WO2006069250A3 - Methods and devices for analysis of clustered data, in particular action potentials (i.e. neuron firing signals in the brain) - Google Patents

Methods and devices for analysis of clustered data, in particular action potentials (i.e. neuron firing signals in the brain) Download PDF

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Publication number
WO2006069250A3
WO2006069250A3 PCT/US2005/046629 US2005046629W WO2006069250A3 WO 2006069250 A3 WO2006069250 A3 WO 2006069250A3 US 2005046629 W US2005046629 W US 2005046629W WO 2006069250 A3 WO2006069250 A3 WO 2006069250A3
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WIPO (PCT)
Prior art keywords
brain
methods
action potentials
analysis
devices
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PCT/US2005/046629
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French (fr)
Other versions
WO2006069250A2 (en
Inventor
Erwin Bert Montgomery Jr
He Huang
Amir H Assadi
Original Assignee
Wisconsin Alumni Res Found
Erwin Bert Montgomery Jr
He Huang
Amir H Assadi
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Application filed by Wisconsin Alumni Res Found, Erwin Bert Montgomery Jr, He Huang, Amir H Assadi filed Critical Wisconsin Alumni Res Found
Priority to US11/722,229 priority Critical patent/US8150795B2/en
Publication of WO2006069250A2 publication Critical patent/WO2006069250A2/en
Publication of WO2006069250A3 publication Critical patent/WO2006069250A3/en

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    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06FELECTRIC DIGITAL DATA PROCESSING
    • G06F18/00Pattern recognition
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06FELECTRIC DIGITAL DATA PROCESSING
    • G06F2218/00Aspects of pattern recognition specially adapted for signal processing
    • G06F2218/22Source localisation; Inverse modelling

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  • Engineering & Computer Science (AREA)
  • Theoretical Computer Science (AREA)
  • Data Mining & Analysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Evolutionary Biology (AREA)
  • Evolutionary Computation (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Artificial Intelligence (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)

Abstract

Methods for clustering of multi-dimensional data allow unsupervised grouping of multi-dimensional data points into clusters having like characteristics. The methods may be usefully applied to extracellular action potentials (neuronal spikes) measured from the brain, whereby spike data may be grouped in accordance with dimensions such as spike period, spike shape, etc., to assist in identification and location of individual neurons and/or regions of the brain.
PCT/US2005/046629 2004-12-22 2005-12-22 Methods and devices for analysis of clustered data, in particular action potentials (i.e. neuron firing signals in the brain) WO2006069250A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US11/722,229 US8150795B2 (en) 2004-12-22 2005-12-22 Methods and devices for analysis of clustered data, in particular action potentials (i.e. neuron firing signals in the brain)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63850904P 2004-12-22 2004-12-22
US60/638,509 2004-12-22

Publications (2)

Publication Number Publication Date
WO2006069250A2 WO2006069250A2 (en) 2006-06-29
WO2006069250A3 true WO2006069250A3 (en) 2009-04-09

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PCT/US2005/046629 WO2006069250A2 (en) 2004-12-22 2005-12-22 Methods and devices for analysis of clustered data, in particular action potentials (i.e. neuron firing signals in the brain)

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US (1) US8150795B2 (en)
WO (1) WO2006069250A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070255127A1 (en) * 2006-03-20 2007-11-01 Frederick Mintz Mobile electroencephalograph data collection and diagnosis system
US8660635B2 (en) 2006-09-29 2014-02-25 Medtronic, Inc. Method and apparatus for optimizing a computer assisted surgical procedure
TWI385544B (en) * 2009-09-01 2013-02-11 Univ Nat Pingtung Sci & Tech Density-based data clustering method
TWI391837B (en) * 2009-09-23 2013-04-01 Univ Nat Pingtung Sci & Tech Data clustering method based on density
CA2781650C (en) * 2009-11-24 2020-08-25 Zymeworks Inc. Density based clustering for multidimensional data
US9208515B2 (en) 2011-03-08 2015-12-08 Affinnova, Inc. System and method for concept development
US9208132B2 (en) 2011-03-08 2015-12-08 The Nielsen Company (Us), Llc System and method for concept development with content aware text editor
US20120259676A1 (en) 2011-04-07 2012-10-11 Wagner John G Methods and apparatus to model consumer choice sourcing
US9311383B1 (en) 2012-01-13 2016-04-12 The Nielsen Company (Us), Llc Optimal solution identification system and method
US9799041B2 (en) 2013-03-15 2017-10-24 The Nielsen Company (Us), Llc Method and apparatus for interactive evolutionary optimization of concepts
WO2014152010A1 (en) 2013-03-15 2014-09-25 Affinnova, Inc. Method and apparatus for interactive evolutionary algorithms with respondent directed breeding
US20150073958A1 (en) * 2013-09-12 2015-03-12 Bank Of America Corporation RESEARCH REPORT RECOMMENDATION ENGINE ("R+hu 3 +lE")
US10152653B2 (en) 2014-07-31 2018-12-11 Hewlett-Packard Development Company, L.P. Spatial analysis with attribute graphs
US10478616B2 (en) 2014-08-20 2019-11-19 Greenville Neuromodulation Center Method and system for physiological target localization from macroelectrode recordings and monitoring spinal cord function
US10147108B2 (en) 2015-04-02 2018-12-04 The Nielsen Company (Us), Llc Methods and apparatus to identify affinity between segment attributes and product characteristics
US11471092B2 (en) 2016-06-20 2022-10-18 Greenville Neuromodulation Center Microelectrode with hemoglobin or iron sensor and methods of guiding same
CN107085765A (en) * 2017-04-14 2017-08-22 重庆邮电大学 A kind of regional economy appraisal procedure analyzed based on Unsupervised clustering with grey theory
ES2733746R1 (en) * 2018-04-13 2020-03-12 Fundacion Para La Investigacion Biomedica Del Hospital Univ De La Princesa METHOD AND NEUROPHYSIOLOGICAL APPARATUS OF IDENTIFICATION OF THE CEREBRAL NUCLEUS

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040193068A1 (en) * 2001-06-13 2004-09-30 David Burton Methods and apparatus for monitoring consciousness

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6463328B1 (en) * 1996-02-02 2002-10-08 Michael Sasha John Adaptive brain stimulation method and system
US6066163A (en) * 1996-02-02 2000-05-23 John; Michael Sasha Adaptive brain stimulation method and system
US6354299B1 (en) * 1997-10-27 2002-03-12 Neuropace, Inc. Implantable device for patient communication
US6459936B2 (en) * 1997-10-27 2002-10-01 Neuropace, Inc. Methods for responsively treating neurological disorders
US6011996A (en) * 1998-01-20 2000-01-04 Medtronic, Inc Dual electrode lead and method for brain target localization in functional stereotactic brain surgery
US6330466B1 (en) * 1998-02-23 2001-12-11 California Institute Of Technology Using a multi-electrode probe in creating an electrophysiological profile during stereotactic neurosurgery
DE19820808C2 (en) * 1998-05-09 2000-11-02 Wolfgang Fleckenstein Insertion device for brain probes
US6253109B1 (en) * 1998-11-05 2001-06-26 Medtronic Inc. System for optimized brain stimulation
US6539263B1 (en) * 1999-06-11 2003-03-25 Cornell Research Foundation, Inc. Feedback mechanism for deep brain stimulation
US6343226B1 (en) * 1999-06-25 2002-01-29 Neurokinetic Aps Multifunction electrode for neural tissue stimulation
CA2397607A1 (en) * 1999-12-17 2001-06-21 Carla M. Mann Magnitude programming for implantable electrical stimulator
US6301492B1 (en) * 2000-01-20 2001-10-09 Electrocore Technologies, Llc Device for performing microelectrode recordings through the central channel of a deep-brain stimulation electrode
US6368147B1 (en) * 2000-03-02 2002-04-09 Microhelix, Inc. Zero insertion force percutaneous connector and flexible brain probe assembly
US6567690B2 (en) * 2000-10-16 2003-05-20 Cole Giller Method and apparatus for probe localization in brain matter
US6606521B2 (en) * 2001-07-09 2003-08-12 Neuropace, Inc. Implantable medical lead
US6662035B2 (en) * 2001-09-13 2003-12-09 Neuropace, Inc. Implantable lead connector assembly for implantable devices and methods of using it
DE50102342D1 (en) * 2001-10-24 2004-06-24 Brainlab Ag Navigated micro-probe
US7774053B2 (en) * 2005-03-31 2010-08-10 Wisconsin Alumni Research Foundation Neural probe array

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040193068A1 (en) * 2001-06-13 2004-09-30 David Burton Methods and apparatus for monitoring consciousness

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MATTOUT J.: "Statistical Method for Source Localization in MEG/EEG Tomographic Reconstruction Problem", 2001, pages 714 - 717 *
OZDAMAR O.: "Detection of Transient EEG Patterns with Adaptive Unsupervised Neural Networks", INTERNATIONAL BIOMEDICAL ENGINEERING DAYS, 1992, pages 192 - 197 *

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Publication number Publication date
WO2006069250A2 (en) 2006-06-29
US8150795B2 (en) 2012-04-03
US20090043220A1 (en) 2009-02-12

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