WO2006044078A2 - Apparatus and method for analysis of molecules - Google Patents
Apparatus and method for analysis of molecules Download PDFInfo
- Publication number
- WO2006044078A2 WO2006044078A2 PCT/US2005/033052 US2005033052W WO2006044078A2 WO 2006044078 A2 WO2006044078 A2 WO 2006044078A2 US 2005033052 W US2005033052 W US 2005033052W WO 2006044078 A2 WO2006044078 A2 WO 2006044078A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- optical
- array
- nucleic acid
- confinements
- target nucleic
- Prior art date
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y20/00—Nanooptics, e.g. quantum optics or photonic crystals
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/10—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type
- G02B6/12—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
- G02B6/13—Integrated optical circuits characterised by the manufacturing method
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0668—Trapping microscopic beads
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0654—Lenses; Optical fibres
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0896—Nanoscaled
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nanotechnology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Optics & Photonics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Molecular Biology (AREA)
- Composite Materials (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Materials Engineering (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05812440A EP1790202A4 (en) | 2004-09-17 | 2005-09-16 | Apparatus and method for analysis of molecules |
CN2005800314830A CN101199241B (en) | 2004-09-17 | 2005-09-16 | Device and method for molecule analysis |
AU2005296200A AU2005296200B2 (en) | 2004-09-17 | 2005-09-16 | Apparatus and method for analysis of molecules |
JP2007532480A JP2008513782A (en) | 2004-09-17 | 2005-09-16 | Apparatus and method for molecular analysis |
EP18184493.7A EP3415641B1 (en) | 2004-09-17 | 2005-09-16 | Method for analysis of molecules |
GB0608338A GB2423819B (en) | 2004-09-17 | 2005-09-16 | Apparatus and method for analysis of molecules |
CA2579150A CA2579150C (en) | 2004-09-17 | 2005-09-16 | Apparatus and method for analysis of molecules |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/944,106 US7170050B2 (en) | 2004-09-17 | 2004-09-17 | Apparatus and methods for optical analysis of molecules |
US10/944,106 | 2004-09-17 | ||
US64900905P | 2005-01-31 | 2005-01-31 | |
US60/649,009 | 2005-01-31 | ||
US65184605P | 2005-02-09 | 2005-02-09 | |
US60/651,846 | 2005-02-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006044078A2 true WO2006044078A2 (en) | 2006-04-27 |
WO2006044078A3 WO2006044078A3 (en) | 2008-02-21 |
Family
ID=36073574
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2005/033052 WO2006044078A2 (en) | 2004-09-17 | 2005-09-16 | Apparatus and method for analysis of molecules |
Country Status (8)
Country | Link |
---|---|
US (4) | US7315019B2 (en) |
EP (2) | EP1790202A4 (en) |
JP (3) | JP2008513782A (en) |
CN (1) | CN101914620B (en) |
AU (1) | AU2005296200B2 (en) |
CA (1) | CA2579150C (en) |
GB (1) | GB2423819B (en) |
WO (1) | WO2006044078A2 (en) |
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WO2009073201A2 (en) | 2007-12-04 | 2009-06-11 | Pacific Biosciences Of California, Inc. | Alternate labeling strategies for single molecule sequencing |
JP2009539411A (en) * | 2006-06-12 | 2009-11-19 | パシフィック バイオサイエンシーズ オブ カリフォルニア, インコーポレイテッド | Substrates for performing analytical reactions |
JP2010523987A (en) * | 2007-04-04 | 2010-07-15 | シネンテツク・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング | Biochip for fluorescence analysis of individual transporters |
WO2013105025A1 (en) * | 2012-01-13 | 2013-07-18 | Koninklijke Philips N.V. | Dna sequencing with reagent recycling on wiregrid |
US8993307B2 (en) | 2008-09-30 | 2015-03-31 | Pacific Biosciences Of California, Inc. | High multiplex arrays and systems |
US9759658B2 (en) | 2014-08-08 | 2017-09-12 | Quantum-Si Incorporated | Integrated device for temporal binning of received photons |
US9863880B2 (en) | 2013-11-17 | 2018-01-09 | Quantum-Si Incorporated | Optical system and assay chip for probing, detecting and analyzing molecules |
US9885657B2 (en) | 2014-08-08 | 2018-02-06 | Quantum-Si Incorporated | Integrated device with external light source for probing detecting and analyzing molecules |
US9921157B2 (en) | 2014-08-08 | 2018-03-20 | Quantum-Si Incorporated | Optical system and assay chip for probing, detecting and analyzing molecules |
US10668444B2 (en) | 2013-02-26 | 2020-06-02 | Illumina, Inc. | Gel patterned surfaces |
WO2022108701A1 (en) * | 2020-11-20 | 2022-05-27 | Illumina, Inc. | Compositions and methods for sequencing using fluorophores and quenchers or donors |
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US20070172866A1 (en) * | 2000-07-07 | 2007-07-26 | Susan Hardin | Methods for sequence determination using depolymerizing agent |
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WO2002044425A2 (en) | 2000-12-01 | 2002-06-06 | Visigen Biotechnologies, Inc. | Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity |
US7668697B2 (en) * | 2006-02-06 | 2010-02-23 | Andrei Volkov | Method for analyzing dynamic detectable events at the single molecule level |
US20040067532A1 (en) | 2002-08-12 | 2004-04-08 | Genetastix Corporation | High throughput generation and affinity maturation of humanized antibody |
US20090186343A1 (en) * | 2003-01-28 | 2009-07-23 | Visigen Biotechnologies, Inc. | Methods for preparing modified biomolecules, modified biomolecules and methods for using same |
US7170050B2 (en) | 2004-09-17 | 2007-01-30 | Pacific Biosciences Of California, Inc. | Apparatus and methods for optical analysis of molecules |
GB2423819B (en) * | 2004-09-17 | 2008-02-06 | Pacific Biosciences California | Apparatus and method for analysis of molecules |
US8535616B2 (en) * | 2005-08-02 | 2013-09-17 | Moxtek, Inc. | Sub-wavelength metallic apertures as light enhancement devices |
US7763423B2 (en) * | 2005-09-30 | 2010-07-27 | Pacific Biosciences Of California, Inc. | Substrates having low density reactive groups for monitoring enzyme activity |
WO2007041621A2 (en) * | 2005-10-03 | 2007-04-12 | Xingsheng Sean Ling | Hybridization assisted nanopore sequencing |
JP2009519717A (en) * | 2005-12-16 | 2009-05-21 | アプレラ コーポレイション | Method and system for fixed phase sequencing |
US20090303479A1 (en) * | 2006-02-06 | 2009-12-10 | Stmicroelectronics S.R.L. | Optical Apparatus and Method for the Inspection of Nucleic Acid Probes by Polarized Radiation |
US7995202B2 (en) * | 2006-02-13 | 2011-08-09 | Pacific Biosciences Of California, Inc. | Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources |
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GB2423819A (en) | 2006-09-06 |
GB0608338D0 (en) | 2006-06-07 |
US7476503B2 (en) | 2009-01-13 |
US20060062531A1 (en) | 2006-03-23 |
US20060061755A1 (en) | 2006-03-23 |
GB2423819B (en) | 2008-02-06 |
CA2579150A1 (en) | 2006-04-27 |
CN101914620B (en) | 2014-02-12 |
WO2006044078A3 (en) | 2008-02-21 |
EP3415641A1 (en) | 2018-12-19 |
JP2008513782A (en) | 2008-05-01 |
JP2016154560A (en) | 2016-09-01 |
AU2005296200A1 (en) | 2006-04-27 |
US20060061754A1 (en) | 2006-03-23 |
US20060063264A1 (en) | 2006-03-23 |
AU2005296200B2 (en) | 2011-07-14 |
CN101914620A (en) | 2010-12-15 |
CA2579150C (en) | 2014-11-25 |
US7302146B2 (en) | 2007-11-27 |
JP6294064B2 (en) | 2018-03-14 |
EP3415641B1 (en) | 2023-11-01 |
EP1790202A4 (en) | 2013-02-20 |
JP2014057601A (en) | 2014-04-03 |
US7315019B2 (en) | 2008-01-01 |
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