WO2006055735A3 - Scanner having spatial light modulator - Google Patents

Scanner having spatial light modulator Download PDF

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Publication number
WO2006055735A3
WO2006055735A3 PCT/US2005/041730 US2005041730W WO2006055735A3 WO 2006055735 A3 WO2006055735 A3 WO 2006055735A3 US 2005041730 W US2005041730 W US 2005041730W WO 2006055735 A3 WO2006055735 A3 WO 2006055735A3
Authority
WO
WIPO (PCT)
Prior art keywords
scanner
light modulator
spatial light
arrangement
monitored
Prior art date
Application number
PCT/US2005/041730
Other languages
French (fr)
Other versions
WO2006055735A2 (en
Inventor
Alan D Kersey
John A Moon
Original Assignee
Illumina Inc
Alan D Kersey
John A Moon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Illumina Inc, Alan D Kersey, John A Moon filed Critical Illumina Inc
Publication of WO2006055735A2 publication Critical patent/WO2006055735A2/en
Publication of WO2006055735A3 publication Critical patent/WO2006055735A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • G01J3/021—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using plane or convex mirrors, parallel phase plates, or particular reflectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G01J3/4406—Fluorescence spectrometry
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G01N2021/6471—Special filters, filter wheel

Abstract

The present invention features incorporating an adaptive spectral filter into a confocal scanner optical arrangement or other suitable optical device to permit real time control of the fluorescence signal spectrum being monitored. This new arrangement would allow for better balancing of the florescence signals in the analysis of the array.
PCT/US2005/041730 2004-11-16 2005-11-16 Scanner having spatial light modulator WO2006055735A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US62876304P 2004-11-16 2004-11-16
US62876404P 2004-11-16 2004-11-16
US60/628,764 2004-11-16
US60/628,763 2004-11-16

Publications (2)

Publication Number Publication Date
WO2006055735A2 WO2006055735A2 (en) 2006-05-26
WO2006055735A3 true WO2006055735A3 (en) 2007-01-04

Family

ID=35976495

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/041730 WO2006055735A2 (en) 2004-11-16 2005-11-16 Scanner having spatial light modulator

Country Status (2)

Country Link
US (1) US7602952B2 (en)
WO (1) WO2006055735A2 (en)

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