WO2006080022A3 - Mri contrast agents for diagnosis and prognosis of tumors - Google Patents
Mri contrast agents for diagnosis and prognosis of tumors Download PDFInfo
- Publication number
- WO2006080022A3 WO2006080022A3 PCT/IL2006/000124 IL2006000124W WO2006080022A3 WO 2006080022 A3 WO2006080022 A3 WO 2006080022A3 IL 2006000124 W IL2006000124 W IL 2006000124W WO 2006080022 A3 WO2006080022 A3 WO 2006080022A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- tumors
- contrast agents
- prognosis
- diagnosis
- mri contrast
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
Abstract
The invention relates to bifunctional conjugates comprising a receptor ligand moiety and a metal binding moiety and complexes thereof with paramagnetic lanthanide or transition metals, and to the use of the metal complexes as contrast agents in magnetic resonance imaging (MRI) of tumors and other abnormalities.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/815,072 US20080305049A1 (en) | 2005-01-31 | 2006-01-31 | Mri Contrast Agents for Diagnosis and Prognosis of Tumors |
EP06701708A EP1848466A4 (en) | 2005-01-31 | 2006-01-31 | Mri contrast agents for diagnosis and prognosis of tumors |
IL184965A IL184965A (en) | 2005-01-31 | 2007-07-31 | Mri contrast agents for diagnosis and prognosis of tumors |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64782105P | 2005-01-31 | 2005-01-31 | |
US60/647,821 | 2005-01-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006080022A2 WO2006080022A2 (en) | 2006-08-03 |
WO2006080022A3 true WO2006080022A3 (en) | 2009-05-07 |
Family
ID=36740902
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IL2006/000124 WO2006080022A2 (en) | 2005-01-31 | 2006-01-31 | Mri contrast agents for diagnosis and prognosis of tumors |
Country Status (3)
Country | Link |
---|---|
US (1) | US20080305049A1 (en) |
EP (1) | EP1848466A4 (en) |
WO (1) | WO2006080022A2 (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5377965B2 (en) | 2005-09-09 | 2013-12-25 | ジョージア ステート ユニバーシティ リサーチ ファウンデーション、インコーポレイテッド | Targeted contrast agents and methods for targeting contrast agents |
WO2007030802A2 (en) * | 2005-09-09 | 2007-03-15 | Georgia State University Research Foundation, Inc. | Targeted contrast agents and methods for targeting contrast agents |
US8175678B2 (en) * | 2005-09-13 | 2012-05-08 | Koninklijke Philips Electronics N.V. | Multiple contrast agent injection for imaging |
US9127293B2 (en) * | 2006-07-26 | 2015-09-08 | The University Of Chicago | Receptor-mediated delivery: compositions and methods |
EP2054514A4 (en) | 2006-08-04 | 2009-11-04 | Univ Georgia State Res Found | Enzyme sensors, methods for preparing and using such sensors, and methods of detecting protease activity |
US8420327B2 (en) | 2006-12-14 | 2013-04-16 | Georgia State University Research Foundation | Analyte sensors, methods for preparing and using such sensors, and methods of detecting analyte activity |
EP3498307A1 (en) | 2008-04-02 | 2019-06-19 | Georgia State University Research Foundation, Inc. | Contrast agents, methods for preparing contrast agents, and methods of imaging |
NO331773B1 (en) * | 2009-12-18 | 2012-03-26 | Ge Healthcare As | Manganese chelates, compositions comprising such and their use as contrast agents for magnetic resonance imaging (MRI) |
WO2012172271A1 (en) * | 2011-06-17 | 2012-12-20 | Centre National De La Recherche Scientifique | Bifunctional phosphonate chelating agents |
EP3101012A1 (en) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | New gadolinium chelate compounds for use in magnetic resonance imaging |
US11353533B2 (en) | 2016-02-24 | 2022-06-07 | Ohio State Innovation Foundation | Methods and devices for contrast agent magnetic resonance imaging |
GB201610738D0 (en) * | 2016-06-20 | 2016-08-03 | Ge Healthcare As | Chelate compounds |
US10975060B2 (en) | 2016-11-28 | 2021-04-13 | Bayer Pharma Aktiengesellschaft | High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging |
CN113164628A (en) | 2018-11-23 | 2021-07-23 | 拜耳股份有限公司 | Contrast medium preparation and preparation method thereof |
CN110407887A (en) * | 2019-04-25 | 2019-11-05 | 上海大学 | Complex, preparation method and its application containing positive quadrivalent iron or manganese complex ion |
KR20230067608A (en) * | 2020-08-14 | 2023-05-16 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | Texapyrin derivatives for manganese chemotherapy, photoacoustic imaging, and photothermal therapy |
CN114105983B (en) * | 2021-11-09 | 2023-08-11 | 国科温州研究院(温州生物材料与工程研究所) | Preparation and application of chiral 1,4,7, 10-tetraaza-2, 6-pyridine cycloparaffin derivative and metal chelate thereof |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5451576A (en) * | 1989-03-06 | 1995-09-19 | Board Of Regents, The University Of Texas System | Tumor imaging and treatment by water soluble texaphyrin metal complexes |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE8502573D0 (en) * | 1985-05-23 | 1985-05-23 | Jouko Kanakre | FLUORESCENT LANTHANIDE CHELATES USEFUL AS LABELS OF PHYSIOLOGICALLY ACTIVE MATERIALS |
US6770261B2 (en) * | 1995-06-02 | 2004-08-03 | Research Corporation Technologies | Magnetic resonance imaging agents for the detection of physiological agents |
US6080839A (en) * | 1998-06-25 | 2000-06-27 | Wallac Oy | Labeling reactants and their use |
DE19905094C1 (en) * | 1999-02-01 | 2000-10-12 | Schering Ag | Gadolinium (III) complexes and their use for two-step forms of radiation therapy and pharmaceutical compositions containing them |
US6673333B1 (en) * | 2000-05-04 | 2004-01-06 | Research Corporation Technologies, Inc. | Functional MRI agents for cancer imaging |
US7018851B2 (en) * | 2003-02-13 | 2006-03-28 | Innotrac Diagnostics Oy | Biospecific binding reactants labeled with new luminescent lanthanide chelates and their use |
-
2006
- 2006-01-31 US US11/815,072 patent/US20080305049A1/en not_active Abandoned
- 2006-01-31 EP EP06701708A patent/EP1848466A4/en not_active Withdrawn
- 2006-01-31 WO PCT/IL2006/000124 patent/WO2006080022A2/en active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5451576A (en) * | 1989-03-06 | 1995-09-19 | Board Of Regents, The University Of Texas System | Tumor imaging and treatment by water soluble texaphyrin metal complexes |
Also Published As
Publication number | Publication date |
---|---|
EP1848466A4 (en) | 2012-11-21 |
EP1848466A2 (en) | 2007-10-31 |
US20080305049A1 (en) | 2008-12-11 |
WO2006080022A2 (en) | 2006-08-03 |
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