WO2006046155A3 - Loadable polyphosphazene-comprising particles for therapeutic and/or diagnostic applications and methods of preparing and using the same - Google Patents
Loadable polyphosphazene-comprising particles for therapeutic and/or diagnostic applications and methods of preparing and using the same Download PDFInfo
- Publication number
- WO2006046155A3 WO2006046155A3 PCT/IB2005/004007 IB2005004007W WO2006046155A3 WO 2006046155 A3 WO2006046155 A3 WO 2006046155A3 IB 2005004007 W IB2005004007 W IB 2005004007W WO 2006046155 A3 WO2006046155 A3 WO 2006046155A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- particles
- mammal
- core
- therapeutic
- polyphosphazene
- Prior art date
Links
- 239000002245 particle Substances 0.000 title abstract 13
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 241000124008 Mammalia Species 0.000 abstract 3
- 239000013543 active substance Substances 0.000 abstract 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 abstract 2
- 239000011248 coating agent Substances 0.000 abstract 2
- 238000000576 coating method Methods 0.000 abstract 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 abstract 1
- 230000017531 blood circulation Effects 0.000 abstract 1
- 210000004204 blood vessel Anatomy 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000000017 hydrogel Substances 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- GKTNLYAAZKKMTQ-UHFFFAOYSA-N n-[bis(dimethylamino)phosphinimyl]-n-methylmethanamine Chemical compound CN(C)P(=N)(N(C)C)N(C)C GKTNLYAAZKKMTQ-UHFFFAOYSA-N 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 239000000700 radioactive tracer Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 238000013268 sustained release Methods 0.000 abstract 1
- 239000012730 sustained-release form Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 125000003652 trifluoroethoxy group Chemical group FC(CO*)(F)F 0.000 abstract 1
- 238000012285 ultrasound imaging Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0404—X-ray contrast preparations containing barium sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
- A61K49/0414—Particles, beads, capsules or spheres
- A61K49/0419—Microparticles, microbeads, microcapsules, microspheres, i.e. having a size or diameter higher or equal to 1 micrometer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Abstract
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2005800366229A CN101090710B (en) | 2004-10-25 | 2005-10-24 | Loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same |
KR1020077011286A KR101153785B1 (en) | 2004-10-25 | 2005-10-24 | Loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same |
AU2005298344A AU2005298344B2 (en) | 2004-10-25 | 2005-10-24 | Loadable polyphosphazene-comprising particles for therapeutic and/or diagnostic applications and methods of preparing and using the same |
EP05825096A EP1804773B1 (en) | 2004-10-25 | 2005-10-24 | Loadable polyphosphazene-comprising particles for therapeutic and/or diagnostic applications and methods of preparing and using the same |
DE602005027229T DE602005027229D1 (en) | 2004-10-25 | 2005-10-24 | LOADABLE POLYPHOSPHAZINE-HOLDING PARTICLES FOR THERAPEUTIC AND / OR DIAGNOSTIC APPLICATIONS AND MANUFACTURING AND USE METHOD THEREFOR |
JP2007537420A JP4885866B2 (en) | 2004-10-25 | 2005-10-24 | Fillable polyphosphazene-containing particles for therapeutic and / or diagnostic applications and methods for their preparation and use |
BRPI0518383-9A BRPI0518383A2 (en) | 2004-10-25 | 2005-10-24 | Chargeable polymeric particles for therapeutical and / or diagnostic applications and methods for preparing and using them |
CA2584122A CA2584122C (en) | 2004-10-25 | 2005-10-24 | Loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same |
AT05825096T ATE503465T1 (en) | 2004-10-25 | 2005-10-24 | LOADABLE POLYPHOSPHAZENE-CONTAINING PARTICLES FOR THERAPEUTIC AND/OR DIAGNOSTIC APPLICATIONS AND PRODUCTION AND USE METHODS THEREOF |
TW094137269A TW200626178A (en) | 2004-10-25 | 2005-10-25 | Loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same |
MYPI20055024A MY147841A (en) | 2004-10-25 | 2005-10-25 | Loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same |
IL182650A IL182650A (en) | 2004-10-25 | 2007-04-18 | Loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same |
HK08105450.4A HK1116058A1 (en) | 2004-10-25 | 2008-05-16 | Loadable polymeric particles contaning polyphosphazene for therapeutic and/or diagnostic applications and methods of preparing and using the same |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62172904P | 2004-10-25 | 2004-10-25 | |
US60/621,729 | 2004-10-25 | ||
US68430705P | 2005-05-24 | 2005-05-24 | |
US60/684,307 | 2005-05-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006046155A2 WO2006046155A2 (en) | 2006-05-04 |
WO2006046155A3 true WO2006046155A3 (en) | 2006-08-17 |
Family
ID=36228155
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2005/004007 WO2006046155A2 (en) | 2004-10-25 | 2005-10-24 | Loadable polyphosphazene-comprising particles for therapeutic and/or diagnostic applications and methods of preparing and using the same |
Country Status (14)
Country | Link |
---|---|
US (4) | US8318209B2 (en) |
EP (1) | EP1804773B1 (en) |
JP (1) | JP4885866B2 (en) |
KR (1) | KR101153785B1 (en) |
AT (1) | ATE503465T1 (en) |
AU (1) | AU2005298344B2 (en) |
BR (1) | BRPI0518383A2 (en) |
CA (1) | CA2584122C (en) |
DE (1) | DE602005027229D1 (en) |
HK (1) | HK1116058A1 (en) |
IL (1) | IL182650A (en) |
MY (1) | MY147841A (en) |
TW (1) | TW200626178A (en) |
WO (1) | WO2006046155A2 (en) |
Cited By (1)
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US9040022B2 (en) | 2005-05-09 | 2015-05-26 | Biosphere Medical, S.A. | Compositions and methods using microspheres and non-ionic contrast agents |
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2012
- 2012-09-20 US US13/623,151 patent/US9511153B2/en active Active
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2016
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Cited By (1)
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US9040022B2 (en) | 2005-05-09 | 2015-05-26 | Biosphere Medical, S.A. | Compositions and methods using microspheres and non-ionic contrast agents |
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JP4885866B2 (en) | 2012-02-29 |
KR20070084341A (en) | 2007-08-24 |
AU2005298344A1 (en) | 2006-05-04 |
US20060088476A1 (en) | 2006-04-27 |
US9511153B2 (en) | 2016-12-06 |
TW200626178A (en) | 2006-08-01 |
AU2005298344B2 (en) | 2011-02-10 |
WO2006046155A2 (en) | 2006-05-04 |
EP1804773A2 (en) | 2007-07-11 |
KR101153785B1 (en) | 2012-07-09 |
US20210290555A1 (en) | 2021-09-23 |
JP2008517899A (en) | 2008-05-29 |
ATE503465T1 (en) | 2011-04-15 |
US11052050B2 (en) | 2021-07-06 |
CA2584122C (en) | 2013-04-30 |
CA2584122A1 (en) | 2006-05-04 |
IL182650A0 (en) | 2007-07-24 |
US20130052142A1 (en) | 2013-02-28 |
US20170172933A1 (en) | 2017-06-22 |
EP1804773B1 (en) | 2011-03-30 |
BRPI0518383A2 (en) | 2008-11-18 |
US8318209B2 (en) | 2012-11-27 |
IL182650A (en) | 2013-01-31 |
HK1116058A1 (en) | 2008-12-19 |
MY147841A (en) | 2013-01-31 |
DE602005027229D1 (en) | 2011-05-12 |
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