WO2006034337A3 - Carbazole and cyclopentaindole derivatives to treat infection with hepatitis c virus - Google Patents

Carbazole and cyclopentaindole derivatives to treat infection with hepatitis c virus Download PDF

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Publication number
WO2006034337A3
WO2006034337A3 PCT/US2005/033803 US2005033803W WO2006034337A3 WO 2006034337 A3 WO2006034337 A3 WO 2006034337A3 US 2005033803 W US2005033803 W US 2005033803W WO 2006034337 A3 WO2006034337 A3 WO 2006034337A3
Authority
WO
WIPO (PCT)
Prior art keywords
hepatitis
cyclopentaindole
carbazole
virus
derivatives
Prior art date
Application number
PCT/US2005/033803
Other languages
French (fr)
Other versions
WO2006034337A2 (en
Inventor
Ariamala Gopalsamy
Gregory Mark Ciszewski
Mengxiao Shi
Kaapjoo Park
Original Assignee
Wyeth Corp
Ariamala Gopalsamy
Gregory Mark Ciszewski
Mengxiao Shi
Kaapjoo Park
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp, Ariamala Gopalsamy, Gregory Mark Ciszewski, Mengxiao Shi, Kaapjoo Park filed Critical Wyeth Corp
Priority to BRPI0515596-7A priority Critical patent/BRPI0515596A/en
Priority to JP2007533604A priority patent/JP2008514611A/en
Priority to AU2005286727A priority patent/AU2005286727A1/en
Priority to EP05815334A priority patent/EP1793819A2/en
Priority to CA002577413A priority patent/CA2577413A1/en
Priority to MX2007003371A priority patent/MX2007003371A/en
Publication of WO2006034337A2 publication Critical patent/WO2006034337A2/en
Publication of WO2006034337A3 publication Critical patent/WO2006034337A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system

Abstract

The invention is directed to a method of treating, preventing, or inhibiting a Hepatitis C viral infection in a mammal comprising contacting the mammal with an effective amount of a compound of the formula (I) wherein substitutions at R1 - R13, m and Y are set forth in the specification
PCT/US2005/033803 2004-09-23 2005-09-21 Carbazole and cyclopentaindole derivatives to treat infection with hepatitis c virus WO2006034337A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
BRPI0515596-7A BRPI0515596A (en) 2004-09-23 2005-09-21 pharmaceutical composition used for the treatment and / or prevention of hcv, and methods of inhibiting hepatitis c polymerase ns5b from treating or preventing hepatitis c infection in a mammal
JP2007533604A JP2008514611A (en) 2004-09-23 2005-09-21 Derivatives of carbazole and cyclopentaindole for treating infection with hepatitis C virus
AU2005286727A AU2005286727A1 (en) 2004-09-23 2005-09-21 Carbazole and cyclopentaindole derivatives to treat infection with Hepatitis C virus
EP05815334A EP1793819A2 (en) 2004-09-23 2005-09-21 Carbazole and cyclopentaindole derivatives to treat infection with hepatitis c virus
CA002577413A CA2577413A1 (en) 2004-09-23 2005-09-21 Carbazole and cyclopentaindole derivatives to treat infection with hepatitis c virus
MX2007003371A MX2007003371A (en) 2004-09-23 2005-09-21 Carbazole and cyclopentaindole derivatives to treat infection with hepatitis c virus.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61214404P 2004-09-23 2004-09-23
US60/612,144 2004-09-23

Publications (2)

Publication Number Publication Date
WO2006034337A2 WO2006034337A2 (en) 2006-03-30
WO2006034337A3 true WO2006034337A3 (en) 2006-09-14

Family

ID=35907017

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/033803 WO2006034337A2 (en) 2004-09-23 2005-09-21 Carbazole and cyclopentaindole derivatives to treat infection with hepatitis c virus

Country Status (9)

Country Link
US (1) US7250441B2 (en)
EP (1) EP1793819A2 (en)
JP (1) JP2008514611A (en)
CN (1) CN101035528A (en)
AU (1) AU2005286727A1 (en)
BR (1) BRPI0515596A (en)
CA (1) CA2577413A1 (en)
MX (1) MX2007003371A (en)
WO (1) WO2006034337A2 (en)

Cited By (5)

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US9108969B2 (en) 2008-08-27 2015-08-18 Arena Pharmaceuticals, Inc. Substituted tricyclic acid derivatives as S1P1 receptor agonists useful in the treatment of autoimmune and inflammatory disorders
US9126932B2 (en) 2008-07-23 2015-09-08 Arena Pharmaceuticals, Inc. Substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives useful in the treatment of autoimmune and inflammatory disorders
US9175320B2 (en) 2010-01-27 2015-11-03 Arena Pharmaceuticals, Inc. Processes for the preparation of (R)-2-(7-4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[B]indol-3-yl)acetic acid and salts thereof
US11555015B2 (en) 2018-09-06 2023-01-17 Arena Pharmaceuticals, Inc. Compounds useful in the treatment of autoimmune and inflammatory disorders
US11566026B2 (en) 2016-12-22 2023-01-31 Incyte Corporation Heterocyclic compounds as immunomodulators

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WO2006121467A2 (en) * 2004-11-22 2006-11-16 Smithkline Beecham Corporation Tetrahydrocarbazole derivatives for treating flaviridae viruses
AR058053A1 (en) 2005-09-19 2008-01-23 Toole Doris C O CRYSTALLINE FORMS POLYMORPHICS OF ACID DIODIUM SALT N- (5-CHLOROSALICILOIL) -8- AMINOCAPRILICO
WO2008024763A2 (en) * 2006-08-25 2008-02-28 Wyeth Identification and characterization of hcv replicon variants with reduced susceptibility to hcv-796, and methods related thereto
AU2007339386B8 (en) 2006-12-22 2013-12-05 Merck Sharp & Dohme Corp. 4, 5-ring annulated indole derivatives for treating or preventing of HCV and related viral infections
CN101631773A (en) 2006-12-22 2010-01-20 先灵公司 4 of treatment or prevention HCV and related viral infections, the 5-ring annulated indole derivatives
WO2008136815A2 (en) 2006-12-22 2008-11-13 Schering Corporation 5, 6-ring annulated indole derivatives and use thereof
ES2381410T3 (en) 2007-05-04 2012-05-28 Vertex Pharmceuticals Incorporated Combination therapy for the treatment of HCV infections
AU2008295483B2 (en) * 2007-08-29 2013-11-21 Merck Sharp & Dohme Corp. Tetracyclic indole derivatives and their use for treating or preventing viral infections
BRPI0816116A2 (en) 2007-08-29 2015-03-03 Schering Corp 2,3-SUBSTITUTED INDOL DERIVATIVES FOR TREATMENT OF VIRAL INFECTIONS.
CN101821252A (en) 2007-08-29 2010-09-01 先灵公司 The indole derivatives and the using method thereof that replace
TW200911807A (en) 2007-08-29 2009-03-16 Schering Corp 2,3-substituted azaindole derivatives and methods of use thereof
KR101396696B1 (en) * 2007-10-10 2014-05-16 노파르티스 아게 Spiropyrrolidines and their use against hcv and hiv infection
JP5249344B2 (en) 2007-11-16 2013-07-31 メルク・シャープ・アンド・ドーム・コーポレーション Indole derivatives substituted at the 3-position of the heterocyclic ring and use thereof
CA2705587A1 (en) 2007-11-16 2009-05-22 Schering Corporation 3-aminosulfonyl substituted indole derivatives and methods of use thereof
EP2303893B1 (en) 2008-06-13 2016-12-07 Merck Sharp & Dohme Corp. Tricyclic indole derivatives
ES2443948T3 (en) 2008-12-19 2014-02-21 Bristol-Myers Squibb Company Carbazole carboxamide compounds useful as kinase inhibitors
SG10201501575VA (en) 2010-03-03 2015-04-29 Arena Pharm Inc Processes for the preparation of s1p1 receptor modulators and crystalline forms thereof
CN105566202B (en) * 2014-10-31 2018-06-22 华东师范大学 A kind of 1,2,3,4- tetrahydro cyclopentyl base indole derivatives and its synthetic method
CN116850181A (en) 2015-01-06 2023-10-10 艾尼纳制药公司 Treatment and S1P 1 Methods of receptor-related disorders
ES2929526T3 (en) 2015-06-22 2022-11-29 Arena Pharm Inc (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl) acid L-arginine crystal salt acetic acid for use in disorders associated with the S1P1 receptor
WO2017070089A1 (en) 2015-10-19 2017-04-27 Incyte Corporation Heterocyclic compounds as immunomodulators
EP4141002A1 (en) 2015-11-19 2023-03-01 Incyte Corporation Heterocyclic compounds as immunomodulators
PL3394033T3 (en) 2015-12-22 2021-05-31 Incyte Corporation Heterocyclic compounds as immunomodulators
TW201808950A (en) 2016-05-06 2018-03-16 英塞特公司 Heterocyclic compounds as immunomodulators
MA45116A (en) 2016-05-26 2021-06-02 Incyte Corp HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS
MX2018016273A (en) 2016-06-20 2019-07-04 Incyte Corp Heterocyclic compounds as immunomodulators.
EP3484866B1 (en) 2016-07-14 2022-09-07 Incyte Corporation Heterocyclic compounds as immunomodulators
MA46045A (en) 2016-08-29 2021-04-28 Incyte Corp HETEROCYCLIC COMPOUNDS USED AS IMMUNOMODULATORS
ES2899402T3 (en) 2016-12-22 2022-03-11 Incyte Corp Pyridine derivatives as immunomodulators
CN110582493B (en) 2016-12-22 2024-03-08 因赛特公司 Benzoxazole derivatives as immunomodulators
CA3053416A1 (en) 2017-02-16 2018-08-23 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of inflammatory bowel disease with extra-intestinal manifestations
MA47504A (en) 2017-02-16 2019-12-25 Arena Pharm Inc COMPOUNDS AND TREATMENT METHODS FOR PRIMITIVE BILIARY ANGIOCHOLITIS
SG11202009440WA (en) 2018-03-30 2020-10-29 Incyte Corp Heterocyclic compounds as immunomodulators
DK3790877T3 (en) 2018-05-11 2023-04-24 Incyte Corp TETRAHYDRO-IMIDAZO[4,5-C]PYRIDINE DERIVATIVES AS PD-L1 IMMUNE MODULATORS
WO2021030162A1 (en) 2019-08-09 2021-02-18 Incyte Corporation Salts of a pd-1/pd-l1 inhibitor
US11401279B2 (en) 2019-09-30 2022-08-02 Incyte Corporation Pyrido[3,2-d]pyrimidine compounds as immunomodulators
TW202120504A (en) 2019-11-11 2021-06-01 美商英塞特公司 Salts and crystalline forms of a pd-1/pd-l1 inhibitor
TW202233615A (en) 2020-11-06 2022-09-01 美商英塞特公司 Crystalline form of a pd-1/pd-l1 inhibitor
WO2022099018A1 (en) 2020-11-06 2022-05-12 Incyte Corporation Process of preparing a pd-1/pd-l1 inhibitor
AU2021373044A1 (en) 2020-11-06 2023-06-08 Incyte Corporation Process for making a pd-1/pd-l1 inhibitor and salts and crystalline forms thereof

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Cited By (7)

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US9126932B2 (en) 2008-07-23 2015-09-08 Arena Pharmaceuticals, Inc. Substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives useful in the treatment of autoimmune and inflammatory disorders
US9522133B2 (en) 2008-07-23 2016-12-20 Arena Pharmaceuticals, Inc. Substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives useful in the treatment of autoimmune and inflammatory disorders
US9108969B2 (en) 2008-08-27 2015-08-18 Arena Pharmaceuticals, Inc. Substituted tricyclic acid derivatives as S1P1 receptor agonists useful in the treatment of autoimmune and inflammatory disorders
US9175320B2 (en) 2010-01-27 2015-11-03 Arena Pharmaceuticals, Inc. Processes for the preparation of (R)-2-(7-4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[B]indol-3-yl)acetic acid and salts thereof
US9447041B2 (en) 2010-01-27 2016-09-20 Arena Pharmaceuticals, Inc. Processes for the preparation of (R)-2-(7-4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[B]indol-3-yl)acetic acid and salts thereof
US11566026B2 (en) 2016-12-22 2023-01-31 Incyte Corporation Heterocyclic compounds as immunomodulators
US11555015B2 (en) 2018-09-06 2023-01-17 Arena Pharmaceuticals, Inc. Compounds useful in the treatment of autoimmune and inflammatory disorders

Also Published As

Publication number Publication date
AU2005286727A1 (en) 2006-03-30
EP1793819A2 (en) 2007-06-13
CN101035528A (en) 2007-09-12
JP2008514611A (en) 2008-05-08
US20060063821A1 (en) 2006-03-23
CA2577413A1 (en) 2006-03-30
BRPI0515596A (en) 2008-07-29
US7250441B2 (en) 2007-07-31
WO2006034337A2 (en) 2006-03-30
MX2007003371A (en) 2007-05-07

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