WO2006044832A3 - Device for tissue engineering - Google Patents

Device for tissue engineering Download PDF

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Publication number
WO2006044832A3
WO2006044832A3 PCT/US2005/037315 US2005037315W WO2006044832A3 WO 2006044832 A3 WO2006044832 A3 WO 2006044832A3 US 2005037315 W US2005037315 W US 2005037315W WO 2006044832 A3 WO2006044832 A3 WO 2006044832A3
Authority
WO
WIPO (PCT)
Prior art keywords
micro
tissue engineering
substantially uniform
implant
layer
Prior art date
Application number
PCT/US2005/037315
Other languages
French (fr)
Other versions
WO2006044832A2 (en
Inventor
Shuvo Roy
George F Muschler
Aaron J Fleischman
Alvaro Mata
Original Assignee
Cleveland Clinic Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cleveland Clinic Foundation filed Critical Cleveland Clinic Foundation
Publication of WO2006044832A2 publication Critical patent/WO2006044832A2/en
Publication of WO2006044832A3 publication Critical patent/WO2006044832A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/35—Fat tissue; Adipocytes; Stromal cells; Connective tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2535/00—Supports or coatings for cell culture characterised by topography
    • C12N2535/10—Patterned coating

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Developmental Biology & Embryology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Prostheses (AREA)

Abstract

An implant includes a plurality of parallel layers spaced apart by a plurality of members. Each layer has a substantially uniform thickness between opposite surfaces and a plurality of openings that permit fluid flow through an interior of the implant defined by the layers. The surfaces of each layer includes an array of micro-structures. Each micro-structure has a substantially uniform shape and an average height of about 1 nm to about 20 µm.
PCT/US2005/037315 2004-10-15 2005-10-14 Device for tissue engineering WO2006044832A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61912104P 2004-10-15 2004-10-15
US60/619,121 2004-10-15

Publications (2)

Publication Number Publication Date
WO2006044832A2 WO2006044832A2 (en) 2006-04-27
WO2006044832A3 true WO2006044832A3 (en) 2009-04-02

Family

ID=36203642

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/037315 WO2006044832A2 (en) 2004-10-15 2005-10-14 Device for tissue engineering

Country Status (2)

Country Link
US (1) US20060229735A1 (en)
WO (1) WO2006044832A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20051854A1 (en) * 2005-10-03 2007-04-04 Sambusseti Antonio PATCH FOR THE REPLACEMENT OF A VESCICAL WALL PORTION FOLLOWED BY PARTIAL VESCITECTOMY
US8975073B2 (en) * 2006-11-21 2015-03-10 The Charles Stark Draper Laboratory, Inc. Microfluidic device comprising silk films coupled to form a microchannel
US20100167401A1 (en) * 2007-03-19 2010-07-01 Vasif Hasirci Stacked, patterned biomaterials and/or tissue engineering scaffolds
US9457497B2 (en) * 2007-06-14 2016-10-04 University Of Rochester Microfluidic device and method of manufacturing the microfluidic device
WO2011137270A1 (en) 2010-04-29 2011-11-03 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Cell and biofactor printable biopapers
EP2782609A1 (en) * 2011-11-23 2014-10-01 Amendia, Inc. Bone graft
US8414654B1 (en) 2011-11-23 2013-04-09 Amendia, Inc. Bone implants and method of manufacture
US9179954B2 (en) 2011-11-23 2015-11-10 Vivex Biomedical, Inc. Bone screw fastener
US8535388B2 (en) 2011-11-23 2013-09-17 Timothy Ganey Bone graft
NZ704003A (en) * 2012-06-21 2017-02-24 Neostem Oncology Llc Bioreactor cartridge and system
US9907654B2 (en) * 2012-12-11 2018-03-06 Dr. H.C. Robert Mathys Stiftung Bone substitute and method for producing the same
EP2940066B1 (en) 2012-12-26 2020-02-05 Spiber Inc. Spider silk protein film, and method for producing same
US9213025B2 (en) * 2013-03-13 2015-12-15 Cpsi Holdings Llc Tissue engineered model
WO2014190005A1 (en) 2013-05-22 2014-11-27 Transient Electronics, Inc. Controlled transformation of non-transient electronics
CN106809801A (en) * 2017-03-29 2017-06-09 广东工业大学 A kind of facture of microchip method and device
US10876095B1 (en) 2018-12-05 2020-12-29 Ultra Small Fibers, LLC Biomimetic lamellar tissue scaffolds
CN110523449B (en) * 2019-09-25 2020-11-24 华南理工大学 Preparation method of transparent ceramic micro-fluidic chip
CN113292332A (en) * 2021-06-11 2021-08-24 四川大学 Calcium phosphate ceramic high-throughput screening model based on 3D printing, preparation method and application

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020095218A1 (en) * 1996-03-12 2002-07-18 Carr Robert M. Tissue repair fabric
US7022522B2 (en) * 1998-11-13 2006-04-04 Limin Guan Macroporous polymer scaffold containing calcium phosphate particles
CA2402737A1 (en) * 2000-03-17 2001-09-27 Emanuele Ostuni Cell patterning technique
WO2001081552A1 (en) * 2000-04-19 2001-11-01 Iowa State University Research Foundation, Inc. Patterned substrates and methods for nerve regeneration
US7052514B2 (en) * 2000-04-28 2006-05-30 Curis, Inc. Methods and reagents for tissue engineering of cartilage in vitro
US6991652B2 (en) * 2000-06-13 2006-01-31 Burg Karen J L Tissue engineering composite
WO2002000149A1 (en) * 2000-06-23 2002-01-03 Drexel University Polymeric, fiber matrix delivery systems for bioactive compounds
AU2001294671A1 (en) * 2000-09-25 2002-04-08 The Board Of Trustees Of The University Of Illinois Microfabrication of membranes for the growth of cells
US7048963B2 (en) * 2001-11-30 2006-05-23 Cambridge Polymers Group, Inc. Layered aligned polymer structures and methods of making same
US6759446B2 (en) * 2002-05-02 2004-07-06 The Ohio State University Research Foundation Polymer nanocomposite foams
US7049348B2 (en) * 2002-07-06 2006-05-23 Kensey Nash Corporation Resorbable structure for treating and healing of tissue defects
US7070923B1 (en) * 2003-06-26 2006-07-04 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration (Nasa) Provision of carbon nanotube bucky paper cages for immune shielding of cells, tissues, and medical devices
US8025831B2 (en) * 2004-05-24 2011-09-27 Agency For Science, Technology And Research Imprinting of supported and free-standing 3-D micro- or nano-structures

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BAO ET AL.: "Nanoimprinting over topography and multilayer three-dimensional printing.", JOURNAL OF VACUUM SCIENCE AND TECHNOLOGY B, vol. 20, no. 6, November 2002 (2002-11-01), pages 2881 - 2886, XP012009652, DOI: doi:10.1116/1.1526355 *
FOLCH ET AL.: "Stacks of Microfabricated Structures as Scaffolds for Cell culture and Tissue Engineering.", BIOMEDICAL MICRODEVICES, vol. 2, no. 3, 2000, pages 207 - 214 *
MATA ET AL.: "Analysis of Connective Tissue Progenitor Cell Behavior on Polydimethylsilozane Smoothe and Channel Micro-Textures.", BIOMEDICAL MICRODEYICES, vol. 4, no. 4, 2002, pages 267 - 275 *
MATA ET AL.: "Growth of connective tissue progenitor cells on microtextured polydimethylsiloxane surfaces.", J BIOMED MATER RES, vol. 62, no. 4, 2002, pages 499 - 506 *

Also Published As

Publication number Publication date
US20060229735A1 (en) 2006-10-12
WO2006044832A2 (en) 2006-04-27

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