WO2006006153A1 - Device and method for non-invasive optical measurements - Google Patents
Device and method for non-invasive optical measurements Download PDFInfo
- Publication number
- WO2006006153A1 WO2006006153A1 PCT/IL2005/000720 IL2005000720W WO2006006153A1 WO 2006006153 A1 WO2006006153 A1 WO 2006006153A1 IL 2005000720 W IL2005000720 W IL 2005000720W WO 2006006153 A1 WO2006006153 A1 WO 2006006153A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- light
- diffuser
- body portion
- detector unit
- assembly
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0048—Detecting, measuring or recording by applying mechanical forces or stimuli
- A61B5/0053—Detecting, measuring or recording by applying mechanical forces or stimuli by applying pressure, e.g. compression, indentation, palpation, grasping, gauging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14552—Details of sensors specially adapted therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6813—Specially adapted to be attached to a specific body part
- A61B5/6825—Hand
- A61B5/6826—Finger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/683—Means for maintaining contact with the body
- A61B5/6838—Clamps or clips
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
Definitions
- This invention relates to a device and method for non-invasive optical measurements on a human body, which is particularly useful for measuring blood-related parameters.
- Non-invasive (in vivo) methods for measuring various blood-related parameters have become very popular due to the fact that these measurements, in distinction to invasive ones, do not involve the physical withdrawal of a blood sample from the patient's body.
- Optical monitoring techniques of the kind specified utilize the detection of light transmitted or reflected from the location on the patient's body under measurement, and are based on spectrophotometric measurements enabling the indication of the presence of various blood constituents based on known spectral behaviors of these constituents.
- the two main challenges, that any non-invasive optical method has to deal with, are as follows: (1) the low signal-to-noise ratio, and, (2) the large variability of individual parameters influencing the signal of concrete patients.
- Most of these techniques utilize a measurement optical device or probe, designed in a manner to be attached to the patient's finger, which includes an optical assembly for irradiating the finger with light and detecting its light response.
- the conventional devices of the kind specified such as a pulse oximeter, which is the generally accepted standard of everyday clinical practice, provide for measuring enhanced optical pulsatile signals caused by the changes in the volume of a blood flowing through a fleshy medium (e.g., finger).
- This technique utilizes the condition of the "artificial blood kinetics" rather than the natural blood kinetics taking place when the state of blood cessation is not achieved.
- a condition of the artificial kinetics is achieved with the optical characteristics of the blood associated with the light response being different from those at the natural blood kinetics.
- the scattering properties of blood depend on the size and shape of scatterers (aggregates).
- time changes of the light response at the condition of artificial kinetics depend on the changes in the shape and average size of the scattering centers in the medium, i.e., red blood cells (RBC) aggregation (Rouleaux effect).
- the accuracy (i.e., signal-to-noise ratio) of the technique based on the artificial kinetics as well as selectivity of the optical measurements can be substantially better when compared with those based on measurements of the blood parameters at natural kinetics.
- the present invention provides for detecting the optical response formed by both light reflected from the illuminated body portion and light transmitted therethrough.
- reflected light and “transmitted light” used herein signify light components detected at, respectively, the same side of the body portion at which the illumination is applied and the opposite side, and actually both light portions include light scattered from the illuminated region.
- the present invention utilizes redirecting reflections of light on its way towards the region of interest (i.e., blood vessel) back to the region of interest. This is implemented using a diffuser accommodated in the optical path of light reflected from the body portion under measurements. Due to the provision of a diffuser, illuminating light that is reflected from the skin and bones is "collected” and directed back to the region of interest. The use of a diffuser stabilizes both the reflected and transmitted responses of the illuminated region, and causes a stable increase of the reflected signal. - A -
- an optical measurement device for use in non-invasive measurements on a patient's body, the device comprising:
- an illumination assembly configured and operable to generate illuminating light of a predetermined wavelength range
- a detection assembly comprising a first detector unit for detecting a first light signal transmitted through an illuminated body portion and generating first measured data indicative of the detected transmitted light, and a second detector unit for detecting a second light signal reflected from the illuminated body portion and generating second measured data indicative of the detected reflected light;
- a light directing assembly comprising a light diffuser for scattering back light incident thereto, to thereby direct the illuminating light or the light coming from the body portion back towards the body portion, thereby increasing amount of light reaching a region of interest inside the body portion and thus maximizing homogeneity of the first and second detected light signals.
- the light diffuser extends along at least a part of the body portion at the illuminated side thereof.
- the diffuser may be formed with an optical window for allowing passage of light from the illumination assembly towards the body portion; and/or with an optical window for allowing light passage from the body portion to the second detector unit.
- the diffuser may for example be, but not limited to, of dimensions of about 20x24mm, and may be made of a material such as PVC, Polyurethan.
- the device may be configured for operating in the occlusion-release mode.
- the device includes a pressurizing assembly operable for applying an over-systolic pressure to the patient's body so as to create a condition of artificial blood kinetics in the region of interest and maintain this condition for a certain time period.
- the pressurizing assembly may be configured and operable for applying a secondary controllably varying under- or over- systolic pressure to the body within the region of interest, so as to alter said condition of artificial blood kinetics over a predetermined time interval within said certain time period, to thereby modulate the amount of blood under measurements.
- the device is configured as finger holder. This may be a clip member for enclosing the body portion between its upper and lower arms, one of the upper and lower arms carrying the illumination assembly, the diffuser and the second detector unit, and the other arm carrying the first detector unit. Alternatively, this may be a ring-like device.
- such a ring may be designed as two U-shaped semi-ring portions, one carrying the illumination assembly, the diffuser and the second detector unit, and the other carrying the first detector unit.
- the pressurizing assembly is associated with one of the U-shaped portions being in the form of an air cushion on the inner side of said portion, in which case the air cushion is made of a light diffusing material, thereby presenting said diffuser.
- a method for use in non-invasive optical measurements on a patient's body utilizing illumination of a region of interest inside the body portion and detection of light response of the region of interest, the method comprising: - collecting light coming from the body portion and directing at least a part of the collected light back to the body portion;
- Fig. 1 is a schematic illustration of a measurement device of the present invention utilizing a diffuser
- Fig. 2 illustrates a measurement device according to a specific example of the invention
- Figs. 3A and 3B illustrate the result of typical optical measurements without a diffuser
- Figs. 4A and 4B illustrate the results of measurements utilizing the device of the present invention with a diffuser.
- FIG. 1 there is schematically illustrated an optical measurement device 10 of the present invention for use in non-invasive measurements on a patient's body, e.g., patient's finger F.
- the device 10 includes an illumination assembly 12; a detection assembly 14; and a light directing assembly 16.
- a control unit 20 is provided for operating the illumination and detection assemblies and for receiving and processing measured data coming from the detection assembly.
- the illumination assembly 12 is accommodated so as to direct illuminating light towards the finger F.
- the illumination assembly 12 may utilize one or more light emitting elements, e.g., LED(s).
- a matrix of LEDs is used.
- the illumination assembly 12 is designed for generating light of different wavelengths (at least two different wavelengths), which can be implemented by using different light emitting elements or a single broadband illuminator.
- the light detection assembly 14 includes a first detector unit 14A accommodated substantially opposite the illumination assembly 12 for detecting a first light signal transmitted through the finger F and generating first measured data MD 1 indicative thereof, and includes a second detector unit 14B accommodated adjacent to the illumination assembly 12 for detecting a second light signal reflected from the inside of the finger and generating second measured data MD 2 indicative thereof.
- Each of the detector units 14A and 14B includes one or more frequency selective detector (e.g., a matrix of detectors), such as spectrophotometer and/or photodiode typically equipped with frequency selective filter and amplifying means, which are not specifically shown.
- the light emitting element(s) as well as a detectors may be accommodated aside the finger in which case light is directed towards and away from the respective locations on the finger via fibers.
- the light directing assembly 16 includes a diffuser 18 accommodated proximate the finger portion under measurements at the illuminating side, so as to collect light reflections from the finger and reflect them back towards the inside of the finger, thereby increasing the amount of light reaching the blood vessel in the finger.
- the diffuser 18 extends along the finger portion and is formed with an optical window 19 so as to allow passage of illuminating light towards the finger.
- the reflection-mode deflector 14B may be accommodated adjacent to the diffuser slightly aside thereof to detect reflected light propagating along axes that do not intersect with the diffuser, or alternatively, may be vertically aligned with the diffuser in which case the diffuser 18 is formed with an additional optical window 19 allowing passage of light therethrough towards the detector 14B.
- the diffuser is made of a semi-transparent material, capable to diffuse visible and near-infrared light.
- the attenuation coefficient and spatial distribution of diffused light has to be a very weak function of wavelength in the operating spectral region.
- the diffuser has a certain minimal size so as to ensure that the majority of the body surface (e.g., surface of the patient's finger provides efficient return of reflected light to the examined media (e.g., about 48mm 2 , e.g., dimensions of about 20x24mm).
- the diffuser thus "collects" light that is typically reflected from the skin and bone while propagating towards the blood vessel and reflects this light back to the blood vessel to thereby increase the amount of light reaching the blood vessel.
- the device 10 may be designed as a finger holder in the form of a clip member attachable to a patient's finger so as to enclose a finger portion between upper and lower arms HA and HB of the clip member (similar to the conventionally used pulse oximeter).
- One of the upper and lower arms - lower arm HB in the present example carries the illumination assembly 12, the diffuser 18 and the reflection-mode detector unit 14B 5 and the other arm HA carries the transmission-mode detector unit 14A.
- the diffuser 18 extends along at least a part of the inner surface of the lower arm HB of the clip member.
- the measurement device 10 is configured for operating with the so-called "occlusion-release mode".
- the device 10 includes a pressurizing assembly 22 having an occluder arrangement (occlusion cuff) 24 associated with a drive mechanism 25 operable by the control unit 20 for applying an over-systolic pressure to the patient's finger F to create a state of blood flow cessation in the vicinity of a measurement location ML (where optical measurements are applied).
- the pressurizing assembly 22 may also be operable to apply a secondary controllably varying under- or over-systolic pressure to the measurement location ML, which in the present example of Fig. 1 is implemented using another cuff 26 associated with a drive mechanism 27.
- the primary over-systolic pressure is applied to a finger location L 1 upstream of the measurement location ML with respect to the blood flow direction, and the variable secondary pressure is periodically applied to a location L 2 in the closest vicinity of the measurement location while in the state of temporarily blood flow cessation, thus implementing the so-called "multiple- occlusion" mode.
- the principles of the present invention consisting of using a diffuser and detecting both light transmitted through and reflected from the region of interest, can advantageously be used in measurements based on detecting a pulsatile signal of a light response of the medium (such as in the conventional pulse oximeter), and in the occlusion-based measurements where a non-pulsatile signal is detected. This will be described further below with reference to Figs. 3A-3B and 4A-4B.
- the parameter of interest e.g., glucose concentration in blood
- the parameter of interest may be calculated independently from transmission and reflection signals.
- the measurement results are defined as an outlier.
- Fig. 2 illustrates a specific but not limiting example of a measurement device 100 of the present invention.
- the device 100 is designed like a ring, formed by two portions HlA and HlB each of a substantially U-shaped cross-section arranged with respect to each other for enclosing and holding therebetween a portion of the patient's finger (not shown here).
- the U-shape parts 111 A and 11 IB are made of a rigid or semi-rigid material, such as metal or plastic. In the cross-section, these U-shape parts can, for example, be of semi-circle or semi-oval forms.
- the parts HlA and HlB can partially overlap over a predetermined distance.
- the measurement device (probe) 100 comprises an illumination assembly (not shown) mounted on a holding frame 112 associated with the semi-ring HlB; a light detection assembly including a transmission-mode detector unit (not shown) mounted on a holding frame 114A associated with the semi-ring HlA so as to be substantially opposite the illumination assembly, and a reflection-mode detector unit (not shown) mounted on the semi-ring 11 IB; and a diffuser 118 located on the inner surface of the semi-ring HlB.
- the illumination assembly can include a plurality of light sources (e.g., LEDs) associated with a suitable drive mechanism (not shown) operated by a control unit, or a single broad band illuminator.
- the light source (or multiple light sources) radiates the measurement location of the finger through an aperture (optical window) 119 in the diffuser 118.
- another aperture 121 is provided in the diffuser 118 to allow passage of light from the illuminated region to the reflection-mode detector. It should, however, be understood that the provision of this aperture is optional since the reflection-mode deflector may be accommodated adjacent to the diffuser slightly aside thereof to detect reflected light propagating along axes that do not intersect with the diffuser.
- the diffuser may be a separate element.
- the diffuser may be configured to be put onto a finger, so as to be located between the finger and the illumination/detection arrangement of the measurement device.
- the diffuser may be in the form of a thin elastic cover for wrapping at least a part of the body portion (e.g., finger), and configured to enable optical measurements therethrough.
- the diffuser may be formed with an optical windows, which when the device is put in operation is aligned with the optical path of illuminating light, and possibly also including an additional optical window aligned with the reflection mode detector.
- the device 100 further includes a pressurizing assembly that includes an air cushion 124 associated with a drive mechanism
- the cushion 124 is made of a light diffusing material thus presenting the diffuser 118.
- a locking device 126 further fixes the parts HlA and 11 IB to thereby apply a certain preliminary pressure to start the measurement procedure.
- the locking device may be implemented by any suitable known means (e.g., including a teeth arrangement and a spring assembly) and is aimed at preventing the opening of the ring-like probe.
- the cushion 124 which in the present example is associated with the lower semi-ring 11 IB, is operated to press the finger to the upper semi-ring 111 A to thereby apply an over-systolic pressure (e.g., 220- 250mmHg) and create a blood flow cessation in the finger.
- a variable over-systolic secondary pressure is supplied through the cushion 124.
- the primary over-systolic pressure as well as the secondary pressure is applied to the same location on the finger via the same pressurizing assembly (cushion 124).
- Figs. 3A-3B and 4A-4B showing experimental results: Figs. 3 A and 3B illustrate the results of measurements with no diffuser and Figs. 4A and 4B illustrate the same with the diffuser-based device of the present invention.
- FIG. 3A shows the time variation of a detected light response of a measurement location inside a patient's finger.
- the finger is illuminated with 720nm light, and light reflected from the finger is measured.
- a graph G 1 has a pulsatile- signal part L 1 measured during a lOOsec time period prior to the application of an over-systolic pressure, and a non-pulsatile part IZ 1 continuously measured after the application of such pressure. Both the pulsatile and non-pulsatile reflected signals decrease during the measurements.
- the finger is illuminated with 720nm light, and time variations of light reflected from the finger Gi and that of light transmitted through the finger G 2 are measured.
- Measured reflected signal Gi has an initial pulsatile signal part Li and a further non-pulsatile signal part L'i resulting from the occlusion; and measured transmitted signal has initial pulsatile signal part L 2 and a further non-pulsatile signal part L' 2 .
- the reflection occlusion-signal L'i decreases, and transmission occlusion-signal increases with time.
- Figs. 4A and 4B show the measurements with the diffuser for, respectively, reflection mode, and both reflection and transmission modes. As shown, when using the diffuser, all the signal parts increase during the measurements.
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05758928.5A EP1773183B1 (en) | 2004-07-08 | 2005-07-06 | Device and method for non-invasive optical measurements |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/885,885 US7313425B2 (en) | 2004-07-08 | 2004-07-08 | Device and method for non-invasive optical measurements |
US10/885,885 | 2004-07-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2006006153A1 true WO2006006153A1 (en) | 2006-01-19 |
Family
ID=34980181
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IL2005/000720 WO2006006153A1 (en) | 2004-07-08 | 2005-07-06 | Device and method for non-invasive optical measurements |
Country Status (3)
Country | Link |
---|---|
US (1) | US7313425B2 (en) |
EP (1) | EP1773183B1 (en) |
WO (1) | WO2006006153A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010115621A2 (en) | 2009-04-11 | 2010-10-14 | Fresenius Medical Care Deutschland Gmbh | Device and method for measuring a blood constituent in blood for an extracorporeal blood treatment device |
Families Citing this family (153)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6391005B1 (en) | 1998-03-30 | 2002-05-21 | Agilent Technologies, Inc. | Apparatus and method for penetration with shaft having a sensor for sensing penetration depth |
US8641644B2 (en) | 2000-11-21 | 2014-02-04 | Sanofi-Aventis Deutschland Gmbh | Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means |
US9226699B2 (en) | 2002-04-19 | 2016-01-05 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling module with a continuous compression tissue interface surface |
US7025774B2 (en) | 2001-06-12 | 2006-04-11 | Pelikan Technologies, Inc. | Tissue penetration device |
US8337419B2 (en) | 2002-04-19 | 2012-12-25 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US9427532B2 (en) | 2001-06-12 | 2016-08-30 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
ATE485766T1 (en) | 2001-06-12 | 2010-11-15 | Pelikan Technologies Inc | ELECTRICAL ACTUATING ELEMENT FOR A LANCET |
WO2002100254A2 (en) | 2001-06-12 | 2002-12-19 | Pelikan Technologies, Inc. | Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge |
US7316700B2 (en) | 2001-06-12 | 2008-01-08 | Pelikan Technologies, Inc. | Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties |
US9795747B2 (en) | 2010-06-02 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
US7344507B2 (en) | 2002-04-19 | 2008-03-18 | Pelikan Technologies, Inc. | Method and apparatus for lancet actuation |
US7981056B2 (en) | 2002-04-19 | 2011-07-19 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
US7331931B2 (en) | 2002-04-19 | 2008-02-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7674232B2 (en) | 2002-04-19 | 2010-03-09 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7976476B2 (en) | 2002-04-19 | 2011-07-12 | Pelikan Technologies, Inc. | Device and method for variable speed lancet |
US8702624B2 (en) | 2006-09-29 | 2014-04-22 | Sanofi-Aventis Deutschland Gmbh | Analyte measurement device with a single shot actuator |
US7909778B2 (en) | 2002-04-19 | 2011-03-22 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US9795334B2 (en) | 2002-04-19 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US9248267B2 (en) | 2002-04-19 | 2016-02-02 | Sanofi-Aventis Deustchland Gmbh | Tissue penetration device |
US7901362B2 (en) | 2002-04-19 | 2011-03-08 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7547287B2 (en) | 2002-04-19 | 2009-06-16 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8221334B2 (en) | 2002-04-19 | 2012-07-17 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7491178B2 (en) | 2002-04-19 | 2009-02-17 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7297122B2 (en) | 2002-04-19 | 2007-11-20 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7232451B2 (en) | 2002-04-19 | 2007-06-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8579831B2 (en) | 2002-04-19 | 2013-11-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US8360992B2 (en) | 2002-04-19 | 2013-01-29 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7892183B2 (en) | 2002-04-19 | 2011-02-22 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
US7892185B2 (en) | 2002-04-19 | 2011-02-22 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
US8267870B2 (en) | 2002-04-19 | 2012-09-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling with hybrid actuation |
US9314194B2 (en) | 2002-04-19 | 2016-04-19 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8784335B2 (en) | 2002-04-19 | 2014-07-22 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling device with a capacitive sensor |
US7226461B2 (en) | 2002-04-19 | 2007-06-05 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device with sterility barrier release |
US7229458B2 (en) | 2002-04-19 | 2007-06-12 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7289837B2 (en) * | 2002-10-01 | 2007-10-30 | Nellcor Puritan Bennett Incorpoated | Forehead sensor placement |
US8574895B2 (en) | 2002-12-30 | 2013-11-05 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus using optical techniques to measure analyte levels |
ATE476137T1 (en) | 2003-05-30 | 2010-08-15 | Pelikan Technologies Inc | METHOD AND DEVICE FOR INJECTING LIQUID |
WO2004107964A2 (en) | 2003-06-06 | 2004-12-16 | Pelikan Technologies, Inc. | Blood harvesting device with electronic control |
WO2006001797A1 (en) | 2004-06-14 | 2006-01-05 | Pelikan Technologies, Inc. | Low pain penetrating |
US7047056B2 (en) * | 2003-06-25 | 2006-05-16 | Nellcor Puritan Bennett Incorporated | Hat-based oximeter sensor |
US7591801B2 (en) | 2004-02-26 | 2009-09-22 | Dexcom, Inc. | Integrated delivery device for continuous glucose sensor |
US9135402B2 (en) | 2007-12-17 | 2015-09-15 | Dexcom, Inc. | Systems and methods for processing sensor data |
US20190357827A1 (en) | 2003-08-01 | 2019-11-28 | Dexcom, Inc. | Analyte sensor |
US8626257B2 (en) | 2003-08-01 | 2014-01-07 | Dexcom, Inc. | Analyte sensor |
US8886273B2 (en) | 2003-08-01 | 2014-11-11 | Dexcom, Inc. | Analyte sensor |
US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
EP1671096A4 (en) | 2003-09-29 | 2009-09-16 | Pelikan Technologies Inc | Method and apparatus for an improved sample capture device |
US8412297B2 (en) | 2003-10-01 | 2013-04-02 | Covidien Lp | Forehead sensor placement |
EP1680014A4 (en) | 2003-10-14 | 2009-01-21 | Pelikan Technologies Inc | Method and apparatus for a variable user interface |
US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
US8364230B2 (en) | 2006-10-04 | 2013-01-29 | Dexcom, Inc. | Analyte sensor |
US8425417B2 (en) | 2003-12-05 | 2013-04-23 | Dexcom, Inc. | Integrated device for continuous in vivo analyte detection and simultaneous control of an infusion device |
US8425416B2 (en) | 2006-10-04 | 2013-04-23 | Dexcom, Inc. | Analyte sensor |
US8774886B2 (en) | 2006-10-04 | 2014-07-08 | Dexcom, Inc. | Analyte sensor |
US8364231B2 (en) | 2006-10-04 | 2013-01-29 | Dexcom, Inc. | Analyte sensor |
US8287453B2 (en) | 2003-12-05 | 2012-10-16 | Dexcom, Inc. | Analyte sensor |
US11633133B2 (en) | 2003-12-05 | 2023-04-25 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
US8423114B2 (en) | 2006-10-04 | 2013-04-16 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
EP1706026B1 (en) | 2003-12-31 | 2017-03-01 | Sanofi-Aventis Deutschland GmbH | Method and apparatus for improving fluidic flow and sample capture |
US7822454B1 (en) | 2005-01-03 | 2010-10-26 | Pelikan Technologies, Inc. | Fluid sampling device with improved analyte detecting member configuration |
US8808228B2 (en) | 2004-02-26 | 2014-08-19 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
US8828203B2 (en) | 2004-05-20 | 2014-09-09 | Sanofi-Aventis Deutschland Gmbh | Printable hydrogels for biosensors |
EP1765194A4 (en) | 2004-06-03 | 2010-09-29 | Pelikan Technologies Inc | Method and apparatus for a fluid sampling device |
US9775553B2 (en) | 2004-06-03 | 2017-10-03 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a fluid sampling device |
US7783333B2 (en) | 2004-07-13 | 2010-08-24 | Dexcom, Inc. | Transcutaneous medical device with variable stiffness |
US7310544B2 (en) | 2004-07-13 | 2007-12-18 | Dexcom, Inc. | Methods and systems for inserting a transcutaneous analyte sensor |
US7857760B2 (en) | 2004-07-13 | 2010-12-28 | Dexcom, Inc. | Analyte sensor |
US7376451B2 (en) * | 2004-10-27 | 2008-05-20 | General Electric Company | Measurement and treatment system and method |
US8652831B2 (en) | 2004-12-30 | 2014-02-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte measurement test time |
US8175671B2 (en) | 2006-09-22 | 2012-05-08 | Nellcor Puritan Bennett Llc | Medical sensor for reducing signal artifacts and technique for using the same |
US8396527B2 (en) | 2006-09-22 | 2013-03-12 | Covidien Lp | Medical sensor for reducing signal artifacts and technique for using the same |
US8190224B2 (en) | 2006-09-22 | 2012-05-29 | Nellcor Puritan Bennett Llc | Medical sensor for reducing signal artifacts and technique for using the same |
US8478377B2 (en) | 2006-10-04 | 2013-07-02 | Dexcom, Inc. | Analyte sensor |
US8447376B2 (en) | 2006-10-04 | 2013-05-21 | Dexcom, Inc. | Analyte sensor |
US8275438B2 (en) | 2006-10-04 | 2012-09-25 | Dexcom, Inc. | Analyte sensor |
US8562528B2 (en) | 2006-10-04 | 2013-10-22 | Dexcom, Inc. | Analyte sensor |
US8449464B2 (en) | 2006-10-04 | 2013-05-28 | Dexcom, Inc. | Analyte sensor |
US8298142B2 (en) | 2006-10-04 | 2012-10-30 | Dexcom, Inc. | Analyte sensor |
US8157730B2 (en) | 2006-12-19 | 2012-04-17 | Valencell, Inc. | Physiological and environmental monitoring systems and methods |
US8652040B2 (en) | 2006-12-19 | 2014-02-18 | Valencell, Inc. | Telemetric apparatus for health and environmental monitoring |
EP2152350A4 (en) | 2007-06-08 | 2013-03-27 | Dexcom Inc | Integrated medicament delivery device for use with continuous analyte sensor |
CN101848672A (en) | 2007-09-13 | 2010-09-29 | 密苏里大学董事会 | Optical device components |
CN101903757B (en) * | 2007-10-04 | 2012-08-29 | 密苏里大学董事会 | Optical device components |
EP2227132B1 (en) | 2007-10-09 | 2023-03-08 | DexCom, Inc. | Integrated insulin delivery system with continuous glucose sensor |
US7961305B2 (en) * | 2007-10-23 | 2011-06-14 | The Curators Of The University Of Missouri | Optical device components |
US8251903B2 (en) | 2007-10-25 | 2012-08-28 | Valencell, Inc. | Noninvasive physiological analysis using excitation-sensor modules and related devices and methods |
US8417312B2 (en) | 2007-10-25 | 2013-04-09 | Dexcom, Inc. | Systems and methods for processing sensor data |
US8290559B2 (en) | 2007-12-17 | 2012-10-16 | Dexcom, Inc. | Systems and methods for processing sensor data |
US8577434B2 (en) * | 2007-12-27 | 2013-11-05 | Covidien Lp | Coaxial LED light sources |
US8199007B2 (en) * | 2007-12-31 | 2012-06-12 | Nellcor Puritan Bennett Llc | Flex circuit snap track for a biometric sensor |
US8396528B2 (en) | 2008-03-25 | 2013-03-12 | Dexcom, Inc. | Analyte sensor |
US10542919B2 (en) * | 2008-03-25 | 2020-01-28 | St. Louis Medical Devices, Inc. | Method and system for non-invasive blood glucose detection utilizing spectral data of one or more components other than glucose |
EP2265324B1 (en) | 2008-04-11 | 2015-01-28 | Sanofi-Aventis Deutschland GmbH | Integrated analyte measurement system |
EP3556290A1 (en) * | 2008-05-22 | 2019-10-23 | St. Louis Medical Devices, Inc. | Method and system for non-invasive optical blood glucose detection utilizing spectral data analysis |
EP2326239B1 (en) | 2008-07-03 | 2017-06-21 | Masimo Laboratories, Inc. | Protrusion for improving spectroscopic measurement of blood constituents |
US8203704B2 (en) | 2008-08-04 | 2012-06-19 | Cercacor Laboratories, Inc. | Multi-stream sensor for noninvasive measurement of blood constituents |
US8364220B2 (en) | 2008-09-25 | 2013-01-29 | Covidien Lp | Medical sensor and technique for using the same |
US8257274B2 (en) * | 2008-09-25 | 2012-09-04 | Nellcor Puritan Bennett Llc | Medical sensor and technique for using the same |
DE102008056252A1 (en) * | 2008-10-07 | 2010-04-15 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Apparatus and method for detecting a respiration of a living being |
DE102008056250A1 (en) * | 2008-10-07 | 2010-04-15 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Device for detecting at least one vital parameter of a person in a motor vehicle and device for monitoring at least one vital parameter of a person in a motor vehicle |
DE102008056251A1 (en) * | 2008-10-07 | 2010-04-15 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Device and method for detecting a vital parameter |
US8346330B2 (en) | 2008-10-13 | 2013-01-01 | Masimo Corporation | Reflection-detector sensor position indicator |
US20100113899A1 (en) * | 2008-11-06 | 2010-05-06 | Mark Ries Robinson | Alignment System for Optically Sampling a Hand |
US9375169B2 (en) | 2009-01-30 | 2016-06-28 | Sanofi-Aventis Deutschland Gmbh | Cam drive for managing disposable penetrating member actions with a single motor and motor and control system |
US9750462B2 (en) | 2009-02-25 | 2017-09-05 | Valencell, Inc. | Monitoring apparatus and methods for measuring physiological and/or environmental conditions |
US8788002B2 (en) | 2009-02-25 | 2014-07-22 | Valencell, Inc. | Light-guiding devices and monitoring devices incorporating same |
WO2010098912A2 (en) | 2009-02-25 | 2010-09-02 | Valencell, Inc. | Light-guiding devices and monitoring devices incorporating same |
US8515515B2 (en) | 2009-03-25 | 2013-08-20 | Covidien Lp | Medical sensor with compressible light barrier and technique for using the same |
US8781548B2 (en) | 2009-03-31 | 2014-07-15 | Covidien Lp | Medical sensor with flexible components and technique for using the same |
RU2595488C2 (en) | 2009-04-01 | 2016-08-27 | Дзе Кьюрейторз Оф Дзе Юниверсити Оф Миссури | Optical spectroscopic device for non-invasive determination of glucose in blood and corresponding method of application |
US8708907B2 (en) * | 2009-05-06 | 2014-04-29 | Elfi-Tech | Method and apparatus for determining one or more blood parameters from analog electrical signals |
JP5522353B2 (en) * | 2009-05-29 | 2014-06-18 | 任天堂株式会社 | Biological information measuring device |
US8666466B2 (en) * | 2009-06-10 | 2014-03-04 | Medtronic, Inc. | Device and method for monitoring of absolute oxygen saturation and tissue hemoglobin concentration |
US8352008B2 (en) * | 2009-06-10 | 2013-01-08 | Medtronic, Inc. | Active noise cancellation in an optical sensor signal |
EP2440285B1 (en) * | 2009-06-10 | 2021-08-04 | Medtronic, Inc. | Tissue oxygenation monitoring in heart failure |
US9126049B2 (en) * | 2009-06-10 | 2015-09-08 | Medtronic, Inc. | Shock reduction using absolute calibrated tissue oxygen saturation and total hemoglobin volume fraction |
WO2010144662A1 (en) * | 2009-06-10 | 2010-12-16 | Medtronic, Inc. | Absolute calibrated tissue oxygen saturation and total hemoglobin volume fraction |
US8311601B2 (en) | 2009-06-30 | 2012-11-13 | Nellcor Puritan Bennett Llc | Reflectance and/or transmissive pulse oximeter |
US8521245B2 (en) * | 2009-09-11 | 2013-08-27 | Medtronic, Inc. | Method and apparatus for post-shock evaluation using tissue oxygenation measurements |
US8965476B2 (en) | 2010-04-16 | 2015-02-24 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8761853B2 (en) | 2011-01-20 | 2014-06-24 | Nitto Denko Corporation | Devices and methods for non-invasive optical physiological measurements |
US8888701B2 (en) | 2011-01-27 | 2014-11-18 | Valencell, Inc. | Apparatus and methods for monitoring physiological data during environmental interference |
WO2012142502A2 (en) | 2011-04-15 | 2012-10-18 | Dexcom Inc. | Advanced analyte sensor calibration and error detection |
US9427191B2 (en) | 2011-07-25 | 2016-08-30 | Valencell, Inc. | Apparatus and methods for estimating time-state physiological parameters |
WO2013019494A2 (en) | 2011-08-02 | 2013-02-07 | Valencell, Inc. | Systems and methods for variable filter adjustment by heart rate metric feedback |
US10856749B2 (en) | 2013-01-28 | 2020-12-08 | Valencell, Inc. | Physiological monitoring devices having sensing elements decoupled from body motion |
US10319538B1 (en) * | 2013-03-15 | 2019-06-11 | Innovative Switchgear IP, LLC | Interrupter having unitary external terminal and internal contact |
CA2912270A1 (en) * | 2013-07-30 | 2015-02-05 | Gordon Black | Quantifying neutrophil concentration in blood |
WO2015168235A1 (en) * | 2014-05-01 | 2015-11-05 | Everyone Care Technologies, Llc | Physiological sensors, systems, kits and methods therefor |
WO2015175360A1 (en) * | 2014-05-13 | 2015-11-19 | Montefiore Medical Center | Pulseless oximeter to estimate arterial oxygen saturation noninvasively in patients with weak or absent pulses |
US20160029898A1 (en) | 2014-07-30 | 2016-02-04 | Valencell, Inc. | Physiological Monitoring Devices and Methods Using Optical Sensors |
EP3199100A1 (en) | 2014-08-06 | 2017-08-02 | Valencell, Inc. | Earbud with a physiological information sensor module |
US9977947B2 (en) * | 2015-08-25 | 2018-05-22 | Gingy Technology Inc. | Fingerprint identification method and device thereof |
US9794653B2 (en) | 2014-09-27 | 2017-10-17 | Valencell, Inc. | Methods and apparatus for improving signal quality in wearable biometric monitoring devices |
WO2017070463A1 (en) | 2015-10-23 | 2017-04-27 | Valencell, Inc. | Physiological monitoring devices and methods that identify subject activity type |
US10945618B2 (en) | 2015-10-23 | 2021-03-16 | Valencell, Inc. | Physiological monitoring devices and methods for noise reduction in physiological signals based on subject activity type |
US10638960B2 (en) | 2015-10-26 | 2020-05-05 | Reveal Biosensors, Inc. | Optical physiologic sensor methods |
CN105266780A (en) * | 2015-11-24 | 2016-01-27 | 京东方科技集团股份有限公司 | Intelligent wearable device and detection method for biological characteristic information |
US10537285B2 (en) | 2016-03-04 | 2020-01-21 | Masimo Corporation | Nose sensor |
US10993662B2 (en) | 2016-03-04 | 2021-05-04 | Masimo Corporation | Nose sensor |
US11350837B2 (en) | 2016-03-30 | 2022-06-07 | Elfi-Tech Ltd. | Method and apparatus for optically measuring blood pressure |
US11134901B2 (en) | 2016-03-30 | 2021-10-05 | Elfi-Tech Ltd. | Method and apparatus for optically measuring blood pressure |
US10966662B2 (en) | 2016-07-08 | 2021-04-06 | Valencell, Inc. | Motion-dependent averaging for physiological metric estimating systems and methods |
WO2018194992A1 (en) | 2017-04-18 | 2018-10-25 | Masimo Corporation | Nose sensor |
US11331022B2 (en) | 2017-10-24 | 2022-05-17 | Dexcom, Inc. | Pre-connected analyte sensors |
CA3077720A1 (en) | 2017-10-24 | 2019-05-02 | Dexcom, Inc. | Pre-connected analyte sensors |
US11426093B2 (en) | 2018-09-18 | 2022-08-30 | Reveal Biosensors, Inc. | Energy conversion monitoring devices, systems, and methods |
KR102640331B1 (en) * | 2018-10-19 | 2024-02-26 | 삼성전자주식회사 | Apparatus and method for estimating bio-information, and apparatus for supporting bio-information estimation |
WO2022061262A1 (en) * | 2020-09-21 | 2022-03-24 | PAVmed Inc. | Systems and methods for non-invasive solute measurement |
US11734974B2 (en) * | 2021-04-21 | 2023-08-22 | Hornady Mannfacturing Company | Safe with biometric lock mechanism |
USD997365S1 (en) | 2021-06-24 | 2023-08-29 | Masimo Corporation | Physiological nose sensor |
US20230121237A1 (en) * | 2021-10-14 | 2023-04-20 | HyperSpectral APD, LLC | Systems and methods for screening nutrients or chemical compositions using diversifiers for noise reduction |
CN113786172B (en) * | 2021-11-17 | 2022-02-22 | 深圳市脉度科技有限公司 | Physiological parameter measuring system and method |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4685464A (en) * | 1985-07-05 | 1987-08-11 | Nellcor Incorporated | Durable sensor for detecting optical pulses |
US5782757A (en) * | 1991-03-21 | 1998-07-21 | Masimo Corporation | Low-noise optical probes |
US6115621A (en) * | 1997-07-30 | 2000-09-05 | Nellcor Puritan Bennett Incorporated | Oximetry sensor with offset emitters and detector |
WO2001096872A2 (en) * | 2000-06-11 | 2001-12-20 | Orsense Ltd. | Method and device for measuring concentration of glucose or other substances in blood |
US20020077535A1 (en) * | 1999-03-09 | 2002-06-20 | Orsense Ltd. | Device for enhancement and quality improvement of blood-related signals for use in a system for non-invasive measurements of blood-related signals |
US20030036690A1 (en) * | 2001-06-20 | 2003-02-20 | Geddes Leslie A. | Body-member-illuminating pressure cuff for use in optical noninvasive measurement of blood parameters |
US20040054290A1 (en) * | 1995-01-03 | 2004-03-18 | Britton Chance | Spectrophotometer for in vivo examination of biological tissue |
WO2004105596A1 (en) * | 2003-06-03 | 2004-12-09 | Orsense Ltd. | Method and system for use in non-invasive optical measurements of blood parameters |
WO2004112574A2 (en) * | 2003-06-19 | 2004-12-29 | Optix Lp | Method and apparatus for optical sampling to reduce interfering variances |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4825872A (en) * | 1988-08-05 | 1989-05-02 | Critikon, Inc. | Finger sensor for pulse oximetry system |
US5069214A (en) * | 1988-12-14 | 1991-12-03 | Gms Engineering Corporation | Flash reflectance oximeter |
JPH06103257B2 (en) * | 1988-12-19 | 1994-12-14 | 大塚電子株式会社 | Method and apparatus for measuring absorption coefficient of substance using light scattering |
US5152296A (en) * | 1990-03-01 | 1992-10-06 | Hewlett-Packard Company | Dual-finger vital signs monitor |
US6222189B1 (en) * | 1992-07-15 | 2001-04-24 | Optix, Lp | Methods of enhancing optical signals by mechanical manipulation in non-invasive testing |
US5425360A (en) * | 1992-07-24 | 1995-06-20 | Sensormedics Corporation | Molded pulse oximeter sensor |
HU216847B (en) * | 1995-05-23 | 1999-12-28 | Gyula Domján | Method and arrangement for prompt non-invasive determination of blood parameters |
US6018673A (en) * | 1996-10-10 | 2000-01-25 | Nellcor Puritan Bennett Incorporated | Motion compatible sensor for non-invasive optical blood analysis |
DE19880369C1 (en) * | 1997-03-25 | 2002-08-08 | Siemens Ag | Method and device for the non-invasive in vivo determination of blood substances |
US5817010A (en) * | 1997-03-25 | 1998-10-06 | Ohmeda Inc. | Disposable sensor holder |
IL124787A0 (en) * | 1998-06-07 | 1999-01-26 | Itamar Medical C M 1997 Ltd | Pressure applicator devices particularly useful for non-invasive detection of medical conditions |
IL124965A (en) * | 1998-06-17 | 2002-08-14 | Orsense Ltd | Non-invasive method of optical measurements for determining concentration of a substance in blood |
US6213952B1 (en) * | 1999-09-28 | 2001-04-10 | Orsense Ltd. | Optical device for non-invasive measurement of blood related signals utilizing a finger holder |
MXPA02003412A (en) * | 1999-10-07 | 2004-09-10 | K Mills Alexander | Method and apparatus for non invasive continuous determination of physiological parameters of a patient s blood. |
US6400971B1 (en) | 1999-10-12 | 2002-06-04 | Orsense Ltd. | Optical device for non-invasive measurement of blood-related signals and a finger holder therefor |
AU1678800A (en) | 1999-12-22 | 2001-07-03 | Orsense Ltd. | A method of optical measurements for determining various parameters of the patient's blood |
IL135077A0 (en) | 2000-03-15 | 2001-05-20 | Orsense Ltd | A probe for use in non-invasive measurements of blood related parameters |
-
2004
- 2004-07-08 US US10/885,885 patent/US7313425B2/en active Active
-
2005
- 2005-07-06 EP EP05758928.5A patent/EP1773183B1/en active Active
- 2005-07-06 WO PCT/IL2005/000720 patent/WO2006006153A1/en active Application Filing
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4685464A (en) * | 1985-07-05 | 1987-08-11 | Nellcor Incorporated | Durable sensor for detecting optical pulses |
US5782757A (en) * | 1991-03-21 | 1998-07-21 | Masimo Corporation | Low-noise optical probes |
US20040054290A1 (en) * | 1995-01-03 | 2004-03-18 | Britton Chance | Spectrophotometer for in vivo examination of biological tissue |
US6115621A (en) * | 1997-07-30 | 2000-09-05 | Nellcor Puritan Bennett Incorporated | Oximetry sensor with offset emitters and detector |
US20020077535A1 (en) * | 1999-03-09 | 2002-06-20 | Orsense Ltd. | Device for enhancement and quality improvement of blood-related signals for use in a system for non-invasive measurements of blood-related signals |
WO2001096872A2 (en) * | 2000-06-11 | 2001-12-20 | Orsense Ltd. | Method and device for measuring concentration of glucose or other substances in blood |
US20030036690A1 (en) * | 2001-06-20 | 2003-02-20 | Geddes Leslie A. | Body-member-illuminating pressure cuff for use in optical noninvasive measurement of blood parameters |
WO2004105596A1 (en) * | 2003-06-03 | 2004-12-09 | Orsense Ltd. | Method and system for use in non-invasive optical measurements of blood parameters |
WO2004112574A2 (en) * | 2003-06-19 | 2004-12-29 | Optix Lp | Method and apparatus for optical sampling to reduce interfering variances |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010115621A2 (en) | 2009-04-11 | 2010-10-14 | Fresenius Medical Care Deutschland Gmbh | Device and method for measuring a blood constituent in blood for an extracorporeal blood treatment device |
DE102009017304A1 (en) | 2009-04-11 | 2010-10-21 | Fresenius Medical Care Deutschland Gmbh | Apparatus and method for measuring a blood component in blood for an extracorporeal blood treatment device |
US9265872B2 (en) | 2009-04-11 | 2016-02-23 | Fresenius Medical Care Deutschland Gmbh | Device and method for measuring a blood constituent in blood for an extracorporeal blood treating device |
Also Published As
Publication number | Publication date |
---|---|
EP1773183A1 (en) | 2007-04-18 |
US7313425B2 (en) | 2007-12-25 |
US20060009685A1 (en) | 2006-01-12 |
EP1773183B1 (en) | 2014-12-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1773183B1 (en) | Device and method for non-invasive optical measurements | |
EP1292216B1 (en) | Device for measuring concentration of glucose or other substances in blood | |
US7386336B2 (en) | Method and system for use in non-invasive optical measurements of blood parameters | |
US7254432B2 (en) | Method and device for non-invasive measurements of blood parameters | |
US7167734B2 (en) | Method for optical measurements of tissue to determine disease state or concentration of an analyte | |
JP4176480B2 (en) | Method and apparatus for improving the accuracy of non-invasive hematocrit measurements | |
US5370114A (en) | Non-invasive blood chemistry measurement by stimulated infrared relaxation emission | |
US20050131286A1 (en) | Non-invasive measurement of blood analytes | |
WO1993007801A1 (en) | Method and apparatus for non-invasive blood analyte determination | |
US8017407B2 (en) | Device and method for monitoring blood parameters | |
CA2404925A1 (en) | Method and device for the noninvasive determination of hemoglobin and hematocrit | |
WO2000016688A9 (en) | Non-invasive blood component analyzer | |
JPH07136152A (en) | Method and device for uninvasively measuring concentration of blood component of animal | |
JP2001513351A (en) | Optical glucose detector | |
WO2006079797A2 (en) | Apparatus for measurement of analyte concentration | |
JP2015062716A (en) | Method and system for non-invasive blood glucose detection utilizing spectral data of one or more components other than glucose | |
JP2004290544A (en) | Blood analyzer | |
KR100464324B1 (en) | Method and apparatus for measuring concentration of constituents in body fluids | |
EP1628564B1 (en) | Method and system for use in non-invasive optical measurements of blood parameters | |
KR20150050523A (en) | Noninvasive measurement of analyte concentration using a fiberless transflectance probe | |
KR20230126508A (en) | Spectroscopic principle-based non-invasive concentration measurement method and system for performing the same | |
GB2402472A (en) | Non-invasive optical measurement of blood parameters |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWW | Wipo information: withdrawn in national office |
Country of ref document: DE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2005758928 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 2005758928 Country of ref document: EP |