WO2006048642A3 - Mass spectrometer - Google Patents

Mass spectrometer Download PDF

Info

Publication number
WO2006048642A3
WO2006048642A3 PCT/GB2005/004238 GB2005004238W WO2006048642A3 WO 2006048642 A3 WO2006048642 A3 WO 2006048642A3 GB 2005004238 W GB2005004238 W GB 2005004238W WO 2006048642 A3 WO2006048642 A3 WO 2006048642A3
Authority
WO
WIPO (PCT)
Prior art keywords
separator
potential wells
mobility spectrometer
ion
ion mobility
Prior art date
Application number
PCT/GB2005/004238
Other languages
French (fr)
Other versions
WO2006048642A2 (en
Inventor
Robert Harold Bateman
Kevin Giles
Steven Derek Pringle
Jason Lee Wildgoose
Original Assignee
Micromass Ltd
Robert Harold Bateman
Kevin Giles
Steven Derek Pringle
Jason Lee Wildgoose
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP15161900.4A priority Critical patent/EP2913840B1/en
Priority to JP2007539630A priority patent/JP4913066B2/en
Priority to EP05800123.1A priority patent/EP1810314B1/en
Priority to CA2585565A priority patent/CA2585565C/en
Priority to US11/718,213 priority patent/US7829841B2/en
Priority to EP21153070.4A priority patent/EP3855474A1/en
Application filed by Micromass Ltd, Robert Harold Bateman, Kevin Giles, Steven Derek Pringle, Jason Lee Wildgoose filed Critical Micromass Ltd
Publication of WO2006048642A2 publication Critical patent/WO2006048642A2/en
Publication of WO2006048642A3 publication Critical patent/WO2006048642A3/en
Priority to US12/917,720 priority patent/US8299422B2/en
Priority to US13/663,191 priority patent/US8569687B2/en
Priority to US14/064,616 priority patent/US8735805B2/en
Priority to US14/256,301 priority patent/US9048073B2/en
Priority to US14/725,451 priority patent/US9410927B2/en
Priority to US15/231,045 priority patent/US10724990B2/en
Priority to US16/927,549 priority patent/US11385202B2/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622—Ion mobility spectrometry
    • G01N27/623—Ion mobility spectrometry combined with mass spectrometry
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0031—Step by step routines describing the use of the apparatus
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/062—Ion guides
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/062—Ion guides
    • H01J49/065—Ion guides having stacked electrodes, e.g. ring stack, plate stack
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/062—Ion guides
    • H01J49/065—Ion guides having stacked electrodes, e.g. ring stack, plate stack
    • H01J49/066—Ion funnels
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/40—Time-of-flight spectrometers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/40—Time-of-flight spectrometers
    • H01J49/401—Time-of-flight spectrometers characterised by orthogonal acceleration, e.g. focusing or selecting the ions, pusher electrode
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)

Abstract

A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator (4) and an ion guide (6) arranged downstream of the ion mobility spectrometer or separator (4). A plurality of axial potential wells are created in the ion guide (6) so that ions received from the ion mobility spectrometer or separator (4) become confined in separate axial potential wells. The potential wells maintain the fidelity and/or composition of ions received from the ion mobility spectrometer or separator (4). The potential wells are translated along the length of the ion guide (6).
PCT/GB2005/004238 2004-11-04 2005-11-03 Mass spectrometer WO2006048642A2 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
EP15161900.4A EP2913840B1 (en) 2004-11-04 2005-11-03 Mass spectrometer
JP2007539630A JP4913066B2 (en) 2004-11-04 2005-11-03 Mass spectrometer
EP05800123.1A EP1810314B1 (en) 2004-11-04 2005-11-03 Mass spectrometer
CA2585565A CA2585565C (en) 2004-11-04 2005-11-03 Mass spectrometer
US11/718,213 US7829841B2 (en) 2004-11-04 2005-11-03 Mass spectrometer
EP21153070.4A EP3855474A1 (en) 2004-11-04 2005-11-03 Mass spectrometer
US12/917,720 US8299422B2 (en) 2004-11-04 2010-11-02 Mass spectrometer
US13/663,191 US8569687B2 (en) 2004-11-04 2012-10-29 Mass spectrometer
US14/064,616 US8735805B2 (en) 2004-11-04 2013-10-28 Mass spectrometer
US14/256,301 US9048073B2 (en) 2004-11-04 2014-04-18 Mass spectrometer
US14/725,451 US9410927B2 (en) 2004-11-04 2015-05-29 Mass spectrometer
US15/231,045 US10724990B2 (en) 2004-11-04 2016-08-08 Mass spectrometer
US16/927,549 US11385202B2 (en) 2004-11-04 2020-07-13 Mass spectrometer

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0424426.5 2004-11-04
GBGB0424426.5A GB0424426D0 (en) 2004-11-04 2004-11-04 Mass spectrometer
US62821504P 2004-11-16 2004-11-16
US60/628,215 2004-11-16

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US11/718,213 A-371-Of-International US7829841B2 (en) 2004-11-04 2005-11-03 Mass spectrometer
US12/917,720 Continuation US8299422B2 (en) 2004-11-04 2010-11-02 Mass spectrometer

Publications (2)

Publication Number Publication Date
WO2006048642A2 WO2006048642A2 (en) 2006-05-11
WO2006048642A3 true WO2006048642A3 (en) 2006-12-21

Family

ID=33523199

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2005/004238 WO2006048642A2 (en) 2004-11-04 2005-11-03 Mass spectrometer

Country Status (6)

Country Link
US (8) US7829841B2 (en)
EP (3) EP1810314B1 (en)
JP (1) JP4913066B2 (en)
CA (2) CA2585565C (en)
GB (2) GB0424426D0 (en)
WO (1) WO2006048642A2 (en)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020115056A1 (en) * 2000-12-26 2002-08-22 Goodlett David R. Rapid and quantitative proteome analysis and related methods
GB0305796D0 (en) * 2002-07-24 2003-04-16 Micromass Ltd Method of mass spectrometry and a mass spectrometer
GB0514964D0 (en) 2005-07-21 2005-08-24 Ms Horizons Ltd Mass spectrometer devices & methods of performing mass spectrometry
GB0424426D0 (en) * 2004-11-04 2004-12-08 Micromass Ltd Mass spectrometer
GB0426520D0 (en) * 2004-12-02 2005-01-05 Micromass Ltd Mass spectrometer
EP1884980B8 (en) 2004-12-07 2011-09-21 Micromass UK Limited Mass spectrometer
GB0426900D0 (en) * 2004-12-08 2005-01-12 Micromass Ltd Mass spectrometer
US8440968B2 (en) * 2005-02-14 2013-05-14 Micromass Uk Limited Ion-mobility analyser
GB0503010D0 (en) * 2005-02-14 2005-03-16 Micromass Ltd Mass spectrometer
US7484774B2 (en) 2005-05-03 2009-02-03 Ti Group Automotive Systems, Llc Redundant latch/verifier for a quick connector
JP4843250B2 (en) * 2005-05-13 2011-12-21 株式会社日立ハイテクノロジーズ Method for identifying substances using mass spectrometry
WO2006130475A2 (en) * 2005-05-27 2006-12-07 Ionwerks, Inc. Multi-beam ion mobility time-of-flight mass spectrometry with multi-channel data recording
DE102005025499B4 (en) * 2005-06-03 2007-09-27 Bruker Daltonik Gmbh Mass spectrometric mixture analysis
GB2432712B (en) * 2005-11-23 2007-12-27 Micromass Ltd Mass spectrometer
US8026477B2 (en) 2006-03-03 2011-09-27 Ionsense, Inc. Sampling system for use with surface ionization spectroscopy
US7700913B2 (en) 2006-03-03 2010-04-20 Ionsense, Inc. Sampling system for use with surface ionization spectroscopy
US7420161B2 (en) * 2006-03-09 2008-09-02 Thermo Finnigan Llc Branched radio frequency multipole
US7453059B2 (en) * 2006-03-10 2008-11-18 Varian Semiconductor Equipment Associates, Inc. Technique for monitoring and controlling a plasma process
US7476849B2 (en) * 2006-03-10 2009-01-13 Varian Semiconductor Equipment Associates, Inc. Technique for monitoring and controlling a plasma process
US7497480B2 (en) 2006-04-07 2009-03-03 Ti Group Automotive Systems, Llc Hybrid quick connector
GB0608470D0 (en) * 2006-04-28 2006-06-07 Micromass Ltd Mass spectrometer
EP2035121A4 (en) 2006-05-26 2010-04-28 Ionsense Inc Apparatus for holding solids for use with surface ionization technology
GB0612503D0 (en) * 2006-06-23 2006-08-02 Micromass Ltd Mass spectrometer
EP2038913B1 (en) 2006-07-10 2015-07-08 Micromass UK Limited Mass spectrometer
GB0624740D0 (en) * 2006-12-12 2007-01-17 Micromass Ltd Mass spectrometer
GB0624993D0 (en) * 2006-12-14 2007-01-24 Micromass Ltd Mass spectrometer
CA2672526C (en) * 2006-12-14 2016-08-23 Micromass Uk Limited Mass spectrometer
GB0701476D0 (en) * 2007-01-25 2007-03-07 Micromass Ltd Mass spectrometer
GB0705730D0 (en) 2007-03-26 2007-05-02 Micromass Ltd Mass spectrometer
US8507850B2 (en) * 2007-05-31 2013-08-13 Perkinelmer Health Sciences, Inc. Multipole ion guide interface for reduced background noise in mass spectrometry
US8901487B2 (en) 2007-07-20 2014-12-02 George Washington University Subcellular analysis by laser ablation electrospray ionization mass spectrometry
US7964843B2 (en) 2008-07-18 2011-06-21 The George Washington University Three-dimensional molecular imaging by infrared laser ablation electrospray ionization mass spectrometry
US8067730B2 (en) 2007-07-20 2011-11-29 The George Washington University Laser ablation electrospray ionization (LAESI) for atmospheric pressure, In vivo, and imaging mass spectrometry
GB0714301D0 (en) * 2007-07-21 2007-08-29 Ionoptika Ltd Secondary ion mass spectrometry and secondary neutral mass spectrometry using a multiple-plate buncher
GB0723183D0 (en) * 2007-11-23 2008-01-09 Micromass Ltd Mass spectrometer
GB0801309D0 (en) * 2008-01-24 2008-03-05 Micromass Ltd Mass spectrometer
US7675031B2 (en) * 2008-05-29 2010-03-09 Thermo Finnigan Llc Auxiliary drag field electrodes
US8026475B2 (en) * 2008-08-19 2011-09-27 Thermo Finnigan Llc Method and apparatus for a dual gate for a mass spectrometer
US8207497B2 (en) 2009-05-08 2012-06-26 Ionsense, Inc. Sampling of confined spaces
US8716655B2 (en) * 2009-07-02 2014-05-06 Tricorntech Corporation Integrated ion separation spectrometer
WO2011017409A1 (en) * 2009-08-05 2011-02-10 Indiana University Research And Technology Corporation Apparatus for determining masses at high pressure
US8604419B2 (en) * 2010-02-04 2013-12-10 Thermo Fisher Scientific (Bremen) Gmbh Dual ion trapping for ion/ion reactions in a linear RF multipole trap with an additional DC gradient
US8552917B2 (en) * 2010-04-28 2013-10-08 The Boeing Company Wide angle multibeams
GB2476844B (en) * 2010-05-24 2011-12-07 Fasmatech Science And Technology Llc Improvements relating to the control of ions
GB201019337D0 (en) * 2010-11-16 2010-12-29 Micromass Ltd Controlling hydrogen-deuterium exchange on a spectrum by spectrum basis
GB2486484B (en) * 2010-12-17 2013-02-20 Thermo Fisher Scient Bremen Ion detection system and method
US8822949B2 (en) 2011-02-05 2014-09-02 Ionsense Inc. Apparatus and method for thermal assisted desorption ionization systems
GB201104220D0 (en) * 2011-03-14 2011-04-27 Micromass Ltd Ion guide with orthogonal sampling
GB201104292D0 (en) 2011-03-15 2011-04-27 Micromass Ltd M/z targets attenuation on time of flight instruments
US8901488B1 (en) 2011-04-18 2014-12-02 Ionsense, Inc. Robust, rapid, secure sample manipulation before during and after ionization for a spectroscopy system
EP2732457A4 (en) 2011-07-14 2015-09-16 Univ George Washington Plume collimation for laser ablation electrospray ionization mass spectrometry
US8921772B2 (en) * 2011-11-02 2014-12-30 Leco Corporation Ion mobility spectrometer
WO2013137883A1 (en) * 2012-03-15 2013-09-19 Shimadzu Corporation An ion-mobility spectrometer including a decelarating ion gate
GB201205009D0 (en) * 2012-03-22 2012-05-09 Micromass Ltd Multi-dimensional survey scans for improved data dependent acquisitions (DDA)
CN103367090B (en) * 2012-03-30 2016-12-21 岛津分析技术研发（上海）有限公司 ion analyzer and ion analysis method
DE102012008259B4 (en) * 2012-04-25 2014-06-26 Bruker Daltonik Gmbh Ion generation in mass spectrometers by cluster bombardment
US8791409B2 (en) * 2012-07-27 2014-07-29 Thermo Fisher Scientific (Bremen) Gmbh Method and analyser for analysing ions having a high mass-to-charge ratio
WO2014066284A1 (en) * 2012-10-22 2014-05-01 President And Fellows Of Harvard College Accurate and interference-free multiplexed quantitative proteomics using mass spectrometry
US8969797B2 (en) * 2012-10-28 2015-03-03 Shimadzu Corporation MS/MS type mass spectrometer
WO2014135865A1 (en) * 2013-03-06 2014-09-12 Micromass Uk Limited Time shift for improved ion mobility spectrometry or separation digitisation
CA2903623C (en) 2013-03-06 2021-04-20 Micromass Uk Limited Optimised ion mobility separation timescales for targeted ions
GB201304039D0 (en) * 2013-03-06 2013-04-17 Micromass Ltd Time shift improved IMS digitisation
GB201304037D0 (en) * 2013-03-06 2013-04-17 Micromass Ltd Optimised ion mobility separation timescales for targeted ions
GB2517670B (en) * 2013-03-15 2020-04-29 Smiths Detection Watford Ltd Ion modification
US9455132B2 (en) * 2013-05-30 2016-09-27 Agilent Technologies, Inc. Ion mobility spectrometry-mass spectrometry (IMS-MS) with improved ion transmission and IMS resolution
EP3069373B1 (en) * 2013-11-12 2024-03-13 Micromass UK Limited Method of correlating precursor and fragment ions
GB201319958D0 (en) * 2013-11-12 2013-12-25 Micromass Ltd Method of correlating precursor and fragment ions
GB201321246D0 (en) * 2013-12-02 2014-01-15 Micromass Ltd Capillary electrophoresis - mass spectrometry linked scanning
WO2015082889A1 (en) 2013-12-02 2015-06-11 Micromass Uk Limited Method of charge state selection
DE112015001187B4 (en) * 2014-03-10 2022-12-22 Micromass Uk Limited Process for separating ions according to a physicochemical property
US10600627B2 (en) * 2014-05-30 2020-03-24 Micromass Uk Limited Hybrid mass spectrometer
WO2015185941A1 (en) * 2014-06-06 2015-12-10 Micromass Uk Limited Mobility selective attenuation
WO2015189607A1 (en) * 2014-06-10 2015-12-17 Micromass Uk Limited Segmented linear ion mobility spectrometer driver
US9337007B2 (en) 2014-06-15 2016-05-10 Ionsense, Inc. Apparatus and method for generating chemical signatures using differential desorption
US9972480B2 (en) * 2015-01-30 2018-05-15 Agilent Technologies, Inc. Pulsed ion guides for mass spectrometers and related methods
US9891194B2 (en) * 2015-11-03 2018-02-13 Bruker Daltonik Gmbh Acquisition of fragment ion mass spectra of ions separated by their mobility
GB201608653D0 (en) * 2016-05-17 2016-06-29 Micromass Ltd Ion mobility seperator
WO2017210427A1 (en) 2016-06-03 2017-12-07 President And Fellows Of Harvard College Techniques for high throughput targeted proteomic analysis and related systems and methods
JP6750687B2 (en) * 2016-12-15 2020-09-02 株式会社島津製作所 Mass spectrometer
WO2018125441A1 (en) * 2016-12-28 2018-07-05 Rapiscan Systems, Inc. Ionization chamber having a potential-well for ion trapping and ion compression
US10241079B2 (en) * 2017-05-24 2019-03-26 Bruker Daltonik Gmbh Mass spectrometer with tandem ion mobility analyzers
US11709156B2 (en) 2017-09-18 2023-07-25 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved analytical analysis
US11709155B2 (en) 2017-09-18 2023-07-25 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
JP2021524991A (en) 2018-05-14 2021-09-16 モビリオン・システムズ，インコーポレイテッド Connection of ion mobility spectrometer and mass spectrometer
WO2019229463A1 (en) 2018-05-31 2019-12-05 Micromass Uk Limited Mass spectrometer having fragmentation region
GB201808890D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Bench-top time of flight mass spectrometer
GB201808949D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Bench-top time of flight mass spectrometer
US11367607B2 (en) 2018-05-31 2022-06-21 Micromass Uk Limited Mass spectrometer
GB201808894D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Mass spectrometer
GB201808892D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Mass spectrometer
GB201808912D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Bench-top time of flight mass spectrometer
GB201808936D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Bench-top time of flight mass spectrometer
US20220202317A1 (en) * 2018-06-05 2022-06-30 Trace Matters Scientific Llc System and method for mass spectrometry imaging
US11430645B2 (en) 2018-10-09 2022-08-30 Dh Technologies Development Pte. Ltd. Electron beam throttling for electron capture dissociation
WO2020167372A1 (en) * 2019-02-15 2020-08-20 Ohio State Innovation Foundation Surface-induced dissociation devices and methods
CN114051428A (en) 2019-05-21 2022-02-15 莫比莱昂系统有限公司 Voltage control for ion mobility separation
WO2021102406A1 (en) 2019-11-22 2021-05-27 MOBILion Systems, Inc. Mobility based filtering of ions
US11918936B2 (en) 2020-01-17 2024-03-05 Waters Technologies Corporation Performance and dynamic range for oligonucleotide bioanalysis through reduction of non specific binding
EP4133264A4 (en) 2020-04-06 2024-05-01 Mobilion Systems Inc Systems and methods for two-dimensional mobility based filtering of ions
US11953466B2 (en) 2020-05-22 2024-04-09 MOBILion Systems, Inc. Methods and apparatus for trapping and accumulation of ions
EP3916755A1 (en) * 2020-05-26 2021-12-01 Thermo Finnigan LLC Methods and apparatus for high speed mass spectrometry
EP4161683A1 (en) 2020-06-05 2023-04-12 Mobilion Systems, Inc. Apparatus and methods for ion manipulation having improved duty cycle
US20230008420A1 (en) * 2021-06-30 2023-01-12 MOBILion Systems, Inc. Ion Funnels Having Improved Pressure Distribution and Flow Characteristics
GB202204106D0 (en) * 2022-03-23 2022-05-04 Micromass Ltd Mass spectrometer having high duty cycle

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5905258A (en) * 1997-06-02 1999-05-18 Advanced Research & Techology Institute Hybrid ion mobility and mass spectrometer
US20020070338A1 (en) * 2000-12-08 2002-06-13 Loboda Alexander V. Ion mobility spectrometer incorporating an ion guide in combination with an MS device
US20030213900A1 (en) * 2002-05-17 2003-11-20 Hoyes John Brian Mass spectrometer
US20040026614A1 (en) * 2002-05-31 2004-02-12 Bateman Robert Harold Mass Spectrometer
GB2394356A (en) * 2002-08-05 2004-04-21 Micromass Ltd Mass spectrometer having an ion trap

Family Cites Families (121)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3668383A (en) 1969-01-09 1972-06-06 Franklin Gno Corp Apparatus and methods for separating, detecting, and measuring trace gases
US3621240A (en) 1969-05-27 1971-11-16 Franklin Gro Corp Apparatus and methods for detecting and identifying trace gases
US3626178A (en) 1970-02-20 1971-12-07 Franklin Gno Corp Gas or liquid chromatograph with detector employing ion-molecule reactions and ion drift
US3626179A (en) 1970-04-03 1971-12-07 Franklin Gno Corp High temperature method and apparatus for analyzing gaseous samples
US3812355A (en) 1971-12-09 1974-05-21 Gno F Corp Apparatus and methods for measuring ion mass as a function of mobility
DE2205713A1 (en) 1972-02-08 1973-08-23 Viktor Dr Ing Winkler DOUBLE ION BEAM METHOD FOR QUANTITATIVE (ABSOLUTE) MASS SPECTROMETRIC MEASUREMENTS
US3845301A (en) 1972-05-10 1974-10-29 Franklin Gno Corp Apparatus and methods employing ion analysis apparatus with enhanced gas flow
US3902064A (en) 1974-07-12 1975-08-26 Robert A Young Ion mobility mass spectrometer
US4234791A (en) 1978-11-13 1980-11-18 Research Corporation Tandem quadrupole mass spectrometer for selected ion fragmentation studies and low energy collision induced dissociator therefor
US4261698A (en) 1980-01-23 1981-04-14 International Business Machines Corporation Trace oxygen detector
US4855595A (en) 1986-07-03 1989-08-08 Allied-Signal Inc. Electric field control in ion mobility spectrometry
US4823368A (en) 1987-06-30 1989-04-18 Rikagaku Kenkyujyo Open counter for low energy electron detection with suppressed background noise
WO1989006044A1 (en) 1987-12-24 1989-06-29 Unisearch Limited Mass spectrometer
GB2217103B (en) 1988-04-06 1992-09-23 Graseby Ionics Ltd Ion mobility detector
US4987767A (en) 1989-06-09 1991-01-29 Research Corporation Technologies, Inc. Exposive detection screening system
US5073713A (en) 1990-05-29 1991-12-17 Battelle Memorial Institute Detection method for dissociation of multiple-charged ions
US5070240B1 (en) 1990-08-29 1996-09-10 Univ Brigham Young Apparatus and methods for trace component analysis
US5140158A (en) 1990-10-05 1992-08-18 The United States Of America As Represented By The United States Department Of Energy Method for discriminative particle selection
US5210412A (en) 1991-01-31 1993-05-11 Wayne State University Method for analyzing an organic sample
CA2158642A1 (en) 1993-03-19 1994-09-29 Hubert Koster Dna sequencing by mass spectrometry via exonuclease degradation
US5689111A (en) 1995-08-10 1997-11-18 Analytica Of Branford, Inc. Ion storage time-of-flight mass spectrometer
EP1533829A3 (en) 1994-02-28 2006-06-07 Analytica Of Branford, Inc. Multipole ion guide for mass spectrometry
US5420424A (en) 1994-04-29 1995-05-30 Mine Safety Appliances Company Ion mobility spectrometer
US5504326A (en) 1994-10-24 1996-04-02 Indiana University Foundation Spatial-velocity correlation focusing in time-of-flight mass spectrometry
DE19511333C1 (en) 1995-03-28 1996-08-08 Bruker Franzen Analytik Gmbh Method and device for orthogonal injection of ions into a time-of-flight mass spectrometer
US5569917A (en) 1995-05-19 1996-10-29 Varian Associates, Inc. Apparatus for and method of forming a parallel ion beam
JPH095298A (en) 1995-06-06 1997-01-10 Varian Assoc Inc Method of detecting kind of selected ion in quadrupole ion trap
US5552600A (en) 1995-06-07 1996-09-03 Barringer Research Limited Pressure stabilized ion mobility spectrometer
WO1997007530A1 (en) 1995-08-11 1997-02-27 Mds Health Group Limited Spectrometer with axial field
US5811059A (en) 1995-10-16 1998-09-22 The United States Of America As Represented By The Secretary Of The Army Automated, on-demand ion mobility spectrometry analysis of gas chromatograph effluents
DE69635963T2 (en) 1995-12-23 2006-12-14 The Queen's University Of Belfast, Belfast GAS INTAKE SYSTEM
DE19628179C2 (en) 1996-07-12 1998-04-23 Bruker Franzen Analytik Gmbh Device and method for injecting ions into an ion trap
EP1008167A4 (en) 1997-03-14 2006-08-23 Univ George Washington A device for continuous isotope ratio monitoring following fluorine based chemical reactions
WO1998040520A1 (en) 1997-03-14 1998-09-17 Hybridon, Inc. Method for sequencing of modified nucleic acids using electrospray ionization-fourier transform mass spectrometry
US6323482B1 (en) * 1997-06-02 2001-11-27 Advanced Research And Technology Institute, Inc. Ion mobility and mass spectrometer
US6960761B2 (en) 1997-06-02 2005-11-01 Advanced Research & Technology Institute Instrument for separating ions in time as functions of preselected ion mobility and ion mass
US6498342B1 (en) 1997-06-02 2002-12-24 Advanced Research & Technology Institute Ion separation instrument
GB9717926D0 (en) 1997-08-22 1997-10-29 Micromass Ltd Methods and apparatus for tandem mass spectrometry
US5789745A (en) 1997-10-28 1998-08-04 Sandia Corporation Ion mobility spectrometer using frequency-domain separation
US6040575A (en) 1998-01-23 2000-03-21 Analytica Of Branford, Inc. Mass spectrometry from surfaces
US6124592A (en) 1998-03-18 2000-09-26 Technispan Llc Ion mobility storage trap and method
US6107628A (en) * 1998-06-03 2000-08-22 Battelle Memorial Institute Method and apparatus for directing ions and other charged particles generated at near atmospheric pressures into a region under vacuum
US6621077B1 (en) 1998-08-05 2003-09-16 National Research Council Canada Apparatus and method for atmospheric pressure-3-dimensional ion trapping
CA2260572A1 (en) 1998-08-05 2000-02-05 Randy W. Purves Apparatus and method for atmospheric pressure 3-dimensional ion trapping
US6713758B2 (en) 1998-08-05 2004-03-30 National Research Council Of Canada Spherical side-to-side FAIMS
US6504149B2 (en) 1998-08-05 2003-01-07 National Research Council Canada Apparatus and method for desolvating and focussing ions for introduction into a mass spectrometer
WO2000008457A1 (en) 1998-08-05 2000-02-17 National Research Council Canada Apparatus and method for atmospheric pressure 3-dimensional ion trapping
WO2000017908A2 (en) 1998-09-23 2000-03-30 Wisconsin Alumni Research Foundation Charge reduction in electrospray mass spectrometry
US6507019B2 (en) 1999-05-21 2003-01-14 Mds Inc. MS/MS scan methods for a quadrupole/time of flight tandem mass spectrometer
US6495823B1 (en) 1999-07-21 2002-12-17 The Charles Stark Draper Laboratory, Inc. Micromachined field asymmetric ion mobility filter and detection system
US6690004B2 (en) 1999-07-21 2004-02-10 The Charles Stark Draper Laboratory, Inc. Method and apparatus for electrospray-augmented high field asymmetric ion mobility spectrometry
US6815668B2 (en) 1999-07-21 2004-11-09 The Charles Stark Draper Laboratory, Inc. Method and apparatus for chromatography-high field asymmetric waveform ion mobility spectrometry
US6512224B1 (en) 1999-07-21 2003-01-28 The Charles Stark Draper Laboratory, Inc. Longitudinal field driven field asymmetric ion mobility filter and detection system
US7164122B2 (en) 2000-02-29 2007-01-16 Ionwerks, Inc. Ion mobility spectrometer
US6897437B2 (en) 2000-02-29 2005-05-24 Ionwerks Mobility spectrometer
US6825461B2 (en) 2000-03-14 2004-11-30 National Research Council Canada FAIMS apparatus and method with ion diverting device
US20030089847A1 (en) 2000-03-14 2003-05-15 Roger Guevremont Tandem high field asymmetric waveform ion mobility spectrometry ( faims)/ion mobility spectrometry
CA2402793C (en) 2000-03-14 2009-06-16 National Research Council Of Canada Improved parallel plate geometry faims apparatus and method
US6545268B1 (en) 2000-04-10 2003-04-08 Perseptive Biosystems Preparation of ion pulse for time-of-flight and for tandem time-of-flight mass analysis
AU2001285228A1 (en) 2000-08-24 2002-03-04 Newton Scientific, Inc. Sample introduction interface for analytical processing of a sample placed on a substrate
US6683301B2 (en) 2001-01-29 2004-01-27 Analytica Of Branford, Inc. Charged particle trapping in near-surface potential wells
US6627883B2 (en) * 2001-03-02 2003-09-30 Bruker Daltonics Inc. Apparatus and method for analyzing samples in a dual ion trap mass spectrometer
US6797945B2 (en) 2001-03-29 2004-09-28 Wisconsin Alumni Research Foundation Piezoelectric charged droplet source
EP1402561A4 (en) * 2001-05-25 2007-06-06 Analytica Of Branford Inc Atmospheric and vacuum pressure maldi ion source
US7041967B2 (en) * 2001-05-25 2006-05-09 Mds Inc. Method of mass spectrometry, to enhance separation of ions with different charges
US7586088B2 (en) 2001-06-21 2009-09-08 Micromass Uk Limited Mass spectrometer and method of mass spectrometry
US6762404B2 (en) 2001-06-25 2004-07-13 Micromass Uk Limited Mass spectrometer
US20030000921A1 (en) * 2001-06-29 2003-01-02 Ted Liang Mask repair with electron beam-induced chemical etching
US7274015B2 (en) 2001-08-08 2007-09-25 Sionex Corporation Capacitive discharge plasma ion source
US7091481B2 (en) 2001-08-08 2006-08-15 Sionex Corporation Method and apparatus for plasma generation
US7635841B2 (en) * 2001-12-12 2009-12-22 Micromass Uk Limited Method of mass spectrometry
AU2003201232A1 (en) 2002-02-08 2003-09-02 Ionalytics Corporation Faims with non-destructive detection of selectively transmitted ions
US6630662B1 (en) 2002-04-24 2003-10-07 Mds Inc. Setup for mobility separation of ions implementing an ion guide with an axial field and counterflow of gas
US6872939B2 (en) 2002-05-17 2005-03-29 Micromass Uk Limited Mass spectrometer
GB2390478B (en) 2002-05-17 2004-06-02 Micromass Ltd Mass spectrometer
US6794641B2 (en) * 2002-05-30 2004-09-21 Micromass Uk Limited Mass spectrometer
GB2397433B (en) * 2002-05-30 2006-03-29 Micromass Ltd Mass spectrometer
US7095013B2 (en) 2002-05-30 2006-08-22 Micromass Uk Limited Mass spectrometer
US6791078B2 (en) 2002-06-27 2004-09-14 Micromass Uk Limited Mass spectrometer
GB0305796D0 (en) * 2002-07-24 2003-04-16 Micromass Ltd Method of mass spectrometry and a mass spectrometer
US7071467B2 (en) 2002-08-05 2006-07-04 Micromass Uk Limited Mass spectrometer
CA2502445C (en) 2002-09-25 2011-08-23 Ionalytics Corporation Faims apparatus and method for separating ions
US7417225B2 (en) 2002-09-25 2008-08-26 Thermo Finnigan Llc Apparatus and method for adjustment of ion separation resolution in FAIMS
AU2003298597A1 (en) 2002-10-12 2004-05-25 Sionex Corporation NOx MONITOR USING DIFFERENTIAL MOBILITY SPECTROMETRY
US6642516B1 (en) 2002-12-18 2003-11-04 Agilent Technologies, Inc. Apparatus and method of laser dissociation for mass spectrometry
JP2006522340A (en) 2003-04-02 2006-09-28 メルク　エンド　カムパニー　インコーポレーテッド Analyzing mass spectrometry data
US7459693B2 (en) * 2003-04-04 2008-12-02 Bruker Daltonics, Inc. Ion guide for mass spectrometers
US20040195503A1 (en) * 2003-04-04 2004-10-07 Taeman Kim Ion guide for mass spectrometers
US6992283B2 (en) * 2003-06-06 2006-01-31 Micromass Uk Limited Mass spectrometer
GB0313016D0 (en) 2003-06-06 2003-07-09 Ms Horizons Ltd Ion extraction
CN1829911B (en) 2003-06-20 2011-04-20 杨百翰大学 Single device for ion mobility and ion trap mass spectrometry
US7385187B2 (en) * 2003-06-21 2008-06-10 Leco Corporation Multi-reflecting time-of-flight mass spectrometer and method of use
US7093623B2 (en) 2003-06-27 2006-08-22 The Gillette Company Methods of providing refueling for fuel cell-powered devices
US7071465B2 (en) 2003-10-14 2006-07-04 Washington State University Research Foundation Ion mobility spectrometry method and apparatus
US6967325B2 (en) * 2003-10-30 2005-11-22 Battelle Memorial Institute High performance ion mobility spectrometry using hourglass electrodynamic funnel and internal ion funnel
US6818890B1 (en) * 2003-10-30 2004-11-16 Battelle Memorial Institute High performance ion mobility spectrometry using hourglass electrodynamic funnel and internal ion funnel
GB2409927B (en) 2004-01-09 2006-09-27 Microsaic Systems Ltd Micro-engineered electron multipliers
CA2551991A1 (en) 2004-01-13 2005-07-28 Sionex Corporation Methods and apparatus for enhanced sample identification based on combined analytical techniques
EP1562041B1 (en) 2004-01-22 2016-11-09 Thermo Finnigan Llc Apparatus and method for establishing a temperature gradient within a FAIMS analyzer region
EP1562042A3 (en) 2004-01-22 2007-02-21 Ionalytics Corporation Method and apparatus for FAIMS for In-Line analysis of multiple samples
CA2499115A1 (en) 2004-03-03 2005-09-03 Ionalytics Corporation Method and apparatus for selecting inlets of a multiple inlet faims
GB0408751D0 (en) 2004-04-20 2004-05-26 Micromass Ltd Mass spectrometer
GB0420408D0 (en) 2004-09-14 2004-10-20 Micromass Ltd Mass spectrometer
JP4513488B2 (en) 2004-10-06 2010-07-28 株式会社日立製作所 Ion mobility analyzer and ion mobility analysis method
GB0424426D0 (en) * 2004-11-04 2004-12-08 Micromass Ltd Mass spectrometer
GB0426520D0 (en) 2004-12-02 2005-01-05 Micromass Ltd Mass spectrometer
GB0503010D0 (en) 2005-02-14 2005-03-16 Micromass Ltd Mass spectrometer
US8440968B2 (en) 2005-02-14 2013-05-14 Micromass Uk Limited Ion-mobility analyser
GB0506665D0 (en) 2005-04-01 2005-05-11 Micromass Ltd Mass spectrometer
GB0522933D0 (en) 2005-11-10 2005-12-21 Micromass Ltd Mass spectrometer
US8890058B2 (en) 2005-11-16 2014-11-18 Shimadzu Corporation Mass spectrometer
KR100716495B1 (en) 2005-11-23 2007-05-10 창원대학교 산학협력단 Apparatus for digital imaging photodetector using gas electron multiplier
JP5022611B2 (en) 2006-03-02 2012-09-12 独立行政法人理化学研究所 Method for manufacturing gas electron amplification foil
GB0613900D0 (en) 2006-07-13 2006-08-23 Micromass Ltd Mass spectrometer
GB2457556B (en) 2007-02-26 2010-02-17 Micromass Ltd Helical ion guide
GB2457769B (en) 2007-09-14 2010-07-14 Micromass Ltd Method of ion mobility separation
GB0723487D0 (en) 2007-11-30 2008-01-09 Micromass Ltd Mass spectrometer
GB0801309D0 (en) 2008-01-24 2008-03-05 Micromass Ltd Mass spectrometer
GB0815397D0 (en) 2008-08-22 2008-10-01 Micromass Ltd Mass spectrometer
GB201111568D0 (en) * 2011-07-06 2011-08-24 Micromass Ltd Apparatus and method of mass spectrometry
EP3945314B1 (en) * 2020-07-31 2022-10-26 Bruker Daltonics GmbH & Co. KG Method and apparatus for data independent combined ion mobility and mass spectroscopy analysis

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5905258A (en) * 1997-06-02 1999-05-18 Advanced Research & Techology Institute Hybrid ion mobility and mass spectrometer
US20020070338A1 (en) * 2000-12-08 2002-06-13 Loboda Alexander V. Ion mobility spectrometer incorporating an ion guide in combination with an MS device
US20030213900A1 (en) * 2002-05-17 2003-11-20 Hoyes John Brian Mass spectrometer
US20040026614A1 (en) * 2002-05-31 2004-02-12 Bateman Robert Harold Mass Spectrometer
GB2394356A (en) * 2002-08-05 2004-04-21 Micromass Ltd Mass spectrometer having an ion trap

Also Published As

Publication number Publication date
US20070278397A1 (en) 2007-12-06
CA2861514A1 (en) 2006-05-11
US8299422B2 (en) 2012-10-30
GB2421840B (en) 2007-11-28
GB0424426D0 (en) 2004-12-08
US20150260683A1 (en) 2015-09-17
US9410927B2 (en) 2016-08-09
US8735805B2 (en) 2014-05-27
EP3855474A1 (en) 2021-07-28
US20200340946A1 (en) 2020-10-29
JP4913066B2 (en) 2012-04-11
US7829841B2 (en) 2010-11-09
CA2861514C (en) 2016-10-04
EP1810314A2 (en) 2007-07-25
US20170089862A1 (en) 2017-03-30
CA2585565C (en) 2016-09-06
GB0522485D0 (en) 2005-12-14
US10724990B2 (en) 2020-07-28
EP2913840A1 (en) 2015-09-02
US20140048704A1 (en) 2014-02-20
US20140224978A1 (en) 2014-08-14
US20110042565A1 (en) 2011-02-24
CA2585565A1 (en) 2006-05-11
GB2421840A (en) 2006-07-05
US9048073B2 (en) 2015-06-02
EP2913840B1 (en) 2021-04-28
US20130056629A1 (en) 2013-03-07
US11385202B2 (en) 2022-07-12
WO2006048642A2 (en) 2006-05-11
US8569687B2 (en) 2013-10-29
EP1810314B1 (en) 2015-04-01
JP2008519410A (en) 2008-06-05

Similar Documents

Publication Publication Date Title
WO2006048642A3 (en) Mass spectrometer
WO2009007739A3 (en) Mass spectrometer
WO2006061593A3 (en) Mass spectrometer
WO2006061625A3 (en) Mass spectrometer
WO2007066114A3 (en) Mass spectrometer
WO2008071967A3 (en) Mass spectrometer
AU2003222693A1 (en) Apparatus and method for mobility separation of ions utilizing an ion guide with an axial field and counterflow of gas
GB0601735D0 (en) Ion mobility spectrometer and its method of operation
WO2006130149A3 (en) Mass spectrometer and methods of increasing dispersion between ion beams
EP1271608A3 (en) Mass spectrometer
WO2007060436A3 (en) Mass spectrometer
WO2007062303A3 (en) Ion mobility spectrometer
ATE542131T1 (en) MASS SPECTROMETRY
WO2005110396A3 (en) Nitrated lipids and methods of making and using thereof
WO2006129106A3 (en) Mass spectrometer
AU2003244485A1 (en) Faims apparatus having plural ion inlets and method therefore
WO2008028159A3 (en) Apparatus and methods for analyzing ions
GB0126525D0 (en) A quadrupole ion trap device, methods of operating a quadrupole ion trap device and a mass spectrometer including the quadrupole ion trap device
GB0214432D0 (en) Ion mobility mass spectrometer
AU2003213944A1 (en) Improved axial ejection resolution in multipole mass spectrometers
GB0108187D0 (en) Mass spectrometer and methods of mass spectrometry
WO2007125297A3 (en) Mass spectrometer
EP1591784A4 (en) Column for ion chromatograph, suppressor and ion chromatograph
WO2005116378A3 (en) Multiplexed tandem mass spectrometry
WO2007003437A3 (en) Cage for the introduction into an intervertebral-disc compartment

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KN KP KR KZ LC LK LR LS LT LU LV LY MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2585565

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2005800123

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2007539630

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 11718213

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 2005800123

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 11718213

Country of ref document: US