WO2006071778A3 - Treatment of parkinson's disease and related disorders using postpartum derived cells - Google Patents

Treatment of parkinson's disease and related disorders using postpartum derived cells Download PDF

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Publication number
WO2006071778A3
WO2006071778A3 PCT/US2005/046809 US2005046809W WO2006071778A3 WO 2006071778 A3 WO2006071778 A3 WO 2006071778A3 US 2005046809 W US2005046809 W US 2005046809W WO 2006071778 A3 WO2006071778 A3 WO 2006071778A3
Authority
WO
WIPO (PCT)
Prior art keywords
parkinson
disease
treatment
related disorders
derived cells
Prior art date
Application number
PCT/US2005/046809
Other languages
French (fr)
Other versions
WO2006071778A2 (en
Inventor
Darin J Messina
Sanjay Mistry
L S Klaudyne Hong
Brian C Kramer
Michael J Romanko
Original Assignee
Ethicon Inc
Darin J Messina
Sanjay Mistry
L S Klaudyne Hong
Brian C Kramer
Michael J Romanko
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ethicon Inc, Darin J Messina, Sanjay Mistry, L S Klaudyne Hong, Brian C Kramer, Michael J Romanko filed Critical Ethicon Inc
Priority to DK05855380.1T priority Critical patent/DK1835924T3/en
Priority to PL05855380T priority patent/PL1835924T3/en
Priority to AU2005322133A priority patent/AU2005322133B2/en
Priority to EP05855380.1A priority patent/EP1835924B1/en
Priority to JP2007548532A priority patent/JP5425399B2/en
Priority to SI200531797T priority patent/SI1835924T1/en
Priority to CA2589063A priority patent/CA2589063C/en
Publication of WO2006071778A2 publication Critical patent/WO2006071778A2/en
Publication of WO2006071778A3 publication Critical patent/WO2006071778A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/03—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from non-embryonic pluripotent stem cells

Abstract

Cells derived from postpartum tissue such as the umbilical cord and placenta, pharmaceutical compositions comprising such cells, and methods for using such cells and pharmaceutical compositions to treat patients having a neurodegenerative condition of the substantia nigra or striatum, such as Parkinson's disease, are provided.
PCT/US2005/046809 2004-12-23 2005-12-22 Treatment of parkinson's disease and related disorders using postpartum derived cells WO2006071778A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DK05855380.1T DK1835924T3 (en) 2004-12-23 2005-12-22 TREATMENT OF PARKINSON'S DISEASE AND RELATED DISEASES WHEN USING POSTPARTUM OBTAINED CELLS
PL05855380T PL1835924T3 (en) 2004-12-23 2005-12-22 Treatment of parkinson's disease and related disorders using postpartum derived cells
AU2005322133A AU2005322133B2 (en) 2004-12-23 2005-12-22 Treatment of Parkinson's disease and related disorders using postpartum derived cells
EP05855380.1A EP1835924B1 (en) 2004-12-23 2005-12-22 Treatment of parkinson's disease and related disorders using postpartum derived cells
JP2007548532A JP5425399B2 (en) 2004-12-23 2005-12-22 Treatment of Parkinson's disease and related disorders using postpartum-derived cells
SI200531797T SI1835924T1 (en) 2004-12-23 2005-12-22 Treatment of parkinson's disease and related disorders using postpartum derived cells
CA2589063A CA2589063C (en) 2004-12-23 2005-12-22 Treatment of parkinson's disease and related disorders using postpartum derived cells

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63896604P 2004-12-23 2004-12-23
US60/638,966 2004-12-23

Publications (2)

Publication Number Publication Date
WO2006071778A2 WO2006071778A2 (en) 2006-07-06
WO2006071778A3 true WO2006071778A3 (en) 2006-08-17

Family

ID=36480918

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2005/046880 WO2006071802A2 (en) 2004-12-23 2005-12-22 Treatment of stroke and other acute neural degenerative disorders using postpartum derived cells
PCT/US2005/046809 WO2006071778A2 (en) 2004-12-23 2005-12-22 Treatment of parkinson's disease and related disorders using postpartum derived cells

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2005/046880 WO2006071802A2 (en) 2004-12-23 2005-12-22 Treatment of stroke and other acute neural degenerative disorders using postpartum derived cells

Country Status (10)

Country Link
US (1) US7875273B2 (en)
EP (2) EP1835924B1 (en)
JP (4) JP5425400B2 (en)
AU (2) AU2005322068B2 (en)
CA (2) CA2589063C (en)
DK (1) DK1835924T3 (en)
PL (1) PL1835924T3 (en)
PT (1) PT1835924E (en)
SI (1) SI1835924T1 (en)
WO (2) WO2006071802A2 (en)

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US9234172B2 (en) 2003-06-27 2016-01-12 DePuy Synthes Products, Inc. Repair and regeneration of ocular tissue using postpartum-derived cells
US9498501B2 (en) 2003-06-27 2016-11-22 DePuy Synthes Products, Inc. Postpartum cells derived from umbilical cord tissue, and methods of making and using the same
US9572840B2 (en) 2003-06-27 2017-02-21 DePuy Synthes Products, Inc. Regeneration and repair of neural tissue using postpartum-derived cells
US9592258B2 (en) 2003-06-27 2017-03-14 DePuy Synthes Products, Inc. Treatment of neurological injury by administration of human umbilical cord tissue-derived cells

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US9234172B2 (en) 2003-06-27 2016-01-12 DePuy Synthes Products, Inc. Repair and regeneration of ocular tissue using postpartum-derived cells
US9498501B2 (en) 2003-06-27 2016-11-22 DePuy Synthes Products, Inc. Postpartum cells derived from umbilical cord tissue, and methods of making and using the same
US9572840B2 (en) 2003-06-27 2017-02-21 DePuy Synthes Products, Inc. Regeneration and repair of neural tissue using postpartum-derived cells
US9592258B2 (en) 2003-06-27 2017-03-14 DePuy Synthes Products, Inc. Treatment of neurological injury by administration of human umbilical cord tissue-derived cells
US9125906B2 (en) 2005-12-28 2015-09-08 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using umbilical cord tissue-derived cells
US9585918B2 (en) 2005-12-28 2017-03-07 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using umbilical cord tissue-derived cells

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