WO2006000785A1 - Improvements relating to automatic injection devices - Google Patents

Improvements relating to automatic injection devices Download PDF

Info

Publication number
WO2006000785A1
WO2006000785A1 PCT/GB2005/002487 GB2005002487W WO2006000785A1 WO 2006000785 A1 WO2006000785 A1 WO 2006000785A1 GB 2005002487 W GB2005002487 W GB 2005002487W WO 2006000785 A1 WO2006000785 A1 WO 2006000785A1
Authority
WO
WIPO (PCT)
Prior art keywords
syringe
plunger
housing
injection device
needle
Prior art date
Application number
PCT/GB2005/002487
Other languages
French (fr)
Inventor
Stephen Bicknell
Joseph F. Julian
William L. Rudzena
Original Assignee
Owen Mumford Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to KR20067026814A priority Critical patent/KR101202123B1/en
Priority to AU2005256832A priority patent/AU2005256832B2/en
Application filed by Owen Mumford Limited filed Critical Owen Mumford Limited
Priority to EP05758156.3A priority patent/EP1758627B1/en
Priority to KR1020117021471A priority patent/KR101210122B1/en
Priority to ES05758156.3T priority patent/ES2672336T3/en
Priority to CA 2571571 priority patent/CA2571571C/en
Priority to IN4769DEN2014 priority patent/IN2014DN04769A/en
Priority to JP2007517459A priority patent/JP2008503296A/en
Priority to BRPI0512554-5A priority patent/BRPI0512554B1/en
Priority to MXPA06015056A priority patent/MXPA06015056A/en
Priority to MX2012000282A priority patent/MX345765B/en
Priority to NZ552340A priority patent/NZ552340A/en
Priority to US11/630,507 priority patent/US7938802B2/en
Publication of WO2006000785A1 publication Critical patent/WO2006000785A1/en
Priority to US13/072,289 priority patent/US8162887B2/en
Priority to US13/443,384 priority patent/US8668670B2/en
Priority to US14/109,363 priority patent/US9017287B2/en
Priority to US14/669,616 priority patent/US9764090B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/206—With automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31501—Means for blocking or restricting the movement of the rod or piston
    • A61M2005/31508—Means for blocking or restricting the movement of the rod or piston provided on the piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3287—Accessories for bringing the needle into the body; Automatic needle insertion

Definitions

  • automatic injection device which when operated cause the needle of a syringe to be moved forwardly so that it projects from a protective housing prior to actuation of the syringe to express a dose of liquid through the needle. It is important to try to ensure that the syringe is moved bodily forward to expose the needle before the liquid charge is pressurised so that dribbling from the needle does not occur before the actual injection takes place. It is an object of this invention to provide a mechanism which operates in this desired manner.
  • an injection device for causing a dose of liquid to be ejected from the needle at one end of a syringe located within a housing of the device, the syringe being movable by a plunger, upon release of an actuating bias member at one end of the housing, to move the syringe, from a first position wherein the needle is shrouded by the housing, to a second position wherein the needle projects from the other end of the housing, the plunger being in the form of a rod with a longitudinally centrally located flexible projecting portion which, prior to release of said actuating bias member, is situated beyond the other end of the syringe, such that a primary movement of the plunger, under the bias of the actuating bias member, will cause the projecting portion to bear against the other end of the syringe such that the syringe is moved from said first to said second position, whereupon arresting of further movement of the syringe, results in the flexible portion coll
  • the projecting portion will remain in its projecting position (in order to move the syringe from the first to the second position) until the force increases to such an extent which allows the projecting portion to collapse inwardly so that the plunger can then move within the syringe to cause the liquid to be expressed through the syringe.
  • the projecting portion can comprise one or more flexible elbows projecting beyond the normal circumference of the rod, but compressible into said circumference. This could be in the form of two elbows defined either side of a longitudinal slit in the rod. The elbows could be pre-formed as a pair of arms either side of the longitudinal slit between upper and lower solid portions of the rod.
  • the injection device will contain a return bias member acting between the syringe housing and the other end of the syringe to hold the syringe retracted within the housing until the actuating bias member is released.
  • One or more of the bias members provided within the housing can be in the form of a coil spring.
  • the syringe comprises a 3 incorporating a liquid dose held in place by a bung 4 and having a needle 5 through which the dose can be ejected by applying pressure to the bung 4.
  • the 3 has an enlarged head 6.
  • a plunger 7 is biased forwardly by a coil spring 8, but is held back in a latched position (Figure 1) until such time as a trigger shown schematically at 11 is actuated to release the plunger and the spring 8.
  • the syringe 1 Prior to use the syringe 1 is held retracted in the housing 2 by a coil spring 9. It will be seen that the plunger 7 is in the form of a rod having a central portion which defines a pair of projecting elbows 10. These can be pre-formed as part of a moulded plunger 7.
  • the projecting elbow portions 10 are flexible so that they can be moved inwardly to cause that portion of the rod to adopt a circumference similar to that of the rest of the rod.
  • the expanded region formed by the elbows 10 rests against the head 6 of the 3 and the force provided is sufficient to compress the spring 9 until such time as the head 6 abuts the top of the housing 2, whereupon further movement of the 3 is arrested.
  • the continual bias created by the spring 8 then causes the elbows 10 to be compressed inwardly as they enter into the interior of the 3.
  • the plunger With the elbows 10 in the collapsed state, the plunger can then move relatively easily within the 3 so as to act upon the bung 4 and thus cause the contents of the syringe to be ejected through the needle 5.
  • the illustrated configuration of the plunger 7 provides several technical advantages. It can be moulded integrally. Also the collapsing movement of the projecting elbows provides an arrangement which can provide a suitable injection force to cause the needle to enter the skin to a suitable depth, but then provide a relatively low drag against the inner wall of the syringe container so that the major portion of the thrust of the spring for the remainder of its stroke is applied to the bung 4. It will be appreciated that other configurations of collapsing projection could be used in place of the collapsing elbows.

Abstract

An injection device comprises a syringe (1) extendible against a spring bias (9) from a retracted position in a housing (2) to a projecting injecting position. A spring biased plunger has collapsible elbows (10) which, when the plunger is released, initially engage the end of the syringe to drive it to the projecting position, whereupon arresting of the syringe movement causes the elbows to collapse inside the syringe to allow the plunger to engage and drive the bung (3).

Description

Improvements relating to automatic injection devices There are various forms of automatic injection device which when operated cause the needle of a syringe to be moved forwardly so that it projects from a protective housing prior to actuation of the syringe to express a dose of liquid through the needle. It is important to try to ensure that the syringe is moved bodily forward to expose the needle before the liquid charge is pressurised so that dribbling from the needle does not occur before the actual injection takes place. It is an object of this invention to provide a mechanism which operates in this desired manner. According to the invention there is provided an injection device for causing a dose of liquid to be ejected from the needle at one end of a syringe located within a housing of the device, the syringe being movable by a plunger, upon release of an actuating bias member at one end of the housing, to move the syringe, from a first position wherein the needle is shrouded by the housing, to a second position wherein the needle projects from the other end of the housing, the plunger being in the form of a rod with a longitudinally centrally located flexible projecting portion which, prior to release of said actuating bias member, is situated beyond the other end of the syringe, such that a primary movement of the plunger, under the bias of the actuating bias member, will cause the projecting portion to bear against the other end of the syringe such that the syringe is moved from said first to said second position, whereupon arresting of further movement of the syringe, results in the flexible portion collapsing inwardly so that it enters the syringe, thus enabling the plunger to move by a secondary movement, within the syringe, into contact with and to act upon a plug to compress the liquid within the syringe and cause expression of the liquid through the syringe needle. With such an arrangement, the projecting portion will remain in its projecting position (in order to move the syringe from the first to the second position) until the force increases to such an extent which allows the projecting portion to collapse inwardly so that the plunger can then move within the syringe to cause the liquid to be expressed through the syringe. The projecting portion can comprise one or more flexible elbows projecting beyond the normal circumference of the rod, but compressible into said circumference. This could be in the form of two elbows defined either side of a longitudinal slit in the rod. The elbows could be pre-formed as a pair of arms either side of the longitudinal slit between upper and lower solid portions of the rod. Preferably the injection device will contain a return bias member acting between the syringe housing and the other end of the syringe to hold the syringe retracted within the housing until the actuating bias member is released. One or more of the bias members provided within the housing can be in the form of a coil spring. The invention may be performed in various ways and a preferred example thereof will now be described, with reference to the accompanying diagrammatic drawings, in which: Figure 1 Figure 1 is a sectional view through an injection device of this invention prior to use; and Figures 2 and 3 are similar views showing successive stages of operation of the injection member. The injection device shown in the drawings comprises a syringe 1 located within a protective housing 2. The syringe comprises a 3 incorporating a liquid dose held in place by a bung 4 and having a needle 5 through which the dose can be ejected by applying pressure to the bung 4. The 3 has an enlarged head 6. A plunger 7 is biased forwardly by a coil spring 8, but is held back in a latched position (Figure 1) until such time as a trigger shown schematically at 11 is actuated to release the plunger and the spring 8. Prior to use the syringe 1 is held retracted in the housing 2 by a coil spring 9. It will be seen that the plunger 7 is in the form of a rod having a central portion which defines a pair of projecting elbows 10. These can be pre-formed as part of a moulded plunger 7. The projecting elbow portions 10 are flexible so that they can be moved inwardly to cause that portion of the rod to adopt a circumference similar to that of the rest of the rod. As can be seen in Figure 2, when the plunger is released and biased by the spring 8 the expanded region formed by the elbows 10 rests against the head 6 of the 3 and the force provided is sufficient to compress the spring 9 until such time as the head 6 abuts the top of the housing 2, whereupon further movement of the 3 is arrested. The continual bias created by the spring 8 then causes the elbows 10 to be compressed inwardly as they enter into the interior of the 3. With the elbows 10 in the collapsed state, the plunger can then move relatively easily within the 3 so as to act upon the bung 4 and thus cause the contents of the syringe to be ejected through the needle 5. The illustrated configuration of the plunger 7 provides several technical advantages. It can be moulded integrally. Also the collapsing movement of the projecting elbows provides an arrangement which can provide a suitable injection force to cause the needle to enter the skin to a suitable depth, but then provide a relatively low drag against the inner wall of the syringe container so that the major portion of the thrust of the spring for the remainder of its stroke is applied to the bung 4. It will be appreciated that other configurations of collapsing projection could be used in place of the collapsing elbows.

Claims

Claims 1. An injection device for causing a dose of liquid to be ejected from the needle at one end of a syringe (1) located within a housing (2) of the device, the syringe being movable by a plunger (7), upon release of an actuating bias member (8) at one end of the housing (2), to move the syringe (1), from a first position wherein the needle (5) is shrouded by the housing (2), to a second position wherein the needle projects from the other end of the housing, the plunger being in the form of a rod with a longitudinally centrally located flexible projecting portion which, prior to release of said actuating bias member, is situated beyond the other end (6) of the syringe (1), such that a primary movement of the plunger (7), under the bias of the actuating bias member (8), will cause the projecting portion (10) to bear against the other end (6) of the syringe such that the syringe is moved from said first to said second position, whereupon arresting of further movement of the syringe, results in the flexible portion (10) collapsing inwardly so that it enters the syringe, thus enabling the plunger (7) to move by a secondary movement, within the syringe, into contact with and to act upon a plug (4) to compress the liquid within the syringe and cause expression of the liquid through the syringe needle (5). 2. An injection device as claimed in claim 1 , wherein the projecting portion (10) comprises one or more flexible elbows projecting beyond the normal circumference of the rod (7), but compressible into said circumference. 3. An injection device as claimed in claim 1 or claim 2, wherein two elbows (10) are defined either side of a longitudinal slit in the rod (7). 4. An injection device as claimed in any one of claims 1 to 3, wherein the elbows are preformed as a pair of arms (10) either side of the longitudinal slit between upper and lower solid portions of the rod (7). 5. An injection device as claimed in any one of claims 1 to 4, including a return bias member (9) acting between the syringe housing (2) and the other end of the syringe (6) to hold the syringe (1) retracted within the housing (2) until the actuating bias member (8) is released. 6. An injection device as claimed in claims 1 to 5, wherein one or more of the bias members (8, 9) provided within the housing is in the form of a coil spring. 7. An injection device comprising: a housing (2); a syringe (1) slideably mounted within said housing for movement between a shrouded retracted position and an extended injecting position; a bung (4) slideably mounted in said syringe (1) and moveable to expel a liquid dose through a needle (5) at the distal end of the syringe; a plunger (7) having an end operable to engage said bung (4) and transmitting an expulsion force thereto, and a bias spring (8) operable to move said plunger from a first position to a second position, characterised in that said plunger is provided with at least one integrally formed collapsible projecting region (10) which is outside said syringe when said plunger (7) is at its first position but which in use on movement away from said first position engages the proximal end (6) of said syringe (1) to drive it to its extended position whereupon arresting of further movement of said syringe (1) causes said collapsible projecting region (10) to collapse inwardly to allow said plunger to engage said bung (4) and expel a liquid dose.
PCT/GB2005/002487 2004-06-23 2005-06-23 Improvements relating to automatic injection devices WO2006000785A1 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
US11/630,507 US7938802B2 (en) 2004-06-23 2005-06-23 Automatic injection devices
JP2007517459A JP2008503296A (en) 2004-06-23 2005-06-23 Improvements regarding automatic injection devices
EP05758156.3A EP1758627B1 (en) 2004-06-23 2005-06-23 Improvements relating to automatic injection devices
KR1020117021471A KR101210122B1 (en) 2004-06-23 2005-06-23 Improvements relating to automatic injection devices
ES05758156.3T ES2672336T3 (en) 2004-06-23 2005-06-23 Improvements related to automatic injection devices
CA 2571571 CA2571571C (en) 2004-06-23 2005-06-23 Improvements relating to automatic injection devices
IN4769DEN2014 IN2014DN04769A (en) 2004-06-23 2005-06-23
KR20067026814A KR101202123B1 (en) 2004-06-23 2005-06-23 Improvements relating to automatic injection devices
BRPI0512554-5A BRPI0512554B1 (en) 2004-06-23 2005-06-23 INJECTION DEVICE
MX2012000282A MX345765B (en) 2004-06-23 2005-06-23 Improvements relating to automatic injection devices.
MXPA06015056A MXPA06015056A (en) 2004-06-23 2005-06-23 Improvements relating to automatic injection devices.
NZ552340A NZ552340A (en) 2004-06-23 2005-06-23 Improvements relating to automatic injection devices
AU2005256832A AU2005256832B2 (en) 2004-06-23 2005-06-23 Improvements relating to automatic injection devices
US13/072,289 US8162887B2 (en) 2004-06-23 2011-03-25 Automatic injection devices
US13/443,384 US8668670B2 (en) 2004-06-23 2012-04-10 Automatic injection devices
US14/109,363 US9017287B2 (en) 2004-06-23 2013-12-17 Automatic injection devices
US14/669,616 US9764090B2 (en) 2004-06-23 2015-03-26 Relating to automatic injection devices

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0414054.7 2004-06-23
GB0414054A GB0414054D0 (en) 2004-06-23 2004-06-23 Improvements relating to automatic injection devices

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US11/630,507 A-371-Of-International US7938802B2 (en) 2004-06-23 2005-06-23 Automatic injection devices
US13/072,289 Continuation US8162887B2 (en) 2004-06-23 2011-03-25 Automatic injection devices

Publications (1)

Publication Number Publication Date
WO2006000785A1 true WO2006000785A1 (en) 2006-01-05

Family

ID=32800025

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2005/002487 WO2006000785A1 (en) 2004-06-23 2005-06-23 Improvements relating to automatic injection devices

Country Status (17)

Country Link
US (5) US7938802B2 (en)
EP (3) EP1758627B1 (en)
JP (5) JP2008503296A (en)
KR (2) KR101202123B1 (en)
CN (4) CN103055381A (en)
AU (1) AU2005256832B2 (en)
BR (1) BRPI0512554B1 (en)
CA (2) CA2571571C (en)
ES (1) ES2672336T3 (en)
GB (1) GB0414054D0 (en)
HK (1) HK1184738A1 (en)
IN (1) IN2014DN04769A (en)
MX (2) MX345765B (en)
NZ (3) NZ587235A (en)
RU (1) RU2387460C2 (en)
WO (1) WO2006000785A1 (en)
ZA (1) ZA200700289B (en)

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US9265887B2 (en) 2011-01-24 2016-02-23 Abbvie Biotechnology Ltd. Automatic injection devices having overmolded gripping surfaces
US9339610B2 (en) 2011-01-24 2016-05-17 Abbvie Biotechnology Ltd Removal of needle shield from syringes and automatic injection devices
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