WO2006036834A3 - MODIFIED Fc MOLECULES - Google Patents

MODIFIED Fc MOLECULES Download PDF

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Publication number
WO2006036834A3
WO2006036834A3 PCT/US2005/034273 US2005034273W WO2006036834A3 WO 2006036834 A3 WO2006036834 A3 WO 2006036834A3 US 2005034273 W US2005034273 W US 2005034273W WO 2006036834 A3 WO2006036834 A3 WO 2006036834A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptide
domain
screening
molecules
modify
Prior art date
Application number
PCT/US2005/034273
Other languages
French (fr)
Other versions
WO2006036834A2 (en
Inventor
Colin Gegg
Fei Xiong
Karen C Sitney
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EA200700623A priority Critical patent/EA011879B1/en
Priority to BRPI0516011-1A priority patent/BRPI0516011A/en
Priority to CN200580038596.3A priority patent/CN101103045B/en
Priority to CA2580796A priority patent/CA2580796C/en
Priority to DK05814444.5T priority patent/DK1797127T3/en
Priority to AU2005289685A priority patent/AU2005289685B2/en
Priority to MX2007003320A priority patent/MX2007003320A/en
Priority to ES05814444.5T priority patent/ES2629397T3/en
Application filed by Amgen Inc filed Critical Amgen Inc
Priority to JP2007533681A priority patent/JP5017116B2/en
Priority to SI200532161T priority patent/SI1797127T1/en
Priority to EP05814444.5A priority patent/EP1797127B1/en
Publication of WO2006036834A2 publication Critical patent/WO2006036834A2/en
Publication of WO2006036834A3 publication Critical patent/WO2006036834A3/en
Priority to IL182139A priority patent/IL182139A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/06—Anabolic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/10—Immunoglobulin or domain(s) thereof as scaffolds for inserted non-Ig peptide sequences, e.g. for vaccination purposes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Abstract

The present invention concerns molecules and a process in which one or more biologically active peptides are incorporated into an Fc domain. In this invention, pharmacologically active compounds may be prepared by a process comprising (a) selecting at least one peptide that modulates the activity of a protein of interest; and (b) preparing a pharmacologic agent comprising an amino acid sequence of the selected peptide in a loop region of an Fc domain. This process may be employed to modify an Fc domain that is already linked through an N- or C-terminus or sidechain to a peptide or to a polypeptide (e.g., etanercept). This process may also be employed to modify an Fc domain that is part of an antibody (e.g., adalimumab, epratuzumab, infliximab, Herceptin®, and the like). In this way, different molecules can be produced that have additional functionalities, such as a binding domain to a different epitope or an additional binding domain to the precursor molecule's existing epitope. The peptide can be selected, for example, by phage display, E. coli display, ribosome display, RNA-peptide screening, yeast-based screening, chemical-peptide screening, rational design, or protein structural analysis.
PCT/US2005/034273 2004-09-24 2005-09-23 MODIFIED Fc MOLECULES WO2006036834A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
MX2007003320A MX2007003320A (en) 2004-09-24 2005-09-23 Modified fc molecules.
CN200580038596.3A CN101103045B (en) 2004-09-24 2005-09-23 The Fc molecule modified
CA2580796A CA2580796C (en) 2004-09-24 2005-09-23 Modified fc molecules having peptides inserted in internal loop regions
DK05814444.5T DK1797127T3 (en) 2004-09-24 2005-09-23 Modified Fc molecules
AU2005289685A AU2005289685B2 (en) 2004-09-24 2005-09-23 Modified Fc molecules
EA200700623A EA011879B1 (en) 2004-09-24 2005-09-23 MODIFIED Fc MOLECULES
ES05814444.5T ES2629397T3 (en) 2004-09-24 2005-09-23 Modified Fc molecules
BRPI0516011-1A BRPI0516011A (en) 2004-09-24 2005-09-23 modified fc molecules
JP2007533681A JP5017116B2 (en) 2004-09-24 2005-09-23 Modified Fc molecule
SI200532161T SI1797127T1 (en) 2004-09-24 2005-09-23 Modified fc molecules
EP05814444.5A EP1797127B1 (en) 2004-09-24 2005-09-23 Modified fc molecules
IL182139A IL182139A (en) 2004-09-24 2007-03-22 Modified human igg fc domain, a process for preparing a pharmacologically active compound, a modified antibody comprising igg fc domain and a process for preparing the modified antibody

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61268004P 2004-09-24 2004-09-24
US60/612,680 2004-09-24

Publications (2)

Publication Number Publication Date
WO2006036834A2 WO2006036834A2 (en) 2006-04-06
WO2006036834A3 true WO2006036834A3 (en) 2006-06-29

Family

ID=35911109

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/034273 WO2006036834A2 (en) 2004-09-24 2005-09-23 MODIFIED Fc MOLECULES

Country Status (17)

Country Link
US (7) US7442778B2 (en)
EP (1) EP1797127B1 (en)
JP (1) JP5017116B2 (en)
KR (1) KR100920282B1 (en)
CN (1) CN101103045B (en)
AU (1) AU2005289685B2 (en)
BR (1) BRPI0516011A (en)
CA (1) CA2580796C (en)
DK (1) DK1797127T3 (en)
EA (1) EA011879B1 (en)
ES (1) ES2629397T3 (en)
IL (1) IL182139A (en)
MA (1) MA28989B1 (en)
MX (1) MX2007003320A (en)
SI (1) SI1797127T1 (en)
WO (1) WO2006036834A2 (en)
ZA (1) ZA200702222B (en)

Cited By (3)

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US9255149B2 (en) 2008-05-02 2016-02-09 F-Star Biotechnologische Forschungs- Und Entwicklungsges.M.B.H Cytotoxic immunoglobulin
US9493578B2 (en) 2009-09-02 2016-11-15 Xencor, Inc. Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
US11952422B2 (en) 2017-12-05 2024-04-09 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule comprising altered antibody variable region binding CD3 and CD137

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ZA200702222B (en) 2009-04-29
US20090041768A1 (en) 2009-02-12
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AU2005289685A1 (en) 2006-04-06
MA28989B1 (en) 2007-11-01
US7662931B2 (en) 2010-02-16
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IL182139A (en) 2014-05-28

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