WO2005113035A2 - Metallic coils enlaced with biological or biodegradable or synthetic polymers or fibers for embolization of a body cavity - Google Patents
Metallic coils enlaced with biological or biodegradable or synthetic polymers or fibers for embolization of a body cavity Download PDFInfo
- Publication number
- WO2005113035A2 WO2005113035A2 PCT/US2005/018087 US2005018087W WO2005113035A2 WO 2005113035 A2 WO2005113035 A2 WO 2005113035A2 US 2005018087 W US2005018087 W US 2005018087W WO 2005113035 A2 WO2005113035 A2 WO 2005113035A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- comprised
- coil
- fibers
- metal wire
- coating
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/18—Materials at least partially X-ray or laser opaque
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
- A61B17/12113—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/1214—Coils or wires
- A61B17/12145—Coils or wires having a pre-set deployed three-dimensional shape
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/1214—Coils or wires
- A61B17/1215—Coils or wires comprising additional materials, e.g. thrombogenic, having filaments, having fibers, being coated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/1214—Coils or wires
- A61B17/12154—Coils or wires having stretch limiting means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/022—Metals or alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L31/125—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L31/128—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix containing other specific inorganic fillers not covered by A61L31/126 or A61L31/127
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00004—(bio)absorbable, (bio)resorbable, resorptive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00526—Methods of manufacturing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/36—Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices
Definitions
- This invention relates to vaso-occlusion devices for forming an occlusion (embolism) at a desired vascular location, in particular at the site of an aneurism.
- the devices are helical wire coils preferably with enlaced fibrous materials providing an increased surface area to facilitate high rates of desired bioactions such as bioactive material release or embolic interactions between the device's surface and the patient's bloodstream.
- the coils may be coated with at least a single layer including a bioactive material.
- Body cavity embolism e.g. brain blood vessel aneurysm occlusion by detachable coils, liquid embolism, particle embolism, balloon embolism
- body cavity embolism is a treatment that may have a high incidence of recurrence. Due to insufficient healing at the aneurysm/parent artery interface, mechanical and biological forces, incompletely understood, create a new expansion of aneurysm. That is the aneurysm reforms or recurs after endovascular, embolic treatment.
- Pt/lr coils are packed in aneurysms so that they occupy ⁇ 20% to 30% of the aneurysm volume and reduce the inflow of blood into the aneurysm.
- Aneurismal blood at 70% to 80% by volume, clots by stagnation.
- the clotted blood organizes and proceeds through a series of steps similar to those occurring at any wound in the body: (1) hemostasis, (2) inflammation, (3) tissue formation, and (4) remodeling.
- An aneurysm so treated is excluded from the arterial circulation.
- the clotted blood may not organize, the coil mass compacts and/or new blood flow — coupled with the diseased arterial tissue — allows expansion of the aneurysm.
- the aneurysm recurs and remains susceptible to rupture and hemorrhagic stroke.
- Embolic devices such as electrolytically-detached Pt/lr coils, have been designed with coatings that swell in aqueous solution or that provoke a mild inflammatory response.
- One form of device contains a polyacrylamide hydrogel attached to the Pt/lr detachable coil. As the coil resides in blood, the hydrogel swells and occupies more space than bare metal coils, leading to higher packing densities (-40% to 50%).
- Helical coils are one form of device that has been extensively employed. Hans Henkes, et al., NEUROSURGERY 54, No. 2, 268 (2004) describe the results of over 1800 procedures involving helical coils and conclude that such devices are safe and efficacious for occlusion for patients with intracranial aneurysms.
- United States Patent Number 5,658,308 issued to Snyder describes a helical metal device with from one to several hundred axial fibrous strands passing through its center and optionally filaments attached to the windings of the coil. These filaments are recited to be bioactive or nonbioactive and to enhance the ability of the coil to occlude the site at which it is placed.
- United States Patent Number 5, 935,145 issued to Villar and Aganon describes helical coils two fibrous members, each of a different material, attached. One of the materials is preferably biodegradable. The other is preferably not biodegradable.
- United States Patent Number 6,299,627 issued to Eder et al. describes devices with coils or braids and two coatings including an inner coating and another coating selected to affect the solubility of the inner coating.
- vaso-occlusion devices comprised of a coil, e.g., a metallic coil enlaced with biological, biodegradable or synthetic polymer fibers.
- bioactive agents biological, biodegradable, or synthetic
- concentrations or in greater amounts can be used at higher concentrations or in greater amounts than previously used. The same concentration or amount can be spread over a larger contact surface area.
- the amount of additional surface area provided by the enlaced fibers should be at least 0.1 times the surface area provided by the metallic coil itself, to as much as 10 or greater times the surface area provided by the metallic coil itself.
- this invention provides a vaso-occlusion device comprising:
- a helical coil of 0.025 mm or larger metal wire the coil sized for insertion to a point of use in the vascular network of a patient for occluding blood flow and having a plurality of windings and having a first surface area
- a plurality of fibrous elements enlaced through the helical coil and having outwardly extending ends said fibrous elements presenting a bioactive outer surface and collectively having a second surface area with the second surface area being at least 0.1 times the first surface area.
- the majority of the fibrous elements each enlace a single winding of the helical coil. In additional embodiments the majority of the fibrous elements each enlace two or more windings of the helical coil.
- the fibrous elements can be made of a bioactive material or a nonbioactive material. They can be stable in the conditions of use or they can undergo biodegradation in that setting. They can include a coating of bioactive material on a core of nonbioactive material or on a core of bioactive material. They may include a coating comprised at least partially of a nonbioactive material.
- the bioactive material can be a naturally-occurring material or a synthetic material. Synthetic material may include any material made by the human hand including, but not limited to engineered versions of nanturally occurring material, e.g., molecules.
- An exemplary family of materials for forming the fibers or for coating the fibers include copolymers of glycolic acid with lactic acid copolymers.
- this invention provides methods of producing these devices by enlacing fibers, before or after coating, into the helical coils as well as methods for treating a patient to embolize a body site by placing a device of this invention at the site in need of embolization.
- Figure 1 is a not-to-scale side view of a vaso-occlusive coil showing three representative embodiments of the fibers which are present enlaced into it. Three areas are identified in Fig. 1. Area 2-2' shows an embodiment where the fibers are enlaced around a single loop of the coil. Area 3-3' shows an embodiment where the fibers are enlaced through a single loop of the coil. Area 4-4' shows an embodiment where the fibers are enlaced through a plurality of loops of the coil.
- Figure 2 is an expanded scale view of the 2-2' area of Fig 1 which shows an embodiment where the fibers are enlaced around a single loop of the coil.
- Figure 3 is an expanded scale view of the 3-3' area of Fig 1 which shows an embodiment where the fibers are enlaced through a single loop of the coil.
- Figure 3' is an expanded scale view of the 3-3' area of Fig 1 which shows an embodiment where the fibers are enlaced through a pair of loops of the coil.
- Figure 4 is an expanded scale view of the 4-4'area of Fig 1 which shows an embodiment where the fibers are enlaced in an "S" pattern through a plurality of loops of the coil.
- Figure 5 is an expanded scale view similar to Fig 4 with a variation in the way the fibers are enlaced.
- two sets of fibers are enlaced adjacent to each other in "S" patterns on the coil.
- Figure 6 is a not-to-scale partial cross section of a type of fiber or a type of coil useful in the present invention having a core and an outer coating.
- Figure 7a is a not-to-scale side view of an example of one embodiment of the invention comprising a vaso-occlusive coil which includes a stretch resistant member fixedly attached to the coil and a plurality of fibers, where each fiber is wrapped around the stretch resistant member at least twice.
- Figure 7b is a not-to-scale top view of the embodiment of the invention shown in Figure 7a.
- the vaso-occlusion devices of this invention are made up of a coil, e.g. a metal coil preferably with enlaced fibers pendant therefrom.
- the devices are in the form of a helix and may be comprised of a simple single helix.
- the coils are coils on coils having a primary helical coil wound into a secondary helix or other secondary shape with fibers enlaced through the primary coil such as shown in Figure 1.
- a device 10 is shown having a metal coil 12 having a large or secondary helix having a diameter Ds and a small or primary helix having a diameter Dp.
- a plurality of fibers 14, 16, and 18 are shown enlaced through the coils of the primary helix in configurations captured in lines 2-2', 3-3' and 4-4' and thereafter depicted in expanded scale in Figures 2, 3, 3' and 4 respectively. It will be appreciated that these four enlacing configurations are merely representative and that equivalent configurations which suitably associate the fibers with the coils are also contemplated within the scope of this invention.
- the wire making up the coil 12 may be a biocompatible metal, that is a metal that does not react adversely with the tissues and fluids it comes in contact with when used in the body.
- the metals may also be radio opaque so that the position and location of the coils in the body can be monitored with radiological techniques.
- Suitable metals include, but are not limited to the noble metals such as the platinum group metals which include platinum, palladium, rhodium and rhenium as well as iridium, gold, silver, tungsten, and tantalum and alloys of these metals with one another. Additional useful metals may include the super elastic metals such as "Nitinol" and the like.
- Nickel-titanium alloys having about 0.4 to about 0.5 molar fraction nickel and 0.5 to 0.6 molar fraction titanium; aluminum-nickel alloys having about 0.35 to 0.4 molar fraction aluminum; and the like.
- Platinum-iridium and platinum- tungsten alloys having predominant fractions of platinum are most preferred metals.
- the metal component may be comprised of a wire.
- the wire commonly has a diameter of from about 0.025 to about 0.09 mm, from about 0.03 to about 0.08 mm from about 0.04 to about 0.06 mm.
- the wire has a diameter of about 0.05 mm.
- the wire may be comprised only of a primary shape e.g., a simple single helix.
- the wire component may comprise a primary shape e.g., helical coil and a secondary shape.
- the secondary shape may comprise a complicated three dimensional shape.
- the wire can comprise a coil of coils or double helix.
- the outer or secondary diameter of the outer helix may be from about 1 to about 25 mm in some embodiments and from about 2 to 20 mm in certain other embodiments.
- the primary (inner) helix may typically have an outside diameter of from about 0.1 to about 0.8 mm in some embodiments, and from about 0.15 to about 0.6 mm in other embodiments and from about 0.2 to about 0.4 mm in yet other embodiments.
- Certain specific embodiments provide for coils having a primary diameter of about 0.28 mm sized to pass through a correspondingly dimensioned catheter.
- Yet other embodiments provide for coils having a primary diameter of about 0.24mm sized to pass through a correspondingly dimensioned catheter.
- the secondary helix may have from about 0.5 to about 20 windings per cm in some embodiments and from about 1 to about 10 windings per cm in other embodiments.
- the inner or primary coil may have from about 2 to about 50 windings per mm in some embodiments and from about 5 to about 40 windings per mm in other embodiments. These primary coil winding values are determined on the primary coil without added fibers. As fibers are added they typically expand the primary helix to some degree as they enlace through the primary helical coils. Thus, in Figures 1 , 2, 3 and 4 the primary helix coils are depicted with a pitch that allows for free space between adjacent coils.
- this extra spacing between the coils is shown to make up to about 60% of the overall secondary helix length. While this configuration is certainly acceptable in many settings, in other settings it may be desirable to have the spacing between the coils small enough (or nonexistent) so as to permit the fibers, when added, to distort the coil and permit the coil to apply pressure to grip the fibers and hold them in place. This latter situation is referred to as a "fiber gripping" configuration for the primary coil. Accordingly, in certain embodiments the extra spacing between adjacent primary coil windings can range from about 0 % to about 80% of the overall unstretched primary helix length. A fiber- gripping configuration may be achieved when the extra spacing between adjacent coils is in the range of from about 0% to about 25% of the total length.
- the unstretched overall axial length of the devices of this invention ranges from about 5 to about 400 mm in some embodiments and from about 10 to about 300 mm in other embodiments. This length may be selected depending upon the particular application of use and may be longer than 400 mm in some embodiments.
- the fibers that comprise part of the devices of the invention are enlaced through the primary coils of the helixes.
- the fibers that comprise part of the devices of the invention are wrapped at least twice around a stretch resistant member disposed within the central lumen of the coil, typically attached at each end thereof.
- the fiber may be tied to the coil or the stretch resistant member, e.g., via a knot.
- the fiber may be tied and laced around the coil or the stretch resistant member or both.
- the fiber is not tied or knotted, but is laced or wound around the coil or the stretch resistant member or both.
- the fibers may be flexible and may be cut to shorter lengths to accommodate coil delivery through a microcatheter.
- one suitable lacing configuration may include fibers laced around a single coil 20 of the primary helix with both ends of a single fiber 14 extending radially from the coil 12 in the same general direction. This can occur with a single fiber such as 14c-14c' or with a plurality of fibers 14e-14e'.
- the fibers may be comprised of monofilaments or yarns.
- the fibers may be comprised of single fibers or bundles of associated fibers.
- the bundles of fibers may range from two fibers to about 50 fibers or more.
- the fibers are not drawn to scale in any of these drawings. In certain i embodiments, they may extend from the secondary coil at least about 0.05 mm.
- the fibers may have diameters ranging from about 0.01 mm to about 0.60 mm in some embodiments. In other embodiments the fibers may have diameters ranging from about 0.02 mm to about 0.05 mm. In the case of yarns, the overall yarn diameter will typically be in these ranges with the individual filaments making up the yarn being smaller in diameter.
- one embodiment of the invention contemplates enlacing the fibers 16 such that they extend out of opposite sides of the primary winding 12.
- a single fiber 16a-16a' can enlace and pass by a single coil 22 of helix 12.
- a bundle of fibers 16b-16b' can enlace and pass by a single coil 22'.
- the fibers in this embodiment may be of similar dimensions to those set forth in Figure 2.
- a bundle of fibers 16c-16c' or an individual fiber 16d-16d' may be laced through a pair of adjacent coils 24 and 24' in the primary helix.
- This configuration may advantageously provide a fiber- gripping spacing between adjacent coils.
- the fibers that are enlaced through the primary helix of the coil may be enlaced back and forth across the coil in an "S" configuration to facilitate gripping of the fibers by the coil and minimize the likelihood that they are dislodged in use.
- a bundle of fibers 28 first laces though windings 32 and 34 of coil 12 leaving a tail 30 extending a suitable distance as set forth above.
- the bundle 28 forms loop 38 spanning a number of windings 36. This number may be as small as one winding or may be as large as 10-12 windings. In certain embodiments the number of windings may be substantially larger than 12.
- certain embodiments of the invention provide at least one winding looped by a fiber, e.g. 38 in Figure 4. Then the fibers may be enlaced through windings 40 and 42 and out the other side of coil 12 to form a corresponding opposite loop 46 which spans a number of windings 44 which may be about the same as the number of windings described for 38. The fibers may then be enlaced through windings 48 and 50 and end at 28' to form a tail 52 similar to tail 28.
- Figure 5 shows that multiple bundles forming the double looped "S" configuration 28 and 28A through 28' and 28A' are also contemplated. These multiple loops may be arrayed parallel to one another and enlace adjacent windings as depicted in Figure 5 but may also vary from one another and be more random, if desired.
- the device of the invention may be comprised of a stretch resistant member.
- the stretch resistant member may prevent movement or elongation or deformation of the device e.g., during retrieval or repositioning.
- the stretch resistant member may be fixedly attached to at least one end of the device. In certain embodiments it may be fixedly attached to both ends of the device. In some embodiments, the stretch resistant member may axially traverse the interior region or lumen of the coil.
- the stretch resistant member may be made from a wide variety of materials. These include any of the materials, e.g., metals, described as suitable for making the coil.
- the stretch resistant member may be comprised of a radiopaque material. It may also be comprised of a polymer.
- at least one fiber is wrapped at least two times round the stretch resistant member.
- the invention provides for a plurality of fibers, e.g. at least one bundle or a plurality of bundles wrapped at least two times round the stretch resistant member. Wrapping the fiber around the stretch resistant member at least twice advantageously provides a means of securing at least one fiber to the device.
- the fiber may not be tied or knotted to the device thereby avoiding potentially obstructive bundles which might hinder deployment of the device or might mechanically damage the device.
- the fibers may be comprised of polymeric materials.
- the polymeric materials may include materials approved for use as implants in the body or which could be so approved. They may be nonbiodegradable polymers such as polyethylene, polyacrylics, polypropylene, polyvinylchloride, polyamides such as nylon, e.g., Nylon 6.6, polyurethanes, polyvinylpyrrolidone, polyvinyl alcohols, polyvinylacetate, cellulose acetate, polystyrene, polytetrafluoroethylene, polyesters such as polyethylene terephthalate (Dacron), silk, cotton, and the like.
- the nonbiodegradable materials for the polymer component may comprise polyesters, polyethers, polyamides and polyfluorocarbons.
- the polymers can be biodegradable as well.
- Representative biodegradable polymers include: polyglycolic acid/polylactic acid (PGLA), polycaprolactone (PCL), polyhydroxybutyrate valerate (PHBV), polyorthoester (POE), polyethyleneoxide/polybutylene terephthalate (PEO/PBTP), polylactic acid (PLA), polyglycolic acid (PGA), poly (p-dioxanone), poly (valetolactone), poly (tartronic acid), poly ( ⁇ malonic acid), poly (propylene fumarate), poly (anhydrides); and tyrosine-based polycarbonates.
- PGLA polyglycolic acid/polylactic acid
- PCL polycaprolactone
- PHBV polyhydroxybutyrate valerate
- POE polyorthoester
- PEO/PBTP polyethyleneoxide/polybutylene terephthalate
- PLA polylactic acid
- PGA polyglycolic acid
- the biodegradable polymer may be comprised of copolymers of lactic acid and glycolic acid.
- the copolymer may be comprised of glycolic/lactic acid in the ratio of 90:10.
- the ratio of glycolic to lactic acid is chosen from 99:1 ; 90:10; 95:5; 50:50; 10:90; 5:95; 1 :99.
- the fibers may be comprised of Nylon 6.6
- the fibers may be coated with at least a single coating of bioactive material (e.g. growth factors, genes, collagen, peptides, oligonucleotides, marine biopolymers such as chitosan, various mono-, di-, and poly-saccahrides such as hyaloronic acid and the like or combinations thereof).
- bioactive material e.g. growth factors, genes, collagen, peptides, oligonucleotides, marine biopolymers such as chitosan, various mono-, di-, and poly-saccahrides such as hyaloronic acid and the like or combinations thereof.
- a plurality of coatings is contemplated.
- the fibers may be coated with a non-bioactive material, or a combination of bioactive and non-bioactive material applied as a single layer or a plurality of layers.
- the fibers can include within their body a bioactive material.
- the bioactive material can be present in a coating applied to the coil, the stretch resistant member, or to the fibers or to any combination of the three.
- the bioactive coating may be applied to the coil as a single layer and the fibers with or without bioactive coating can be omitted. In other embodiments, however, the bioactive material is dispersed in the fiber or coated on the fiber. As shown in Figure 6 this configuration involves a core of metal coil or fiber 30 with single outer coating comprising bioactive material 32.
- the bioactive material e.g., coatings may be proteinaceous e.g., a collageneous coating.
- Collageneous coatings may be of a wide variety of types, including natural or synthetic.
- the bioactive material comprises a photo polymerizable collagen coating which will bind both with the metal with or without added bioactive agents.
- suitable collageneous materials include those having the same surface functional groups as do Type I and Type IV natural collagens.
- the bioactive material or agent present in the polymer itself or the coating if present may have one or more functions, including, but not limited to, reducing friction, providing a therapeutic for local or blood borne delivery, or reducing thrombosis, coagulation or platelet activity.
- the bioactive material may be hydrophilic, e.g. a lubricious hydrophilic material such as hyaluronic acid. Examples of suitable hydrophilic compounds include polyvinyl alcohol (PVA), polyvinylpyrrolidone (PVP), polyacrylamide and the like.
- the bioactive material may be hydrophobic. Hydrophobic compounds include membrane lipids such as phosphatidyl choline, fatty acid esters and the like.
- the bioactive material may include water soluble therapeutics.
- water-soluble therapeutics include thrombolytics such as tissue plasminogen activator (TPA), streptokinase, urokinase, hirudin and growth factors such as vEGF.
- TPA tissue plasminogen activator
- streptokinase streptokinase
- urokinase urokinase
- hirudin growth factors
- growth factors such as vEGF.
- the bioactive material may include fat soluble therapeutics, e.g., fat soluble vitamins.
- the bioactive coating or material may also promote cell attachment. It may also be thrombogenic.
- bioactive coatings or materials which increase cell attachment and/or thrombogenicity include both natural and synthetic compounds, e.g. collagen, fibrinogen, vitronectin, other plasma proteins, growth factors (e.g.
- vEGF vascular endothelial growth factor
- synthetic peptides of these and other proteins or peptides having attached RGD (arginine glycine-aspartic acid) residues generally at one of both termini or other cell adhesion peptides, i.e., GRGDY, oligonucleotides, full or partial DNA constructs, natural or synthetic phospholipids or polymers with phosphorylcholine functionality.
- the devices of this invention may be introduced to a selected site and thus the device of the invention may be used in treating a variety of maladies.
- the aneurysm itself may be filled with a plurality of devices.
- only one device may be administered.
- an emboli Shortly after the devices are placed within the aneurysm, an emboli may begin to form optionally under the influence of the bioactive material..
- a selected site may be reached through the vascular system using a collection of specifically chosen catheters and guide wires.
- a large catheter is introduced through an entry site in the vasculature. Typically, this would be through a femoral artery in the groin. Other entry sites sometimes chosen are found in the neck and are in general well known by physicians who practice this type of medicine.
- a guiding catheter is then used to provide a safe passageway from the entry site to a region near the site to be treated.
- a guiding catheter in treating a site in the human brain, would be chosen which would extend from the entry site at the femoral artery, up through the large arteries extending to the heart, around the heart through the aortic arch, and downstream through one of the arteries extending from the upper side of the aorta.
- a guidewire and neurovascular catheter are then placed though the guiding catheter as a unit. Once the tip of the guidewire reaches the end of the guiding catheter, it is then extended by the physician, with the aid of fluoroscopy to the site to be treated using the vaso-occlusive devices of this invention.
- the guidewire is advanced first from the guide catheter tip to the treatment site, followed by the neurovascular catheter.
- the guidewire is then withdrawn.
- the neurovascular catheter then has an open lumen to the outside of the body.
- the device of the invention is then pushed through the lumen to the treatment site and detached from the catheter.
- the device may be held in place because of its shape, size or volume.
- a T- 10 platinum coil is obtained and fastened to a flat surface at its ends. It has a primary helix diameter of 0.028 mm.
- a plurality of Vicryl 90/100 PGLA sutures with diameters of from 0.099 mm to 0.029 mm are obtained. These sutures are made up of a bundle of 6-7 small microfibers about 12 ⁇ m in diameter. A single monofilament of similar size could also be employed.
- the fibers are cut into about 2 cm lengths and physically enlaced in between windings of the T-10 coil in the configurations shown in Figures 2- 5. This is done until a total of about 10-20 fibers per cm extend away from the coils. The fibers are trimmed to have 2-4 cm lengths extending from the coils.
- the fibers are coated with bioactive material or if they contain bioactive material, the surface area provided by the fibers would enhance delivery and activity.
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007527550A JP4723584B2 (en) | 2004-05-21 | 2005-05-23 | Coil made of metal to occlude a body cavity wrapped with a biological, biodegradable or synthetic polymer or fiber |
CA2567331A CA2567331C (en) | 2004-05-21 | 2005-05-23 | Metallic coils enlaced with biological or biodegradable or synthetic polymers or fibers for embolization of a body cavity |
EP05756033A EP1761178B1 (en) | 2004-05-21 | 2005-05-23 | Metallic coils enlaced with biological or biodegradable or synthetic polymers or fibers for embolization of a body cavity |
DE602005025215T DE602005025215D1 (en) | 2004-05-21 | 2005-05-23 | METAL COILS EMBOSSED BY ORGANIC OR BIODEGRADABLE OR SYNTHETIC POLYMERS OR FIBERS FOR THE EMBOLIZATION OF A BODY HEIGHT |
AT05756033T ATE490736T1 (en) | 2004-05-21 | 2005-05-23 | METAL COILS COVERED WITH BIOLOGICAL OR BIODEGRADABLE OR SYNTHETIC POLYMERS OR FIBERS FOR EMBOLIZING A BODY CAVITY |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57371004P | 2004-05-21 | 2004-05-21 | |
US60/573,710 | 2004-05-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2005113035A2 true WO2005113035A2 (en) | 2005-12-01 |
WO2005113035A3 WO2005113035A3 (en) | 2006-02-23 |
Family
ID=34978919
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2005/018087 WO2005113035A2 (en) | 2004-05-21 | 2005-05-23 | Metallic coils enlaced with biological or biodegradable or synthetic polymers or fibers for embolization of a body cavity |
Country Status (8)
Country | Link |
---|---|
US (2) | US7896899B2 (en) |
EP (2) | EP1761178B1 (en) |
JP (2) | JP4723584B2 (en) |
AT (1) | ATE490736T1 (en) |
CA (1) | CA2567331C (en) |
DE (1) | DE602005025215D1 (en) |
ES (2) | ES2357243T3 (en) |
WO (1) | WO2005113035A2 (en) |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007073549A2 (en) * | 2005-12-19 | 2007-06-28 | Boston Scientific Scimed, Inc. | Coated embolic coils with fibers |
WO2008109228A2 (en) * | 2007-03-05 | 2008-09-12 | Boston Scientific Limited | Deploying embolic coils |
WO2010014075A1 (en) * | 2007-07-27 | 2010-02-04 | Microvention, Inc. | Detachable coil incorporating stretch resistance |
JP2010521231A (en) * | 2007-03-13 | 2010-06-24 | マイクロ セラピューティクス, インコーポレイテッド | Implant including a coil and a stretch resistant member |
WO2014165023A1 (en) * | 2013-03-12 | 2014-10-09 | Carnegie Mellon University | Coated vaso-occclusive device for treatment of aneurysms |
FR3008304A1 (en) * | 2013-07-15 | 2015-01-16 | Balt Extrusion | ENDOPROTHESIS FOR THE TREATMENT IN PARTICULAR AN ANEURYSM |
US9198665B2 (en) | 2004-09-22 | 2015-12-01 | Covidien Lp | Micro-spiral implantation device |
US10299755B2 (en) | 2007-12-21 | 2019-05-28 | Microvention, Inc. | System and method for locating detachment zone of a detachable implant |
US10660645B2 (en) | 2013-03-15 | 2020-05-26 | Embo Medical Limited | Embolization systems |
US10675039B2 (en) | 2013-03-15 | 2020-06-09 | Embo Medical Limited | Embolisation systems |
US10893868B2 (en) | 2012-01-20 | 2021-01-19 | Covidien Lp | Aneurysm treatment coils |
US10898215B2 (en) | 2017-10-16 | 2021-01-26 | Retriever Medical, Inc. | Method to remove a thrombus |
US11090057B2 (en) | 2013-03-15 | 2021-08-17 | Embo Medical Limited | Embolisation systems |
WO2021233553A1 (en) * | 2020-05-22 | 2021-11-25 | Clearstream Technologies Limited | Embolisation devices and methods of manufacturing the same |
US11382643B2 (en) | 2017-10-16 | 2022-07-12 | Retriever Medical, Inc. | Clot removal methods and devices with multiple independently controllable elements |
US11439402B2 (en) | 2019-04-18 | 2022-09-13 | Clearstream Technologies Limited | Embolization devices and methods of manufacturing the same |
US11589881B2 (en) | 2017-10-16 | 2023-02-28 | Retriever Medical, Inc. | Clot removal methods and devices with multiple independently controllable elements |
Families Citing this family (102)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070093889A1 (en) * | 1999-01-27 | 2007-04-26 | Wu Benjamin M | Non-Fragmenting Low Friction Bioactive Absorbable Coils for Brain Aneurysm Therapy |
US6280457B1 (en) * | 1999-06-04 | 2001-08-28 | Scimed Life Systems, Inc. | Polymer covered vaso-occlusive devices and methods of producing such devices |
US8048104B2 (en) | 2000-10-30 | 2011-11-01 | Dendron Gmbh | Device for the implantation of occlusion spirals |
US7727221B2 (en) | 2001-06-27 | 2010-06-01 | Cardiac Pacemakers Inc. | Method and device for electrochemical formation of therapeutic species in vivo |
JP4351405B2 (en) * | 2001-08-29 | 2009-10-28 | インターナショナル・ビジネス・マシーンズ・コーポレーション | Transcoding system and annotation management device |
US8425549B2 (en) | 2002-07-23 | 2013-04-23 | Reverse Medical Corporation | Systems and methods for removing obstructive matter from body lumens and treating vascular defects |
JP2004261234A (en) * | 2003-02-20 | 2004-09-24 | Kaneka Medix Corp | Internal indwelling device for forming embolus |
DE102004003265A1 (en) * | 2004-01-21 | 2005-08-11 | Dendron Gmbh | Device for the implantation of electrically isolated occlusion coils |
ES2357243T3 (en) | 2004-05-21 | 2011-04-20 | Micro Therapeutics, Inc. | METAL SPIRALS INTERLATED WITH POLYMERS OR BIOLOGICAL OR BIODEGRADABLE OR SYNTHETIC FIBERS FOR THE EMBOLIZATION OF A BODY CAVITY. |
ATE417552T1 (en) * | 2004-09-22 | 2009-01-15 | Dendron Gmbh | MEDICAL IMPLANT |
US8535345B2 (en) * | 2004-10-07 | 2013-09-17 | DePuy Synthes Products, LLC | Vasoocclusive coil with biplex windings to improve mechanical properties |
DE102005019782A1 (en) * | 2005-04-28 | 2006-11-09 | Dendron Gmbh | Device for implantation of occlusion coils with internal securing means |
US8152839B2 (en) * | 2005-12-19 | 2012-04-10 | Boston Scientific Scimed, Inc. | Embolic coils |
US8840660B2 (en) | 2006-01-05 | 2014-09-23 | Boston Scientific Scimed, Inc. | Bioerodible endoprostheses and methods of making the same |
US8089029B2 (en) | 2006-02-01 | 2012-01-03 | Boston Scientific Scimed, Inc. | Bioabsorbable metal medical device and method of manufacture |
US20070239194A1 (en) * | 2006-04-05 | 2007-10-11 | Boston Scientific Scimed, Inc. | Vaso-occlusive devices having expandable fibers |
US8048150B2 (en) | 2006-04-12 | 2011-11-01 | Boston Scientific Scimed, Inc. | Endoprosthesis having a fiber meshwork disposed thereon |
JP5230602B2 (en) | 2006-04-17 | 2013-07-10 | タイコ ヘルスケア グループ リミテッド パートナーシップ | System and method for mechanically positioning an endovascular implant |
US8777979B2 (en) | 2006-04-17 | 2014-07-15 | Covidien Lp | System and method for mechanically positioning intravascular implants |
US8052743B2 (en) | 2006-08-02 | 2011-11-08 | Boston Scientific Scimed, Inc. | Endoprosthesis with three-dimensional disintegration control |
JP2010503491A (en) | 2006-09-15 | 2010-02-04 | ボストン サイエンティフィック リミテッド | Bioerodible endoprosthesis with biologically stable inorganic layers |
CA2663220A1 (en) | 2006-09-15 | 2008-03-20 | Boston Scientific Limited | Medical devices and methods of making the same |
EP2068782B1 (en) | 2006-09-15 | 2011-07-27 | Boston Scientific Limited | Bioerodible endoprostheses |
EP2081616B1 (en) | 2006-09-15 | 2017-11-01 | Boston Scientific Scimed, Inc. | Bioerodible endoprostheses and methods of making the same |
US8002821B2 (en) | 2006-09-18 | 2011-08-23 | Boston Scientific Scimed, Inc. | Bioerodible metallic ENDOPROSTHESES |
DE602007010669D1 (en) | 2006-12-28 | 2010-12-30 | Boston Scient Ltd | HREN FOR THIS |
CN101677821B (en) * | 2007-03-13 | 2014-05-14 | 泰科保健集团有限合伙公司 | Implant and mandrel |
DE102007038446A1 (en) * | 2007-08-14 | 2009-02-19 | pfm Produkte für die Medizin AG | Embolisiereinrichtung |
US8052745B2 (en) * | 2007-09-13 | 2011-11-08 | Boston Scientific Scimed, Inc. | Endoprosthesis |
US9220522B2 (en) * | 2007-10-17 | 2015-12-29 | Covidien Lp | Embolus removal systems with baskets |
US8066757B2 (en) | 2007-10-17 | 2011-11-29 | Mindframe, Inc. | Blood flow restoration and thrombus management methods |
US8926680B2 (en) * | 2007-11-12 | 2015-01-06 | Covidien Lp | Aneurysm neck bridging processes with revascularization systems methods and products thereby |
US20100022951A1 (en) * | 2008-05-19 | 2010-01-28 | Luce, Forward, Hamilton 7 Scripps, Llp | Detachable hub/luer device and processes |
US11337714B2 (en) | 2007-10-17 | 2022-05-24 | Covidien Lp | Restoring blood flow and clot removal during acute ischemic stroke |
US20100174309A1 (en) * | 2008-05-19 | 2010-07-08 | Mindframe, Inc. | Recanalization/revascularization and embolus addressing systems including expandable tip neuro-microcatheter |
US8088140B2 (en) | 2008-05-19 | 2012-01-03 | Mindframe, Inc. | Blood flow restorative and embolus removal methods |
US10123803B2 (en) | 2007-10-17 | 2018-11-13 | Covidien Lp | Methods of managing neurovascular obstructions |
US8585713B2 (en) | 2007-10-17 | 2013-11-19 | Covidien Lp | Expandable tip assembly for thrombus management |
US8545514B2 (en) * | 2008-04-11 | 2013-10-01 | Covidien Lp | Monorail neuro-microcatheter for delivery of medical devices to treat stroke, processes and products thereby |
US20100256600A1 (en) * | 2009-04-04 | 2010-10-07 | Ferrera David A | Neurovascular otw pta balloon catheter and delivery system |
US9198687B2 (en) * | 2007-10-17 | 2015-12-01 | Covidien Lp | Acute stroke revascularization/recanalization systems processes and products thereby |
US8034075B2 (en) | 2007-11-09 | 2011-10-11 | Micrus Endovascular Corporation | Tethered coil for treatment of body lumens |
EP2237828A4 (en) * | 2008-01-07 | 2013-06-05 | Intersect Partners Llc | Novel enhanced ptna rapid exchange type of catheter system |
JP5457373B2 (en) | 2008-02-22 | 2014-04-02 | コヴィディエン リミテッド パートナーシップ | Device for blood flow recovery |
EP2460478B1 (en) * | 2008-04-21 | 2021-09-08 | Covidien LP | Braid-ball embolic devices and delivery systems |
US10716573B2 (en) | 2008-05-01 | 2020-07-21 | Aneuclose | Janjua aneurysm net with a resilient neck-bridging portion for occluding a cerebral aneurysm |
US10028747B2 (en) | 2008-05-01 | 2018-07-24 | Aneuclose Llc | Coils with a series of proximally-and-distally-connected loops for occluding a cerebral aneurysm |
EP2285901B1 (en) | 2008-05-06 | 2020-07-22 | CJ CheilJedang Corporation | Biodegradable polyester blends |
US7998192B2 (en) | 2008-05-09 | 2011-08-16 | Boston Scientific Scimed, Inc. | Endoprostheses |
US8236046B2 (en) | 2008-06-10 | 2012-08-07 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis |
ES2528655T3 (en) * | 2008-06-27 | 2015-02-11 | Kabusiki Kaisha Kyoto Iryo Sekkei | Vascular cannula |
US7985252B2 (en) | 2008-07-30 | 2011-07-26 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis |
EP2320829A1 (en) * | 2008-07-31 | 2011-05-18 | Boston Scientific Scimed, Inc. | Coils for vascular implants or other uses |
US8382824B2 (en) | 2008-10-03 | 2013-02-26 | Boston Scientific Scimed, Inc. | Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides |
WO2010101901A2 (en) | 2009-03-02 | 2010-09-10 | Boston Scientific Scimed, Inc. | Self-buffering medical implants |
KR20110043799A (en) * | 2009-10-16 | 2011-04-28 | 강호창 | Micro-coil assembly |
US9814562B2 (en) | 2009-11-09 | 2017-11-14 | Covidien Lp | Interference-relief type delivery detachment systems |
US9358140B1 (en) | 2009-11-18 | 2016-06-07 | Aneuclose Llc | Stent with outer member to embolize an aneurysm |
US8668732B2 (en) | 2010-03-23 | 2014-03-11 | Boston Scientific Scimed, Inc. | Surface treated bioerodible metal endoprostheses |
US8353952B2 (en) * | 2010-04-07 | 2013-01-15 | Medtronic Vascular, Inc. | Stent with therapeutic substance |
US8795313B2 (en) | 2011-09-29 | 2014-08-05 | Covidien Lp | Device detachment systems with indicators |
US8945171B2 (en) | 2011-09-29 | 2015-02-03 | Covidien Lp | Delivery system for implantable devices |
US9579104B2 (en) | 2011-11-30 | 2017-02-28 | Covidien Lp | Positioning and detaching implants |
KR101315443B1 (en) * | 2011-12-02 | 2013-10-07 | 강호창 | Micro-coil assembly |
US10342548B2 (en) | 2012-01-13 | 2019-07-09 | W. L. Gore & Associates, Inc. | Occlusion devices and methods of their manufacture and use |
US9687245B2 (en) | 2012-03-23 | 2017-06-27 | Covidien Lp | Occlusive devices and methods of use |
US9326774B2 (en) | 2012-08-03 | 2016-05-03 | Covidien Lp | Device for implantation of medical devices |
US9475930B2 (en) | 2012-08-17 | 2016-10-25 | Metabolix, Inc. | Biobased rubber modifiers for polymer blends |
US9119948B2 (en) | 2013-02-20 | 2015-09-01 | Covidien Lp | Occlusive implants for hollow anatomical structures, delivery systems, and related methods |
US9763667B2 (en) | 2013-03-14 | 2017-09-19 | Cook Medical Technologies Llc | Embolization coil with barbed fiber |
WO2014145012A2 (en) | 2013-03-15 | 2014-09-18 | Covidien Lp | Delivery and detachment mechanisms for vascular implants |
EP3004225A1 (en) | 2013-05-30 | 2016-04-13 | Metabolix, Inc. | Recyclate blends |
US9681876B2 (en) | 2013-07-31 | 2017-06-20 | EMBA Medical Limited | Methods and devices for endovascular embolization |
US10010328B2 (en) | 2013-07-31 | 2018-07-03 | NeuVT Limited | Endovascular occlusion device with hemodynamically enhanced sealing and anchoring |
CN106456933B (en) | 2013-12-20 | 2020-03-13 | 微仙美国有限公司 | Catheter system |
US10611903B2 (en) | 2014-03-27 | 2020-04-07 | Cj Cheiljedang Corporation | Highly filled polymer systems |
US9713475B2 (en) | 2014-04-18 | 2017-07-25 | Covidien Lp | Embolic medical devices |
US9814466B2 (en) | 2014-08-08 | 2017-11-14 | Covidien Lp | Electrolytic and mechanical detachment for implant delivery systems |
US9808256B2 (en) | 2014-08-08 | 2017-11-07 | Covidien Lp | Electrolytic detachment elements for implant delivery systems |
EP3193744A4 (en) * | 2014-09-15 | 2018-07-04 | Donald K. Jones | Intralumenal occlusion devices having improved properties |
US10857012B2 (en) | 2015-01-20 | 2020-12-08 | Neurogami Medical, Inc. | Vascular implant |
US10736730B2 (en) | 2015-01-20 | 2020-08-11 | Neurogami Medical, Inc. | Vascular implant |
US10925611B2 (en) | 2015-01-20 | 2021-02-23 | Neurogami Medical, Inc. | Packaging for surgical implant |
US11484319B2 (en) | 2015-01-20 | 2022-11-01 | Neurogami Medical, Inc. | Delivery system for micrograft for treating intracranial aneurysms |
JP6763864B2 (en) | 2015-01-20 | 2020-09-30 | ニューロガミ メディカル インコーポレイテッド | Micrografts and usage for the treatment of intracranial aneurysms |
EP3266390B1 (en) * | 2015-03-03 | 2020-08-05 | Kaneka Medix Corporation | Vascular embolization tool and production method therefor |
DE202015102060U1 (en) * | 2015-04-24 | 2016-07-27 | Pfm Medical Ag | A medical implant for occluding a defect opening, vessel, organ passage, or other opening in a human or animal body |
US9717503B2 (en) | 2015-05-11 | 2017-08-01 | Covidien Lp | Electrolytic detachment for implant delivery systems |
US10729447B2 (en) | 2016-02-10 | 2020-08-04 | Microvention, Inc. | Devices for vascular occlusion |
US20190076231A1 (en) | 2016-03-10 | 2019-03-14 | Keystone Heart Ltd. | Intra-Aortic Device |
US10828039B2 (en) | 2016-06-27 | 2020-11-10 | Covidien Lp | Electrolytic detachment for implantable devices |
US10828037B2 (en) | 2016-06-27 | 2020-11-10 | Covidien Lp | Electrolytic detachment with fluid electrical connection |
US11051822B2 (en) | 2016-06-28 | 2021-07-06 | Covidien Lp | Implant detachment with thermal activation |
WO2019027966A1 (en) | 2017-07-31 | 2019-02-07 | Boston Scientific Scimed, Inc. | Dilator with engagement region |
EP3668419B1 (en) | 2017-08-15 | 2024-04-03 | Boston Scientific Scimed, Inc. | Occlusive medical device system |
US10874402B2 (en) | 2017-10-10 | 2020-12-29 | Boston Scientific Scimed, Inc. | Detachable RF energized occlusive device |
US11284902B2 (en) | 2018-02-01 | 2022-03-29 | Boston Scientific Scimed, Inc. | Method of making a vascular occlusion device |
WO2019152775A1 (en) | 2018-02-01 | 2019-08-08 | Boston Scientific Scimed, Inc. | Medical device release system |
US11672946B2 (en) | 2019-09-24 | 2023-06-13 | Boston Scientific Scimed, Inc. | Protection and actuation mechanism for controlled release of implantable embolic devices |
CN116370007A (en) * | 2019-12-24 | 2023-07-04 | 上海微创心脉医疗科技(集团)股份有限公司 | Plugging device and system |
US20220313267A1 (en) * | 2021-03-31 | 2022-10-06 | DePuy Synthes Products, Inc. | Bio-absorbable coiled fiber |
CN114081570B (en) * | 2021-12-08 | 2024-03-08 | 杭州拓脉医疗科技有限公司 | Spring ring for embolizing aneurysm and blood vessel |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4677191A (en) * | 1984-07-06 | 1987-06-30 | Wada Pure Chemical Ind., Ltd. | Copolymer and method for producing the same |
EP0368571A2 (en) * | 1988-11-07 | 1990-05-16 | MITSUI TOATSU CHEMICALS, Inc. | Preparation process for bioabsorbable polyester |
US5485496A (en) * | 1994-09-22 | 1996-01-16 | Cornell Research Foundation, Inc. | Gamma irradiation sterilizing of biomaterial medical devices or products, with improved degradation and mechanical properties |
US5746734A (en) * | 1992-10-30 | 1998-05-05 | International Therapeutics Corporation | Introducer cartridge for delivering an embolization device |
US5766219A (en) * | 1995-04-20 | 1998-06-16 | Musc Foundation For Research Development | Anatomically shaped vasoocclusive device and method for deploying same |
US5935145A (en) * | 1998-02-13 | 1999-08-10 | Target Therapeutics, Inc. | Vaso-occlusive device with attached polymeric materials |
US5976162A (en) * | 1996-04-10 | 1999-11-02 | Target Therapeutics, Inc. | Soft-ended fibered micro vaso-occlusive devices |
US6193728B1 (en) * | 1995-06-30 | 2001-02-27 | Target Therapeutics, Inc. | Stretch resistant vaso-occlusive coils (II) |
US6280457B1 (en) * | 1999-06-04 | 2001-08-28 | Scimed Life Systems, Inc. | Polymer covered vaso-occlusive devices and methods of producing such devices |
US20040098029A1 (en) * | 2000-10-18 | 2004-05-20 | Scimed Life Systems, Inc. | Non-overlapping spherical three-dimensional coil |
Family Cites Families (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3174851A (en) | 1961-12-01 | 1965-03-23 | William J Buehler | Nickel-base alloys |
US4238194A (en) * | 1966-10-04 | 1980-12-09 | General Electric Company | Nuclei analysis of solid substances |
US3834394A (en) | 1969-11-21 | 1974-09-10 | R Sessions | Occlusion device and method and apparatus for inserting the same |
US3753700A (en) | 1970-07-02 | 1973-08-21 | Raychem Corp | Heat recoverable alloy |
US4346712A (en) | 1979-04-06 | 1982-08-31 | Kuraray Company, Ltd. | Releasable balloon catheter |
US4545367A (en) | 1982-07-16 | 1985-10-08 | Cordis Corporation | Detachable balloon catheter and method of use |
US4994069A (en) | 1988-11-02 | 1991-02-19 | Target Therapeutics | Vaso-occlusion coil and method |
US6083220A (en) | 1990-03-13 | 2000-07-04 | The Regents Of The University Of California | Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas |
US5122136A (en) | 1990-03-13 | 1992-06-16 | The Regents Of The University Of California | Endovascular electrolytically detachable guidewire tip for the electroformation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas |
USRE42756E1 (en) | 1990-03-13 | 2011-09-27 | The Regents Of The University Of California | Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas |
US5354295A (en) | 1990-03-13 | 1994-10-11 | Target Therapeutics, Inc. | In an endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas |
US5226911A (en) | 1991-10-02 | 1993-07-13 | Target Therapeutics | Vasoocclusion coil with attached fibrous element(s) |
US5304194A (en) | 1991-10-02 | 1994-04-19 | Target Therapeutics | Vasoocclusion coil with attached fibrous element(s) |
US5256146A (en) | 1991-10-11 | 1993-10-26 | W. D. Ensminger | Vascular catheterization system with catheter anchoring feature |
US5443478A (en) | 1992-09-02 | 1995-08-22 | Board Of Regents, The University Of Texas System | Multi-element intravascular occlusion device |
US5382259A (en) | 1992-10-26 | 1995-01-17 | Target Therapeutics, Inc. | Vasoocclusion coil with attached tubular woven or braided fibrous covering |
US5423849A (en) | 1993-01-15 | 1995-06-13 | Target Therapeutics, Inc. | Vasoocclusion device containing radiopaque fibers |
US6123007A (en) * | 1993-05-19 | 2000-09-26 | Metal Storm Limited | Barrel assembly |
US5423829A (en) | 1993-11-03 | 1995-06-13 | Target Therapeutics, Inc. | Electrolytically severable joint for endovascular embolic devices |
US5624449A (en) | 1993-11-03 | 1997-04-29 | Target Therapeutics | Electrolytically severable joint for endovascular embolic devices |
US6001092A (en) | 1994-06-24 | 1999-12-14 | Target Therapeutics, Inc. | Complex coils having fibered centers |
US5549624A (en) * | 1994-06-24 | 1996-08-27 | Target Therapeutics, Inc. | Fibered vasooclusion coils |
IL116561A0 (en) | 1994-12-30 | 1996-03-31 | Target Therapeutics Inc | Severable joint for detachable devices placed within the body |
US5911731A (en) * | 1995-04-20 | 1999-06-15 | Target Therapeutics, Inc. | Anatomically shaped vasoocclusive devices |
US6143007A (en) | 1995-04-28 | 2000-11-07 | Target Therapeutics, Inc. | Method for making an occlusive device |
US5624461A (en) | 1995-06-06 | 1997-04-29 | Target Therapeutics, Inc. | Three dimensional in-filling vaso-occlusive coils |
EP0754435B1 (en) | 1995-06-30 | 2000-11-08 | Target Therapeutics, Inc. | Stretch-resistant vaso-occlusive coils |
US5853418A (en) * | 1995-06-30 | 1998-12-29 | Target Therapeutics, Inc. | Stretch resistant vaso-occlusive coils (II) |
US5582619A (en) | 1995-06-30 | 1996-12-10 | Target Therapeutics, Inc. | Stretch resistant vaso-occlusive coils |
US5847963A (en) * | 1995-10-19 | 1998-12-08 | Gaiski; Stephen N. | Method for monitoring the effect of adjustments of paint application equipment |
US5658308A (en) | 1995-12-04 | 1997-08-19 | Target Therapeutics, Inc. | Bioactive occlusion coil |
AU690862B2 (en) | 1995-12-04 | 1998-04-30 | Target Therapeutics, Inc. | Fibered micro vaso-occlusive devices |
US5797126A (en) * | 1996-02-16 | 1998-08-18 | Helbling; Edward | Automatic theater ticket concierge |
DE19703482A1 (en) | 1997-01-31 | 1998-08-06 | Ernst Peter Prof Dr M Strecker | Stent |
US5891192A (en) | 1997-05-22 | 1999-04-06 | The Regents Of The University Of California | Ion-implanted protein-coated intralumenal implants |
US6766219B1 (en) * | 1997-05-29 | 2004-07-20 | Gary Marcel Hasey | Apparatus for controlling and monitoring of dispensing of oral medications |
US5984929A (en) | 1997-08-29 | 1999-11-16 | Target Therapeutics, Inc. | Fast detaching electronically isolated implant |
US6511468B1 (en) | 1997-10-17 | 2003-01-28 | Micro Therapeutics, Inc. | Device and method for controlling injection of liquid embolic composition |
US6146373A (en) | 1997-10-17 | 2000-11-14 | Micro Therapeutics, Inc. | Catheter system and method for injection of a liquid embolic composition and a solidification agent |
US7070607B2 (en) | 1998-01-27 | 2006-07-04 | The Regents Of The University Of California | Bioabsorbable polymeric implants and a method of using the same to create occlusions |
WO1999044538A1 (en) | 1998-01-27 | 1999-09-10 | The Regents Of The University Of California | Biodegradable polymer/protein based coils for intralumenal implants |
US5941888A (en) | 1998-02-18 | 1999-08-24 | Target Therapeutics, Inc. | Vaso-occlusive member assembly with multiple detaching points |
US6013089A (en) * | 1998-04-17 | 2000-01-11 | Goldberg; Barry A. | Tongue cleaner |
US20020087184A1 (en) | 1998-06-18 | 2002-07-04 | Eder Joseph C. | Water-soluble coating for bioactive devices |
US5980550A (en) | 1998-06-18 | 1999-11-09 | Target Therapeutics, Inc. | Water-soluble coating for bioactive vasoocclusive devices |
WO2000045868A1 (en) | 1999-02-05 | 2000-08-10 | The Regents Of The University Of California | Thermo-reversible polymer for intralumenal implant |
US6221066B1 (en) | 1999-03-09 | 2001-04-24 | Micrus Corporation | Shape memory segmented detachable coil |
DE10010840A1 (en) | 1999-10-30 | 2001-09-20 | Dendron Gmbh | Device for implanting occlusion coils uses coils electrolytically corrodable at several points at intervals so variable sized lengths can be separated by electrolysis |
US8048104B2 (en) | 2000-10-30 | 2011-11-01 | Dendron Gmbh | Device for the implantation of occlusion spirals |
DE10118017B4 (en) | 2001-04-10 | 2017-04-13 | Dendron Gmbh | Occlusion coil and device for implantation of occlusion coils |
JP2005500121A (en) | 2001-08-27 | 2005-01-06 | デンドロン・ゲー・エム・ベー・ハー | Occlusion means detention device |
EP1296467B1 (en) * | 2001-09-24 | 2004-02-25 | Evolium S.A.S. | Method for synchronizing terrestrial nodes equipped with GNSS receivers and belonging to a terrestrial network |
DE10155191A1 (en) | 2001-11-12 | 2003-05-22 | Dendron Gmbh | Medical implant |
US7485122B2 (en) | 2002-06-27 | 2009-02-03 | Boston Scientific Scimed, Inc. | Integrated anchor coil in stretch-resistant vaso-occlusive coils |
DE10233085B4 (en) | 2002-07-19 | 2014-02-20 | Dendron Gmbh | Stent with guide wire |
US20040170685A1 (en) * | 2003-02-26 | 2004-09-02 | Medivas, Llc | Bioactive stents and methods for use thereof |
DE102004003265A1 (en) | 2004-01-21 | 2005-08-11 | Dendron Gmbh | Device for the implantation of electrically isolated occlusion coils |
US7323006B2 (en) * | 2004-03-30 | 2008-01-29 | Xtent, Inc. | Rapid exchange interventional devices and methods |
ES2357243T3 (en) | 2004-05-21 | 2011-04-20 | Micro Therapeutics, Inc. | METAL SPIRALS INTERLATED WITH POLYMERS OR BIOLOGICAL OR BIODEGRADABLE OR SYNTHETIC FIBERS FOR THE EMBOLIZATION OF A BODY CAVITY. |
WO2006032291A1 (en) | 2004-09-22 | 2006-03-30 | Dendron Gmbh | Micro-spiral implantation device |
ATE417552T1 (en) | 2004-09-22 | 2009-01-15 | Dendron Gmbh | MEDICAL IMPLANT |
DE102005019782A1 (en) | 2005-04-28 | 2006-11-09 | Dendron Gmbh | Device for implantation of occlusion coils with internal securing means |
JP5230602B2 (en) | 2006-04-17 | 2013-07-10 | タイコ ヘルスケア グループ リミテッド パートナーシップ | System and method for mechanically positioning an endovascular implant |
US7689889B2 (en) * | 2006-08-24 | 2010-03-30 | Cisco Technology, Inc. | Content addressable memory entry coding for error detection and correction |
AU2008226694B8 (en) | 2007-03-13 | 2013-06-20 | Covidien Lp | An implant including a coil and a stretch-resistant member |
CN101677821B (en) | 2007-03-13 | 2014-05-14 | 泰科保健集团有限合伙公司 | Implant and mandrel |
EP2341843A1 (en) | 2008-07-22 | 2011-07-13 | Micro Therapeutics, Inc. | Vascular remodeling device |
EP2349431B1 (en) | 2008-08-19 | 2015-01-21 | Covidien LP | Detachable tip microcatheter |
-
2005
- 2005-05-23 ES ES05756033T patent/ES2357243T3/en active Active
- 2005-05-23 CA CA2567331A patent/CA2567331C/en not_active Expired - Fee Related
- 2005-05-23 US US11/134,998 patent/US7896899B2/en active Active
- 2005-05-23 JP JP2007527550A patent/JP4723584B2/en not_active Expired - Fee Related
- 2005-05-23 WO PCT/US2005/018087 patent/WO2005113035A2/en active Application Filing
- 2005-05-23 DE DE602005025215T patent/DE602005025215D1/en active Active
- 2005-05-23 EP EP05756033A patent/EP1761178B1/en active Active
- 2005-05-23 ES ES10194009.6T patent/ES2440650T3/en active Active
- 2005-05-23 AT AT05756033T patent/ATE490736T1/en not_active IP Right Cessation
- 2005-05-23 EP EP10194009.6A patent/EP2316355B1/en active Active
-
2011
- 2011-01-20 US US13/010,671 patent/US8267955B2/en active Active
- 2011-02-23 JP JP2011037486A patent/JP5052682B2/en active Active
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4677191A (en) * | 1984-07-06 | 1987-06-30 | Wada Pure Chemical Ind., Ltd. | Copolymer and method for producing the same |
EP0368571A2 (en) * | 1988-11-07 | 1990-05-16 | MITSUI TOATSU CHEMICALS, Inc. | Preparation process for bioabsorbable polyester |
US5746734A (en) * | 1992-10-30 | 1998-05-05 | International Therapeutics Corporation | Introducer cartridge for delivering an embolization device |
US5485496A (en) * | 1994-09-22 | 1996-01-16 | Cornell Research Foundation, Inc. | Gamma irradiation sterilizing of biomaterial medical devices or products, with improved degradation and mechanical properties |
US5766219A (en) * | 1995-04-20 | 1998-06-16 | Musc Foundation For Research Development | Anatomically shaped vasoocclusive device and method for deploying same |
US6193728B1 (en) * | 1995-06-30 | 2001-02-27 | Target Therapeutics, Inc. | Stretch resistant vaso-occlusive coils (II) |
US5976162A (en) * | 1996-04-10 | 1999-11-02 | Target Therapeutics, Inc. | Soft-ended fibered micro vaso-occlusive devices |
US5935145A (en) * | 1998-02-13 | 1999-08-10 | Target Therapeutics, Inc. | Vaso-occlusive device with attached polymeric materials |
US6280457B1 (en) * | 1999-06-04 | 2001-08-28 | Scimed Life Systems, Inc. | Polymer covered vaso-occlusive devices and methods of producing such devices |
US20040098029A1 (en) * | 2000-10-18 | 2004-05-20 | Scimed Life Systems, Inc. | Non-overlapping spherical three-dimensional coil |
Cited By (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9198665B2 (en) | 2004-09-22 | 2015-12-01 | Covidien Lp | Micro-spiral implantation device |
WO2007073549A2 (en) * | 2005-12-19 | 2007-06-28 | Boston Scientific Scimed, Inc. | Coated embolic coils with fibers |
WO2007073549A3 (en) * | 2005-12-19 | 2007-10-18 | Boston Scient Scimed Inc | Coated embolic coils with fibers |
WO2008109228A2 (en) * | 2007-03-05 | 2008-09-12 | Boston Scientific Limited | Deploying embolic coils |
WO2008109228A3 (en) * | 2007-03-05 | 2009-04-30 | Boston Scient Ltd | Deploying embolic coils |
US10524799B2 (en) | 2007-03-05 | 2020-01-07 | Boston Scientific Scimed, Inc. | Deploying embolic coils |
US9289215B2 (en) | 2007-03-13 | 2016-03-22 | Covidien Lp | Implant including a coil and a stretch-resistant member |
JP2010521231A (en) * | 2007-03-13 | 2010-06-24 | マイクロ セラピューティクス, インコーポレイテッド | Implant including a coil and a stretch resistant member |
US11045205B2 (en) | 2007-07-27 | 2021-06-29 | Microvention, Inc. | Detachable coil incorporating stretch resistance |
WO2010014075A1 (en) * | 2007-07-27 | 2010-02-04 | Microvention, Inc. | Detachable coil incorporating stretch resistance |
US11918230B2 (en) | 2007-07-27 | 2024-03-05 | Microvention, Inc. | Detachable coil incorporating stretch resistance |
US10076338B2 (en) | 2007-07-27 | 2018-09-18 | Microvention, Inc. | Detachable coil incorporating stretch resistance |
US10299755B2 (en) | 2007-12-21 | 2019-05-28 | Microvention, Inc. | System and method for locating detachment zone of a detachable implant |
US10893868B2 (en) | 2012-01-20 | 2021-01-19 | Covidien Lp | Aneurysm treatment coils |
US9655999B2 (en) | 2013-03-12 | 2017-05-23 | Carnegie Mellon University | Coated vaso-occlusive device for treatment of aneurysms |
US10034966B2 (en) | 2013-03-12 | 2018-07-31 | Carnegie Mellon University | Coated vaso-occlusive device and methods for treatment of aneurysms |
WO2014165023A1 (en) * | 2013-03-12 | 2014-10-09 | Carnegie Mellon University | Coated vaso-occclusive device for treatment of aneurysms |
US10660645B2 (en) | 2013-03-15 | 2020-05-26 | Embo Medical Limited | Embolization systems |
US10675039B2 (en) | 2013-03-15 | 2020-06-09 | Embo Medical Limited | Embolisation systems |
US11571218B2 (en) | 2013-03-15 | 2023-02-07 | Embo Medical Limited | Embolisation systems |
US11090057B2 (en) | 2013-03-15 | 2021-08-17 | Embo Medical Limited | Embolisation systems |
US11684371B2 (en) | 2013-03-15 | 2023-06-27 | Embo Medical Limited | Embolization systems |
FR3008304A1 (en) * | 2013-07-15 | 2015-01-16 | Balt Extrusion | ENDOPROTHESIS FOR THE TREATMENT IN PARTICULAR AN ANEURYSM |
US11382643B2 (en) | 2017-10-16 | 2022-07-12 | Retriever Medical, Inc. | Clot removal methods and devices with multiple independently controllable elements |
US11589881B2 (en) | 2017-10-16 | 2023-02-28 | Retriever Medical, Inc. | Clot removal methods and devices with multiple independently controllable elements |
US11633202B1 (en) | 2017-10-16 | 2023-04-25 | Retriever Medical, Inc. | Catheter based retrieval device with proximal body having axial freedom of movement |
US10898215B2 (en) | 2017-10-16 | 2021-01-26 | Retriever Medical, Inc. | Method to remove a thrombus |
US11439402B2 (en) | 2019-04-18 | 2022-09-13 | Clearstream Technologies Limited | Embolization devices and methods of manufacturing the same |
WO2021233553A1 (en) * | 2020-05-22 | 2021-11-25 | Clearstream Technologies Limited | Embolisation devices and methods of manufacturing the same |
Also Published As
Publication number | Publication date |
---|---|
EP2316355A1 (en) | 2011-05-04 |
JP4723584B2 (en) | 2011-07-13 |
EP1761178A2 (en) | 2007-03-14 |
EP2316355B1 (en) | 2013-09-18 |
US7896899B2 (en) | 2011-03-01 |
JP2011136189A (en) | 2011-07-14 |
ES2357243T3 (en) | 2011-04-20 |
US8267955B2 (en) | 2012-09-18 |
JP2008500148A (en) | 2008-01-10 |
WO2005113035A3 (en) | 2006-02-23 |
CA2567331C (en) | 2012-08-14 |
DE602005025215D1 (en) | 2011-01-20 |
ES2440650T3 (en) | 2014-01-29 |
US20110118777A1 (en) | 2011-05-19 |
ATE490736T1 (en) | 2010-12-15 |
US20060036281A1 (en) | 2006-02-16 |
CA2567331A1 (en) | 2005-12-01 |
EP1761178B1 (en) | 2010-12-08 |
JP5052682B2 (en) | 2012-10-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2567331C (en) | Metallic coils enlaced with biological or biodegradable or synthetic polymers or fibers for embolization of a body cavity | |
US11723667B2 (en) | Filamentary devices for treatment of vascular defects | |
US20230338035A1 (en) | Filamentary devices for treatment of vascular defects | |
US20230270441A1 (en) | Devices for therapeutic vascular procedures | |
AU2016201406B2 (en) | Filamentary devices for treatment of vascular defects | |
US10238393B2 (en) | Multiple layer filamentary devices for treatment of vascular defects |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2567331 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2007527550 Country of ref document: JP |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWW | Wipo information: withdrawn in national office |
Country of ref document: DE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2005756033 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 2005756033 Country of ref document: EP |