WO2005118166A3 - Pharmaceutical composition containing irbesartan - Google Patents

Pharmaceutical composition containing irbesartan Download PDF

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Publication number
WO2005118166A3
WO2005118166A3 PCT/IB2005/002689 IB2005002689W WO2005118166A3 WO 2005118166 A3 WO2005118166 A3 WO 2005118166A3 IB 2005002689 W IB2005002689 W IB 2005002689W WO 2005118166 A3 WO2005118166 A3 WO 2005118166A3
Authority
WO
WIPO (PCT)
Prior art keywords
irbesartan
pharmaceutical composition
composition containing
formulation
provides
Prior art date
Application number
PCT/IB2005/002689
Other languages
French (fr)
Other versions
WO2005118166A2 (en
Inventor
Gershon Kolatkar
Erela Zisman
Original Assignee
Teva Pharma
Gershon Kolatkar
Erela Zisman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma, Gershon Kolatkar, Erela Zisman filed Critical Teva Pharma
Priority to EP05775601A priority Critical patent/EP1750862B1/en
Priority to PL05775601T priority patent/PL1750862T3/en
Priority to JP2007514218A priority patent/JP4880591B2/en
Priority to CA2568640A priority patent/CA2568640C/en
Priority to AT05775601T priority patent/ATE493973T1/en
Priority to AU2005249794A priority patent/AU2005249794A1/en
Priority to DE602005025755T priority patent/DE602005025755D1/en
Publication of WO2005118166A2 publication Critical patent/WO2005118166A2/en
Publication of WO2005118166A3 publication Critical patent/WO2005118166A3/en
Priority to IL179718A priority patent/IL179718A0/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2027Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41841,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10Antioedematous agents; Diuretics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Abstract

This invention relates to pharmaceutical compositions containing irbesartan, providing oral formulations with a high relative amount or concentration of irbesartan. In one embodiment, the present invention provides an oral formulation of irbesartan containing greater than 70% w/w irbesartan. In another embodiment, the invention provides an oral formulation of irbesartan which exhibits a dissolution profile according to which greater than about 85% of the Irbesartan is dissolved within about 30 minutes using USP apparatus 2, placing the tablet in 1000mL of 0.1N hydrochloric acid at 37°C with paddle speed of 50 rpm. The formulation can optionally contain at least one additional active ingredient.
PCT/IB2005/002689 2004-06-04 2005-06-02 Pharmaceutical composition containing irbesartan WO2005118166A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
EP05775601A EP1750862B1 (en) 2004-06-04 2005-06-02 Pharmaceutical composition containing irbesartan
PL05775601T PL1750862T3 (en) 2004-06-04 2005-06-02 Pharmaceutical composition containing irbesartan
JP2007514218A JP4880591B2 (en) 2004-06-04 2005-06-02 Pharmaceutical composition comprising irbesartan
CA2568640A CA2568640C (en) 2004-06-04 2005-06-02 Pharmaceutical composition containing irbesartan
AT05775601T ATE493973T1 (en) 2004-06-04 2005-06-02 PHARMACEUTICAL COMPOSITION CONTAINING IRBESARTAN
AU2005249794A AU2005249794A1 (en) 2004-06-04 2005-06-02 Pharmaceutical composition containing irbesartan
DE602005025755T DE602005025755D1 (en) 2004-06-04 2005-06-02 IRBESARTAN PHARMACEUTICAL COMPOSITION CONTAINING
IL179718A IL179718A0 (en) 2004-06-04 2006-11-30 Pharmaceutical composition containing irbesartan

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57742704P 2004-06-04 2004-06-04
US60/577,427 2004-06-04

Publications (2)

Publication Number Publication Date
WO2005118166A2 WO2005118166A2 (en) 2005-12-15
WO2005118166A3 true WO2005118166A3 (en) 2006-07-27

Family

ID=35463389

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/002689 WO2005118166A2 (en) 2004-06-04 2005-06-02 Pharmaceutical composition containing irbesartan

Country Status (11)

Country Link
US (2) US8226977B2 (en)
EP (1) EP1750862B1 (en)
JP (2) JP4880591B2 (en)
AT (1) ATE493973T1 (en)
AU (1) AU2005249794A1 (en)
CA (1) CA2568640C (en)
DE (1) DE602005025755D1 (en)
ES (1) ES2282062T1 (en)
IL (1) IL179718A0 (en)
PL (1) PL1750862T3 (en)
WO (1) WO2005118166A2 (en)

Families Citing this family (25)

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EP1806130B1 (en) * 2006-01-09 2010-03-31 KRKA, D.D., Novo Mesto Solid pharmaceutical composition comprising irbesartan
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GB0617171D0 (en) * 2006-08-31 2006-10-11 Generics Uk Ltd Novel compositions and methods
CA2563690C (en) * 2006-10-12 2014-10-07 Pharmascience Inc. Pharmaceutical compositions comprising intra- and extra- granular fractions
JP5527921B2 (en) * 2006-12-22 2014-06-25 エスエス製薬株式会社 Oral solid composition concealing bitterness
WO2008102235A1 (en) * 2007-02-20 2008-08-28 Aurobindo Pharma Limited Controlled release formulations of alfuzosin
WO2009017812A2 (en) * 2007-08-01 2009-02-05 Teva Pharmaceutical Industries Ltd. Pharmaceutical composition of candesartan
PT2065035E (en) 2007-11-28 2010-10-04 Lesvi Laboratorios Sl Pharmaceutical formulations containing irbesartan
JP5296456B2 (en) * 2008-08-26 2013-09-25 大日本住友製薬株式会社 Irbesartan-containing pharmaceutical composition with good dissolution and orally disintegrating tablet
WO2011010316A1 (en) * 2009-07-20 2011-01-27 Hetero Research Foundation Pharmaceutical compositions of irbesartan
WO2011141783A2 (en) 2010-04-13 2011-11-17 Micro Labs Limited Pharmaceutical composition comprising irbesartan
JP5946135B2 (en) * 2012-03-29 2016-07-05 塩野義製薬株式会社 Solid formulation containing trichloromethiazide and crystalline cellulose
JP6018420B2 (en) * 2012-06-05 2016-11-02 ニプロ株式会社 Pharmaceutical composition comprising an angiotensin II receptor antagonist and thiazide diuretic
KR20140030505A (en) * 2012-08-31 2014-03-12 한미약품 주식회사 Pharmaceutical composite capsule formulation comprising irbesartan and hmg-coa reductase inhibitor
JP5714652B2 (en) * 2013-06-13 2015-05-07 大日本住友製薬株式会社 Irbesartan-containing pharmaceutical composition with good dissolution and orally disintegrating tablet
JP5978335B2 (en) * 2015-03-11 2016-08-24 大日本住友製薬株式会社 Irbesartan-containing pharmaceutical composition with good dissolution and orally disintegrating tablet
JP6445923B2 (en) * 2015-04-22 2018-12-26 ダイト株式会社 Preparation of irbesartan-containing tablets
JP6737060B2 (en) * 2015-09-11 2020-08-05 ニプロ株式会社 Method for producing pharmaceutical composition containing irbesartan
JP6151413B2 (en) * 2016-07-25 2017-06-21 大日本住友製薬株式会社 Irbesartan-containing pharmaceutical composition with good dissolution and orally disintegrating tablet
NZ755597A (en) 2017-02-17 2023-06-30 Eidos Therapeutics Inc Processes for preparing ag-10, its intermediates, and salts thereof
JP2017141299A (en) * 2017-05-24 2017-08-17 大日本住友製薬株式会社 Irbesartan-containing pharmaceutical composition showing excellent elution, and orally disintegrable tablet
JP2018168185A (en) * 2018-07-05 2018-11-01 大日本住友製薬株式会社 Irbesartan-containing pharmaceutical composition and orally disintegrable tablet with excellent elution
MA53238A (en) * 2018-08-17 2022-04-13 Eidos Therapeutics Inc AG10 FORMULAS
JP2019203031A (en) * 2019-09-06 2019-11-28 大日本住友製薬株式会社 Irbesartan-containing pharmaceutical composition showing excellent elution, and orally disintegrable tablet

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