WO2006050385A3 - Cardiac motion characterization by strain measurement - Google Patents

Cardiac motion characterization by strain measurement Download PDF

Info

Publication number
WO2006050385A3
WO2006050385A3 PCT/US2005/039535 US2005039535W WO2006050385A3 WO 2006050385 A3 WO2006050385 A3 WO 2006050385A3 US 2005039535 W US2005039535 W US 2005039535W WO 2006050385 A3 WO2006050385 A3 WO 2006050385A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissue location
strain measurement
subject methods
cardiac motion
motion characterization
Prior art date
Application number
PCT/US2005/039535
Other languages
French (fr)
Other versions
WO2006050385A2 (en
Inventor
Marc Jenson
Todd Thompson
Olivier Colliou
George M Savage
Mark Zdeblick
Jeremy Frank
Lawrence Arne
Robert White
Original Assignee
Proteus Biomedical Inc
Marc Jenson
Todd Thompson
Olivier Colliou
George M Savage
Mark Zdeblick
Jeremy Frank
Lawrence Arne
Robert White
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Proteus Biomedical Inc, Marc Jenson, Todd Thompson, Olivier Colliou, George M Savage, Mark Zdeblick, Jeremy Frank, Lawrence Arne, Robert White filed Critical Proteus Biomedical Inc
Priority to US11/718,201 priority Critical patent/US8121687B2/en
Publication of WO2006050385A2 publication Critical patent/WO2006050385A2/en
Publication of WO2006050385A3 publication Critical patent/WO2006050385A3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/056Transvascular endocardial electrode systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/103Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/11Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb
    • A61B5/1107Measuring contraction of parts of the body, e.g. organ, muscle
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6851Guide wires
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6852Catheters
    • A61B5/6857Catheters with a distal pigtail shape
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6852Catheters
    • A61B5/6858Catheters with a distal basket, e.g. expandable basket
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0261Strain gauges
    • A61B2562/0266Optical strain gauges
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/686Permanently implanted devices, e.g. pacemakers, other stimulators, biochips
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362Heart stimulators
    • A61N1/3627Heart stimulators for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy

Abstract

Methods for evaluating motion of a cardiac tissue location, e.g., heart wall, are provided. In the subject methods, timing of a signal obtain from a strain gauge stably associated with the tissue location of interest is employed to evaluate movement of the cardiac tissue location. Also provided are systems, devices and related compositions for practicing the subject methods. The subject methods and devices find use in a variety of different applications, including cardiac resynchronization therapy.
PCT/US2005/039535 2004-11-01 2005-10-31 Cardiac motion characterization by strain measurement WO2006050385A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US11/718,201 US8121687B2 (en) 2004-11-01 2005-10-31 Cardiac motion characterization by strain measurement

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US62442704P 2004-11-01 2004-11-01
US60/624,427 2004-11-01
US63824704P 2004-12-20 2004-12-20
US60/638,247 2004-12-20
US63894704P 2004-12-22 2004-12-22
US60/638,947 2004-12-22
US66774905P 2005-03-31 2005-03-31
US60/667,749 2005-03-31

Publications (2)

Publication Number Publication Date
WO2006050385A2 WO2006050385A2 (en) 2006-05-11
WO2006050385A3 true WO2006050385A3 (en) 2007-02-01

Family

ID=36319784

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/039535 WO2006050385A2 (en) 2004-11-01 2005-10-31 Cardiac motion characterization by strain measurement

Country Status (2)

Country Link
US (1) US8121687B2 (en)
WO (1) WO2006050385A2 (en)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7771363B2 (en) 2004-12-21 2010-08-10 Proteus Biomedical, Inc. Coronary sinus sensing device
EP1933698A2 (en) 2005-09-16 2008-06-25 The Ohio State University Method and apparatus for detecting intraventricular dyssynchrony
US8131043B2 (en) 2005-09-16 2012-03-06 The Ohio State University Method and apparatus for detecting interventricular dyssynchrony
US8672936B2 (en) * 2005-10-13 2014-03-18 St. Jude Medical, Atrial Fibrillation Division, Inc. Systems and methods for assessing tissue contact
US8679109B2 (en) * 2005-10-13 2014-03-25 St. Jude Medical, Atrial Fibrillation Division, Inc. Dynamic contact assessment for electrode catheters
AU2006305967B2 (en) * 2005-10-27 2013-02-07 St. Jude Medical, Atrial Fibrillation Division, Inc. Systems and methods for electrode contact assessment
WO2007064259A1 (en) * 2005-11-30 2007-06-07 St. Jude Medical Ab Implantable cardiac stimulator, system, device and method for monitoring cardiac synchrony
US8620430B2 (en) 2006-06-30 2013-12-31 Cardiac Pacemakers, Inc. Selection of pacing sites to enhance cardiac performance
US7848822B2 (en) * 2006-11-14 2010-12-07 Cardiac Pacemakers, Inc. Cardiac force sensor and methods of use
US8725255B2 (en) * 2006-11-17 2014-05-13 Cardiac Pacemakers, Inc. Cardiac resynchronization therapy optimization using cardiac activation sequence information
US20080154141A1 (en) * 2006-12-26 2008-06-26 Cardiac Pacemakers, Inc. Intravascular Flow Sensor
US10085798B2 (en) 2006-12-29 2018-10-02 St. Jude Medical, Atrial Fibrillation Division, Inc. Ablation electrode with tactile sensor
US8226648B2 (en) 2007-12-31 2012-07-24 St. Jude Medical, Atrial Fibrillation Division, Inc. Pressure-sensitive flexible polymer bipolar electrode
US7610089B1 (en) 2007-02-21 2009-10-27 Pacesetter, Inc. Implantable strain sensor for medical diagnostics
US8068909B2 (en) * 2007-06-27 2011-11-29 Cardiac Pacemakers, Inc. Measurement of cardiac performance with movement sensors and related methods
US9242100B2 (en) 2012-08-07 2016-01-26 Nuax, Inc. Optical fiber-fine wire lead for electrostimulation and sensing
US9513443B2 (en) 2008-05-28 2016-12-06 John Lawrence Erb Optical fiber-fine wire conductor and connectors
US9025598B1 (en) 2012-03-22 2015-05-05 Nuax, Inc. Cable/guidewire/interconnects communication apparatus and methods
US8692117B2 (en) 2008-05-28 2014-04-08 Cardia Access, Inc. Durable fine wire electrical conductor suitable for extreme environment applications
US20100331941A1 (en) * 2008-05-28 2010-12-30 Walsh Robert G Implantable fine wire lead for electrostimulation and sensing
US9193313B2 (en) 2012-03-22 2015-11-24 Nuax, Inc. Methods and apparatuses involving flexible cable/guidewire/interconnects
US8014864B2 (en) * 2008-06-17 2011-09-06 Pacesetter, Inc. Cardiomechanical assessment for cardiac resynchronization therapy
AU2009276603B2 (en) 2008-07-30 2015-11-12 Ecole Polytechinique Federale De Lausanne (Epfl) Apparatus and method for optimized stimulation of a neurological target
US10080499B2 (en) * 2008-07-30 2018-09-25 Medtronic, Inc. Implantable medical system including multiple sensing modules
JP2012503501A (en) 2008-09-25 2012-02-09 シーエーイー ヘルスケア インク Simulation of medical image diagnosis
US9314634B2 (en) * 2008-11-03 2016-04-19 Pacesetter, Inc. Initiation tests and guidelines for implementing cardiac therapy
US8788064B2 (en) 2008-11-12 2014-07-22 Ecole Polytechnique Federale De Lausanne Microfabricated neurostimulation device
EP2448634A1 (en) * 2009-07-01 2012-05-09 Medtronic, Inc. Implantable medical device including mechanical stress sensor
US9687656B2 (en) 2009-07-08 2017-06-27 Pacesetter, Inc. Arterial blood pressure monitoring devices, systems and methods for use while pacing
EP2490612A1 (en) * 2009-10-23 2012-08-29 Koninklijke Philips Electronics N.V. Optical sensing - enabled interventional instruments for rapid distributed measurements of biophysical parameters
US8774937B2 (en) 2009-12-01 2014-07-08 Ecole Polytechnique Federale De Lausanne Microfabricated surface neurostimulation device and methods of making and using the same
US8758257B2 (en) * 2009-12-24 2014-06-24 Renzo Cecere Instrument including a movement sensor for positioning an effective portion and method of using same
AU2011234422B2 (en) 2010-04-01 2015-11-05 Ecole Polytechnique Federale De Lausanne (Epfl) Device for interacting with neurological tissue and methods of making and using the same
US9301690B2 (en) * 2010-04-22 2016-04-05 University Of Houston System Device, system, and method for a stress sensing medical needle
EP2608712A4 (en) * 2010-08-23 2017-12-27 Landy Aaron Toth System and method for monitoring a surgical site
US8636718B2 (en) 2010-12-30 2014-01-28 St. Jude Medical, Atrial Fibrillation Division, Inc. Method of assembling a positioning sensor and associated wiring on a medical tool
US9855405B2 (en) 2011-04-29 2018-01-02 Medtronic, Inc. Burr hole cap assembly with therapy delivery member orientation feature
WO2012176091A1 (en) * 2011-06-23 2012-12-27 Koninklijke Philips Electronics N.V. Composite fiber guidewires
CN103957792B (en) * 2011-10-20 2017-05-03 皇家飞利浦有限公司 Shape sensing devices for real-time mechanical function assessment of an internal organ
US8861830B2 (en) 2011-11-07 2014-10-14 Paieon Inc. Method and system for detecting and analyzing heart mechanics
WO2014026105A1 (en) * 2012-08-10 2014-02-13 Intermountain Invention Managment, Llc Epicardial lead placement apparatus, systems, and methods
EP2903507B1 (en) * 2012-10-04 2017-01-11 MED-EL Elektromedizinische Geraete GmbH Electromechanical measurement of stapedius muscle/tendon activity
EP2719425B1 (en) 2012-10-12 2015-04-08 Sorin CRM SAS Implantable cardiac stimulation probe along the ventricular septal wall and/or the left ventricle free wall
US10791991B2 (en) 2012-12-31 2020-10-06 Philips Image Guided Therapy Corporation Intravascular devices, systems, and methods
US20140236254A1 (en) * 2013-02-20 2014-08-21 Boston Scientific Scimed, Inc. Devices and methods for treatment of the alimentary tract
US9423311B2 (en) * 2013-03-14 2016-08-23 Behzad Moslehi Movement and expression sensor
US9232485B2 (en) * 2013-08-23 2016-01-05 Pacesetter, Inc. System and method for selectively communicating with an implantable medical device
US10973462B2 (en) * 2014-05-04 2021-04-13 Scott J. Rapp Fiber optic based devices and methods for monitoring soft tissue
CN110585588A (en) 2014-05-16 2019-12-20 阿莱瓦神经治疗股份有限公司 Implantable microelectrode device
US11311718B2 (en) 2014-05-16 2022-04-26 Aleva Neurotherapeutics Sa Device for interacting with neurological tissue and methods of making and using the same
EP4233972A3 (en) * 2014-07-22 2023-10-18 Koninklijke Philips N.V. Intravascular devices, systems, and methods having a core wire with multiple flattened sections
US9474894B2 (en) 2014-08-27 2016-10-25 Aleva Neurotherapeutics Deep brain stimulation lead
US9403011B2 (en) 2014-08-27 2016-08-02 Aleva Neurotherapeutics Leadless neurostimulator
US10226304B2 (en) * 2014-12-15 2019-03-12 The Johns Hopkins University Shape tracking of a dexterous continuum manipulator
US11229402B2 (en) * 2015-05-29 2022-01-25 Microvention, Inc. Catheter circuit
CN109069824B (en) 2016-02-02 2022-09-16 阿莱瓦神经治疗股份有限公司 Treatment of autoimmune diseases using deep brain stimulation
AT518541B1 (en) * 2016-05-09 2017-11-15 Teufelberger Seil Ges M B H steel cable
US10702692B2 (en) 2018-03-02 2020-07-07 Aleva Neurotherapeutics Neurostimulation device
CA3096892A1 (en) * 2018-04-13 2019-10-17 9681345 Canada Inc. Physiological monitoring device and method
NL2020869B1 (en) * 2018-05-03 2019-11-12 Fugro Tech Bv A body for holding a fiber optic strain sensor, a system including the body, and a method for determining strain in an object.
US11903683B2 (en) * 2018-08-03 2024-02-20 Chelak Medical Solutions Inc Non-barometric determination of hemodynamic effects of cardiac arrhythmias using signals sensed by an implantable device
WO2020047096A1 (en) * 2018-08-28 2020-03-05 The Board Of Trustees Of The Leland Stanford Junior University Measuring chordae tendineae forces using fiber bragg grating optical force sensors
US11266828B2 (en) 2018-12-06 2022-03-08 Medtronic, Inc. Implantable medical lead with moveable conductors
US11357993B2 (en) 2018-12-06 2022-06-14 Medtronic, Inc. Implantable medical lead with moveable conductors
US11690624B2 (en) * 2019-06-21 2023-07-04 Covidien Lp Reload assembly injection molded strain gauge
CN115461106A (en) * 2020-05-05 2022-12-09 生物风险投资有限责任公司 Endotracheal intubation cuff with integrated sensor
WO2023212748A1 (en) 2022-04-29 2023-11-02 Chelak Medical Solution Inc. Systems, devices, and methods for miniaturization of fiber bragg grating interrogation for integration into implantable devices
WO2024035769A1 (en) * 2022-08-10 2024-02-15 Fort Wayne Metals Research Products, Llc Composite wire with coating

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4989611A (en) * 1988-08-19 1991-02-05 Seismed Instruments, Inc. Cardiac compression wave measuring system and method
US5218972A (en) * 1988-04-29 1993-06-15 Healthdyne, Inc. Biomedical force measuring apparatus
US5496361A (en) * 1993-07-14 1996-03-05 Pacesetter, Inc. System and method for detecting cardiac arrhythmias using a cardiac wall acceleration sensor signal
US5868678A (en) * 1993-06-30 1999-02-09 Medex, Inc. Two-part medical pressure transducer with diaphragm stand-offs
US6120457A (en) * 1997-07-02 2000-09-19 Johnson & Johnson Professional, Inc. In vivo zeroing of catheter pressure sensor
US20040015081A1 (en) * 2002-07-19 2004-01-22 Kramer Andrew P. Method and apparatus for quantification of cardiac wall motion asynchrony
US6782755B2 (en) * 2000-07-06 2004-08-31 California Institute Of Technology Surface-micromachined pressure sensor and high pressure application

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3971363A (en) * 1975-05-05 1976-07-27 Nasa Myocardium wall thickness transducer and measuring method
JPH0797010B2 (en) * 1986-03-26 1995-10-18 株式会社日立製作所 Semiconductor strain gage bridge circuit
US5178151A (en) * 1988-04-20 1993-01-12 Sackner Marvin A System for non-invasive detection of changes of cardiac volumes and aortic pulses
US5241964A (en) * 1990-10-31 1993-09-07 Medwave, Incorporated Noninvasive, non-occlusive method and apparatus which provides a continuous indication of arterial pressure and a beat-by-beat characterization of the arterial system
US6406420B1 (en) * 1997-01-02 2002-06-18 Myocor, Inc. Methods and devices for improving cardiac function in hearts
US5941904A (en) * 1997-09-12 1999-08-24 Sulzer Intermedics Inc. Electromagnetic acceleration transducer for implantable medical device
US6285906B1 (en) * 1999-05-26 2001-09-04 Impulse Dynamics N. V. Muscle contraction assist device
US20030004440A1 (en) * 2001-06-29 2003-01-02 Brenneman Rodney A. Apparatus and method for monitoring performance of minimally invasive direct cardiac compression
US7203541B2 (en) * 2004-03-12 2007-04-10 Medtronic, Inc. Real-time optimization of right to left ventricular timing sequence in bi-ventricular pacing of heart failure patients

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5218972A (en) * 1988-04-29 1993-06-15 Healthdyne, Inc. Biomedical force measuring apparatus
US4989611A (en) * 1988-08-19 1991-02-05 Seismed Instruments, Inc. Cardiac compression wave measuring system and method
US5868678A (en) * 1993-06-30 1999-02-09 Medex, Inc. Two-part medical pressure transducer with diaphragm stand-offs
US5496361A (en) * 1993-07-14 1996-03-05 Pacesetter, Inc. System and method for detecting cardiac arrhythmias using a cardiac wall acceleration sensor signal
US6120457A (en) * 1997-07-02 2000-09-19 Johnson & Johnson Professional, Inc. In vivo zeroing of catheter pressure sensor
US6782755B2 (en) * 2000-07-06 2004-08-31 California Institute Of Technology Surface-micromachined pressure sensor and high pressure application
US20040015081A1 (en) * 2002-07-19 2004-01-22 Kramer Andrew P. Method and apparatus for quantification of cardiac wall motion asynchrony

Also Published As

Publication number Publication date
US8121687B2 (en) 2012-02-21
WO2006050385A2 (en) 2006-05-11
US20080255629A1 (en) 2008-10-16

Similar Documents

Publication Publication Date Title
WO2006050385A3 (en) Cardiac motion characterization by strain measurement
WO2006042039A3 (en) Continuous field tomography
WO2006113323A3 (en) Techniques for compensating movement of a treatment target in a patient
WO2003037181A3 (en) Non-invasive method and device to monitor cardiac parameters
WO2009064785A3 (en) Method and device to administer anesthetic and or vosactive agents according to non-invasively monitored cardiac and or neurological parameters
WO2010049827A3 (en) Training progress indicator
WO2008011079A3 (en) Noninvasively measuring hemodynamic parameters
WO2008103390A3 (en) Orthostasis detection system and method
WO2008057883A3 (en) System and method for monitoring cardiorespiratory parameters
WO2006026008A3 (en) Method and apparatus for improved ultrasonic strain measurements of soft tissue
EP1968433A4 (en) Implantable device for telemetric measurement of blood pressure/temperature within the heart
EP1968449A4 (en) Implantable device for telemetric measurement of blood pressure/temperature within the heart
NZ625712A (en) An amorphous and a crystalline form of genz 112638 hemitartrate as inhibitor of glucosylceramide synthase
WO2012055498A8 (en) Method for myocardial segment work analysis
UY31727A (en) POLISUSTITUTED DERIVATIVES OF 2-ARIL-6-PHENYL-IMIDAZO [1,2-A] PYRIDINS, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS
WO2014020484A3 (en) A method and system to identify motion artifacts and improve reliability of measurements and alarms in photoplethysmographic measurements
NO20070176L (en) New fluorine glycoside derivatives of pyrazoles, drugs containing these compounds and their use
WO2006076068A3 (en) Hemodynamic assessment/adjustment
WO2006105085A3 (en) Biofeedback method and apparatus
EP1897490A3 (en) Correlation of cardiac electrical maps with body surface measurements
WO2008106396A3 (en) Method and system for monitoring oxygenation levels of a compartment for detecting conditions of a compartment syndrome
WO2007098367A3 (en) Method and apparatus for stimulating a denervated muscle
WO2009024967A3 (en) Method and system for cardiovascular system diagnosis
EP1806099A4 (en) Ultrasonographic device and ultrasonographic device control method
CA2561590A1 (en) Novel method for the preparation of intermediates useful for the synthesis of vitamin d analogues

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KN KP KR KZ LC LK LR LS LT LU LV LY MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

DPE2 Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 05815964

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 11718201

Country of ref document: US