WO2006073950A3 - Nanoparticles for protein drug delivery - Google Patents

Nanoparticles for protein drug delivery Download PDF

Info

Publication number
WO2006073950A3
WO2006073950A3 PCT/US2005/047125 US2005047125W WO2006073950A3 WO 2006073950 A3 WO2006073950 A3 WO 2006073950A3 US 2005047125 W US2005047125 W US 2005047125W WO 2006073950 A3 WO2006073950 A3 WO 2006073950A3
Authority
WO
WIPO (PCT)
Prior art keywords
drug delivery
nanoparticles
protein drug
chitosan
poly
Prior art date
Application number
PCT/US2005/047125
Other languages
French (fr)
Other versions
WO2006073950B1 (en
WO2006073950A2 (en
Inventor
Hosheng Tu
Hsing-Wen Sung
Original Assignee
Nanomega Medical Corp
Hosheng Tu
Hsing-Wen Sung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/029,082 external-priority patent/US7265090B2/en
Application filed by Nanomega Medical Corp, Hosheng Tu, Hsing-Wen Sung filed Critical Nanomega Medical Corp
Priority to CA2592991A priority Critical patent/CA2592991C/en
Priority to BRPI0518093-7A priority patent/BRPI0518093A/en
Priority to JP2007549559A priority patent/JP5384831B2/en
Priority to CN2005800449397A priority patent/CN101360486B/en
Priority to EP05857226A priority patent/EP1833470A4/en
Priority to AU2005322940A priority patent/AU2005322940B2/en
Publication of WO2006073950A2 publication Critical patent/WO2006073950A2/en
Publication of WO2006073950A3 publication Critical patent/WO2006073950A3/en
Publication of WO2006073950B1 publication Critical patent/WO2006073950B1/en
Priority to HK09102982.7A priority patent/HK1122508A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less

Abstract

The invention discloses the nanoparticles composed of chitosan, poly-Ϝ-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.
PCT/US2005/047125 2005-01-04 2005-12-27 Nanoparticles for protein drug delivery WO2006073950A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA2592991A CA2592991C (en) 2005-01-04 2005-12-27 Nanoparticles for protein drug delivery
BRPI0518093-7A BRPI0518093A (en) 2005-01-04 2005-12-27 dose of nanoparticles to a patient, method of enhancing intestinal paracellular transport or paracellular blood transport from the brain and oral dose of nanoparticles that intensifies intestinal paracellular transport or paracellular blood transport from the brain
JP2007549559A JP5384831B2 (en) 2005-01-04 2005-12-27 Nanoparticles for protein drug delivery
CN2005800449397A CN101360486B (en) 2005-01-04 2005-12-27 Nanoparticles for protein drug delivery
EP05857226A EP1833470A4 (en) 2005-01-04 2005-12-27 Nanoparticles for protein drug delivery
AU2005322940A AU2005322940B2 (en) 2005-01-04 2005-12-27 Nanoparticles for protein drug delivery
HK09102982.7A HK1122508A1 (en) 2005-01-04 2009-03-30 Nanoparticles for protein drug delivery

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11/029,082 2005-01-04
US11/029,082 US7265090B2 (en) 2004-10-05 2005-01-04 Nanoparticles for paracellular drug delivery
US11/284,734 2005-11-21
US11/284,734 US7282194B2 (en) 2004-10-05 2005-11-21 Nanoparticles for protein drug delivery

Publications (3)

Publication Number Publication Date
WO2006073950A2 WO2006073950A2 (en) 2006-07-13
WO2006073950A3 true WO2006073950A3 (en) 2008-10-30
WO2006073950B1 WO2006073950B1 (en) 2008-12-11

Family

ID=36648027

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/047125 WO2006073950A2 (en) 2005-01-04 2005-12-27 Nanoparticles for protein drug delivery

Country Status (9)

Country Link
US (4) US7282194B2 (en)
EP (1) EP1833470A4 (en)
JP (2) JP5384831B2 (en)
CN (1) CN101360486B (en)
AU (1) AU2005322940B2 (en)
BR (1) BRPI0518093A (en)
CA (1) CA2592991C (en)
HK (1) HK1122508A1 (en)
WO (1) WO2006073950A2 (en)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7282194B2 (en) * 2004-10-05 2007-10-16 Gp Medical, Inc. Nanoparticles for protein drug delivery
US7901711B1 (en) * 2006-04-17 2011-03-08 Gp Medical, Inc. Nanoparticles for protein/peptide delivery and delivery means thereof
US8137697B1 (en) * 2004-10-05 2012-03-20 Gp Medical, Inc. Nanoparticles for protein/peptide delivery and delivery means thereof
US7541028B2 (en) * 2005-01-04 2009-06-02 Gp Medical, Inc. Nanoparticles for monoclonal antibody delivery
US7879361B2 (en) * 2005-01-04 2011-02-01 Gp Medical, Inc. Nanoparticles for drug delivery
EP1774971A1 (en) * 2005-10-14 2007-04-18 Advanced in Vitro Cell Technologies, S.L. Chitosan and heparin nanoparticles
DK1973406T3 (en) 2005-12-28 2014-06-23 Advanced Bionutrition Corp Feed agent for probiotic bakeries comprising a dry blend of polysaccharides, saccharides, glassy polyols
US8968721B2 (en) 2005-12-28 2015-03-03 Advanced Bionutrition Corporation Delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same
ATE504236T1 (en) * 2006-02-27 2011-04-15 Edwards Lifesciences Corp WATER GEL FOR INTRAVENOUS AMPEROMETRIC BIOSENSOR
JP2007291324A (en) * 2006-03-31 2007-11-08 Jsr Corp Oxide particulate-containing polysiloxane composition and its production process
JP2007270056A (en) * 2006-03-31 2007-10-18 Jsr Corp Metal oxide particulate-containing polysiloxane composition and method for producing the same
US8449915B1 (en) * 2006-04-17 2013-05-28 Gp Medical, Inc. Pharmaceutical composition of nanoparticles
KR20090045205A (en) * 2006-06-26 2009-05-07 뮤추얼 파마슈티컬 컴퍼니 아이엔씨. Active agent formulations, methods of making, and methods of use
US20080160096A1 (en) * 2006-07-27 2008-07-03 Janos Berbely Polymeric nanoparticles by ion-ion interactions
CN101148511B (en) * 2006-09-18 2010-10-20 中国科学院过程工程研究所 Method for preparing fluorescent chitosan micro-sphere and application of the same in tracer field
US8946200B2 (en) * 2006-11-02 2015-02-03 Southwest Research Institute Pharmaceutically active nanosuspensions
US8460726B2 (en) * 2006-12-18 2013-06-11 Advanced Bionutrition Corporation Dry food product containing live probiotic
US20080193547A1 (en) * 2006-12-27 2008-08-14 Janos Borbely Polymeric nanoparticles by ion-ion Interactions
ES2430380T3 (en) * 2007-05-09 2013-11-20 Nitto Denko Corporation Compositions that include a hydrophobic compound and a polyamino acid conjugate
WO2009035438A1 (en) * 2007-09-13 2009-03-19 Janos Borbely Polymeric nanoparticles by ion-ion interactions
WO2009065181A1 (en) * 2007-11-21 2009-05-28 Apollo Life Sciences Limited Nanostructures suitable for delivery of agents
IL188647A0 (en) 2008-01-08 2008-11-03 Orina Gribova Adaptable structured drug and supplements administration system (for oral and/or transdermal applications)
US8404850B2 (en) * 2008-03-13 2013-03-26 Southwest Research Institute Bis-quaternary pyridinium-aldoxime salts and treatment of exposure to cholinesterase inhibitors
AU2009240511B2 (en) * 2008-04-24 2015-01-22 Medtronic, Inc. Thiolated chitosan gel
EP2296637B1 (en) * 2008-04-24 2014-04-02 Medtronic, Inc Chitosan-containing protective composition
CA2722145A1 (en) * 2008-04-24 2009-10-29 Medtronic, Inc. Rehydratable thiolated polysaccharide particles and sponge
AU2009240514B2 (en) 2008-04-24 2014-12-18 Medtronic, Inc. Cold ionizing radiation sterilization
AU2009240512B2 (en) * 2008-04-24 2014-07-10 Medtronic, Inc. Protective gel based on chitosan and oxidized polysaccharide
KR20110028631A (en) * 2008-07-01 2011-03-21 닛토덴코 가부시키가이샤 Pharmaceutical composition containing surface-coated microparticles
US8722706B2 (en) * 2008-08-15 2014-05-13 Southwest Research Institute Two phase bioactive formulations of bis-quaternary pyridinium oxime sulfonate salts
US20100104608A1 (en) * 2008-09-26 2010-04-29 Tyco Healthcare Group Lp Reactive surgical implant
US8241654B2 (en) * 2008-09-26 2012-08-14 Tyco Healthcare Group Lp Reactive surgical implant
US8309134B2 (en) * 2008-10-03 2012-11-13 Southwest Research Institute Modified calcium phosphate nanoparticle formation
US20100111919A1 (en) * 2008-10-31 2010-05-06 Tyco Healthcare Group Lp Delayed gelation compositions and methods of use
JP2010132609A (en) * 2008-12-05 2010-06-17 Fujifilm Corp Casein nanoparticle
US20100159010A1 (en) * 2008-12-24 2010-06-24 Mutual Pharmaceutical Company, Inc. Active Agent Formulations, Methods of Making, and Methods of Use
WO2010087781A1 (en) * 2009-01-28 2010-08-05 Agency For Science, Technology And Research Polyelectrolyte complexes with bound peptides
CA2756883C (en) 2009-03-27 2018-01-09 Advanced Bionutrition Corp. Microparticulated vaccines for the oral or nasal vaccination and boostering of animals including fish
MY157343A (en) 2009-05-26 2016-05-31 Advanced Bionutrition Corp Stable dry powder composition comprising biologically active microorganisms and/or bioactive materials and methods of making
US8404281B2 (en) * 2009-06-08 2013-03-26 Avant Garde Therapeutics & Technologies Llc Formulations
WO2010151076A2 (en) * 2009-06-25 2010-12-29 주식회사 바이오리더스 Adjuvant composition comprising (poly-gamma-glutamate)-chitosan nanoparticles
RU2528895C2 (en) 2009-07-09 2014-09-20 Ошади Драг Администрейшн Лтд. Matrix carrier compositions, methods and uses
US8637096B2 (en) 2009-12-04 2014-01-28 Curtis C. Stojan Compositions and method for enhancing insulin activity
US9504750B2 (en) 2010-01-28 2016-11-29 Advanced Bionutrition Corporation Stabilizing composition for biological materials
JP5886763B2 (en) 2010-01-28 2016-03-16 アドバンスド バイオニュートリション コーポレーション Dry glassy composition containing a bioactive substance
US9028873B2 (en) * 2010-02-08 2015-05-12 Southwest Research Institute Nanoparticles for drug delivery to the central nervous system
WO2011100460A2 (en) * 2010-02-11 2011-08-18 Ecole Polytechnique Federale De Lausanne Ccr7 ligand delivery and co-delivery in immunotherapy
JP2011178764A (en) * 2010-03-04 2011-09-15 Ajinomoto Co Inc Intestinal bifidobacterium proliferation promoter and intestinal barrier function-improving agent
EP2417968A1 (en) 2010-07-29 2012-02-15 Consorzio per il Centro di Biomedicina Molecolare Scrl Particle comprising cytokines, antibodies and polymers and use thereof as medicament for the treatment of cancer
AU2011289272B2 (en) 2010-08-13 2015-02-05 Advanced Bionutrition Corporation Dry storage stabilizing composition for biological materials
WO2013081720A1 (en) * 2011-12-02 2013-06-06 Ecosynthetix Ltd. Aptamer bioconjugate drug delivery device
JP6035633B2 (en) 2010-12-02 2016-11-30 グリーンマーク バイオメディカル インコーポレイテッドＧｒｅｅｎＭａｒｋ Ｂｉｏｍｅｄｉｃａｌ， Ｉｎｃ． Aptamer bioconjugate drug delivery system
US9713702B2 (en) * 2011-03-14 2017-07-25 The Board Of Trustee Of The Leland Stanford Junior University Methods of electric field induced delivery of compounds, compositions used in delivery, and systems of delivery
WO2012170017A1 (en) * 2011-06-08 2012-12-13 Avant Garde Therapeutics Inc. Novel formulations
ES2644138T3 (en) 2011-06-13 2017-11-27 Rival S.E.C N, N, N-trialkylpolymers, methods for their preparation and uses thereof
JP5801626B2 (en) * 2011-06-30 2015-10-28 国立大学法人信州大学 Method for producing composite nanofiber
US8883717B2 (en) * 2012-03-30 2014-11-11 Artificial Cell Technologies, Inc. Antigenic compositions and methods
US10555911B2 (en) 2012-05-04 2020-02-11 Yale University Highly penetrative nanocarriers for treatment of CNS disease
US8313774B1 (en) 2012-06-26 2012-11-20 Magnifica Inc. Oral solid composition
TWI511744B (en) * 2013-01-09 2015-12-11 Univ Nat Cheng Kung Biodegradable carrier with arbitrarily adjustable interface charges and particle sizes, a preparing method and a pharmaceutical composition of the same
US11504422B2 (en) 2013-01-09 2022-11-22 National Cheng Kung University Biodegradable nanocomplex
WO2015032971A1 (en) * 2013-09-09 2015-03-12 Lek Pharmaceuticals D.D. Polymer selection for preparation of nps with high protein loading
EP3052091B1 (en) 2013-10-01 2019-04-24 Lifecare Innovations Pvt. Ltd. Sustained release formulations containing methylglyoxal and their therapeutic applications
EP3065782B8 (en) * 2013-11-05 2021-05-26 Elena Molokanova Nanostructure conjugates for modulation of location-specific subtypes of receptors and ion channels
CN103656623B (en) * 2013-12-06 2015-04-15 南通大学 Nanoparticles loaded with neurotrophic factors, and preparation and applications thereof
US11039621B2 (en) 2014-02-19 2021-06-22 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
US11039620B2 (en) 2014-02-19 2021-06-22 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
US9622483B2 (en) 2014-02-19 2017-04-18 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
US11548940B2 (en) 2014-05-15 2023-01-10 Rani Therapeutics, Llc Anti-interleukin antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10227403B2 (en) * 2014-05-15 2019-03-12 Incube Labs, Llc Pharmaceutical compositions and methods for fabrication of solid masses comprising polypeptides and/or proteins
US20170304374A1 (en) * 2014-10-23 2017-10-26 Symbiotic Health Inc. Capsule for the oral administration of biopharmaceuticals
US10953050B2 (en) 2015-07-29 2021-03-23 Advanced Bionutrition Corp. Stable dry probiotic compositions for special dietary uses
KR101882820B1 (en) 2015-12-30 2018-07-30 주식회사 삼양바이오팜 Mucoadhesive pharmaceutical composition and preparation method thereof
US11491114B2 (en) 2016-10-12 2022-11-08 Curioralrx, Llc Formulations for enteric delivery of therapeutic agents
CN108778257B (en) * 2017-01-19 2021-11-16 中山大学 Nanoparticles loaded with therapeutic protein and preparation method thereof
CN107651664B (en) * 2017-10-16 2020-11-06 浙江领蔚生物技术有限公司 Fluorescent carbon nano-particle and application thereof as cell marking material
WO2019191456A1 (en) 2018-03-28 2019-10-03 Greenmark Biomedical Inc. Phosphate crosslinked starch nanoparticle and dental treatments
IL309255A (en) 2021-07-12 2024-02-01 Zidkiyahu Simenhaus Protein containing bio-active compositions comprising cellulose microparticle carriers
CN114470186B (en) * 2022-02-17 2023-10-20 唐颐控股(深圳)有限公司 Preparation method of inhalable nanometer new crown vaccine

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6638918B2 (en) * 2001-11-09 2003-10-28 The Procter & Gamble Company Chitosan compositions

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6268894A (en) * 1993-02-22 1994-09-14 Alza Corporation Compositions for oral delivery of active agents
US5510118A (en) * 1995-02-14 1996-04-23 Nanosystems Llc Process for preparing therapeutic compositions containing nanoparticles
IE80468B1 (en) * 1995-04-04 1998-07-29 Elan Corp Plc Controlled release biodegradable nanoparticles containing insulin
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
PT986404E (en) * 1996-07-10 2002-09-30 West Pharm Serv Drug Res Ltd GENERIC THERAPY DELIVERY SYSTEM WITH ENDOTHELIAL TARGET
US6933331B2 (en) * 1998-05-22 2005-08-23 Nanoproducts Corporation Nanotechnology for drug delivery, contrast agents and biomedical implants
US5972389A (en) * 1996-09-19 1999-10-26 Depomed, Inc. Gastric-retentive, oral drug dosage forms for the controlled-release of sparingly soluble drugs and insoluble matter
IE970794A1 (en) * 1997-09-24 2000-08-23 Elan Corp Plc Composition and method for enhancing paracellular transport across cell layers
WO1999018934A1 (en) * 1997-10-09 1999-04-22 Vanderbilt University Micro-particulate and nano-particulate polymeric delivery system
US6726934B1 (en) * 1997-10-09 2004-04-27 Vanderbilt University Micro-particulate and nano-particulate polymeric delivery system
US6517869B1 (en) * 1997-12-12 2003-02-11 Expression Genetics, Inc. Positively charged poly(alpha-(omega-aminoalkyl)lycolic acid) for the delivery of a bioactive agent via tissue and cellular uptake
FR2780901B1 (en) * 1998-07-09 2000-09-29 Coletica PARTICLES, IN PARTICULAR MICRO- OR NANOPARTICLES OF CROSSLINKED MONOSACCHARIDES AND OLIGOSACCHARIDES, THEIR PREPARATION METHODS AND COSMETIC, PHARMACEUTICAL OR FOOD COMPOSITIONS CONTAINING THE SAME
US6632457B1 (en) * 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
AU4476600A (en) * 1999-04-22 2000-11-10 Vanderbilt University Polymeric encapsulation system promoting angiogenesis
DE50013950D1 (en) * 1999-05-07 2007-02-22 Pharmasol Gmbh MEDICAMENT CARRIER FOR CONTROLLED ACTIVE APPLICATION MADE FROM LIPID MATRIX DRUG CONJUGATES (LAC PARTICLES)
AU1186401A (en) * 1999-06-23 2001-01-22 Sedum Laboratories, Inc. Ionically formulated biomolecule microcarriers
EP1216060A2 (en) * 1999-09-14 2002-06-26 Biomedical Apherese Systeme GmbH Magnetic nanoparticles having biochemical activity, method for the production thereof and their use
CA2470524A1 (en) * 2001-12-21 2003-07-24 David S. Soane Use of oligomers and polymers for drug solublization, stabilization, and delivery
GB0302738D0 (en) 2003-02-06 2003-03-12 Advanced Biopolymers As Composition
ES2226567B1 (en) * 2003-06-20 2006-07-01 Universidad De Santiago De Compostela NANOPARTICULAS OF HIALURONIC ACID.
US7265090B2 (en) * 2004-10-05 2007-09-04 Gp Medical, Inc. Nanoparticles for paracellular drug delivery
US7282194B2 (en) * 2004-10-05 2007-10-16 Gp Medical, Inc. Nanoparticles for protein drug delivery
US7291598B2 (en) 2005-01-04 2007-11-06 Gp Medical, Inc. Nanoparticles for protein drug delivery
US7541028B2 (en) * 2005-01-04 2009-06-02 Gp Medical, Inc. Nanoparticles for monoclonal antibody delivery
US7879819B1 (en) * 2005-01-04 2011-02-01 Gp Medical, Inc. Nanoparticles for protein drug delivery
US7541046B1 (en) * 2005-01-04 2009-06-02 Gp Medical, Inc. Nanoparticles for protein drug delivery
US7611690B2 (en) * 2005-01-04 2009-11-03 Gp Medical, Inc. Nanoparticles for protein drug delivery
US7604795B1 (en) * 2005-01-04 2009-10-20 Gp Medical, Inc. Nanoparticles for protein drug delivery
US20070148251A1 (en) 2005-12-22 2007-06-28 Hossainy Syed F A Nanoparticle releasing medical devices

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6638918B2 (en) * 2001-11-09 2003-10-28 The Procter & Gamble Company Chitosan compositions

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BORCHARD G. ET AL.: "The Potential of Mucoadhesive Polymers in Enhancing Intestinal Peptide Drug Absorption. III: Effects fo Chitosan-Glutamate and Carbomer on Epithelial Tight Junctions In Vitro", JOURNAL OF CONTROLLED RELEASE, vol. 39, 1996, pages 131 - 138, XP002054266 *
LI C.: "Poly(L-glutamic acid) - Anticancer Drug Conjugates", ADVANCED DRUG DELIVERY REVIEWS, vol. 54, 2002, pages 695 - 713, XP001199485 *
MA ET AL.: "Uptake of Chitosan and Associated Insulin in Caco-2 Cell Monolayers: A Comparison Between Chitosan Molecules and Chitosan Nanoparticles", PHARMACEUTICAL RESEARCH, vol. 20, no. 11, 2003, pages 1812 - 1819, XP008119783 *
See also references of EP1833470A4 *
YOON ET AL.: "Production of Poly-gamma-Glutamic Acid by Fed-Batch Culture of Bacillus licheniformis", BIOTECHNOLOGY LETTERS, vol. 22, 2000, pages 585 - 588, XP008119784 *

Also Published As

Publication number Publication date
US20080233200A1 (en) 2008-09-25
JP2008528446A (en) 2008-07-31
WO2006073950B1 (en) 2008-12-11
CN101360486B (en) 2012-09-05
CA2592991C (en) 2012-09-11
WO2006073950A2 (en) 2006-07-13
US7455830B2 (en) 2008-11-25
US20100330167A1 (en) 2010-12-30
AU2005322940A1 (en) 2006-07-13
US20060147539A1 (en) 2006-07-06
HK1122508A1 (en) 2009-05-22
US7282194B2 (en) 2007-10-16
EP1833470A4 (en) 2012-08-22
JP2013177434A (en) 2013-09-09
US7803748B2 (en) 2010-09-28
CA2592991A1 (en) 2006-07-13
CN101360486A (en) 2009-02-04
US20080213354A1 (en) 2008-09-04
US8454966B2 (en) 2013-06-04
EP1833470A2 (en) 2007-09-19
BRPI0518093A (en) 2008-10-28
JP5384831B2 (en) 2014-01-08
AU2005322940B2 (en) 2010-07-08

Similar Documents

Publication Publication Date Title
WO2006073950A3 (en) Nanoparticles for protein drug delivery
USD605082S1 (en) Vehicle body
WO2007103666A3 (en) Implantable medical endoprosthesis delivery systems
EP1594477A4 (en) Active drug delivery in the gastrointestinal tract
WO2007146426A3 (en) Nanoshells for drug delivery
WO2007041584A3 (en) Implantable sensors, implantable pumps, and anti-scarring drug combinations
WO2008144014A3 (en) Bioactive acid agrichemical compositions and use thereof
IL229304A (en) 1',3'-disubstituted- 4- phenyl- 3, 4, 5, 6 -tetrahydro-2h, 1'h - [1, 4'] bipyridinyl- 2'-ones, pharmaceutical compositions comprising them and uses thereof
EP1830755A4 (en) Antimicrobial barriers, systems, and methods formed from hydrophilic polymer structures such as chitosan
GB0818178D0 (en) Devices, systems, and methods for medicament delivery
EP1910080A4 (en) Niobium oxide compositions, nanostructures, bioactive forms and uses thereof
EP1809240A4 (en) Cardiac safe, rapid medication delivery
EP1957793A4 (en) Electrokinetic pump designs and drug delivery systems
WO2006110474A3 (en) Stents with profiles for gripping a balloon catheter and molds for fabricating stents
EP1968684A4 (en) Nasal congestion, obstruction relief, and drug delivery
WO2008067145A3 (en) Self-assembling peptide amphiphiles
WO2008106503A3 (en) Discrete size and shape specific pharmaceutical organic nanoparticles
WO2007103664A3 (en) Implantable medical endoprosthesis delivery system with hub
EP1846028A4 (en) Delivery vehicles, bioactive substances and viral vaccines
IL201730A (en) Derivatives of 1h-benzoimidazol-2-yl-propyl-methyl-amino-ethyl-5-aryl-bicyclo[2.2.2]oct-5-en-2-ol, pharmaceutical compositions comprising them and their use in the manufacture of medicaments
WO2008003050A3 (en) Gallium nitrate formulations
WO2007078271A3 (en) Lansoprazole orally disintegrating tablets
USD623084S1 (en) Grazing reindeer
WO2008060365A3 (en) A self-gelling tunable drug delivery system
WO2006124470A3 (en) Endoprosthesis delivery system

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200580044939.7

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2005322940

Country of ref document: AU

REEP Request for entry into the european phase

Ref document number: 2005857226

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2005857226

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2007549559

Country of ref document: JP

ENP Entry into the national phase

Ref document number: 2592991

Country of ref document: CA

ENP Entry into the national phase

Ref document number: 2005322940

Country of ref document: AU

Date of ref document: 20051227

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: PI0518093

Country of ref document: BR