WO2006062518B1 - Continuous phase composite for musculoskeletal repair - Google Patents

Continuous phase composite for musculoskeletal repair

Info

Publication number
WO2006062518B1
WO2006062518B1 PCT/US2004/041059 US2004041059W WO2006062518B1 WO 2006062518 B1 WO2006062518 B1 WO 2006062518B1 US 2004041059 W US2004041059 W US 2004041059W WO 2006062518 B1 WO2006062518 B1 WO 2006062518B1
Authority
WO
WIPO (PCT)
Prior art keywords
pores
implant
composite
selecting
resorbable
Prior art date
Application number
PCT/US2004/041059
Other languages
French (fr)
Other versions
WO2006062518A2 (en
WO2006062518A3 (en
Inventor
Mark D Borden
Joseph M Hernandez
Edwin C Shors
Original Assignee
Interpore Spine Ltd
Mark D Borden
Joseph M Hernandez
Edwin C Shors
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Interpore Spine Ltd, Mark D Borden, Joseph M Hernandez, Edwin C Shors filed Critical Interpore Spine Ltd
Priority to EP04813384A priority Critical patent/EP1819375A2/en
Publication of WO2006062518A2 publication Critical patent/WO2006062518A2/en
Publication of WO2006062518A3 publication Critical patent/WO2006062518A3/en
Publication of WO2006062518B1 publication Critical patent/WO2006062518B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/4455—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/84—Fasteners therefor or fasteners being internal fixation devices
    • A61B17/86—Pins or screws or threaded wires; nuts therefor
    • A61B17/866—Material or manufacture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/4455—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
    • A61F2/4465—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages having a circular or kidney shaped cross-section substantially perpendicular to the axis of the spine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/4455—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
    • A61F2/447—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages substantially parallelepipedal, e.g. having a rectangular or trapezoidal cross-section
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L31/125—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L31/127—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix containing fillers of phosphorus-containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L31/125—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L31/128—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix containing other specific inorganic fillers not covered by A61L31/126 or A61L31/127
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/146—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/84—Fasteners therefor or fasteners being internal fixation devices
    • A61B17/86—Pins or screws or threaded wires; nuts therefor
    • A61B17/864—Pins or screws or threaded wires; nuts therefor hollow, e.g. with socket or cannulated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00004—(bio)absorbable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/42—Joints for wrists or ankles; for hands, e.g. fingers; for feet, e.g. toes
    • A61F2/4202—Joints for wrists or ankles; for hands, e.g. fingers; for feet, e.g. toes for ankles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
    • A61F2/4603—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof
    • A61F2/4611—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof of spinal prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/30004—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
    • A61F2002/30032—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis differing in absorbability or resorbability, i.e. in absorption or resorption time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/3011—Cross-sections or two-dimensional shapes
    • A61F2002/30112—Rounded shapes, e.g. with rounded corners
    • A61F2002/30133—Rounded shapes, e.g. with rounded corners kidney-shaped or bean-shaped
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/3011—Cross-sections or two-dimensional shapes
    • A61F2002/30138—Convex polygonal shapes
    • A61F2002/30156—Convex polygonal shapes triangular
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/30199—Three-dimensional shapes
    • A61F2002/302—Three-dimensional shapes toroidal, e.g. rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30593—Special structural features of bone or joint prostheses not otherwise provided for hollow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
    • A61F2002/30772—Apertures or holes, e.g. of circular cross section
    • A61F2002/30784—Plurality of holes
    • A61F2002/30785—Plurality of holes parallel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
    • A61F2002/3082—Grooves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
    • A61F2002/30904—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves serrated profile, i.e. saw-toothed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0004—Rounded shapes, e.g. with rounded corners
    • A61F2230/0015—Kidney-shaped, e.g. bean-shaped
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0017—Angular shapes
    • A61F2230/0023—Angular shapes triangular
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0065—Three-dimensional shapes toroidal, e.g. ring-shaped, doughnut-shaped
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/003—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in adsorbability or resorbability, i.e. in adsorption or resorption time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
    • A61F2310/00796—Coating or prosthesis-covering structure made of a phosphorus-containing compound, e.g. hydroxy(l)apatite

Abstract

A composite material for positioning in the anatomy to form a selected function therein. The composite may be resorbable over a selected period of time. The composite may allow for selected bone ingrowth as absorption of the composite occurs.

Claims

AMENDED CLAIMS received by the International Bureau on 31 July 2006 (31.07.2006)What is claimed is:
1. An implantable resorbable material, comprising: a first material operable to be resorbed into an anatomy at a first resorption rate and defining a plurality of pores; a second material operable to be resorbed into the anatomy at a second resorption rate and positioned relative to the first material to fill some of the pores; wherein the first resorption rate of the first material is different than the second resorption rate of the second material.
2. The implantable material of claim 1 , wherein the first resorption rate of the first material assists in bone ingrowth while the second resorption rate of the second material assists in providing a selected strength.
3. The implantable material of claim 1 , wherein the first resorption rate of the first material is faster than the second resorption rate of the second material.
4. The implantable material of claim 1 , wherein the resorption rate of the second material is dependant upon on a molecular weight of the second material.
5. The implantable material of claim 1 , wherein the plurality of pores defines at least one of a plurality of channels or a plurality of interstice spaces.
6. The implantable material of Claim 1 , where the second material positioned in the plurality of pores of the first material defines a composite having a strength over time that lessens substantially linearly.
7. The implantable material of claim 6, wherein the linear lessening of the strength of the composite gradually loads the anatomy relative to the composite.
8. The implantable material of claim 6, wherein rate of strength lessening of the composite is selected based upon the selected second material.
9. The implantable material of Claim 1 , wherein the plurality of pores in the first material includes a first plurality of a first average diameter and a second plurality of a second average diameter.
10. The implantable material of claim 1 , wherein the first material defines a bone growth scaffold.
11. The implantable material of Claim 1 , wherein the second material is positioned in the plurality of pores of the first material in a process selected from a group comprising: injecting the second material into the plurality of pores of the first
AMENDED SHEET (ARTICLE 19) material; positioning a monomer as a flowable material in the plurality of pores and polymerizing the monomer; pulling the second material into the first material, dissolving the second material, placing the second material in the pores of the first material, and precipitating the dissolved first material, or combinations thereof.
12. The implantable material of Claim 1 , wherein the second material comprises a resorbable polymer.
13. The implantable material of Claim 1 , wherein the first material is formed of a material selected from a group that comprises calcium carbonate, calcium sulfate, tricalcium phosphate, biphasic phosphate, hydroxyapatite, a polymer, or combinations thereof.
14. The implantable material of Claim 1 , wherein the second material comprises a polymer selected from the group comprising of polylactic acid, a polyglycolic acid, polyglycolic acid, polycarbonate, polyurethane, poly-amino acids, polyphospazenes, polyhydroxy acids, polyanhydrides, polydioxanone, polyhydroxybutyrate, polycaprolactone, copolymers thereof, or mixtures thereof.
15. The implantable material of claim 1 , further comprising a bone screw having two portions where the first portion is formed of a composite of the first material having pores filled with the second material and the second portion is formed substantially of a material which is the same as the second material.
16. The implantable material of claim 1 , wherein the second material substantially fills at least a portion of the plurality of pores.
17. An implantable resorbable composite material having a selected strength and ingrowth capability, comprising: a scaffold of a resorbable material comprising a first part of the composite and operable to be resorbed into an anatomy and defining a plurality of continuous channels that extend throughout the scaffold; a resorbable polymer injected into and substantially fills at least a sub-plurality of the plurality of continuous channels comprising a second part of the composite so that the resorbable polymer includes a continuous structure; wherein the resorbable polymer is operable to be resorbed at a rate slower than a rate of resorption of the scaffold such that the resorbable polymer is operable to define a support of the bony ingrowth to maintain a selected strength of the composite.
AMENDED SHEET (ARTICLE 19)
18. A resorbable bone screw implant for positioning relative to a selected portion of an anatomy, comprising: a bone screw having a first screw portion, and a second screw portion extending from the first screw portion; wherein the first screw portion comprises a composite formed of a first material defining a plurality of pores and a second material that substantially fills at least a sub-plurality of the plurality of the pores; and the second screw portion is formed of the second material.
19. The implant of claim 18, wherein the second material includes a copolymer of lactic acid and glycolic acid.
20. The implant of claim 18, wherein the second portion defines a tool engaging portion.
21. The implant of claim 18, wherein the first portion defines a bone engaging portion.
22. A resorbable spinal implant for positioning near a vertebral bone, comprising a spinal implant member comprising a composite formed of a first material defining a plurality of pores and a second material that substantially fills at least a sub-plurality of the plurality of pores; wherein the second material is a polymer of lactic acid and forms about 55 wt% to about 65 wt% of the member; and the member is operable to be positioned between a first vertebrae and a second vertebrae.
23. The resorbable spinal implant of claim 22, wherein the first material defines the plurality of pores that are substantially continuous throughout the member.
24. The resorbable spinal implant of claim 22, wherein the second material is operable to resorb at a rate wherein the member remains substantially intact under at least about 2000 Newtons of compressive force after at least six months after implantation.
25. A resorbable implant, comprising: a first means for resorbing at a first rate resorbable to allow bone ingrowth; a second means for resorbing at a second rate to support the bone ingrowth, wherein the first rate is different than the second rate.
AMENDED SHEET (ARTICLE 19)
26. The resorbable implant of claim 25, wherein the first means is a porous material and the second means substantially fills at least a portion of the pores of the porous material.
27. The resorbable implant of claim 25, wherein the second means is operable to support the bone ingrowth between two vertebrae.
28. The resorbable implant of claim 25, further comprising a positioning means for positing the implant means between two vertebrae.
29. A method of forming a resorbable implant, comprising: selecting a first material including a first resorption rate; providing a porous structure of the first material; selecting a second material having a second resorption rate; forming a composite of the porous structure of the first material with the second material, wherein forming the composite includes substantially filling at least a portion of the plurality of the pores with the second material; and forming an implant of the formed composite; wherein the resorption rate of the first material is different than the resorption rate of the second materia! to allow a bone ingrowth after implantation of the implant.
30. The method of claim 29, wherein selecting the second material having the second resorption rate includes selecting a molecular weight of the second material; wherein a higher molecular weight of the second material increases the resorption rate.
31. The method of claim 29, wherein selecting the second material having the second resorption rate includes selecting a rate of strength maintenance by the composite after implanting the implant.
32. The method of Claim 29, wherein selecting the second material includes selecting a material from a group comprising: polylactic acid, a polyglycolic acid, polyglycolic acid, polycarbonate, polyurethane, poly-amino acids, polyphospazenes, polyhydroxy acids, polyanhydrides, polydioxanone, polyhydroxybutyrate, polycaprolactone, copolymers thereof, or mixtures thereof.
33. The method of Claim 29, wherein forming the composite includes forming the composite by a process selected from a group comprising: injecting the second material into the plurality of pores of the first material; positioning a monomer in the plurality of pores in the first material, and polymerizing the monomer positioned in the plurality of pores in the first material to form a polymer in the
AMENDED SHEET (ARTICLE 19) plurality of pores in the first material; pulling the polymer into the in the plurality of pores in the first material; dissolving a polymer, putting the dissolved polymer in the plurality of pores in the first material, and precipitating the polymer; providing a porous polymer matrix as the first material, positioning a material in the pores of the polymer matrix, and forming a ceramic of the material positioned in the pores of the polymer matrix; or combinations thereof.
34. The method of Claim 29, wherein forming the implant includes forming a first portion of the composite and a second portion of at least one of the first material or the second material.
35. The method of claim 34, wherein forming a portion extending from the composite includes forming a at least one of a support portion; a high strength portion, a flexible seam, tool engaging portion, substance releasing portion, or combinations thereof.
36. The method of Claim 29, wherein forming an implant of the formed composite includes forming a screw, a suture anchor, a disk replacement block, a vertebrae replacement block, a bone replacement member, a spinal interbody spacer, a spinal interbody fusion device, a fracture plate, a spinal fusion plate, a graft retaining plate, or combinations thereof.
37. A method of forming a resorbable implant, comprising: selecting a region of the anatomy to position an implant; determining a force produced in the region of the anatomy selected; determining a bone regrowth rate for the region selected; selecting at least one of a first material or a second material depending at least upon the determined force produced in the region of the anatomy selected; selecting at least the other of the first material or the second material depending upon a determined bone regrowth rate for the region selected; and forming the implant of the first material and the second material.
38. The method of claim 37, wherein selecting the first material and selecting the second material includes selecting the first material to resorb faster than the second material.
39. The method of claim 37, wherein selecting the region of the anatomy includes selecting a spinal region; wherein selecting the second material includes selecting a second material to include a resorption rate so that the formed implant maintains a
AMENDED SHEET (ARTICLE 19) compressive strength of at least about 2000 Newtons at least about six months after implantation.
40. The method of claim 37, wherein selecting the region of the anatomy includes selecting a femur; wherein selecting the second material includes selecting a second material to include a resorption rate so that the formed implant has substantially no structural strength after about six months of implantation.
41 . The method of claim 37, wherein the second material is selected based upon a strength reduction profile after implantation of the formed implant.
42. The method of claim 37, wherein selecting at least one of the first material or the second material includes selecting at least a composition and a molecular weight of the second material.
AMENDED SHEET (ARTICLE 19)
PCT/US2004/041059 2004-12-08 2004-12-09 Continuous phase composite for musculoskeletal repair WO2006062518A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP04813384A EP1819375A2 (en) 2004-12-08 2004-12-09 Continuous phase composite for musculoskeletal repair

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63444804P 2004-12-08 2004-12-08
US60/634,448 2004-12-08

Publications (3)

Publication Number Publication Date
WO2006062518A2 WO2006062518A2 (en) 2006-06-15
WO2006062518A3 WO2006062518A3 (en) 2006-08-03
WO2006062518B1 true WO2006062518B1 (en) 2006-11-16

Family

ID=35708973

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/041059 WO2006062518A2 (en) 2004-12-08 2004-12-09 Continuous phase composite for musculoskeletal repair

Country Status (3)

Country Link
US (3) US7879109B2 (en)
EP (1) EP1819375A2 (en)
WO (1) WO2006062518A2 (en)

Families Citing this family (187)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2897259B1 (en) 2006-02-15 2008-05-09 Ldr Medical Soc Par Actions Si INTERSOMATIC TRANSFORAMINAL CAGE WITH INTERBREBAL FUSION GRAFT AND CAGE IMPLANTATION INSTRUMENT
GB0329654D0 (en) 2003-12-23 2004-01-28 Smith & Nephew Tunable segmented polyacetal
US7608092B1 (en) 2004-02-20 2009-10-27 Biomet Sports Medicince, LLC Method and apparatus for performing meniscus repair
EP1763703A4 (en) 2004-05-12 2010-12-08 Massachusetts Inst Technology Manufacturing process, such as three-dimensional printing, including solvent vapor filming and the like
US20060189993A1 (en) 2004-11-09 2006-08-24 Arthrotek, Inc. Soft tissue conduit device
US9801708B2 (en) 2004-11-05 2017-10-31 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US7905904B2 (en) 2006-02-03 2011-03-15 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US8137382B2 (en) 2004-11-05 2012-03-20 Biomet Sports Medicine, Llc Method and apparatus for coupling anatomical features
US8361113B2 (en) 2006-02-03 2013-01-29 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8128658B2 (en) 2004-11-05 2012-03-06 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to bone
US8088130B2 (en) 2006-02-03 2012-01-03 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US9017381B2 (en) 2007-04-10 2015-04-28 Biomet Sports Medicine, Llc Adjustable knotless loops
US7749250B2 (en) 2006-02-03 2010-07-06 Biomet Sports Medicine, Llc Soft tissue repair assembly and associated method
US8118836B2 (en) 2004-11-05 2012-02-21 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US7905903B2 (en) 2006-02-03 2011-03-15 Biomet Sports Medicine, Llc Method for tissue fixation
US7909851B2 (en) 2006-02-03 2011-03-22 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US7857830B2 (en) 2006-02-03 2010-12-28 Biomet Sports Medicine, Llc Soft tissue repair and conduit device
US8298262B2 (en) 2006-02-03 2012-10-30 Biomet Sports Medicine, Llc Method for tissue fixation
US7658751B2 (en) 2006-09-29 2010-02-09 Biomet Sports Medicine, Llc Method for implanting soft tissue
US8840645B2 (en) 2004-11-05 2014-09-23 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8303604B2 (en) 2004-11-05 2012-11-06 Biomet Sports Medicine, Llc Soft tissue repair device and method
US8998949B2 (en) 2004-11-09 2015-04-07 Biomet Sports Medicine, Llc Soft tissue conduit device
WO2006062518A2 (en) 2004-12-08 2006-06-15 Interpore Spine Ltd. Continuous phase composite for musculoskeletal repair
US20070038303A1 (en) * 2006-08-15 2007-02-15 Ebi, L.P. Foot/ankle implant and associated method
US8535357B2 (en) 2004-12-09 2013-09-17 Biomet Sports Medicine, Llc Continuous phase compositions for ACL repair
CA2603400C (en) * 2005-04-01 2015-11-24 Ibalance Medical, Inc. Method and apparatus for performing an open wedge, high tibial osteotomy
AU2006231652A1 (en) 2005-04-05 2006-10-12 Elixir Medical Corporation Degradable implantable medical devices
US20060287676A1 (en) * 2005-06-15 2006-12-21 Rita Prajapati Method of intra-operative coating therapeutic agents onto sutures, composite sutures and methods of use
US20070055373A1 (en) 2005-09-08 2007-03-08 Zimmer Spine, Inc. Facet replacement/spacing and flexible spinal stabilization
FR2891135B1 (en) 2005-09-23 2008-09-12 Ldr Medical Sarl INTERVERTEBRAL DISC PROSTHESIS
US20070066966A1 (en) * 2005-10-03 2007-03-22 Christopher Davey Implantable medical device
US10105207B2 (en) * 2005-10-25 2018-10-23 Globus Medical, Inc. Porous and nonporous materials for tissue grafting and repair
US8029575B2 (en) * 2005-10-25 2011-10-04 Globus Medical, Inc. Porous and nonporous materials for tissue grafting and repair
WO2007089905A2 (en) * 2006-02-01 2007-08-09 Synthes (U.S.A.) Interspinous process spacer
US11311287B2 (en) 2006-02-03 2022-04-26 Biomet Sports Medicine, Llc Method for tissue fixation
US9149267B2 (en) 2006-02-03 2015-10-06 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8562645B2 (en) 2006-09-29 2013-10-22 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable loop
US8562647B2 (en) 2006-09-29 2013-10-22 Biomet Sports Medicine, Llc Method and apparatus for securing soft tissue to bone
US10517587B2 (en) 2006-02-03 2019-12-31 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable loop
US8506597B2 (en) 2011-10-25 2013-08-13 Biomet Sports Medicine, Llc Method and apparatus for interosseous membrane reconstruction
US9468433B2 (en) 2006-02-03 2016-10-18 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable loop
US7959650B2 (en) 2006-09-29 2011-06-14 Biomet Sports Medicine, Llc Adjustable knotless loops
US8968364B2 (en) 2006-02-03 2015-03-03 Biomet Sports Medicine, Llc Method and apparatus for fixation of an ACL graft
US8652172B2 (en) 2006-02-03 2014-02-18 Biomet Sports Medicine, Llc Flexible anchors for tissue fixation
US8771352B2 (en) 2011-05-17 2014-07-08 Biomet Sports Medicine, Llc Method and apparatus for tibial fixation of an ACL graft
US8652171B2 (en) 2006-02-03 2014-02-18 Biomet Sports Medicine, Llc Method and apparatus for soft tissue fixation
US8251998B2 (en) 2006-08-16 2012-08-28 Biomet Sports Medicine, Llc Chondral defect repair
US8574235B2 (en) 2006-02-03 2013-11-05 Biomet Sports Medicine, Llc Method for trochanteric reattachment
US9538998B2 (en) 2006-02-03 2017-01-10 Biomet Sports Medicine, Llc Method and apparatus for fracture fixation
US8597327B2 (en) 2006-02-03 2013-12-03 Biomet Manufacturing, Llc Method and apparatus for sternal closure
US8801783B2 (en) 2006-09-29 2014-08-12 Biomet Sports Medicine, Llc Prosthetic ligament system for knee joint
US9078644B2 (en) 2006-09-29 2015-07-14 Biomet Sports Medicine, Llc Fracture fixation device
US9271713B2 (en) 2006-02-03 2016-03-01 Biomet Sports Medicine, Llc Method and apparatus for tensioning a suture
US11259792B2 (en) 2006-02-03 2022-03-01 Biomet Sports Medicine, Llc Method and apparatus for coupling anatomical features
US8133234B2 (en) 2006-02-27 2012-03-13 Biomet Manufacturing Corp. Patient specific acetabular guide and method
US8864769B2 (en) 2006-02-27 2014-10-21 Biomet Manufacturing, Llc Alignment guides with patient-specific anchoring elements
US9289253B2 (en) 2006-02-27 2016-03-22 Biomet Manufacturing, Llc Patient-specific shoulder guide
US10278711B2 (en) 2006-02-27 2019-05-07 Biomet Manufacturing, Llc Patient-specific femoral guide
US9907659B2 (en) * 2007-04-17 2018-03-06 Biomet Manufacturing, Llc Method and apparatus for manufacturing an implant
US8591516B2 (en) 2006-02-27 2013-11-26 Biomet Manufacturing, Llc Patient-specific orthopedic instruments
US8407067B2 (en) * 2007-04-17 2013-03-26 Biomet Manufacturing Corp. Method and apparatus for manufacturing an implant
US20110046735A1 (en) * 2006-02-27 2011-02-24 Biomet Manufacturing Corp. Patient-Specific Implants
US8608749B2 (en) 2006-02-27 2013-12-17 Biomet Manufacturing, Llc Patient-specific acetabular guides and associated instruments
US9173661B2 (en) 2006-02-27 2015-11-03 Biomet Manufacturing, Llc Patient specific alignment guide with cutting surface and laser indicator
US9339278B2 (en) 2006-02-27 2016-05-17 Biomet Manufacturing, Llc Patient-specific acetabular guides and associated instruments
US20150335438A1 (en) 2006-02-27 2015-11-26 Biomet Manufacturing, Llc. Patient-specific augments
US8282646B2 (en) 2006-02-27 2012-10-09 Biomet Manufacturing Corp. Patient specific knee alignment guide and associated method
US8092465B2 (en) 2006-06-09 2012-01-10 Biomet Manufacturing Corp. Patient specific knee alignment guide and associated method
US8603180B2 (en) 2006-02-27 2013-12-10 Biomet Manufacturing, Llc Patient-specific acetabular alignment guides
US8473305B2 (en) * 2007-04-17 2013-06-25 Biomet Manufacturing Corp. Method and apparatus for manufacturing an implant
US9345548B2 (en) 2006-02-27 2016-05-24 Biomet Manufacturing, Llc Patient-specific pre-operative planning
US8568487B2 (en) 2006-02-27 2013-10-29 Biomet Manufacturing, Llc Patient-specific hip joint devices
US7967868B2 (en) 2007-04-17 2011-06-28 Biomet Manufacturing Corp. Patient-modified implant and associated method
US8608748B2 (en) * 2006-02-27 2013-12-17 Biomet Manufacturing, Llc Patient specific guides
US8858561B2 (en) 2006-06-09 2014-10-14 Blomet Manufacturing, LLC Patient-specific alignment guide
US8535387B2 (en) * 2006-02-27 2013-09-17 Biomet Manufacturing, Llc Patient-specific tools and implants
US8298237B2 (en) * 2006-06-09 2012-10-30 Biomet Manufacturing Corp. Patient-specific alignment guide for multiple incisions
US8241293B2 (en) * 2006-02-27 2012-08-14 Biomet Manufacturing Corp. Patient specific high tibia osteotomy
US9113971B2 (en) 2006-02-27 2015-08-25 Biomet Manufacturing, Llc Femoral acetabular impingement guide
US8377066B2 (en) 2006-02-27 2013-02-19 Biomet Manufacturing Corp. Patient-specific elbow guides and associated methods
US9918740B2 (en) 2006-02-27 2018-03-20 Biomet Manufacturing, Llc Backup surgical instrument system and method
US9795399B2 (en) 2006-06-09 2017-10-24 Biomet Manufacturing, Llc Patient-specific knee alignment guide and associated method
US11259794B2 (en) 2006-09-29 2022-03-01 Biomet Sports Medicine, Llc Method for implanting soft tissue
US8672969B2 (en) 2006-09-29 2014-03-18 Biomet Sports Medicine, Llc Fracture fixation device
US9918826B2 (en) 2006-09-29 2018-03-20 Biomet Sports Medicine, Llc Scaffold for spring ligament repair
US8500818B2 (en) 2006-09-29 2013-08-06 Biomet Manufacturing, Llc Knee prosthesis assembly with ligament link
US20110282392A1 (en) * 2006-10-30 2011-11-17 Tissue Regeneration Systems, Inc. Degradable cage for bone fusion
CA2679365C (en) 2006-11-30 2016-05-03 Smith & Nephew, Inc. Fiber reinforced composite material
WO2008122594A2 (en) * 2007-04-05 2008-10-16 Cinvention Ag Partially biodegradable therapeutic implant for bone and cartilage repair
JP5416090B2 (en) 2007-04-18 2014-02-12 スミス アンド ネフュー ピーエルシー Expansion molding of shape memory polymer
DE602008006181D1 (en) 2007-04-19 2011-05-26 Smith & Nephew Inc GRAFT FIXATION
US9000066B2 (en) 2007-04-19 2015-04-07 Smith & Nephew, Inc. Multi-modal shape memory polymers
FR2916956B1 (en) * 2007-06-08 2012-12-14 Ldr Medical INTERSOMATIC CAGE, INTERVERTEBRAL PROSTHESIS, ANCHORING DEVICE AND IMPLANTATION INSTRUMENTATION
US7567129B2 (en) * 2007-06-29 2009-07-28 Intel Corporation Monolithic flexible power amplifier using integrated tunable matching networks
US7959684B2 (en) * 2007-09-11 2011-06-14 Joy Medical Devices Corporation Method for forming a bioresorbable composite implant in a bone
US8323322B2 (en) * 2007-10-05 2012-12-04 Zimmer Spine, Inc. Medical implant formed from porous metal and method
DE102008044951A1 (en) * 2008-02-05 2009-08-06 Smith & Nephew Orthopaedics Ag Open-pore biocompatible surface layer for an implant, method of manufacture and use
US10010500B2 (en) * 2008-08-21 2018-07-03 Biomet Manufacturing, Llc Ceramic implants affording controlled release of active materials
AU2009318023A1 (en) * 2008-11-20 2011-07-07 Cardiac Pacemakers, Inc. Overmolded components for implantable medical leads and related methods
US20100305710A1 (en) 2009-05-28 2010-12-02 Biomet Manufacturing Corp. Knee Prosthesis
US9399086B2 (en) * 2009-07-24 2016-07-26 Warsaw Orthopedic, Inc Implantable medical devices
DE102009028503B4 (en) 2009-08-13 2013-11-14 Biomet Manufacturing Corp. Resection template for the resection of bones, method for producing such a resection template and operation set for performing knee joint surgery
CN102596109B (en) 2009-09-17 2015-10-21 Ldr控股公司 There is the intervertebral implant of extensible bone fixed part
WO2011037668A1 (en) 2009-09-23 2011-03-31 Zimmer Spine, Inc. Composite implant
RU2573945C2 (en) 2009-12-31 2016-01-27 Лдр Медикал Fastening device, intervertebral implant and device for implantation
US8632547B2 (en) 2010-02-26 2014-01-21 Biomet Sports Medicine, Llc Patient-specific osteotomy devices and methods
WO2011109363A1 (en) * 2010-03-01 2011-09-09 Anulex Technologies, Inc. System for intervertebral disc bulge reduction
US9271744B2 (en) 2010-09-29 2016-03-01 Biomet Manufacturing, Llc Patient-specific guide for partial acetabular socket replacement
CN101954118B (en) * 2010-10-13 2013-03-13 同济大学 Method for preparing aqueous gel/nano hydroxyapatite composite scaffold for hard tissue repair
US9968376B2 (en) 2010-11-29 2018-05-15 Biomet Manufacturing, Llc Patient-specific orthopedic instruments
US9241745B2 (en) 2011-03-07 2016-01-26 Biomet Manufacturing, Llc Patient-specific femoral version guide
US8715289B2 (en) 2011-04-15 2014-05-06 Biomet Manufacturing, Llc Patient-specific numerically controlled instrument
US9675400B2 (en) 2011-04-19 2017-06-13 Biomet Manufacturing, Llc Patient-specific fracture fixation instrumentation and method
US8956364B2 (en) 2011-04-29 2015-02-17 Biomet Manufacturing, Llc Patient-specific partial knee guides and other instruments
US8668700B2 (en) 2011-04-29 2014-03-11 Biomet Manufacturing, Llc Patient-specific convertible guides
US8532807B2 (en) 2011-06-06 2013-09-10 Biomet Manufacturing, Llc Pre-operative planning and manufacturing method for orthopedic procedure
US9084618B2 (en) 2011-06-13 2015-07-21 Biomet Manufacturing, Llc Drill guides for confirming alignment of patient-specific alignment guides
US8764760B2 (en) 2011-07-01 2014-07-01 Biomet Manufacturing, Llc Patient-specific bone-cutting guidance instruments and methods
US20130001121A1 (en) 2011-07-01 2013-01-03 Biomet Manufacturing Corp. Backup kit for a patient-specific arthroplasty kit assembly
US8597365B2 (en) 2011-08-04 2013-12-03 Biomet Manufacturing, Llc Patient-specific pelvic implants for acetabular reconstruction
US9066734B2 (en) 2011-08-31 2015-06-30 Biomet Manufacturing, Llc Patient-specific sacroiliac guides and associated methods
US9295497B2 (en) 2011-08-31 2016-03-29 Biomet Manufacturing, Llc Patient-specific sacroiliac and pedicle guides
US9386993B2 (en) 2011-09-29 2016-07-12 Biomet Manufacturing, Llc Patient-specific femoroacetabular impingement instruments and methods
US9301812B2 (en) 2011-10-27 2016-04-05 Biomet Manufacturing, Llc Methods for patient-specific shoulder arthroplasty
US9554910B2 (en) 2011-10-27 2017-01-31 Biomet Manufacturing, Llc Patient-specific glenoid guide and implants
US9451973B2 (en) 2011-10-27 2016-09-27 Biomet Manufacturing, Llc Patient specific glenoid guide
KR20130046337A (en) 2011-10-27 2013-05-07 삼성전자주식회사 Multi-view device and contol method thereof, display apparatus and contol method thereof, and display system
EP2770918B1 (en) 2011-10-27 2017-07-19 Biomet Manufacturing, LLC Patient-specific glenoid guides
US9357991B2 (en) 2011-11-03 2016-06-07 Biomet Sports Medicine, Llc Method and apparatus for stitching tendons
US9381013B2 (en) 2011-11-10 2016-07-05 Biomet Sports Medicine, Llc Method for coupling soft tissue to a bone
US9370350B2 (en) 2011-11-10 2016-06-21 Biomet Sports Medicine, Llc Apparatus for coupling soft tissue to a bone
US9357992B2 (en) 2011-11-10 2016-06-07 Biomet Sports Medicine, Llc Method for coupling soft tissue to a bone
US9259217B2 (en) 2012-01-03 2016-02-16 Biomet Manufacturing, Llc Suture Button
US9237950B2 (en) 2012-02-02 2016-01-19 Biomet Manufacturing, Llc Implant with patient-specific porous structure
US9399708B2 (en) 2012-04-12 2016-07-26 Howard University Polylactide and calcium phosphate compositions and methods of making the same
US9585764B2 (en) * 2012-07-26 2017-03-07 Warsaw Orthopedic, Inc. Bone implant device
FR2994097B1 (en) * 2012-08-02 2015-08-21 Teknimed RESORBABLE AND RADIO-OPAQUE DEVICE FOR BONE FASTENING
ES2692653T3 (en) 2012-08-21 2018-12-04 Avery Dennison Corporation Systems and methods for manufacturing films, fibers, spheres and other porous articles
EP2917253B2 (en) 2012-11-09 2020-03-04 Howard University Block copolymers for tooth enamel protection
US9204977B2 (en) 2012-12-11 2015-12-08 Biomet Manufacturing, Llc Patient-specific acetabular guide for anterior approach
US9060788B2 (en) 2012-12-11 2015-06-23 Biomet Manufacturing, Llc Patient-specific acetabular guide for anterior approach
ES2497240B1 (en) 2012-12-24 2015-07-20 Servicio Andaluz De Salud Resorbable membrane for guided bone regeneration
US9757119B2 (en) 2013-03-08 2017-09-12 Biomet Sports Medicine, Llc Visual aid for identifying suture limbs arthroscopically
US9839438B2 (en) 2013-03-11 2017-12-12 Biomet Manufacturing, Llc Patient-specific glenoid guide with a reusable guide holder
US9579107B2 (en) 2013-03-12 2017-02-28 Biomet Manufacturing, Llc Multi-point fit for patient specific guide
US9498233B2 (en) 2013-03-13 2016-11-22 Biomet Manufacturing, Llc. Universal acetabular guide and associated hardware
US9826981B2 (en) 2013-03-13 2017-11-28 Biomet Manufacturing, Llc Tangential fit of patient-specific guides
US9918827B2 (en) 2013-03-14 2018-03-20 Biomet Sports Medicine, Llc Scaffold for spring ligament repair
US20140277485A1 (en) * 2013-03-14 2014-09-18 Ranier Limited Intervertebral fusion implant cage
US9517145B2 (en) 2013-03-15 2016-12-13 Biomet Manufacturing, Llc Guide alignment system and method
FR3005569B1 (en) 2013-05-16 2021-09-03 Ldr Medical VERTEBRAL IMPLANT, VERTEBRAL IMPLANT FIXATION DEVICE AND IMPLANTATION INSTRUMENTATION
US20150112349A1 (en) 2013-10-21 2015-04-23 Biomet Manufacturing, Llc Ligament Guide Registration
US10136886B2 (en) 2013-12-20 2018-11-27 Biomet Sports Medicine, Llc Knotless soft tissue devices and techniques
FR3016793B1 (en) 2014-01-30 2021-05-07 Ldr Medical ANCHORING DEVICE FOR SPINAL IMPLANT, SPINAL IMPLANT AND IMPLANTATION INSTRUMENTATION
US20150265745A1 (en) * 2014-03-18 2015-09-24 Globus Medical, Inc Porous and Nonporous Materials for Tissue Grafting and Repair
US10282488B2 (en) 2014-04-25 2019-05-07 Biomet Manufacturing, Llc HTO guide with optional guided ACL/PCL tunnels
FR3020756B1 (en) 2014-05-06 2022-03-11 Ldr Medical VERTEBRAL IMPLANT, VERTEBRAL IMPLANT FIXATION DEVICE AND IMPLANT INSTRUMENTATION
US9408616B2 (en) 2014-05-12 2016-08-09 Biomet Manufacturing, Llc Humeral cut guide
US9615822B2 (en) 2014-05-30 2017-04-11 Biomet Sports Medicine, Llc Insertion tools and method for soft anchor
US9839436B2 (en) 2014-06-03 2017-12-12 Biomet Manufacturing, Llc Patient-specific glenoid depth control
US9561040B2 (en) 2014-06-03 2017-02-07 Biomet Manufacturing, Llc Patient-specific glenoid depth control
US9700291B2 (en) 2014-06-03 2017-07-11 Biomet Sports Medicine, Llc Capsule retractor
US9504550B2 (en) 2014-06-26 2016-11-29 Vertera, Inc. Porous devices and processes for producing same
US9498922B2 (en) 2014-06-26 2016-11-22 Vertera, Inc. Apparatus and process for producing porous devices
US10039543B2 (en) 2014-08-22 2018-08-07 Biomet Sports Medicine, Llc Non-sliding soft anchor
US9833245B2 (en) 2014-09-29 2017-12-05 Biomet Sports Medicine, Llc Tibial tubercule osteotomy
US9826994B2 (en) 2014-09-29 2017-11-28 Biomet Manufacturing, Llc Adjustable glenoid pin insertion guide
US10420597B2 (en) 2014-12-16 2019-09-24 Arthrex, Inc. Surgical implant with porous region
US10363075B2 (en) * 2015-02-09 2019-07-30 Yingze Zhang Porous bionic internal fixation device for promoting healing of fractured bone
US9955980B2 (en) 2015-02-24 2018-05-01 Biomet Sports Medicine, Llc Anatomic soft tissue repair
US9820868B2 (en) 2015-03-30 2017-11-21 Biomet Manufacturing, Llc Method and apparatus for a pin apparatus
US9974534B2 (en) 2015-03-31 2018-05-22 Biomet Sports Medicine, Llc Suture anchor with soft anchor of electrospun fibers
USD815281S1 (en) 2015-06-23 2018-04-10 Vertera, Inc. Cervical interbody fusion device
US10568647B2 (en) 2015-06-25 2020-02-25 Biomet Manufacturing, Llc Patient-specific humeral guide designs
US10226262B2 (en) 2015-06-25 2019-03-12 Biomet Manufacturing, Llc Patient-specific humeral guide designs
WO2017192632A1 (en) 2016-05-03 2017-11-09 Additive Orthopaedics, LLC Bone fixation device and method of use
WO2017210695A1 (en) 2016-06-03 2017-12-07 Additive Orthopaedics, LLC Bone fixation devices
US10779816B2 (en) 2016-07-07 2020-09-22 Medline Industries, Inc. Orthopedic implant, method, and kit
WO2018023131A1 (en) 2016-07-29 2018-02-01 Additive Orthopaedics, LLC Bone fixation device and method of use
US10722310B2 (en) 2017-03-13 2020-07-28 Zimmer Biomet CMF and Thoracic, LLC Virtual surgery planning system and method
CN107468382A (en) * 2017-08-23 2017-12-15 北京爱康宜诚医疗器材有限公司 Ankle joint fusion cage
US10918497B1 (en) 2017-10-24 2021-02-16 Omnia Medical, LLC Multi-material multi-component spinal implant
US11766339B1 (en) 2017-10-24 2023-09-26 Omnia Medical, LLC Multi-material multi-component spinal implant
US11147679B2 (en) 2018-02-05 2021-10-19 Paragon Advanced Technologies, Inc. Bone fixation device
WO2021155248A1 (en) * 2020-01-30 2021-08-05 SDIP Innovations Pty Ltd Bioresorbable implant with inside-out resorption for enhanced bone ingrowth and tissue integration and method of manufacturing thereof
CN111359025B (en) * 2020-04-15 2022-03-15 花沐医疗科技(上海)有限公司 Orderly-absorbed composite absorbable interface screw system with sheath and preparation method thereof
US20230074964A1 (en) * 2021-09-07 2023-03-09 Matthew R. MacEwan Materials and methods for nerve repair and regeneration

Family Cites Families (161)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3929971A (en) 1973-03-30 1975-12-30 Research Corp Porous biomaterials and method of making same
EP0030583B1 (en) * 1979-12-18 1984-06-13 Oscobal Ag Bone replacement material and process for producing a bone replacement material
CA1146301A (en) * 1980-06-13 1983-05-17 J. David Kuntz Intervertebral disc prosthesis
US4450591A (en) * 1981-12-10 1984-05-29 Rappaport Mark J Internal anti-proratory plug assembly and process of installing the same
US4421112A (en) * 1982-05-20 1983-12-20 Minnesota Mining And Manufacturing Company Tibial osteotomy guide assembly and method
DE3325111A1 (en) * 1983-07-12 1985-01-24 Merck Patent Gmbh, 6100 Darmstadt IMPLANTATION MATERIALS
US4834754A (en) * 1983-07-08 1989-05-30 Shearing Steven P Intraocular lens
US4612923A (en) * 1983-12-01 1986-09-23 Ethicon, Inc. Glass-filled, absorbable surgical devices
US4655777A (en) * 1983-12-19 1987-04-07 Southern Research Institute Method of producing biodegradable prosthesis and products therefrom
DE3414924A1 (en) * 1984-04-19 1985-10-31 Klaus Dr.med. Dr.med.habil. 8000 München Draenert COATED ANCHORAGE PART FOR IMPLANTS
US4678470A (en) * 1985-05-29 1987-07-07 American Hospital Supply Corporation Bone-grafting material
US4743256A (en) * 1985-10-04 1988-05-10 Brantigan John W Surgical prosthetic implant facilitating vertebral interbody fusion and method
DE3542744C1 (en) * 1985-12-03 1987-05-27 Ewers Rolf Porous hydroxyapatite material
FI81010C (en) * 1986-09-05 1990-09-10 Biocon Oy Benomplaceringsimplants
US4834757A (en) * 1987-01-22 1989-05-30 Brantigan John W Prosthetic implant
GB8718627D0 (en) * 1987-08-06 1987-09-09 Showell A W Sugicraft Ltd Spinal implants
US5344654A (en) 1988-04-08 1994-09-06 Stryker Corporation Prosthetic devices having enhanced osteogenic properties
US5962028A (en) 1988-04-20 1999-10-05 Norian Corporation Carbonated hydroxyapatite compositions and uses
GB8809863D0 (en) * 1988-04-26 1988-06-02 Ici Plc Composite materials for use in orthopaedics
US5484437A (en) 1988-06-13 1996-01-16 Michelson; Gary K. Apparatus and method of inserting spinal implants
CA1333209C (en) * 1988-06-28 1994-11-29 Gary Karlin Michelson Artificial spinal fusion implants
US5609635A (en) * 1988-06-28 1997-03-11 Michelson; Gary K. Lordotic interbody spinal fusion implants
JPH02124945A (en) 1988-07-27 1990-05-14 Kuraray Co Ltd Water-soluble film
US4961740B1 (en) * 1988-10-17 1997-01-14 Surgical Dynamics Inc V-thread fusion cage and method of fusing a bone joint
US5356630A (en) 1989-02-22 1994-10-18 Massachusetts Institute Of Technology Delivery system for controlled release of bioactive factors
US5522817A (en) 1989-03-31 1996-06-04 United States Surgical Corporation Absorbable surgical fastener with bone penetrating elements
US4976736A (en) * 1989-04-28 1990-12-11 Interpore International Coated biomaterials and methods for making same
US5015255A (en) * 1989-05-10 1991-05-14 Spine-Tech, Inc. Spinal stabilization method
US5053039A (en) * 1989-09-14 1991-10-01 Intermedics Orthopedics Upper tibial osteotomy system
WO1992011843A1 (en) 1991-01-09 1992-07-23 Alza Corporation Bioerodible devices and compositions for diffusional release of agents
US5192327A (en) * 1991-03-22 1993-03-09 Brantigan John W Surgical prosthetic implant for vertebrae
DE4120325A1 (en) 1991-06-20 1992-12-24 Merck Patent Gmbh IMPLANT MATERIAL
US6731988B1 (en) * 1992-01-21 2004-05-04 Sri International System and method for remote endoscopic surgery
US5366507A (en) 1992-03-06 1994-11-22 Sottosanti John S Method for use in bone tissue regeneration
IT228979Y1 (en) 1992-03-09 1998-06-05 Giannini Sandro BIODEGRADABLE PROSTHESIS FOR READY FOOT CORRECTION.
US5766251A (en) 1992-03-13 1998-06-16 Tomihisa Koshino Wedge-shaped spacer for correction of deformed extremities
FR2689400B1 (en) * 1992-04-03 1995-06-23 Inoteb BONE PROSTHESIS MATERIAL CONTAINING CALCIUM CARBONATE PARTICLES DISPERSED IN A BIORESORBABLE POLYMER MATRIX.
US5306309A (en) * 1992-05-04 1994-04-26 Calcitek, Inc. Spinal disk implant and implantation kit
SE9301406D0 (en) 1993-04-27 1993-04-27 Medevelop Ab FOE IMPLANTATION IN THE WEBSITE PROVIDED FOR THE HALLAR ORGAN FOR CONTROLLED RECORDING AND LOCATION FIXING OF WIRELESS WIRES FOR ELECTRIC INFORMATION TRANSFER USEFUL EQUIPMENT AND SET FOR ITS APPLICATION
DE4423826B4 (en) * 1993-07-07 2007-01-04 Pentax Corp. Ceramic vertebral prosthesis
US5425772A (en) * 1993-09-20 1995-06-20 Brantigan; John W. Prosthetic implant for intervertebral spinal fusion
US5490962A (en) * 1993-10-18 1996-02-13 Massachusetts Institute Of Technology Preparation of medical devices by solid free-form fabrication methods
US5626861A (en) * 1994-04-01 1997-05-06 Massachusetts Institute Of Technology Polymeric-hydroxyapatite bone composite
ATE222782T1 (en) 1994-05-24 2002-09-15 Implico Bv BIOMATERIAL AND IMPLANT FOR REPAIR AND REPLACEMENT OF BONE
US5529075A (en) 1994-09-12 1996-06-25 Clark; David Fixation device and method for repair of pronounced hallux valgus
US6180606B1 (en) 1994-09-28 2001-01-30 Gensci Orthobiologics, Inc. Compositions with enhanced osteogenic potential, methods for making the same and uses thereof
US5707962A (en) * 1994-09-28 1998-01-13 Gensci Regeneration Sciences Inc. Compositions with enhanced osteogenic potential, method for making the same and therapeutic uses thereof
DE4435680A1 (en) 1994-10-06 1996-04-11 Merck Patent Gmbh Porous bone substitute materials
US6376573B1 (en) 1994-12-21 2002-04-23 Interpore International Porous biomaterials and methods for their manufacture
US5782919A (en) 1995-03-27 1998-07-21 Sdgi Holdings, Inc. Interbody fusion device and method for restoration of normal spinal anatomy
US5607424A (en) 1995-04-10 1997-03-04 Tropiano; Patrick Domed cage
US6117456A (en) 1995-05-19 2000-09-12 Etex Corporation Methods and products related to the physical conversion of reactive amorphous calcium phosphate
US6027742A (en) * 1995-05-19 2000-02-22 Etex Corporation Bioresorbable ceramic composites
US5601565A (en) 1995-06-02 1997-02-11 Huebner; Randall J. Osteotomy method and apparatus
US6039762A (en) * 1995-06-07 2000-03-21 Sdgi Holdings, Inc. Reinforced bone graft substitutes
US5702449A (en) * 1995-06-07 1997-12-30 Danek Medical, Inc. Reinforced porous spinal implants
EP0847376B1 (en) * 1995-09-01 2005-02-23 Millenium Biologix Inc. An artificial stabilized composition of calcium phosphate phases particularly adapted for supporting bone cell activity
FI98136C (en) * 1995-09-27 1997-04-25 Biocon Oy A tissue-soluble material and process for its manufacture
US5648097A (en) 1995-10-04 1997-07-15 Biotek, Inc. Calcium mineral-based microparticles and method for the production thereof
US5776193A (en) * 1995-10-16 1998-07-07 Orquest, Inc. Bone grafting matrix
US5989289A (en) * 1995-10-16 1999-11-23 Sdgi Holdings, Inc. Bone grafts
US6033582A (en) 1996-01-22 2000-03-07 Etex Corporation Surface modification of medical implants
US5865845A (en) * 1996-03-05 1999-02-02 Thalgott; John S. Prosthetic intervertebral disc
US5722978A (en) 1996-03-13 1998-03-03 Jenkins, Jr.; Joseph Robert Osteotomy system
EP0915967A1 (en) 1996-05-28 1999-05-19 The Board Of Regents Of The University Of Michigan Engineering oral tissues
EP0906128A1 (en) * 1996-05-28 1999-04-07 1218122 Ontario Inc. Resorbable implant biomaterial made of condensed calcium phosphate particles
FR2749756B1 (en) * 1996-06-14 1998-09-11 Bioland PROCESS FOR THE PREPARATION OF AN IMPLANTABLE COMPOSITE MATERIAL, MATERIAL OBTAINED, IMPLANT COMPRISING SUCH MATERIAL, AND IMPLEMENTATION KIT
WO1998009586A1 (en) * 1996-09-04 1998-03-12 Synthes Ag Chur Intervertebral implant
US5895426A (en) 1996-09-06 1999-04-20 Osteotech, Inc. Fusion implant device and method of use
EP0955961B1 (en) * 1996-10-23 2004-03-31 SDGI Holdings, Inc. Spinal spacer
FI105159B (en) * 1996-10-25 2000-06-30 Biocon Ltd Surgical implant, agent or part thereof
US5728159A (en) * 1997-01-02 1998-03-17 Musculoskeletal Transplant Foundation Serrated bone graft
US6224893B1 (en) 1997-04-11 2001-05-01 Massachusetts Institute Of Technology Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering
US6241771B1 (en) * 1997-08-13 2001-06-05 Cambridge Scientific, Inc. Resorbable interbody spinal fusion devices
US6296667B1 (en) 1997-10-01 2001-10-02 Phillips-Origen Ceramic Technology, Llc Bone substitutes
US6417247B1 (en) 1997-10-14 2002-07-09 Beth L. Armstrong Polymer/ceramic composites
US5899939A (en) 1998-01-21 1999-05-04 Osteotech, Inc. Bone-derived implant for load-supporting applications
US6143033A (en) * 1998-01-30 2000-11-07 Synthes (Usa) Allogenic intervertebral implant
US6123731A (en) 1998-02-06 2000-09-26 Osteotech, Inc. Osteoimplant and method for its manufacture
US5984966A (en) 1998-03-02 1999-11-16 Bionx Implants Oy Bioabsorbable bone block fixation implant
US6736849B2 (en) * 1998-03-11 2004-05-18 Depuy Products, Inc. Surface-mineralized spinal implants
US6139585A (en) * 1998-03-11 2000-10-31 Depuy Orthopaedics, Inc. Bioactive ceramic coating and method
JP3360810B2 (en) * 1998-04-14 2003-01-07 ペンタックス株式会社 Method for producing bone replacement material
US6008433A (en) 1998-04-23 1999-12-28 Stone; Kevin R. Osteotomy wedge device, kit and methods for realignment of a varus angulated knee
US6281257B1 (en) * 1998-04-27 2001-08-28 The Regents Of The University Of Michigan Porous composite materials
US6800093B2 (en) * 1998-05-06 2004-10-05 Cortek, Inc. Device for spinal fusion
US6086593A (en) 1998-06-30 2000-07-11 Bonutti; Peter M. Method and apparatus for use in operating on a bone
US6099531A (en) 1998-08-20 2000-08-08 Bonutti; Peter M. Changing relationship between bones
US6406498B1 (en) * 1998-09-04 2002-06-18 Bionx Implants Oy Bioactive, bioabsorbable surgical composite material
FR2782913B1 (en) 1998-09-04 2000-11-10 Perice Ramon Viladot IMPLANT FOR FLAT FOOT
US6165203A (en) 1998-09-11 2000-12-26 Bio Innovation, Ltd. Suture anchor installation devices and methods
US6062168A (en) 1998-09-24 2000-05-16 Host; Douglas R. Sanitary refuse and animal dung collection valet
WO2000021470A1 (en) 1998-10-12 2000-04-20 Therics, Inc. Composites for tissue regeneration and methods of manufacture thereof
US6143314A (en) 1998-10-28 2000-11-07 Atrix Laboratories, Inc. Controlled release liquid delivery compositions with low initial drug burst
US6283997B1 (en) * 1998-11-13 2001-09-04 The Trustees Of Princeton University Controlled architecture ceramic composites by stereolithography
ES2224737T3 (en) 1998-12-14 2005-03-01 Osteotech, Inc., BONE GRAFT MADE OF OSE PARTICLES.
US6102950A (en) 1999-01-19 2000-08-15 Vaccaro; Alex Intervertebral body fusion device
AU760593B2 (en) 1999-02-02 2003-05-15 Wright Medical Technology, Inc. Controlled release composite
US6696073B2 (en) 1999-02-23 2004-02-24 Osteotech, Inc. Shaped load-bearing osteoimplant and methods of making same
US6245108B1 (en) * 1999-02-25 2001-06-12 Spineco Spinal fusion implant
JP3400740B2 (en) * 1999-04-13 2003-04-28 東芝セラミックス株式会社 Calcium phosphate porous sintered body and method for producing the same
US6277149B1 (en) 1999-06-08 2001-08-21 Osteotech, Inc. Ramp-shaped intervertebral implant
US6306424B1 (en) * 1999-06-30 2001-10-23 Ethicon, Inc. Foam composite for the repair or regeneration of tissue
US6333029B1 (en) 1999-06-30 2001-12-25 Ethicon, Inc. Porous tissue scaffoldings for the repair of regeneration of tissue
US6458162B1 (en) * 1999-08-13 2002-10-01 Vita Special Purpose Corporation Composite shaped bodies and methods for their production and use
US6432106B1 (en) 1999-11-24 2002-08-13 Depuy Acromed, Inc. Anterior lumbar interbody fusion cage with locking plate
US6479418B2 (en) * 1999-12-16 2002-11-12 Isotis N.V. Porous ceramic body
US6702821B2 (en) 2000-01-14 2004-03-09 The Bonutti 2003 Trust A Instrumentation for minimally invasive joint replacement and methods for using same
US6770078B2 (en) 2000-01-14 2004-08-03 Peter M. Bonutti Movable knee implant and methods therefor
WO2001055212A2 (en) 2000-01-27 2001-08-02 The General Hospital Corporation Delivery of therapeutic biological from implantable tissue matrices
WO2001078798A1 (en) * 2000-02-10 2001-10-25 Regeneration Technologies, Inc. Assembled implant
US6565572B2 (en) 2000-04-10 2003-05-20 Sdgi Holdings, Inc. Fenestrated surgical screw and method
ES2247113T3 (en) * 2000-05-12 2006-03-01 Osteotech, Inc. DEMINERALIZED BEE IMPLANT ON THE SURFACE AND METHOD TO MANUFACTURE IT
US6332779B1 (en) 2000-07-03 2001-12-25 Osteotech, Inc. Method of hard tissue repair
FR2811543B1 (en) 2000-07-12 2003-07-04 Spine Next Sa INTERSOMATIC IMPLANT
US6716444B1 (en) 2000-09-28 2004-04-06 Advanced Cardiovascular Systems, Inc. Barriers for polymer-coated implantable medical devices and methods for making the same
JP2004512083A (en) * 2000-10-24 2004-04-22 ハウメディカ・オステオニクス・コーポレイション Healing implant device
USD472972S1 (en) 2000-10-27 2003-04-08 Lifenet Bone implant
CA2438033A1 (en) * 2001-02-14 2002-08-22 Osteotech, Inc. Implant derived from bone
US6673075B2 (en) * 2001-02-23 2004-01-06 Albert N. Santilli Porous intervertebral spacer
US6595998B2 (en) * 2001-03-08 2003-07-22 Spinewave, Inc. Tissue distraction device
US6749636B2 (en) 2001-04-02 2004-06-15 Gary K. Michelson Contoured spinal fusion implants made of bone or a bone composite material
WO2002083188A2 (en) * 2001-04-16 2002-10-24 Cassidy James J Dense/porous structures for use as bone substitutes
US6620195B2 (en) 2001-04-18 2003-09-16 Medicinelodge, Inc. Apparatus and method for attaching a graft ligament to a bone
US7235079B2 (en) 2004-11-18 2007-06-26 Acumed Llc Composite bone fasteners
US6391031B1 (en) 2001-05-17 2002-05-21 Eugene P. Toomey Device for the repair of a hallux valgus deformity
US6471725B1 (en) * 2001-07-16 2002-10-29 Third Millenium Engineering, Llc Porous intervertebral distraction spacers
US6916321B2 (en) 2001-09-28 2005-07-12 Ethicon, Inc. Self-tapping resorbable two-piece bone screw
US6686437B2 (en) 2001-10-23 2004-02-03 M.M.A. Tech Ltd. Medical implants made of wear-resistant, high-performance polyimides, process of making same and medical use of same
US7371258B2 (en) 2001-10-26 2008-05-13 St. Jude Medical, Inc. Valved prosthesis with porous substrate
US7488320B2 (en) 2001-11-01 2009-02-10 Renova Orthopedics, Llc Orthopaedic implant fixation using an in-situ formed anchor
US7238203B2 (en) 2001-12-12 2007-07-03 Vita Special Purpose Corporation Bioactive spinal implants and method of manufacture thereof
US7713272B2 (en) 2001-12-20 2010-05-11 Ethicon, Inc. Bioabsorbable coatings of surgical devices
US6840961B2 (en) * 2001-12-21 2005-01-11 Etex Corporation Machinable preformed calcium phosphate bone substitute material implants
US6921402B2 (en) 2001-12-27 2005-07-26 Ethicon, Inc. Polymer-based orthopedic screw and driver system with increased insertion torque tolerance and associated method for making and using same
US6955716B2 (en) * 2002-03-01 2005-10-18 American Dental Association Foundation Self-hardening calcium phosphate materials with high resistance to fracture, controlled strength histories and tailored macropore formation rates
US20040002770A1 (en) * 2002-06-28 2004-01-01 King Richard S. Polymer-bioceramic composite for orthopaedic applications and method of manufacture thereof
US6761739B2 (en) 2002-11-25 2004-07-13 Musculoskeletal Transplant Foundation Cortical and cancellous allograft spacer
US20050107870A1 (en) 2003-04-08 2005-05-19 Xingwu Wang Medical device with multiple coating layers
US20060142853A1 (en) 2003-04-08 2006-06-29 Xingwu Wang Coated substrate assembly
US20050155779A1 (en) 2003-04-08 2005-07-21 Xingwu Wang Coated substrate assembly
US7354442B2 (en) 2003-05-05 2008-04-08 Warsaw Orthopedic, Inc. Bone anchor and methods of using the same
US7300439B2 (en) 2003-06-24 2007-11-27 Depuy Mitek, Inc. Porous resorbable graft fixation pin
USD497993S1 (en) 2003-07-22 2004-11-02 Robert A. Dixon Bioabsorbable structural interbody vertebral implant
US7250055B1 (en) 2003-08-26 2007-07-31 Biomet Manufacturing Corp. Method and apparatus for cement delivering buttress pin
US8016865B2 (en) * 2003-09-29 2011-09-13 Depuy Mitek, Inc. Method of performing anterior cruciate ligament reconstruction using biodegradable interference screw
USD497996S1 (en) 2003-10-24 2004-11-02 Elizabeth Rodriguez Cold compress for relieving pain of breast engorgement
WO2005046746A2 (en) 2003-11-10 2005-05-26 Angiotech International Ag Medical implants and fibrosis-inducing agents
US20070027532A1 (en) 2003-12-22 2007-02-01 Xingwu Wang Medical device
WO2006015316A1 (en) 2004-07-30 2006-02-09 University Of Nebraska Bioresorbable composites and method of formation thereof
WO2006062518A2 (en) 2004-12-08 2006-06-15 Interpore Spine Ltd. Continuous phase composite for musculoskeletal repair
US20070038303A1 (en) 2006-08-15 2007-02-15 Ebi, L.P. Foot/ankle implant and associated method
US8535357B2 (en) 2004-12-09 2013-09-17 Biomet Sports Medicine, Llc Continuous phase compositions for ACL repair
WO2006110197A2 (en) 2005-03-03 2006-10-19 Icon Medical Corp. Polymer biodegradable medical device
US20060199876A1 (en) 2005-03-04 2006-09-07 The University Of British Columbia Bioceramic composite coatings and process for making same
US20060233849A1 (en) 2005-04-13 2006-10-19 Simon Bruce J Composite bone graft material
US7621963B2 (en) 2005-04-13 2009-11-24 Ebi, Llc Composite bone graft material
US7981144B2 (en) 2006-09-21 2011-07-19 Integrity Intellect, Inc. Implant equipped for nerve location and method of use
US20080306584A1 (en) 2007-06-05 2008-12-11 Pamela Kramer-Brown Implantable medical devices for local and regional treatment
US8475505B2 (en) 2008-08-13 2013-07-02 Smed-Ta/Td, Llc Orthopaedic screws
US10010500B2 (en) 2008-08-21 2018-07-03 Biomet Manufacturing, Llc Ceramic implants affording controlled release of active materials

Also Published As

Publication number Publication date
US8679191B2 (en) 2014-03-25
US20110190903A1 (en) 2011-08-04
WO2006062518A2 (en) 2006-06-15
EP1819375A2 (en) 2007-08-22
US9456905B2 (en) 2016-10-04
US20140288663A1 (en) 2014-09-25
WO2006062518A3 (en) 2006-08-03
US7879109B2 (en) 2011-02-01
US20060121084A1 (en) 2006-06-08

Similar Documents

Publication Publication Date Title
WO2006062518B1 (en) Continuous phase composite for musculoskeletal repair
US9308076B2 (en) Bi-phasic compressed porous reinforcement materials suitable for implant
EP2207579B1 (en) Medical implant formed from porous metal
US8119152B2 (en) Implant material and process for producing the same
EP2198896B1 (en) Compressed high density porous materials suitable for implant
EP1011545B1 (en) Resorbable interbody spinal fusion devices
US8679163B2 (en) Compliant osteosynthesis fixation plate
AU2004200966B2 (en) Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof
JP2006230722A (en) Biomaterial for artificial cartilage
CN100490752C (en) Artificial intervertebral disk insertion jig, jig set, and artificial intervertebral disk
US20040117014A1 (en) Prosthetic implant assembly
CN1981879A (en) Implant material for synthetic gristle
US10105207B2 (en) Porous and nonporous materials for tissue grafting and repair
KR20150038519A (en) Resorbable and radiopaque device for bone fixation
TW200300666A (en) Implant material and process for producing the same

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2004813384

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: DE

WWP Wipo information: published in national office

Ref document number: 2004813384

Country of ref document: EP