WO2006000448A3 - Fc-INTERFERON-BETA FUSION PROTEINS - Google Patents

Fc-INTERFERON-BETA FUSION PROTEINS Download PDF

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Publication number
WO2006000448A3
WO2006000448A3 PCT/EP2005/006925 EP2005006925W WO2006000448A3 WO 2006000448 A3 WO2006000448 A3 WO 2006000448A3 EP 2005006925 W EP2005006925 W EP 2005006925W WO 2006000448 A3 WO2006000448 A3 WO 2006000448A3
Authority
WO
WIPO (PCT)
Prior art keywords
fusion proteins
interferon
beta
ifn
nucleic acid
Prior art date
Application number
PCT/EP2005/006925
Other languages
French (fr)
Other versions
WO2006000448A2 (en
Inventor
Stephen D Gillies
Nigel John Watkins
Matthew Paul Baker
King-Ming Lo
Original Assignee
Merck Patent Gmbh
Stephen D Gillies
Nigel John Watkins
Matthew Paul Baker
King-Ming Lo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh, Stephen D Gillies, Nigel John Watkins, Matthew Paul Baker, King-Ming Lo filed Critical Merck Patent Gmbh
Priority to EP05766761A priority Critical patent/EP1761559B1/en
Priority to DE602005016799T priority patent/DE602005016799D1/en
Priority to JP2007517216A priority patent/JP4808709B2/en
Priority to AT05766761T priority patent/ATE443720T1/en
Priority to AU2005256519A priority patent/AU2005256519B2/en
Priority to CA2572015A priority patent/CA2572015C/en
Publication of WO2006000448A2 publication Critical patent/WO2006000448A2/en
Publication of WO2006000448A3 publication Critical patent/WO2006000448A3/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6813Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/555Interferons [IFN]
    • C07K14/565IFN-beta
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Abstract

Disclosed are Fc-interferon-beta (Fc-IFN-β) fusion proteins and nucleic acid molecules encoding them. The Fc- IFN-β fusion proteins include variants of the interferon-beta (IFN-β) protein that are altered to achieve enhanced biological activity, prolonged circulating half-life and greater solubility. Also disclosed are methods of producing the fusion proteins and methods of using the fusion proteins and/or nucleic acid molecules for treating diseases and conditions alleviated by the administration of interferon-beta.
PCT/EP2005/006925 2004-06-28 2005-06-28 Fc-INTERFERON-BETA FUSION PROTEINS WO2006000448A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP05766761A EP1761559B1 (en) 2004-06-28 2005-06-28 Fc-INTERFERON-BETA FUSION PROTEINS
DE602005016799T DE602005016799D1 (en) 2004-06-28 2005-06-28 FC INTERFERON BETA FUSION PROTEINS
JP2007517216A JP4808709B2 (en) 2004-06-28 2005-06-28 Fc-interferon-beta fusion protein
AT05766761T ATE443720T1 (en) 2004-06-28 2005-06-28 FC-INTERFERON-BETA FUSION PROTEINS
AU2005256519A AU2005256519B2 (en) 2004-06-28 2005-06-28 Fc-interferon-beta fusion proteins
CA2572015A CA2572015C (en) 2004-06-28 2005-06-28 Fc-interferon-beta fusion proteins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58338904P 2004-06-28 2004-06-28
US60/583,389 2004-06-28

Publications (2)

Publication Number Publication Date
WO2006000448A2 WO2006000448A2 (en) 2006-01-05
WO2006000448A3 true WO2006000448A3 (en) 2006-03-02

Family

ID=35429166

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/006925 WO2006000448A2 (en) 2004-06-28 2005-06-28 Fc-INTERFERON-BETA FUSION PROTEINS

Country Status (9)

Country Link
US (3) US7670595B2 (en)
EP (1) EP1761559B1 (en)
JP (1) JP4808709B2 (en)
AT (1) ATE443720T1 (en)
AU (1) AU2005256519B2 (en)
CA (1) CA2572015C (en)
DE (1) DE602005016799D1 (en)
ES (1) ES2332924T3 (en)
WO (1) WO2006000448A2 (en)

Cited By (2)

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Publication number Priority date Publication date Assignee Title
CN103570836A (en) * 2013-10-25 2014-02-12 江苏众红生物工程创药研究院有限公司 Recombinant porcine interferon beta1-Fc fusion protein as well as encoding gene and expressing method thereof
CN104530213A (en) * 2014-11-24 2015-04-22 广西大学 Viral hepatitis treatment drug interferon production technology

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