WO2006014606A3 - Medical devices containing copolymers with graft copolymer endblocks for drug delivery - Google Patents

Medical devices containing copolymers with graft copolymer endblocks for drug delivery Download PDF

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Publication number
WO2006014606A3
WO2006014606A3 PCT/US2005/025518 US2005025518W WO2006014606A3 WO 2006014606 A3 WO2006014606 A3 WO 2006014606A3 US 2005025518 W US2005025518 W US 2005025518W WO 2006014606 A3 WO2006014606 A3 WO 2006014606A3
Authority
WO
WIPO (PCT)
Prior art keywords
graft copolymer
drug delivery
medical devices
devices containing
containing copolymers
Prior art date
Application number
PCT/US2005/025518
Other languages
French (fr)
Other versions
WO2006014606A2 (en
Inventor
Frederick H Strickler
Robert E Richard
Original Assignee
Boston Scient Scimed Inc
Frederick H Strickler
Robert E Richard
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Scient Scimed Inc, Frederick H Strickler, Robert E Richard filed Critical Boston Scient Scimed Inc
Priority to EP05775593A priority Critical patent/EP1771218A2/en
Priority to CA002574394A priority patent/CA2574394A1/en
Priority to JP2007522639A priority patent/JP5313498B2/en
Publication of WO2006014606A2 publication Critical patent/WO2006014606A2/en
Publication of WO2006014606A3 publication Critical patent/WO2006014606A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/04—Macromolecular materials
    • A61L29/041—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/048—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow

Abstract

The present invention provides a medical device comprising a release region and a therapeutic agent disposed within over beneath the release region, and the release region includes a copolymer comprising a low Tg block and at least one graft copolymer endblock having a main chain and a plurality of side chains.
PCT/US2005/025518 2004-07-19 2005-07-19 Medical devices containing copolymers with graft copolymer endblocks for drug delivery WO2006014606A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP05775593A EP1771218A2 (en) 2004-07-19 2005-07-19 Medical devices containing copolymers with graft copolymer endblocks for drug delivery
CA002574394A CA2574394A1 (en) 2004-07-19 2005-07-19 Medical devices containing copolymers with graft copolymer endblocks for drug delivery
JP2007522639A JP5313498B2 (en) 2004-07-19 2005-07-19 Medical device comprising a copolymer having a graft copolymer endblock for drug delivery

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/894,397 US7771740B2 (en) 2004-07-19 2004-07-19 Medical devices containing copolymers with graft copolymer endblocks for drug delivery
US10/894,397 2004-07-19

Publications (2)

Publication Number Publication Date
WO2006014606A2 WO2006014606A2 (en) 2006-02-09
WO2006014606A3 true WO2006014606A3 (en) 2006-04-06

Family

ID=35599709

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/025518 WO2006014606A2 (en) 2004-07-19 2005-07-19 Medical devices containing copolymers with graft copolymer endblocks for drug delivery

Country Status (5)

Country Link
US (1) US7771740B2 (en)
EP (1) EP1771218A2 (en)
JP (1) JP5313498B2 (en)
CA (1) CA2574394A1 (en)
WO (1) WO2006014606A2 (en)

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US6306166B1 (en) * 1997-08-13 2001-10-23 Scimed Life Systems, Inc. Loading and release of water-insoluble drugs
WO2004075943A1 (en) * 2003-02-28 2004-09-10 Biointeractions Ltd. Polymeric network system for medical devices and methods of use
EP1781264B1 (en) 2004-08-04 2013-07-24 Evonik Corporation Methods for manufacturing delivery devices and devices thereof
US8535702B2 (en) * 2005-02-01 2013-09-17 Boston Scientific Scimed, Inc. Medical devices having porous polymeric regions for controlled drug delivery and regulated biocompatibility
US8075906B2 (en) * 2005-02-01 2011-12-13 Boston Scientific Scimed, Inc. Medical devices having polymeric regions with copolymers containing hydrocarbon and heteroatom-containing monomeric species
US8367096B2 (en) * 2005-07-19 2013-02-05 Boston Scientific Scimed, Inc. Polymers having covalently bound therapeutic agents
US8663673B2 (en) * 2005-07-29 2014-03-04 Surmodics, Inc. Devices, articles, coatings, and methods for controlled active agent release or hemocompatibility
US8034874B2 (en) * 2005-11-23 2011-10-11 Boston Scientific Scimed, Inc. Medical devices having polymeric regions that contain fluorocarbon-containing block copolymers
US8092818B2 (en) * 2006-05-17 2012-01-10 Boston Scientific Scimed, Inc. Medical devices having bioactive surfaces
US7727541B2 (en) 2006-05-18 2010-06-01 Boston Scientific Scimed, Inc. Medical devices having polymeric regions based on vinyl ether block copolymers
US7914806B2 (en) 2006-06-01 2011-03-29 Boston Scientific Scimed, Inc. Medical devices having improved performance
BRPI0722412B8 (en) * 2006-07-03 2021-06-22 Hemoteq Ag use of a composition consisting of rapamycin or rapamycin and paclitaxel and balloon catheter
AU2007284002B2 (en) * 2006-08-18 2013-12-19 Commonwealth Scientific And Industrial Research Organisation Polymeric coatings and methods for forming them
US7897170B2 (en) 2006-08-25 2011-03-01 Boston Scientific Scimed, Inc. Medical devices having improved mechanical performance
WO2008027589A2 (en) * 2006-09-01 2008-03-06 The University Of Akron Arborescent polymers and process for making same
ES2409759T3 (en) * 2007-01-21 2013-06-27 Hemoteq Ag Medical product for the treatment of stenosis of the channels of the body and for the prevention of threatening stenosis
JP2010522023A (en) * 2007-03-20 2010-07-01 ボストン サイエンティフィック サイムド，インコーポレイテッド Urological medical device for releasing beneficial therapeutics to the prostate
US8202528B2 (en) * 2007-06-05 2012-06-19 Abbott Cardiovascular Systems Inc. Implantable medical devices with elastomeric block copolymer coatings
US9192697B2 (en) * 2007-07-03 2015-11-24 Hemoteq Ag Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
US8124601B2 (en) * 2007-11-21 2012-02-28 Bristol-Myers Squibb Company Compounds for the treatment of Hepatitis C
EP2222281B1 (en) 2007-12-20 2018-12-05 Evonik Corporation Process for preparing microparticles having a low residual solvent volume
US20090208553A1 (en) * 2008-02-15 2009-08-20 University Of Southern Mississippi Monomers and Polymers with Covalently - Attached Active Ingredients
JP2011518247A (en) * 2008-04-16 2011-06-23 ボストン サイエンティフィック サイムド，インコーポレイテッド Medical implant coating compositions based on fluorinated polymers
CN102015888B (en) * 2008-04-24 2012-11-07 普立万公司 Heat resistant polylactic acid compounds
EP2331018B1 (en) * 2008-06-20 2021-11-17 Coloplast A/S Intraluminal device
EP2451496B1 (en) 2009-07-10 2015-07-22 Boston Scientific Scimed, Inc. Use of nanocrystals for a drug delivery balloon
EP2962707B1 (en) 2009-07-17 2019-07-24 Boston Scientific Scimed, Inc. Drug delivery balloons with improved crystal size and density
BR112012006443A2 (en) * 2009-09-22 2017-07-25 Evonik Degussa Corp implant devices that feature variable loading configurations of bioactive agents
EP2611476B1 (en) 2010-09-02 2016-08-10 Boston Scientific Scimed, Inc. Coating process for drug delivery balloons using heat-induced rewrap memory
US20120143347A1 (en) * 2010-12-03 2012-06-07 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Elastomeric, Polymeric Bone Engineering and Regeneration Compositions and Methods of Making
US8669360B2 (en) 2011-08-05 2014-03-11 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form
US9056152B2 (en) 2011-08-25 2015-06-16 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
JP6171227B2 (en) * 2012-02-23 2017-08-02 株式会社リュージュサイエンス Cationic polysaccharide copolymer anticancer drug delivery system
EP2833837B1 (en) * 2012-04-06 2023-03-29 Merlin MD PTE Ltd. Devices for treating an aneurysm

Citations (5)

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Publication number Priority date Publication date Assignee Title
EP0389094A2 (en) * 1989-03-09 1990-09-26 Morton International, Inc. Adhesive blend of polyolefins and grafted block copolymer of polystyrene
US5378760A (en) * 1993-11-10 1995-01-03 Shell Oil Company Blends of polystyrene/polypropylene grafted polymers and elastomeric tetrablock copolymers
US5738902A (en) * 1994-04-15 1998-04-14 Cobe Laboratories, Inc. Biocompatible coated article
US5814329A (en) * 1996-11-12 1998-09-29 Polytherapeutics, Inc. Hydrophilic polystyrene graft copolymer vehicle for intravaginal administration of pharmacologically active agents
US20020107330A1 (en) * 2000-12-12 2002-08-08 Leonard Pinchuk Drug delivery compositions and medical devices containing block copolymer

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DE3643459A1 (en) * 1986-12-19 1988-06-23 Bayer Ag POLYETHERSILOXANE - GRAFT POLYMERISATE
US5919870A (en) * 1995-07-31 1999-07-06 Fmc Corporation Functional telechelic star polymers
US5942243A (en) * 1996-11-12 1999-08-24 Polytherapeutics, Inc. Mucoadhesive compositions for administration of biologically active agents to animal tissue
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US20020045706A1 (en) * 1998-09-22 2002-04-18 Houston Michael R. Biomedical molding materials from semi-solid precursors
US6730313B2 (en) * 2000-01-25 2004-05-04 Edwards Lifesciences Corporation Delivery systems for periadventitial delivery for treatment of restenosis and anastomotic intimal hyperplasia
US20020082679A1 (en) * 2000-12-22 2002-06-27 Avantec Vascular Corporation Delivery or therapeutic capable agents
US7939094B2 (en) 2002-06-19 2011-05-10 Boston Scientific Scimed, Inc. Multiphase polymeric drug release region
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US7364585B2 (en) * 2003-08-11 2008-04-29 Boston Scientific Scimed, Inc. Medical devices comprising drug-loaded capsules for localized drug delivery

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0389094A2 (en) * 1989-03-09 1990-09-26 Morton International, Inc. Adhesive blend of polyolefins and grafted block copolymer of polystyrene
US5378760A (en) * 1993-11-10 1995-01-03 Shell Oil Company Blends of polystyrene/polypropylene grafted polymers and elastomeric tetrablock copolymers
US5738902A (en) * 1994-04-15 1998-04-14 Cobe Laboratories, Inc. Biocompatible coated article
US5814329A (en) * 1996-11-12 1998-09-29 Polytherapeutics, Inc. Hydrophilic polystyrene graft copolymer vehicle for intravaginal administration of pharmacologically active agents
US20020107330A1 (en) * 2000-12-12 2002-08-08 Leonard Pinchuk Drug delivery compositions and medical devices containing block copolymer

Also Published As

Publication number Publication date
CA2574394A1 (en) 2006-02-09
US7771740B2 (en) 2010-08-10
US20060013854A1 (en) 2006-01-19
EP1771218A2 (en) 2007-04-11
JP2008506503A (en) 2008-03-06
JP5313498B2 (en) 2013-10-09
WO2006014606A2 (en) 2006-02-09

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