WO2006007435A1 - Sulfamate and sulfamide derivatives for the treatment of epilepsy and related disorders - Google Patents
Sulfamate and sulfamide derivatives for the treatment of epilepsy and related disorders Download PDFInfo
- Publication number
- WO2006007435A1 WO2006007435A1 PCT/US2005/021513 US2005021513W WO2006007435A1 WO 2006007435 A1 WO2006007435 A1 WO 2006007435A1 US 2005021513 W US2005021513 W US 2005021513W WO 2006007435 A1 WO2006007435 A1 WO 2006007435A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- benzo
- compound
- dihydro
- dioxinyl
- group
- Prior art date
Links
- 0 C1Oc2ccccc2OC*1 Chemical compound C1Oc2ccccc2OC*1 0.000 description 4
- KGALVPYTKQIBAA-UHFFFAOYSA-N CC1Oc2ccccc2CC1 Chemical compound CC1Oc2ccccc2CC1 KGALVPYTKQIBAA-UHFFFAOYSA-N 0.000 description 2
- LSZMXZKYYCESMC-UHFFFAOYSA-N CC1COc2ccccc2OC1 Chemical compound CC1COc2ccccc2OC1 LSZMXZKYYCESMC-UHFFFAOYSA-N 0.000 description 1
- CSRUYHPJWRTHKB-UHFFFAOYSA-N CNC1Oc2ccccc2CC1 Chemical compound CNC1Oc2ccccc2CC1 CSRUYHPJWRTHKB-UHFFFAOYSA-N 0.000 description 1
- MVTNKPIKGGLNDR-UHFFFAOYSA-N NS(NCC1Oc2ccccc2CC1)(=O)=O Chemical compound NS(NCC1Oc2ccccc2CC1)(=O)=O MVTNKPIKGGLNDR-UHFFFAOYSA-N 0.000 description 1
- WRANTHLMINRHTR-SECBINFHSA-N N[C@@H]1Oc2ccccc2CC1 Chemical compound N[C@@H]1Oc2ccccc2CC1 WRANTHLMINRHTR-SECBINFHSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
- C07D321/02—Seven-membered rings
- C07D321/10—Seven-membered rings condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Pyrane Compounds (AREA)
Abstract
Description
Claims
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007516788A JP4884378B2 (en) | 2004-06-16 | 2005-06-16 | Sulfamate and sulfamide derivatives for treating epilepsy and related diseases |
MXPA06014934A MXPA06014934A (en) | 2004-06-16 | 2005-06-16 | Sulfamate and sulfamide derivatives for the treatment of epilepsy and related disorders. |
EP05763399.2A EP1768970B1 (en) | 2004-06-16 | 2005-06-16 | Sulfamate and sulfamide derivatives for the treatment of epilepsy and related disorders |
ES05763399.2T ES2573844T3 (en) | 2004-06-16 | 2005-06-16 | Sulfamide and sulfamate derivatives for the treatment of epilepsy and related disorders |
NZ552056A NZ552056A (en) | 2004-06-16 | 2005-06-16 | Sulfamate and sulfamide derivatives for the treatment of epilepsy and related disorders |
UAA200613517A UA91680C2 (en) | 2004-06-16 | 2005-06-16 | Sulfamate and sulfamide derivatives for the treatment of epilepsy and related disorders |
CA2570606A CA2570606C (en) | 2004-06-16 | 2005-06-16 | Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders |
KR1020077000922A KR101198831B1 (en) | 2004-06-16 | 2005-06-16 | Sulfamate and sulfamide derivatives for the treatment of epilepsy and related disorders |
EA200700035A EA013685B1 (en) | 2004-06-16 | 2005-06-16 | Sulfamate and sulfamide derivatives for the treatment of epileppsy and related disorders |
BRPI0512242-2A BRPI0512242A (en) | 2004-06-16 | 2005-06-16 | sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders |
CN2005800274918A CN101006072B (en) | 2004-06-16 | 2005-06-16 | Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders |
AU2005262496A AU2005262496B2 (en) | 2004-06-16 | 2005-06-16 | Sulfamate and sulfamide derivatives for the treatment of epilepsy and related disorders |
IL180108A IL180108A (en) | 2004-06-16 | 2006-12-14 | Sulfamate and sulfamide derivatives, pharmaceutical compositions containing them, processes for their preparation and uses thereof |
NO20070081A NO20070081L (en) | 2004-06-16 | 2007-01-05 | Sulfamate and sulfamide derivatives for the treatment of epilepsy and related diseases |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58017804P | 2004-06-16 | 2004-06-16 | |
US60/580,178 | 2004-06-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2006007435A1 true WO2006007435A1 (en) | 2006-01-19 |
Family
ID=34972935
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2005/021513 WO2006007435A1 (en) | 2004-06-16 | 2005-06-16 | Sulfamate and sulfamide derivatives for the treatment of epilepsy and related disorders |
Country Status (22)
Country | Link |
---|---|
US (1) | US8084490B2 (en) |
EP (1) | EP1768970B1 (en) |
JP (2) | JP4884378B2 (en) |
CN (1) | CN101006072B (en) |
AR (2) | AR049398A1 (en) |
AU (1) | AU2005262496B2 (en) |
BR (1) | BRPI0512242A (en) |
CA (1) | CA2570606C (en) |
CR (1) | CR8858A (en) |
EA (1) | EA013685B1 (en) |
EC (1) | ECSP067093A (en) |
ES (1) | ES2573844T3 (en) |
IL (1) | IL180108A (en) |
MX (1) | MXPA06014934A (en) |
MY (1) | MY147767A (en) |
NI (1) | NI200600306A (en) |
NO (1) | NO20070081L (en) |
NZ (1) | NZ552056A (en) |
TW (1) | TWI361691B (en) |
UA (1) | UA91680C2 (en) |
WO (1) | WO2006007435A1 (en) |
ZA (1) | ZA200700430B (en) |
Cited By (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007075751A1 (en) * | 2005-12-19 | 2007-07-05 | Janssen Pharmaceutica N.V. | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of depression |
WO2007075752A1 (en) * | 2005-12-19 | 2007-07-05 | Janssen Pharmaceutica N.V. | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of pain |
WO2007092086A2 (en) * | 2005-12-19 | 2007-08-16 | Janssen Pharmaceutica N.V. | Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels |
WO2007075834A3 (en) * | 2005-12-19 | 2007-08-16 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of epilepsy |
WO2007095618A3 (en) * | 2006-02-15 | 2007-10-11 | Janssen Pharmaceutica Nv | Benzo-fused heterocycle sulfamide derivatives for the treatment of migraine |
WO2007137167A2 (en) * | 2006-05-19 | 2007-11-29 | Janssen Pharmaceutica N.V. | Co-therapy for the treatment of epilepsy |
WO2009120192A2 (en) * | 2008-03-26 | 2009-10-01 | Jassen Pharmaceutica, N.V. | Process for the preparation of benzo-fused heteroaryl derivatives |
WO2009120191A1 (en) * | 2008-03-26 | 2009-10-01 | Janssen Pharmaceutica N.V. | Process for the preparation of benzo-fused heteroaryl sulfamates and crystalline form of n- ( ( (2s) -6-chloro-2,3-dihydro-l,4-benzodioxin-2-yl) methyl-sulfamide |
WO2010011548A1 (en) * | 2008-07-22 | 2010-01-28 | Janssen Pharmaceutica Nv | Novel substituted sulfamide derivatives |
US8084490B2 (en) | 2004-06-16 | 2011-12-27 | Janssen Pharmaceutica N.V. | Sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders |
US8283478B2 (en) | 2005-05-20 | 2012-10-09 | Janssen Pharmaceutica Nv | Process for preparation of sulfamide derivatives |
US8492372B2 (en) | 2008-04-29 | 2013-07-23 | Integrated Research Laboratories Sweden Ab | Modulators of dopamine neurotransmission |
US8524766B2 (en) | 2008-04-29 | 2013-09-03 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Modulators of dopamine neurotransmission |
CN101374513B (en) * | 2005-12-19 | 2013-11-27 | 詹森药业有限公司 | Use of benzo-fused heterocycle sulfamide derivatives for preparing drugs of treatment of epilepsy |
US8609849B1 (en) | 2010-11-30 | 2013-12-17 | Fox Chase Chemical Diversity Center, Inc. | Hydroxylated sulfamides exhibiting neuroprotective action and their method of use |
US8691867B2 (en) | 2005-12-19 | 2014-04-08 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction |
US8809385B2 (en) | 2008-06-23 | 2014-08-19 | Janssen Pharmaceutica Nv | Crystalline form of (2S)-(-)-N-(6-chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-sulfamide |
US8937096B2 (en) | 2005-12-19 | 2015-01-20 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder |
USRE48162E1 (en) | 2015-09-17 | 2020-08-18 | Traeger Pellet Grills, Llc | Grill handle towel bar assembly |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR049646A1 (en) * | 2004-06-16 | 2006-08-23 | Janssen Pharmaceutica Nv | USEFUL SULFAMATE AND SULFAMIDE DERIVATIVES FOR THE TREATMENT OF EPILEPSY AND RELATED DISORDERS |
MY142329A (en) * | 2004-08-24 | 2010-11-15 | Janssen Pharmaceutica Nv | Novel benzo-fused heteroaryl sulfamide derivatives useful as anticonvulsant agents. |
AR058389A1 (en) * | 2005-12-19 | 2008-01-30 | Janssen Pharmaceutica Nv | USE OF SULFAMIDE BENZO-FUSED HETEROCICLIC DERIVATIVES FOR THE TREATMENT OF OBESITY |
US20090182141A1 (en) * | 2008-01-07 | 2009-07-16 | Ahmed Abdel-Magid | Process for the preparation of sulfamide derivatives |
US20090247617A1 (en) * | 2008-03-26 | 2009-10-01 | Abdel-Magid Ahmed F | Process for the preparation of benzo-fused heteroaryl sulfamates |
US20090247616A1 (en) * | 2008-03-26 | 2009-10-01 | Smith-Swintosky Virginia L | Use of benzo-fused heterocyle sulfamide derivatives for the treatment of anxiety |
WO2009133109A1 (en) * | 2008-04-29 | 2009-11-05 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Modulators of dopamine neurotransmission |
EP2491014A1 (en) * | 2009-10-21 | 2012-08-29 | Bayer Pharma Aktiengesellschaft | Substituted halophenoxybenzamide derivatives |
WO2013045681A1 (en) | 2011-09-29 | 2013-04-04 | Janssen Pharmaceutica Nv | Improved process for the preparation of sulfamide derivatives |
EP2760851A1 (en) * | 2011-09-29 | 2014-08-06 | Janssen Pharmaceutica, N.V. | Process for the preparation of sulfamide derivatives |
WO2014140220A1 (en) | 2013-03-13 | 2014-09-18 | Janssen Pharmaceutica, N.V. | Process for the preparation of (2,3-dihydro-benzo[b][1,4]dioxin-2-yl) methanol derivatives |
EP3079686B1 (en) * | 2013-12-12 | 2018-10-24 | Bio-Pharm Solutions Co., Ltd. | Sulfamate derivative compound for use in preventing or treating epilepsy |
WO2015088273A1 (en) | 2013-12-12 | 2015-06-18 | Bio-Pharm Solutions, Co., Ltd. | Sulfamate derivative compounds for use in treating or alleviating pain |
KR101758583B1 (en) | 2013-12-12 | 2017-07-14 | (주)바이오팜솔루션즈 | Sulfamate derivative compounds for use in treating or alleviating pain |
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AU2005262496B2 (en) | 2011-10-20 |
US8084490B2 (en) | 2011-12-27 |
NZ552056A (en) | 2010-08-27 |
NI200600306A (en) | 2007-11-27 |
TW200611702A (en) | 2006-04-16 |
AR091400A2 (en) | 2015-02-04 |
AR049398A1 (en) | 2006-07-26 |
IL180108A (en) | 2015-10-29 |
US20060041008A1 (en) | 2006-02-23 |
JP2011246472A (en) | 2011-12-08 |
ES2573844T3 (en) | 2016-06-10 |
MY147767A (en) | 2013-01-31 |
CA2570606A1 (en) | 2006-01-19 |
EA013685B1 (en) | 2010-06-30 |
EP1768970A1 (en) | 2007-04-04 |
EP1768970B1 (en) | 2016-03-09 |
CN101006072A (en) | 2007-07-25 |
JP5416740B2 (en) | 2014-02-12 |
CN101006072B (en) | 2011-10-19 |
MXPA06014934A (en) | 2007-08-21 |
JP4884378B2 (en) | 2012-02-29 |
CR8858A (en) | 2009-01-14 |
AU2005262496A1 (en) | 2006-01-19 |
TWI361691B (en) | 2012-04-11 |
UA91680C2 (en) | 2010-08-25 |
EA200700035A1 (en) | 2007-06-29 |
JP2008503487A (en) | 2008-02-07 |
IL180108A0 (en) | 2007-05-15 |
BRPI0512242A (en) | 2008-02-19 |
CA2570606C (en) | 2013-04-30 |
ECSP067093A (en) | 2007-01-26 |
NO20070081L (en) | 2007-02-26 |
ZA200700430B (en) | 2008-07-30 |
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