WO2006078924A3 - Minimally invasive, sustained, intra-tympanic drug delivery system - Google Patents

Minimally invasive, sustained, intra-tympanic drug delivery system Download PDF

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Publication number
WO2006078924A3
WO2006078924A3 PCT/US2006/002069 US2006002069W WO2006078924A3 WO 2006078924 A3 WO2006078924 A3 WO 2006078924A3 US 2006002069 W US2006002069 W US 2006002069W WO 2006078924 A3 WO2006078924 A3 WO 2006078924A3
Authority
WO
WIPO (PCT)
Prior art keywords
fluid
sustained
intra
delivery
delivery system
Prior art date
Application number
PCT/US2006/002069
Other languages
French (fr)
Other versions
WO2006078924A2 (en
Inventor
John M. Epley
Original Assignee
Epley Medical Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epley Medical Llc filed Critical Epley Medical Llc
Priority to EP06719045.4A priority Critical patent/EP1846095A4/en
Publication of WO2006078924A2 publication Critical patent/WO2006078924A2/en
Publication of WO2006078924A3 publication Critical patent/WO2006078924A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A61N1/306—Arrangements where at least part of the apparatus is introduced into the body

Abstract

A convenient and preferably wearable system and method for implementing the controlled and sustained delivery of a medical liquid through the tympanic membrane and into the middle ear including port structure that produces a minimal opening in the membrane, a wearable and fixated fluid-conduit structure coupleable to the port structure, a reservoir adapted to contain delivery fluid, and an operationally controllable pump system applied to the fluid conduit structure, and/or an iontophoretic electrode system applied within the fluid conduit structure and to the subject's body, and operable to effect the delivery of reservoir-held fluid or medically active ions through the fluid conduit and port structures to the middle ear.
PCT/US2006/002069 2005-01-20 2006-01-20 Minimally invasive, sustained, intra-tympanic drug delivery system WO2006078924A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06719045.4A EP1846095A4 (en) 2005-01-20 2006-01-20 Minimally invasive, sustained, intra-tympanic drug delivery system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64520505P 2005-01-20 2005-01-20
US60/645,205 2005-01-20

Publications (2)

Publication Number Publication Date
WO2006078924A2 WO2006078924A2 (en) 2006-07-27
WO2006078924A3 true WO2006078924A3 (en) 2013-03-14

Family

ID=36692936

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/002069 WO2006078924A2 (en) 2005-01-20 2006-01-20 Minimally invasive, sustained, intra-tympanic drug delivery system

Country Status (2)

Country Link
EP (1) EP1846095A4 (en)
WO (1) WO2006078924A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011115936A1 (en) 2010-03-15 2011-09-22 Lev Rosenblum Device and method for delivering medicine into the tympanic cavity, with sliding assist
CN103002946B (en) 2010-05-02 2014-11-19 内瓦孚有限公司 Modulating function of the facial nerve system or related neural structures via the ear
US9272157B2 (en) 2010-05-02 2016-03-01 Nervive, Inc. Modulating function of neural structures near the ear
US10065047B2 (en) 2013-05-20 2018-09-04 Nervive, Inc. Coordinating emergency treatment of cardiac dysfunction and non-cardiac neural dysfunction
WO2019118330A1 (en) 2017-12-12 2019-06-20 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Thermoresponsive hydrogel containing polymer microparticles for controlled drug delivery to the ear
EP3746018A1 (en) * 2018-02-02 2020-12-09 Tusker Medical, Inc. Systems, apparatus, and methods for transport and delivery of therapeutic substance to middle ear

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3035580A (en) * 1960-12-27 1962-05-22 Guiorguiev Methodi Surgical needle
US6219574B1 (en) * 1996-06-18 2001-04-17 Alza Corporation Device and method for enchancing transdermal sampling

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3645268A (en) * 1969-12-10 1972-02-29 Dagoberto Capote Disposable, presterilized, self-locating and piercing evacuator with ejector tube
CA2460676C (en) * 2001-10-24 2010-03-23 Claude Jolly Implantable fluid delivery apparatuses and implantable electrode
US20100268125A9 (en) * 2002-07-03 2010-10-21 Epley Research, L.L.C. Head-stabilized medical apparatus, system and methodology

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3035580A (en) * 1960-12-27 1962-05-22 Guiorguiev Methodi Surgical needle
US6219574B1 (en) * 1996-06-18 2001-04-17 Alza Corporation Device and method for enchancing transdermal sampling

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1846095A4 *

Also Published As

Publication number Publication date
EP1846095A4 (en) 2014-03-05
EP1846095A2 (en) 2007-10-24
WO2006078924A2 (en) 2006-07-27

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