WO2006071840A8 - Formulations of human growth hormone comprising a non-naturally encoded amino acid - Google Patents

Formulations of human growth hormone comprising a non-naturally encoded amino acid

Info

Publication number
WO2006071840A8
WO2006071840A8 PCT/US2005/047001 US2005047001W WO2006071840A8 WO 2006071840 A8 WO2006071840 A8 WO 2006071840A8 US 2005047001 W US2005047001 W US 2005047001W WO 2006071840 A8 WO2006071840 A8 WO 2006071840A8
Authority
WO
WIPO (PCT)
Prior art keywords
formulations
growth hormone
amino acid
human growth
encoded amino
Prior art date
Application number
PCT/US2005/047001
Other languages
French (fr)
Other versions
WO2006071840A3 (en
WO2006071840A2 (en
Inventor
David C Litzinger
Anna-Maria Hays
Ying Buechler
Original Assignee
Ambrx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to MX2007007587A priority Critical patent/MX2007007587A/en
Priority to EP05857212A priority patent/EP1833993A4/en
Priority to KR1020077016335A priority patent/KR101224781B1/en
Priority to CA2594561A priority patent/CA2594561C/en
Priority to AU2005322019A priority patent/AU2005322019B2/en
Priority to BRPI0519170A priority patent/BRPI0519170A8/en
Priority to CN2005800444355A priority patent/CN101374536B/en
Priority to NZ555386A priority patent/NZ555386A/en
Application filed by Ambrx Inc filed Critical Ambrx Inc
Priority to JP2007548573A priority patent/JP2008525494A/en
Publication of WO2006071840A2 publication Critical patent/WO2006071840A2/en
Publication of WO2006071840A8 publication Critical patent/WO2006071840A8/en
Priority to IL183345A priority patent/IL183345A0/en
Priority to GB0713652A priority patent/GB2436265A/en
Publication of WO2006071840A3 publication Critical patent/WO2006071840A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH] (Somatotropin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormones [GH] (Somatotropin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Abstract

Formulations of modified human growth hormone polypeptides are provided.
PCT/US2005/047001 2004-12-22 2005-12-21 Formulations of human growth hormone comprising a non-naturally encoded amino acid WO2006071840A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
CN2005800444355A CN101374536B (en) 2004-12-22 2005-12-21 Formulations of human growth hormone comprising a non-naturally encoded amino acid
KR1020077016335A KR101224781B1 (en) 2004-12-22 2005-12-21 Formulations of human growth hormone comprising a non-naturally encoded amino acid
CA2594561A CA2594561C (en) 2004-12-22 2005-12-21 Formulations of human growth hormone comprising a non-naturally encoded amino acid
AU2005322019A AU2005322019B2 (en) 2004-12-22 2005-12-21 Formulations of human growth hormone comprising a non-naturally encoded amino acid
BRPI0519170A BRPI0519170A8 (en) 2004-12-22 2005-12-21 human growth hormone formulations comprising an unnaturally encoded amino acid
MX2007007587A MX2007007587A (en) 2004-12-22 2005-12-21 Formulations of human growth hormone comprising a non-naturally encoded amino acid.
NZ555386A NZ555386A (en) 2004-12-22 2005-12-21 Formulations of human growth hormone comprising a non-naturally encoded amino acid
EP05857212A EP1833993A4 (en) 2004-12-22 2005-12-21 Formulations of human growth hormone comprising a non-naturally encoded amino acid
JP2007548573A JP2008525494A (en) 2004-12-22 2005-12-22 Formulations of human growth hormone containing non-naturally encoded amino acids
IL183345A IL183345A0 (en) 2004-12-22 2007-05-21 Formulations of human growth hormone comprising a non-naturally encoded amino acid
GB0713652A GB2436265A (en) 2004-12-22 2007-07-13 Formulations of human growth hormone comprising a non-naturally encoded amino acid

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US63861604P 2004-12-22 2004-12-22
US60/638,616 2004-12-22
US68061705P 2005-05-13 2005-05-13
US60/680,617 2005-05-13
US72803505P 2005-10-17 2005-10-17
US60/728,035 2005-10-17

Publications (3)

Publication Number Publication Date
WO2006071840A2 WO2006071840A2 (en) 2006-07-06
WO2006071840A8 true WO2006071840A8 (en) 2006-10-12
WO2006071840A3 WO2006071840A3 (en) 2008-11-06

Family

ID=36615466

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/047001 WO2006071840A2 (en) 2004-12-22 2005-12-21 Formulations of human growth hormone comprising a non-naturally encoded amino acid

Country Status (14)

Country Link
US (4) US7816320B2 (en)
EP (1) EP1833993A4 (en)
JP (1) JP2008525494A (en)
KR (1) KR101224781B1 (en)
CN (1) CN103520735B (en)
AU (1) AU2005322019B2 (en)
BR (1) BRPI0519170A8 (en)
CA (1) CA2594561C (en)
GB (1) GB2436265A (en)
IL (1) IL183345A0 (en)
MX (1) MX2007007587A (en)
NZ (1) NZ555386A (en)
SG (1) SG161209A1 (en)
WO (1) WO2006071840A2 (en)

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US9238878B2 (en) 2009-02-17 2016-01-19 Redwood Bioscience, Inc. Aldehyde-tagged protein-based drug carriers and methods of use
US9540438B2 (en) 2011-01-14 2017-01-10 Redwood Bioscience, Inc. Aldehyde-tagged immunoglobulin polypeptides and methods of use thereof

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US8586090B2 (en) * 2004-10-05 2013-11-19 Albert Einstein College Of Medicine Of Yeshiva University Melanin nanoshells for protection against radiation and electronic pulses
CN101268098A (en) * 2005-08-30 2008-09-17 诺沃-诺迪斯克保健股份有限公司 Liquid formulations of pegylated growth hormone
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KR100784134B1 (en) * 2006-10-09 2007-12-12 주식회사 대웅 Stable liquid compositions for treating mucositis comprising epidermal growth factor
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ES2436779T3 (en) * 2007-11-12 2014-01-07 Ares Trading S.A. Formulations for TACI-immunoglobulin fusion proteins
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EP2427215A1 (en) * 2009-05-07 2012-03-14 Novo Nordisk Health Care AG Stable pharmaceutical compositions of peptide derivatized using an oxime linker
JP5463531B2 (en) * 2009-07-22 2014-04-09 国立大学法人 東京大学 Polyion complex with PHD2 expression inhibitor
SG181648A1 (en) * 2009-12-15 2012-07-30 Ascendis Pharma As Dry growth hormone composition transiently linked to a polymer carrier
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US9567386B2 (en) 2010-08-17 2017-02-14 Ambrx, Inc. Therapeutic uses of modified relaxin polypeptides
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