B1 (en)
HK (1) HK1204584A1 (en)
NZ (1) NZ550964A (en)
WO (2) WO2006078282A2 (en)

Families Citing this family (181)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060177416A1 (en) 2003-10-14 2006-08-10 Medivas, Llc Polymer particle delivery compositions and methods of use
US6702744B2 (en) 2001-06-20 2004-03-09 Advanced Cardiovascular Systems, Inc. Agents that stimulate therapeutic angiogenesis and techniques and devices that enable their delivery
US8608661B1 (en) 2001-11-30 2013-12-17 Advanced Cardiovascular Systems, Inc. Method for intravascular delivery of a treatment agent beyond a blood vessel wall
US7361368B2 (en) 2002-06-28 2008-04-22 Advanced Cardiovascular Systems, Inc. Device and method for combining a treatment agent and a gel
US20090165784A1 (en) * 2007-12-28 2009-07-02 Tyco Healthcare Group Lp Lubricious intubation device
US7641643B2 (en) 2003-04-15 2010-01-05 Abbott Cardiovascular Systems Inc. Methods and compositions to treat myocardial conditions
US8821473B2 (en) 2003-04-15 2014-09-02 Abbott Cardiovascular Systems Inc. Methods and compositions to treat myocardial conditions
US8038991B1 (en) 2003-04-15 2011-10-18 Abbott Cardiovascular Systems Inc. High-viscosity hyaluronic acid compositions to treat myocardial conditions
US20050208095A1 (en) * 2003-11-20 2005-09-22 Angiotech International Ag Polymer compositions and methods for their use
AU2004322006B2 (en) * 2004-07-31 2012-05-24 Brainguard Co., Ltd. Silk peptide improving neuroprotective and neurofunctional effects and a method of its preparation
CA2577025C (en) * 2004-08-13 2014-01-28 Ottawa Health Research Institute Vision enhancing ophthalmic devices and related methods and compositions
US7854944B2 (en) 2004-12-17 2010-12-21 Advanced Cardiovascular Systems, Inc. Tissue regeneration
US8303972B2 (en) 2005-04-19 2012-11-06 Advanced Cardiovascular Systems, Inc. Hydrogel bioscaffoldings and biomedical device coatings
US20080125745A1 (en) 2005-04-19 2008-05-29 Shubhayu Basu Methods and compositions for treating post-cardial infarction damage
US9539410B2 (en) 2005-04-19 2017-01-10 Abbott Cardiovascular Systems Inc. Methods and compositions for treating post-cardial infarction damage
US8187621B2 (en) 2005-04-19 2012-05-29 Advanced Cardiovascular Systems, Inc. Methods and compositions for treating post-myocardial infarction damage
US8828433B2 (en) 2005-04-19 2014-09-09 Advanced Cardiovascular Systems, Inc. Hydrogel bioscaffoldings and biomedical device coatings
CA2607913C (en) * 2005-05-05 2014-03-18 Cook Biotech Incorporated Implantable materials and methods for inhibiting tissue adhesion formation
US20060287257A1 (en) * 2005-06-20 2006-12-21 Stockel Richard F Pharmaceutical compositions to treat diseases caused by mycobacterium
WO2007033180A1 (en) 2005-09-12 2007-03-22 Abela Pharmaceuticals, Inc. Materials for facilitating administration of dimethyl sulfoxide (dmso) and related compounds
US8480797B2 (en) 2005-09-12 2013-07-09 Abela Pharmaceuticals, Inc. Activated carbon systems for facilitating use of dimethyl sulfoxide (DMSO) by removal of same, related compounds, or associated odors
AU2006291134C1 (en) 2005-09-12 2013-08-15 Abela Pharmaceuticals, Inc. Systems for removing dimethyl sulfoxide (DMSO) or related compounds, or odors associated with same
WO2007033082A2 (en) 2005-09-12 2007-03-22 Abela Pharmaceuticals, Inc. Compositions comprising dimethyl sulfoxide (dmso)
JP5178520B2 (en) 2005-09-22 2013-04-10 メディバス エルエルシー Solid polymer delivery compositions and methods of use thereof
EP1926780B1 (en) 2005-09-22 2013-08-14 Medivas, LLC Bis-( -amino)-diol-diester-containing poly(ester amide) and poly(ester urethane) compositions and methods of use
CN100387711C (en) * 2006-01-06 2008-05-14 青岛科技大学 Silica-gel-carrier surface macroporous chitin substrate for lysozyme affinity chromatography
US20090038701A1 (en) 2006-01-17 2009-02-12 Baxter International Inc. Device, system and method for mixing
US20090319044A1 (en) * 2006-01-31 2009-12-24 Francis Young-In Lee Methods and Compositions for Improving the Incorporation of Orthopaedic and Orthodontic Implants
US20070270970A1 (en) * 2006-03-14 2007-11-22 Sdgi Holdings, Inc. Spinal implants with improved wear resistance
US20070233246A1 (en) * 2006-03-31 2007-10-04 Sdgi Holdings, Inc. Spinal implants with improved mechanical response
WO2007139808A2 (en) * 2006-05-25 2007-12-06 Ayyala Ramesh S Device for delivery of antifibrotic agents & method
KR101443926B1 (en) 2006-06-15 2014-10-02 마이크로벤션, 인코포레이티드 Embolization device constructed from expansible polymer
US7732190B2 (en) 2006-07-31 2010-06-08 Advanced Cardiovascular Systems, Inc. Modified two-component gelation systems, methods of use and methods of manufacture
TWI436793B (en) 2006-08-02 2014-05-11 Baxter Int Rapidly acting dry sealant and methods for use and manufacture
DE102006037158A1 (en) * 2006-08-02 2008-02-14 Bioxsys Gmbh Method for determining the sensitivity of tumors to capecitabine and test kit
US20080039362A1 (en) * 2006-08-09 2008-02-14 Afmedica, Inc. Combination drug therapy for reducing scar tissue formation
US9242005B1 (en) 2006-08-21 2016-01-26 Abbott Cardiovascular Systems Inc. Pro-healing agent formulation compositions, methods and treatments
WO2008034908A2 (en) * 2006-09-22 2008-03-27 Bioxell Spa Use of vitamin d compounds for the prevention of adhesions
US20080078412A1 (en) * 2006-10-03 2008-04-03 Restore Medical, Inc. Tongue implant
US20080078411A1 (en) * 2006-10-03 2008-04-03 Restore Medical, Inc. Tongue implant for sleep apnea
US9005672B2 (en) 2006-11-17 2015-04-14 Abbott Cardiovascular Systems Inc. Methods of modifying myocardial infarction expansion
US8741326B2 (en) 2006-11-17 2014-06-03 Abbott Cardiovascular Systems Inc. Modified two-component gelation systems, methods of use and methods of manufacture
US8192760B2 (en) 2006-12-04 2012-06-05 Abbott Cardiovascular Systems Inc. Methods and compositions for treating tissue using silk proteins
WO2008076383A2 (en) 2006-12-18 2008-06-26 Med Institute Inc. Stent graft with releasable therapeutic agent
US20080226724A1 (en) * 2007-01-19 2008-09-18 Genentech, Inc. Prevention of hydrogel viscosity loss
US8262608B2 (en) * 2007-01-25 2012-09-11 Hyperbranch Medical Technology, Inc. Applicators for multiple component formulations and the like, and methods of use thereof
US20080188932A1 (en) * 2007-02-07 2008-08-07 Harrup Mason K Coated medical implants, methods of coating medical implants, and methods of coating materials
US8591931B2 (en) * 2007-02-14 2013-11-26 Shangdong Intech Medical Technology Co., Ltd Coronary stent with asymmetric drug releasing controlled coating
US8642067B2 (en) 2007-04-02 2014-02-04 Allergen, Inc. Methods and compositions for intraocular administration to treat ocular conditions
US20080255041A1 (en) * 2007-04-11 2008-10-16 Ebi, L.P. Treatment of annulus fibrosis defects
US20080287633A1 (en) * 2007-05-18 2008-11-20 Drumheller Paul D Hydrogel Materials
CA2693969A1 (en) * 2007-07-17 2009-01-22 Medivas, Llc Bioabsorbable elastomeric arterial support device and methods of use
WO2009052376A1 (en) 2007-10-18 2009-04-23 Musc Foundation For Research Development Methods for the diagnosis of genitourinary cancer
US8361052B2 (en) * 2007-10-30 2013-01-29 Uti Limited Partnership Method and system for sustained-release of sclerosing agent
US20090117039A1 (en) * 2007-11-02 2009-05-07 Boston Scientific Scimed, Inc. Charged biodegradable polymers for medical applications
US20130142733A1 (en) * 2007-11-05 2013-06-06 Vanderbilt University Multifunctional degradable nanoparticles with control over size and functionalities
US11254786B2 (en) 2007-11-05 2022-02-22 Vanderbilt University Multifunctional degradable nanoparticles with control over size and functionalities
US20110244006A1 (en) * 2007-11-29 2011-10-06 The Trustees Of Columbia University In The City Of New York Microsphere skin treatment
US20110027379A1 (en) * 2007-12-06 2011-02-03 Cornell University Oligo-Ethylene Glycol-Based Polymer Compositions and Methods of Use
CA2709581C (en) * 2007-12-17 2013-06-11 Anna Love Soft tissue filler
US8299316B2 (en) * 2007-12-18 2012-10-30 Ethicon, Inc. Hemostatic device
US8470035B2 (en) 2007-12-21 2013-06-25 Microvention, Inc. Hydrogel filaments for biomedical uses
JP5530934B2 (en) 2008-01-24 2014-06-25 ユニバーシティ オブ ユタ リサーチ ファンデーション Adhesive composite coacervate and methods of making and using the same
US8283384B2 (en) 2008-01-24 2012-10-09 University Of Utah Research Foundation Adhesive complex coacervates and methods of making and using thereof
JP2011526818A (en) * 2008-07-03 2011-10-20 ヴェッセルテック バイオメディカル，エルエルシー Controlled local release of retinoids to improve neointimal hyperplasia
US8207264B2 (en) * 2008-07-11 2012-06-26 Tyco Healthcare Group Lp Functionalized inclusion complexes as crosslinkers
US8603532B2 (en) 2008-10-20 2013-12-10 Massachusetts Institute Of Technology Nanostructures for drug delivery
BRPI0921494A2 (en) 2008-11-03 2018-10-30 Prad Reasearch And Development Ltd method of planning a underground forming sampling operation, method of controlling a underground forming sampling operation, method of controlling a drilling operation for an underground formation, and method of sampling during the drilling operation.
US9234100B2 (en) 2009-02-20 2016-01-12 Uniboard Canada Inc. Chitosan-based adhesives and uses thereof
US9250106B2 (en) 2009-02-27 2016-02-02 Tandem Diabetes Care, Inc. Methods and devices for determination of flow reservoir volume
AU2010217760B2 (en) 2009-02-27 2015-04-09 Tandem Diabetes Care, Inc. Methods and devices for determination of flow reservoir volume
US10639396B2 (en) 2015-06-11 2020-05-05 Microvention, Inc. Polymers
GB0912855D0 (en) * 2009-07-23 2009-08-26 Orthogem Ltd Composite delivery device
CA2769030C (en) 2009-07-30 2016-05-10 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
BR112012009287A2 (en) 2009-10-26 2017-06-06 Microvention Inc embolization device made of expandable polymer
EP2493314B1 (en) 2009-10-30 2020-04-08 Abela Pharmaceuticals, Inc. Dimethyl sulfoxide (dmso) and methylsulfonylmethane (msm) formulations to treat osteoarthritis
WO2011066471A1 (en) 2009-11-25 2011-06-03 Loma Linda University Medical Center Chitosan-based hemostatic textile
CN102791294A (en) * 2009-12-16 2012-11-21 布里格姆妇女医院股份有限公司 Particles for multiple agent delivery
EP2538929A4 (en) 2010-02-25 2014-07-09 Univ Johns Hopkins Sustained delivery of therapeutic agents to an eye compartment
AU2011232343B2 (en) * 2010-03-25 2015-05-07 Covidien Lp Chemical knots for sutures
AU2011232356B2 (en) 2010-03-25 2015-02-05 Covidien Lp Functionalized adhesive for medical devices
US10987093B2 (en) * 2010-04-05 2021-04-27 Neomend, Inc. Method and apparatus for wound sealant application
SA111320355B1 (en) * 2010-04-07 2015-01-08 Baxter Heathcare S A Hemostatic sponge
US9801738B2 (en) * 2010-04-14 2017-10-31 Northwestern University Liquid cast biodegradable arterial stent
WO2011140519A2 (en) 2010-05-07 2011-11-10 Medicus Biosciences, Llc In vivo gelling pharmaceutical pre-formulation
US8697111B2 (en) 2010-05-12 2014-04-15 Covidien Lp Osteochondral implant comprising osseous phase and chondral phase
EP2575906B1 (en) 2010-05-24 2014-12-10 University of Utah Research Foundation Reinforced adhesive complex coacervates and methods of making and using thereof
CA2812599A1 (en) 2010-11-12 2012-05-18 University Of Utah Research Foundation Simple adhesive coacervates and methods of making and using thereof
US8551525B2 (en) 2010-12-23 2013-10-08 Biostructures, Llc Bone graft materials and methods
US9770527B2 (en) 2011-01-04 2017-09-26 Bender Analytical Holding B.V. Cross-linked polymers and implants derived from electrophilically activated polyoxazoline
WO2012106317A1 (en) 2011-01-31 2012-08-09 Northwestern University Injectable thermoresponsive polyelectrolytes
US9327037B2 (en) 2011-02-08 2016-05-03 The Johns Hopkins University Mucus penetrating gene carriers
US9456823B2 (en) 2011-04-18 2016-10-04 Terumo Corporation Embolic devices
US9873765B2 (en) 2011-06-23 2018-01-23 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
JP6045575B2 (en) 2011-06-23 2016-12-14 ディーエスエム アイピー アセッツ ビー．ブイ． Novel biodegradable polyesteramide copolymers for drug delivery
CN103732330A (en) * 2011-06-28 2014-04-16 犹他大学研究基金会 Adhesive complex coacervates and methods of making and using thereof
US11083821B2 (en) 2011-08-10 2021-08-10 C.P. Medical Corporation Biocompatible hydrogel polymer formulations for the controlled delivery of biomolecules
US10111985B2 (en) 2011-08-10 2018-10-30 Medicus Biosciences, Llc Biocompatible hydrogel polymer formulations for the controlled delivery of biomolecules
JP6159973B2 (en) 2012-01-02 2017-07-12 ユニヴェルシテイト ヘントＵｎｉｖｅｒｓｉｔｅｉｔ Ｇｅｎｔ Polyoxazoline polymers and methods for their production, conjugates of these polymers and their medical use
KR101401632B1 (en) 2012-02-20 2014-06-03 주식회사 제노스 Baloon carteter and method for producing the same
US20150037422A1 (en) * 2012-02-22 2015-02-05 Trustees Of Tufts College Compositions and methods for ocular delivery of a therapeutic agent
US8851173B2 (en) 2012-03-09 2014-10-07 Halliburton Energy Services, Inc. Set-delayed cement compositions comprising pumice and associated methods
US9790132B2 (en) 2012-03-09 2017-10-17 Halliburton Energy Services, Inc. Set-delayed cement compositions comprising pumice and associated methods
US10202751B2 (en) 2012-03-09 2019-02-12 Halliburton Energy Services, Inc. Set-delayed cement compositions comprising pumice and associated methods
US10195764B2 (en) 2012-03-09 2019-02-05 Halliburton Energy Services, Inc. Set-delayed cement compositions comprising pumice and associated methods
JP6178399B2 (en) * 2012-03-16 2017-08-09 ベンデル アナリティカル ホールディング ビー．ブイ．Ｂｅｎｄｅｒ Ａｎａｌｙｔｉｃａｌ Ｈｏｌｄｉｎｇ Ｂ．Ｖ． Crosslinked polymers derived from nucleophilically activated polyoxazolines and medical products
CA2867381C (en) 2012-03-16 2016-09-20 The Johns Hopkins University Controlled release formulations for the delivery of hif-1 inhibitors
EA030318B1 (en) 2012-03-16 2018-07-31 Дзе Джонс Хопкинс Юниверсити Non-linear multiblock copolymer-drug conjugates for the delivery of active agents
WO2013158781A1 (en) 2012-04-18 2013-10-24 Microvention, Inc. Embolic devices
US8999292B2 (en) 2012-05-01 2015-04-07 Translatum Medicus Inc. Methods for treating and diagnosing blinding eye diseases
US9533068B2 (en) 2012-05-04 2017-01-03 The Johns Hopkins University Drug loaded microfiber sutures for ophthalmic application
CA2873105C (en) 2012-05-11 2018-01-16 Medicus Biosciences, Llc Biocompatible hydrogel treatments for retinal detachment
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
US9132171B2 (en) 2012-05-23 2015-09-15 Wisconsin Alumni Research Foundation Test of insulin as a drug to reduce restenosis of vessels
NL2008861C2 (en) * 2012-05-23 2013-11-26 Urogyn B V Composition for soft tissue treatment.
US9351993B2 (en) 2012-06-14 2016-05-31 Microvention, Inc. Polymeric treatment compositions
WO2014022807A2 (en) * 2012-08-03 2014-02-06 Alumend, Llc Compositions and methods of using the compositions for plaque softening
AU2013331439B2 (en) 2012-10-15 2016-05-12 Microvention, Inc. Polymeric treatment compositions
US9220807B2 (en) * 2012-11-04 2015-12-29 Miba Medical Inc. Non-toxic cross-linker for hyaluronic acid
EP3013354B1 (en) * 2013-01-16 2020-08-19 Alumend, LLC Composition for decreasing inflammatory response in a blood vessel
US20140212355A1 (en) 2013-01-28 2014-07-31 Abbott Cardiovascular Systems Inc. Trans-arterial drug delivery
US10568975B2 (en) 2013-02-05 2020-02-25 The Johns Hopkins University Nanoparticles for magnetic resonance imaging tracking and methods of making and using thereof
WO2014123665A1 (en) 2013-02-06 2014-08-14 Kci Licensing, Inc. Polymers, preparation and use thereof
ES2678875T3 (en) 2013-03-04 2018-08-20 DERMELLE, LLC d/b/a ETERNOGEN, LLC In situ polymerization collagen composition for injection
AU2014236385B2 (en) 2013-03-14 2019-01-24 Theragenics Corporation Biocompatible hydrogel polymer matrix for delivery of cells
US10624865B2 (en) 2013-03-14 2020-04-21 Pathak Holdings Llc Methods, compositions, and devices for drug/live cell microarrays
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
US10188824B2 (en) * 2013-05-13 2019-01-29 The Arizona Board Of Regents On Behalf Of The University Of Arizona Aerostasis in pulmonary surgery
JP2017503017A (en) * 2013-12-18 2017-01-26 ウィンドギャップ メディカル， インコーポレイテッド Drug mixing and delivery system and method
US9682218B2 (en) 2013-12-23 2017-06-20 Carefusion 2200, Inc. Pleurodesis device and method
US10124090B2 (en) 2014-04-03 2018-11-13 Terumo Corporation Embolic devices
US9259357B2 (en) 2014-04-16 2016-02-16 Loma Linda University Composition, preparation, and use of chitosan shards for biomedical applications
WO2015167751A1 (en) 2014-04-29 2015-11-05 Microvention, Inc. Polymers
EP3137124B1 (en) 2014-04-29 2019-01-09 Microvention, Inc. Polymers including active agents
US10022475B2 (en) * 2014-05-01 2018-07-17 Bao Tran Body augmentation device
US9913927B2 (en) 2014-07-14 2018-03-13 University Of Utah Research Foundation In situ solidifying complex coacervates and methods of making and using thereof
CA2954191A1 (en) * 2014-07-30 2016-02-04 Lifecell Corporation Methods for selection of age-appropriate tissues
AU2015328825B2 (en) 2014-10-06 2019-02-21 Gatt Technologies B.V. Tissue-adhesive porous haemostatic product
AU2015364280A1 (en) 2014-12-18 2017-07-06 Windgap Medical, Inc. Method and compositions for dissolving or solubilizing therapeutic agents
JP6720447B2 (en) 2014-12-18 2020-07-08 ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． Drug delivery system for delivery of acid sensitive drugs
CN105561404B (en) * 2015-01-07 2019-07-26 北京赛奇科科技有限公司 A kind of medical material and preparation method thereof to prevent adhesion for gynemetrics
CA2974715C (en) 2015-01-27 2020-05-05 The Johns Hopkins University Hypotonic hydrogel formulations for enhanced transport of active agents at mucosal surfaces
CN106264777A (en) * 2015-06-08 2017-01-04 三鼎生物科技股份有限公司 Auxiliary dacryagogue
US10368874B2 (en) 2016-08-26 2019-08-06 Microvention, Inc. Embolic compositions
WO2018106777A1 (en) 2016-12-07 2018-06-14 Henkel IP & Holding GmbH Syringe with piston assembly
CN110381854A (en) * 2017-01-05 2019-10-25 考恩特兰有限公司 Method for being implanted into and reversing stimulating responsive implantation material
US10912859B2 (en) 2017-03-08 2021-02-09 Baxter International Inc. Additive able to provide underwater adhesion
US11202848B2 (en) 2017-03-08 2021-12-21 Baxter International Inc. Surgical adhesive able to glue in wet conditions
WO2019074965A1 (en) 2017-10-09 2019-04-18 Microvention, Inc. Radioactive liquid embolic
US10709815B2 (en) * 2017-10-16 2020-07-14 Kent State University Biodegradable, biocompatible 3D liquid crystal elastomeric foam scaffolds having tailor-made animal (human) pore cell sizes via a salt leaching method are capable of growing tissue therein for therapeutic reconstruction of damaged and/or diseased tissue or organs
KR101989054B1 (en) * 2017-11-28 2019-06-13 (주)다림티센 Hemostatic agent and container containing the same
US11896234B2 (en) 2018-01-26 2024-02-13 Fluidx Medical Technology, Llc Apparatus and method of using in situ solidifying complex coacervates for vascular occlusion
CN108211909B (en) * 2018-03-05 2024-02-06 常城 Dyeing paste mixing device for dyeing hair and dyeing method thereof capable of keeping dyeing consistency
CN108744060B (en) * 2018-05-29 2021-05-07 四川大学 Bone repair material capable of being injected with multiple pore structures and preparation method thereof
CN109045354B (en) * 2018-07-26 2020-12-08 华中科技大学 In-situ forming injectable hydrogel for comprehensive repair of bone-cartilage
CN112957516B (en) * 2018-08-20 2022-08-09 稳得希林(杭州)生物科技有限公司 Polysaccharide-based tissue adhesive medical adhesive and application thereof
EP3920894A4 (en) * 2019-02-06 2022-11-09 The University of North Carolina at Chapel Hill Compositions and methods for inhibiting post-surgical adhesions
EP3934659A4 (en) * 2019-03-05 2022-12-14 Medcura, Inc. System and method to reduce tissue or organ adhesion
CN114072163A (en) * 2019-05-09 2022-02-18 芝加哥大学 New material for healing skin wound and preventing scar
US11753382B2 (en) 2019-06-25 2023-09-12 Translatum Medicus Inc. Processes of making 2-((1-benzyl-1H-indazol-3-yl)methoxy)-2-methylpropanoic acid and its derivatives
BR112022000511A2 (en) * 2019-07-12 2022-03-03 Gatt Tech B V Biocompatible flexible hemostatic sheet, sealed packaging and homeostatic sheet preparation method
CN110540404B (en) * 2019-10-17 2022-06-10 广州润虹医药科技股份有限公司 Calcium phosphate bone cement with hollow through structure, preparation method and application thereof
CN112730015B (en) * 2019-10-28 2022-11-22 上海云泽生物科技有限公司 Dilution for stabilizing tacrolimus and application thereof
EP4100072A1 (en) * 2020-02-04 2022-12-14 Boston Scientific Scimed Inc. Injectable in vivo crosslinking materials for use as soft tissue fillers
US11739166B2 (en) 2020-07-02 2023-08-29 Davol Inc. Reactive polysaccharide-based hemostatic agent
SE2050826A1 (en) * 2020-07-02 2022-01-03 Capitainer Ab Functionalized blood sampling device and method for peth measurement
CN112129946A (en) * 2020-08-16 2020-12-25 陆修委 Preparation method and application of sugar-free chain type inert protein sealant
US11339045B2 (en) 2020-10-20 2022-05-24 Elkay Manufacturing Company Flavor and additive delivery systems and methods for beverage dispensers
US20240033399A1 (en) * 2020-12-18 2024-02-01 Ethicon, Inc. Methods and Devices for Changing the Flow Rates of PH Modifying Fluids for Controlling Cross-Linking Rates of Reactive Components of Biocompatible Sealing Compositions
CN112705054B (en) * 2020-12-24 2022-06-24 健帆生物科技集团股份有限公司 Hollow fiber membrane, preparation method thereof and dialyzer
CN113018461B (en) * 2021-03-09 2022-07-26 南京邮电大学 Fucoidin embolism microsphere capable of magnetic resonance imaging and preparation method thereof
EP4252787A1 (en) * 2021-04-14 2023-10-04 Beijing Biosis Healing Biological Technology Co., Ltd. Medical hydrogel and preparation method therefor and use thereof
CN113101039B (en) * 2021-04-26 2022-10-18 金浙滔 Oviduct contraceptive device, implanting device and extracting device
CN113416292B (en) * 2021-04-30 2022-07-19 山东师范大学 Hydrogel capable of loading high-hydrophobicity drugs and preparation method and application thereof
CN113846054B (en) * 2021-09-23 2023-05-16 四川大学 Matrix material for directly reprogramming fibroblast into osteoblast, preparation method and reprogramming method
CN114099784B (en) * 2021-10-26 2022-09-16 四川兴科蓉药业有限责任公司 Injection type skin filling composition and preparation method and application thereof
WO2024042535A1 (en) * 2022-08-20 2024-02-29 Jawaharlal Nehru Centre For Advanced Scientific Research Hemostatic composite, its method and applications thereof
CN115403723B (en) * 2022-08-24 2023-10-13 中原工学院 Preparation method and application of lithium anode modified based on covalent organic framework material
CN116448996B (en) * 2023-03-22 2023-11-21 卡秋(江苏)生物科技有限公司 Preparation method of polymerase-antibody complex with bead structure
CN116570757B (en) * 2023-07-05 2023-10-03 北京镧系生物科技有限公司 Double-component in-situ adhesive based on super-charged protein, and preparation method and application thereof
CN117504137B (en) * 2024-01-05 2024-03-12 山东瑞安泰医疗技术有限公司 Cardiac pacemaker fixing device and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010003126A1 (en) * 1995-10-05 2001-06-07 Rhee Woonza M. Method of making crosslinked polymer matrices in tissue treatment applications
WO2002102864A1 (en) * 2001-06-15 2002-12-27 Cohesion Technologies, Inc. Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
WO2003080144A1 (en) * 2002-03-22 2003-10-02 Kuros Biosurgery Ag Composition for hard tissue augmentation

Family Cites Families (194)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3091542A (en) 1960-09-20 1963-05-28 Dow Chemical Co Insolubilization of water-soluble cellulose ethers
NL126192C (en) 1964-07-16
US3619371A (en) 1967-07-03 1971-11-09 Nat Res Dev Production of a polymeric matrix having a biologically active substance bound thereto
SE343210B (en) 1967-12-20 1972-03-06 Pharmacia Ab
US4008341A (en) * 1968-10-11 1977-02-15 W. R. Grace & Co. Curable liquid polymer compositions
US3742955A (en) 1970-09-29 1973-07-03 Fmc Corp Fibrous collagen derived product having hemostatic and wound binding properties
US3810473A (en) 1972-12-04 1974-05-14 Avicon Inc Liquid-laid, non-woven, fibrous collagen derived surgical web having hemostatic and wound sealing properties
US3876501A (en) 1973-05-17 1975-04-08 Baxter Laboratories Inc Binding enzymes to activated water-soluble carbohydrates
GB1479268A (en) 1973-07-05 1977-07-13 Beecham Group Ltd Pharmaceutical compositions
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
DE2360794C2 (en) 1973-12-06 1984-12-06 Hoechst Ag, 6230 Frankfurt Process for the production of peptides
US3949073A (en) 1974-11-18 1976-04-06 The Board Of Trustees Of Leland Stanford Junior University Process for augmenting connective mammalian tissue with in situ polymerizable native collagen solution
CH596313A5 (en) 1975-05-30 1978-03-15 Battelle Memorial Institute
US4237229A (en) * 1975-06-10 1980-12-02 W. R. Grace & Co. Immobilization of biological material with polyurethane polymers
IL47468A (en) 1975-06-12 1979-05-31 Rehovot Res Prod Process for the cross-linking of proteins using water soluble cross-linking agents
US4488911A (en) 1975-10-22 1984-12-18 Luck Edward E Non-antigenic collagen and articles of manufacture
US4002531A (en) 1976-01-22 1977-01-11 Pierce Chemical Company Modifying enzymes with polyethylene glycol and product produced thereby
NL7704659A (en) 1976-05-12 1977-11-15 Battelle Institut E V BONE REPLACEMENT, BONE JOINT, OR PROSTHESIS ANCHORING MATERIAL.
GB1578348A (en) 1976-08-17 1980-11-05 Pharmacia Ab Products and a method for the therapeutic suppression of reaginic antibodies responsible for common allergic
SE431758B (en) * 1977-03-04 1984-02-27 Pharmacia Fine Chemicals Ab AS THE USE OF THE TIOLATION REAGENT OR BERRY MATRIX FOR ENZYMERS DERIVATIVE OF A SH GROUPING POLYMER
CH628074A5 (en) 1977-03-10 1982-02-15 Ciba Geigy Ag HARDENABLE MIXTURES BASED ON EPOXY COMPOUNDS.
US4164559A (en) 1977-09-21 1979-08-14 Cornell Research Foundation, Inc. Collagen drug delivery device
US4404970A (en) 1978-05-19 1983-09-20 Sawyer Philip Nicholas Hemostatic article and methods for preparing and employing the same
US4390519A (en) 1978-05-19 1983-06-28 Sawyer Philip Nicholas Bandage with hemostatic agent and methods for preparing and employing the same
US4238480A (en) 1978-05-19 1980-12-09 Sawyer Philip Nicholas Method for preparing an improved hemostatic agent and method of employing the same
FR2449610A1 (en) 1979-01-02 1980-09-19 Remy Ets Pierre INVIOLABLE STOPPING PROCESS FOR SCREW BOTTLE
JPS6023084B2 (en) 1979-07-11 1985-06-05 味の素株式会社 blood substitute
US4412947A (en) 1979-09-12 1983-11-01 Seton Company Collagen sponge
US4279812A (en) 1979-09-12 1981-07-21 Seton Company Process for preparing macromolecular biologically active collagen
DE2943520C2 (en) 1979-10-27 1982-05-19 Fa. Carl Freudenberg, 6940 Weinheim Process for the production of collagen sponge for medical or cosmetic purposes
US4378017A (en) 1980-03-21 1983-03-29 Kureha Kagaku Kogyo Kabushiki Kaisha Composite material of de-N-acetylated chitin and fibrous collagen
CS216992B1 (en) 1980-07-21 1982-12-31 Miroslav Stol Composite polymere material for the biological and medicinal utilitation and method of preparation thereof
US4314380A (en) 1980-09-26 1982-02-09 Koken Co., Ltd. Artificial bone
US4415665A (en) 1980-12-12 1983-11-15 Pharmacia Fine Chemicals Ab Method of covalently binding biologically active organic substances to polymeric substances
US4414147A (en) 1981-04-17 1983-11-08 Massachusetts Institute Of Technology Methods of decreasing the hydrophobicity of fibroblast and other interferons
JPS57206622A (en) 1981-06-10 1982-12-18 Ajinomoto Co Inc Blood substitute
EP0067671B1 (en) * 1981-06-12 1989-11-15 National Research Development Corporation Hydrogels
US4451568A (en) 1981-07-13 1984-05-29 Battelle Memorial Institute Composition for binding bioactive substances
US4357274A (en) 1981-08-06 1982-11-02 Intermedicat Gmbh Process for the manufacture of sclero protein transplants with increased biological stability
US4415628A (en) 1981-10-26 1983-11-15 Seton Company Moisture vapor permeable sheet materials
JPS5896026A (en) 1981-10-30 1983-06-07 Nippon Chemiphar Co Ltd Novel urokinase derivative, its preparation and thrombolytic agent containing the same
FR2517315B1 (en) 1981-11-30 1985-12-20 Tech Cuir Centre PROCESS FOR THE PREPARATION OF NEW FORMS OF COLLAGEN, NATIVE OR DERETICULATED, WITH PRESERVED HELICOIDAL STRUCTURE, ASSOCIATED WITH MUCOPOLYSACCHARIDES AND THEIR APPLICATIONS IN PARTICULAR IN THE COSMETOLOGICAL, PHARMACEUTICAL, ANALYTICAL AND OTHER FIELDS
US4424208A (en) 1982-01-11 1984-01-03 Collagen Corporation Collagen implant material and method for augmenting soft tissue
US4582640A (en) 1982-03-08 1986-04-15 Collagen Corporation Injectable cross-linked collagen implant material
US4578067A (en) 1982-04-12 1986-03-25 Alcon (Puerto Rico) Inc. Hemostatic-adhesive, collagen dressing for severed biological surfaces
JPS58180162A (en) 1982-04-19 1983-10-21 株式会社高研 Anti-thrombosis medical material
US4461298A (en) * 1982-07-26 1984-07-24 Ethicon, Inc. Composite sutures of silk and hydrophobic thermoplastic elastomers
US4544516A (en) 1982-07-28 1985-10-01 Battelle Development Corporation Collagen orientation
US4737544A (en) 1982-08-12 1988-04-12 Biospecific Technologies, Inc. Biospecific polymers
US4973493A (en) 1982-09-29 1990-11-27 Bio-Metric Systems, Inc. Method of improving the biocompatibility of solid surfaces
JPS6028936A (en) 1983-07-27 1985-02-14 Koken:Kk Atherocollagen aqueous solution and its preparation
US4563351A (en) 1983-08-01 1986-01-07 Forsyth Dental Infirmary For Children Self-gelling therapeutic compositions for topical application
US4448718A (en) 1983-09-13 1984-05-15 Massachusetts Institute Of Technology Method for the preparation of collagen-glycosaminoglycan composite materials
US4515637A (en) 1983-11-16 1985-05-07 Seton Company Collagen-thrombin compositions
US4487865A (en) 1983-12-15 1984-12-11 Biomatrix, Inc. Polymeric articles modified with hyaluronate
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
MX163953B (en) 1984-03-27 1992-07-03 Univ New Jersey Med PROCEDURE FOR PREPARING A BIODEGRADABLE COLLAGEN MATRIX
US4789663A (en) 1984-07-06 1988-12-06 Collagen Corporation Methods of bone repair using collagen
JPS6145765A (en) 1984-08-07 1986-03-05 宇部興産株式会社 Blood vessel prosthesis and its production
US4553974A (en) 1984-08-14 1985-11-19 Mayo Foundation Treatment of collagenous tissue with glutaraldehyde and aminodiphosphonate calcification inhibitor
US4687820A (en) 1984-08-22 1987-08-18 Cuno Incorporated Modified polypeptide supports
US4557764A (en) 1984-09-05 1985-12-10 Collagen Corporation Process for preparing malleable collagen and the product thereof
US4563350A (en) 1984-10-24 1986-01-07 Collagen Corporation Inductive collagen based bone repair preparations
US4888366A (en) 1984-10-24 1989-12-19 Collagen Corporation Inductive collagen-based bone repair preparations
GB8430252D0 (en) 1984-11-30 1985-01-09 Beecham Group Plc Compounds
US4582865A (en) 1984-12-06 1986-04-15 Biomatrix, Inc. Cross-linked gels of hyaluronic acid and products containing such gels
US5128326A (en) 1984-12-06 1992-07-07 Biomatrix, Inc. Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same
US4600533A (en) 1984-12-24 1986-07-15 Collagen Corporation Collagen membranes for medical use
US4732863A (en) 1984-12-31 1988-03-22 University Of New Mexico PEG-modified antibody with reduced affinity for cell surface Fc receptors
US4636526A (en) 1985-02-19 1987-01-13 The Dow Chemical Company Composites of unsintered calcium phosphates and synthetic biodegradable polymers useful as hard tissue prosthetics
US4695602A (en) 1985-02-28 1987-09-22 Lnp Corporation Fiber reinforced thermoplastics containing silicone interpenetrating polymer networks
US4839345A (en) * 1985-03-09 1989-06-13 Nippon Oil And Fats Co., Ltd. Hydrated adhesive gel and method for preparing the same
US5099013A (en) 1985-03-12 1992-03-24 Biomatrix, Inc, Hylan preparation and method of recovery thereof from animal tissues
US4642117A (en) 1985-03-22 1987-02-10 Collagen Corporation Mechanically sheared collagen implant material and method
CA1260391A (en) 1985-03-28 1989-09-26 Karl A. Piez Xenogeneic collagen/mineral preparations in bone repair
DE3521684A1 (en) 1985-06-18 1986-12-18 Dr. Müller-Lierheim KG, Biologische Laboratorien, 8033 Planegg METHOD FOR COATING POLYMERS
DE3675588D1 (en) 1985-06-19 1990-12-20 Ajinomoto Kk HAEMOGLOBIN TIED TO A POLY (ALKENYLENE OXIDE).
US4766106A (en) 1985-06-26 1988-08-23 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
US5202431A (en) 1985-07-08 1993-04-13 Fidia, S.P.A. Partial esters of hyaluronic acid
US4851513A (en) 1985-09-06 1989-07-25 Minnesota Mining And Manufacturing Company Viscoelastic collagen solution for opthalmic use and method of preparation
JPS63502354A (en) 1986-01-06 1988-09-08 ザ　ユニヴァーシティ　オブ　メルボルン collagen products
US4774227A (en) 1986-02-14 1988-09-27 Collagen Corporation Collagen compositions for bone repair containing autogeneic marrow
US4983580A (en) 1986-04-04 1991-01-08 Allergan, Inc. Methods and materials for use in corneal wound healing
ES2004281A6 (en) 1986-04-04 1988-12-16 Univ Jefferson Method of treating a synthetic naturally occurring surface with a collagen laminate to support microvascular endothelial cell growth, and the surface itself
US4745180A (en) 1986-06-27 1988-05-17 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using heparin fragments
US4979959A (en) 1986-10-17 1990-12-25 Bio-Metric Systems, Inc. Biocompatible coating for solid surfaces
US4865602A (en) 1986-11-06 1989-09-12 Collagen Corporation Gamma irradiation of collagen/mineral mixtures
FR2616318A1 (en) 1987-06-15 1988-12-16 Centre Nat Rech Scient ARTIFICIAL SKIN AND PROCESS FOR PREPARING THE SAME
US4829099A (en) * 1987-07-17 1989-05-09 Bioresearch, Inc. Metabolically acceptable polyisocyanate adhesives
US6030958A (en) * 1987-09-18 2000-02-29 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
US6235726B1 (en) * 1987-09-18 2001-05-22 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
US4937270A (en) 1987-09-18 1990-06-26 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
US6174999B1 (en) * 1987-09-18 2001-01-16 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
US5017229A (en) 1990-06-25 1991-05-21 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
US5364622A (en) 1987-12-04 1994-11-15 Dr. Karl Thomae Gmbh Methods for preventing adhesions to organs and parts of organs by application of tissue plasminogen activator and hydroxyethylcellulose hydrogel
US4886866A (en) * 1987-12-21 1989-12-12 W. R. Grace & Co.-Conn. Contact lenses based on biocompatible polyurethane and polyurea-urethane hydrated polymers
US4950699A (en) 1988-01-11 1990-08-21 Genetic Laboratories, Inc. Wound dressing incorporating collagen in adhesive layer
US4847325A (en) 1988-01-20 1989-07-11 Cetus Corporation Conjugation of polymer to colony stimulating factor-1
US5192316A (en) 1988-02-16 1993-03-09 Allergan, Inc. Ocular device
US5024742A (en) 1988-02-24 1991-06-18 Cedars-Sinai Medical Center Method of crosslinking amino acid containing polymers using photoactivatable chemical crosslinkers
US4923467A (en) 1988-03-02 1990-05-08 Thompson Keith P Apparatus and process for application and adjustable reprofiling of synthetic lenticules for vision correction
US5156622A (en) 1988-03-02 1992-10-20 Thompson Keith P Apparatus and process for application and adjustable reprofiling of synthetic lenticules for vision correction
FR2628634B1 (en) 1988-03-15 1990-07-13 Imedex VISCERAL SURGERY PATCH
JPH01265970A (en) 1988-04-19 1989-10-24 Shiseido Co Ltd Collagen water solution or water dispersion solution including hyaluronic acid
US5290552A (en) 1988-05-02 1994-03-01 Matrix Pharmaceutical, Inc./Project Hear Surgical adhesive material
US4950483A (en) 1988-06-30 1990-08-21 Collagen Corporation Collagen wound healing matrices and process for their production
US5167960A (en) 1988-08-03 1992-12-01 New England Deaconess Hospital Corporation Hirudin-coated biocompatible substance
US5162430A (en) 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US5527856A (en) * 1988-11-21 1996-06-18 Collagen Corporation Method of preparing crosslinked biomaterial compositions for use in tissue augmentation
US5306500A (en) 1988-11-21 1994-04-26 Collagen Corporation Method of augmenting tissue with collagen-polymer conjugates
US5614587A (en) 1988-11-21 1997-03-25 Collagen Corporation Collagen-based bioadhesive compositions
US5264214A (en) 1988-11-21 1993-11-23 Collagen Corporation Composition for bone repair
US5510418A (en) * 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
US5936035A (en) 1988-11-21 1999-08-10 Cohesion Technologies, Inc. Biocompatible adhesive compositions
US5304595A (en) 1988-11-21 1994-04-19 Collagen Corporation Collagen-polymer conjugates
US5643464A (en) * 1988-11-21 1997-07-01 Collagen Corporation Process for preparing a sterile, dry crosslinking agent
US5475052A (en) 1988-11-21 1995-12-12 Collagen Corporation Collagen-synthetic polymer matrices prepared using a multiple step reaction
US5565519A (en) * 1988-11-21 1996-10-15 Collagen Corporation Clear, chemically modified collagen-synthetic polymer conjugates for ophthalmic applications
US5550187A (en) * 1988-11-21 1996-08-27 Collagen Corporation Method of preparing crosslinked biomaterial compositions for use in tissue augmentation
DE3903672C1 (en) * 1989-02-08 1990-02-01 Lohmann Gmbh & Co Kg
US5324844A (en) 1989-04-19 1994-06-28 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
US5122614A (en) 1989-04-19 1992-06-16 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
US5141747A (en) 1989-05-23 1992-08-25 Minnesota Mining And Manufacturing Company Denatured collagen membrane
US5201764A (en) 1990-02-28 1993-04-13 Autogenesis Technologies, Inc. Biologically compatible collagenous reaction product and articles useful as medical implants produced therefrom
US5104957A (en) 1990-02-28 1992-04-14 Autogenesis Technologies, Inc. Biologically compatible collagenous reaction product and articles useful as medical implants produced therefrom
JP3210009B2 (en) 1990-04-02 2001-09-17 ザ、プロクター、エンド、ギャンブル、カンパニー Granular absorbent polymer composition containing interparticle crosslinked aggregates
US5196027A (en) 1990-05-02 1993-03-23 Thompson Keith P Apparatus and process for application and adjustable reprofiling of synthetic lenticules for vision correction
US5204110A (en) * 1990-05-02 1993-04-20 Ndm Acquisition Corp. High absorbency hydrogel wound dressing
US5219564A (en) 1990-07-06 1993-06-15 Enzon, Inc. Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
US5292362A (en) 1990-07-27 1994-03-08 The Trustees Of Columbia University In The City Of New York Tissue bonding and sealing composition and method of using the same
US5209776A (en) 1990-07-27 1993-05-11 The Trustees Of Columbia University In The City Of New York Tissue bonding and sealing composition and method of using the same
SE466754B (en) 1990-09-13 1992-03-30 Berol Nobel Ab COVALENT BINDING POLYMERS TO HYDROPHILIC SURFACES
US5131875A (en) 1990-10-12 1992-07-21 Lee Warren D Dual motor control and steering system for watercraft
US5410016A (en) 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5626863A (en) 1992-02-28 1997-05-06 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5169754A (en) 1990-10-31 1992-12-08 Coulter Corporation Biodegradable particle coatings having a protein covalently immobilized by means of a crosslinking agent and processes for making same
US5163956A (en) 1990-11-06 1992-11-17 General Electric Company Methods and lenticules for modifying the cornea
US6559119B1 (en) * 1990-11-27 2003-05-06 Loyola University Of Chicago Method of preparing a tissue sealant-treated biomedical material
US5219895A (en) 1991-01-29 1993-06-15 Autogenesis Technologies, Inc. Collagen-based adhesives and sealants and methods of preparation and use thereof
US5156613A (en) 1991-02-13 1992-10-20 Interface Biomedical Laboratories Corp. Collagen welding rod material for use in tissue welding
US5208219A (en) 1991-02-14 1993-05-04 Celtrix Pharmaceuticals Inc. Method for inducing bone growth
US5118667A (en) 1991-05-03 1992-06-02 Celtrix Pharmaceuticals, Inc. Bone growth factors and inhibitors of bone resorption for promoting bone formation
JPH07503943A (en) 1991-10-29 1995-04-27 クローバー　コンソリデイテッド，リミテッド Cross-linked polysaccharides, polycations and lipids useful for encapsulation and drug release
DE69229004D1 (en) 1991-11-07 1999-05-27 Univ Southern California COMPOSITIONS AND METHODS FOR PREVENTING ADHESION FORMATION
US5405366A (en) * 1991-11-12 1995-04-11 Nepera, Inc. Adhesive hydrogels having extended use lives and process for the preparation of same
US5147374A (en) * 1991-12-05 1992-09-15 Alfredo Fernandez Prosthetic mesh patch for hernia repair
US5176692A (en) * 1991-12-09 1993-01-05 Wilk Peter J Method and surgical instrument for repairing hernia
US5385606A (en) 1992-07-06 1995-01-31 Kowanko; Nicholas Adhesive composition and method
US5428022A (en) * 1992-07-29 1995-06-27 Collagen Corporation Composition of low type III content human placental collagen
US5514379A (en) 1992-08-07 1996-05-07 The General Hospital Corporation Hydrogel compositions and methods of use
US5614549A (en) 1992-08-21 1997-03-25 Enzon, Inc. High molecular weight polymer-based prodrugs
AU675252B2 (en) * 1992-12-18 1997-01-30 Tremco, Inc. Fast-curing, high strength, two-part sealants using acetoacetate-amine cure chemistry
US5298643A (en) 1992-12-22 1994-03-29 Enzon, Inc. Aryl imidate activated polyalkylene oxides
US5349001A (en) 1993-01-19 1994-09-20 Enzon, Inc. Cyclic imide thione activated polyalkylene oxides
US5667839A (en) * 1993-01-28 1997-09-16 Collagen Corporation Human recombinant collagen in the milk of transgenic animals
US5321095A (en) 1993-02-02 1994-06-14 Enzon, Inc. Azlactone activated polyalkylene oxides
US5549904A (en) 1993-06-03 1996-08-27 Orthogene, Inc. Biological adhesive composition and method of promoting adhesion between tissue surfaces
FR2707878A1 (en) 1993-07-21 1995-01-27 Imedex New adhesive compositions for surgical use.
FR2707992B1 (en) * 1993-07-21 1995-10-13 Flamel Tech Sa New organic products containing reactive thiol functions, one of their preparation processes and the biomaterials containing them.
US5939385A (en) 1993-08-13 1999-08-17 Zymogenetics, Inc. Transglutaminase cross-linkable polypeptides and methods relating thereto
EP0724888B1 (en) * 1993-09-16 2003-05-21 Ogita Biomaterial Laboratories Co. Ltd. Wound covering material and wound covering composition
US5605976A (en) 1995-05-15 1997-02-25 Enzon, Inc. Method of preparing polyalkylene oxide carboxylic acids
US5643575A (en) 1993-10-27 1997-07-01 Enzon, Inc. Non-antigenic branched polymer conjugates
EP0705298B1 (en) * 1993-12-01 2002-03-27 Bioartificial Gel Technologies Inc. Albumin based hydrogel
FR2715309B1 (en) 1994-01-24 1996-08-02 Imedex Adhesive composition, for surgical use, based on collagen modified by oxidative cutting and not crosslinked.
US5578661A (en) * 1994-03-31 1996-11-26 Nepera, Inc. Gel forming system for use as wound dressings
US5505952A (en) 1994-04-19 1996-04-09 United States Surgical Corporation Modified synthetic cross-linked amino acid polymers and medical devices formed therefrom
US5583114A (en) * 1994-07-27 1996-12-10 Minnesota Mining And Manufacturing Company Adhesive sealant composition
FR2726571B1 (en) * 1994-11-03 1997-08-08 Izoret Georges BIOLOGICAL GLUE, PREPARATION METHOD AND APPLICATION DEVICE FOR BIOLOGICAL GLUE, AND HARDENERS FOR BIOLOGICAL GLUE
CA2167455A1 (en) * 1995-01-19 1996-07-20 Kevin Cooper Absorbable polyalkylene diglycolates
US5550172A (en) * 1995-02-07 1996-08-27 Ethicon, Inc. Utilization of biocompatible adhesive/sealant materials for securing surgical devices
US5464929A (en) * 1995-03-06 1995-11-07 Ethicon, Inc. Absorbable polyoxaesters
US5580923A (en) 1995-03-14 1996-12-03 Collagen Corporation Anti-adhesion films and compositions for medical use
US5900245A (en) * 1996-03-22 1999-05-04 Focal, Inc. Compliant tissue sealants
US5612052A (en) * 1995-04-13 1997-03-18 Poly-Med, Inc. Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof
US5817303A (en) * 1995-05-05 1998-10-06 Protein Polymer Technologies, Inc. Bonding together tissue with adhesive containing polyfunctional crosslinking agent and protein polymer
JPH11506649A (en) * 1995-06-06 1999-06-15 クウォンティック バイオメディカル パートナーズ Wound sealant preparation and application device and method
US6833408B2 (en) * 1995-12-18 2004-12-21 Cohesion Technologies, Inc. Methods for tissue repair using adhesive materials
US5752974A (en) 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
US5681904A (en) 1996-04-01 1997-10-28 Minnesota Mining And Manufacturing Company Azido polymers having improved burn rate
US5763589A (en) * 1997-01-09 1998-06-09 Incyte Pharmaceuticals, Inc. Human membrane protein
US5854382A (en) * 1997-08-18 1998-12-29 Meadox Medicals, Inc. Bioresorbable compositions for implantable prostheses
JP2001520979A (en) * 1997-10-27 2001-11-06 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Methods and pharmaceutical compositions for retinal wound closure
EP1137373A4 (en) 1998-12-04 2004-05-19 Chandrashekhar P Pathak Biocompatible crosslinked polymers
CA2359318C (en) 1999-02-01 2009-06-30 Donald Elbert Biomaterials formed by nucleophilic addition reaction to conjugated unsaturated groups
US6312725B1 (en) * 1999-04-16 2001-11-06 Cohesion Technologies, Inc. Rapid gelling biocompatible polymer composition
US6258124B1 (en) * 1999-05-10 2001-07-10 C. R. Bard, Inc. Prosthetic repair fabric
WO2001013884A2 (en) * 1999-08-26 2001-03-01 Basf Aktiengesellschaft Cosmetic and/or pharmaceutical preparations with polymers containing polysiloxanes and the uses thereof
DK1218437T3 (en) 1999-08-27 2009-10-19 Angiodevice Internat Gmbh Preparations forming interpenetrating polymer networks for use as high-strength medical sealants
EP1083184A3 (en) * 1999-09-07 2002-07-17 Basf Aktiengesellschaft Silicon-containing polymers, their preparation and their use
JP4227265B2 (en) 1999-10-18 2009-02-18 キヤノン株式会社 Laser light quantity control device
US6296607B1 (en) * 2000-10-20 2001-10-02 Praxis, Llc. In situ bulking device
US20030232013A1 (en) * 2002-02-22 2003-12-18 Gary Sieckman Therapeutic and diagnostic targeting of cancers cells with tumor homing peptides
EP1364663A1 (en) * 2002-05-21 2003-11-26 Commonwealth Scientific And Industrial Research Organisation Ocular devices with functionalized surface with adhesive properties

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010003126A1 (en) * 1995-10-05 2001-06-07 Rhee Woonza M. Method of making crosslinked polymer matrices in tissue treatment applications
WO2002102864A1 (en) * 2001-06-15 2002-12-27 Cohesion Technologies, Inc. Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
WO2003080144A1 (en) * 2002-03-22 2003-10-02 Kuros Biosurgery Ag Composition for hard tissue augmentation

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