WO2006023725A3 - FLUORESCENT pH DETECTOR SYSTEM AND RELATED METHODS - Google Patents

FLUORESCENT pH DETECTOR SYSTEM AND RELATED METHODS Download PDF

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Publication number
WO2006023725A3
WO2006023725A3 PCT/US2005/029559 US2005029559W WO2006023725A3 WO 2006023725 A3 WO2006023725 A3 WO 2006023725A3 US 2005029559 W US2005029559 W US 2005029559W WO 2006023725 A3 WO2006023725 A3 WO 2006023725A3
Authority
WO
WIPO (PCT)
Prior art keywords
fluorescent
substrate
detector
wavelengths
probe
Prior art date
Application number
PCT/US2005/029559
Other languages
French (fr)
Other versions
WO2006023725A2 (en
Inventor
Michael W Reed
Steven J Geelhood
Paul C Harris
Randy D Pfalzgraf
Original Assignee
Blood Cell Storage Inc
Michael W Reed
Steven J Geelhood
Paul C Harris
Randy D Pfalzgraf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Blood Cell Storage Inc, Michael W Reed, Steven J Geelhood, Paul C Harris, Randy D Pfalzgraf filed Critical Blood Cell Storage Inc
Priority to CA002577340A priority Critical patent/CA2577340A1/en
Priority to AU2005277258A priority patent/AU2005277258B2/en
Priority to JP2007528042A priority patent/JP5017113B2/en
Priority to EP05787826A priority patent/EP1787107A2/en
Priority to CN2005800339611A priority patent/CN101036046B/en
Publication of WO2006023725A2 publication Critical patent/WO2006023725A2/en
Publication of WO2006023725A3 publication Critical patent/WO2006023725A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G01N21/80—Indicating pH value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769—Measurement method of reaction-produced change in sensor
    • G01N2021/7786—Fluorescence

Abstract

Fluorescent pH detector and methods for measuring pH using the fluorescent ph detector. A method and a system for measuring a sample property such as pH or carbon dioxide concentration using a probe for delivering excitation light and receiving emission light at at least two wavelengths from a fluorescent species immobilised on a substrate. The probe is physically isolated for example by a window from the fluorescent species on the substrate. The light received at the first and second wavelengths is used to determine the sample property. In addition a tip can be provided over the substrate in such a way as to permit the analyte to contact the substrate for example via a semi permeable membrane.
PCT/US2005/029559 2004-08-19 2005-08-19 FLUORESCENT pH DETECTOR SYSTEM AND RELATED METHODS WO2006023725A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002577340A CA2577340A1 (en) 2004-08-19 2005-08-19 Fluorescent ph detector system and related methods
AU2005277258A AU2005277258B2 (en) 2004-08-19 2005-08-19 Fluorescent pH detector system and related methods
JP2007528042A JP5017113B2 (en) 2004-08-19 2005-08-19 Fluorescent pH detection system and related methods
EP05787826A EP1787107A2 (en) 2004-08-19 2005-08-19 FLUORESCENT pH DETECTOR SYSTEM AND RELATED METHODS
CN2005800339611A CN101036046B (en) 2004-08-19 2005-08-19 Fluorescent pH detector system and related methods

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US60268404P 2004-08-19 2004-08-19
US60/602,684 2004-08-19
US67439305P 2005-04-22 2005-04-22
US60/674,393 2005-04-22

Publications (2)

Publication Number Publication Date
WO2006023725A2 WO2006023725A2 (en) 2006-03-02
WO2006023725A3 true WO2006023725A3 (en) 2006-05-18

Family

ID=35385411

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/029559 WO2006023725A2 (en) 2004-08-19 2005-08-19 FLUORESCENT pH DETECTOR SYSTEM AND RELATED METHODS

Country Status (8)

Country Link
US (3) US7608460B2 (en)
EP (1) EP1787107A2 (en)
JP (1) JP5017113B2 (en)
KR (1) KR20070085230A (en)
CN (1) CN101036046B (en)
AU (1) AU2005277258B2 (en)
CA (1) CA2577340A1 (en)
WO (1) WO2006023725A2 (en)

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