WO2005110516A2 - Multi-chamber sequential dose dispensing syringe - Google Patents
Multi-chamber sequential dose dispensing syringe Download PDFInfo
- Publication number
- WO2005110516A2 WO2005110516A2 PCT/US2005/014299 US2005014299W WO2005110516A2 WO 2005110516 A2 WO2005110516 A2 WO 2005110516A2 US 2005014299 W US2005014299 W US 2005014299W WO 2005110516 A2 WO2005110516 A2 WO 2005110516A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- stopper
- valve
- syringe
- chamber
- liquid
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M2005/1787—Syringes for sequential delivery of fluids, e.g. first medicament and then flushing liquid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3128—Incorporating one-way valves, e.g. pressure-relief or non-return valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
- A61M5/286—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
Definitions
- This invention relates to multi-chamber syringes and, in particular, to syringes which dispense fluid from each chamber sequentially.
- flush solutions are also used to keep an infusion line patent or open.
- streamlining basic procedures, such as IV catheter flushing can save significant clinician time.
- flushing usually necessitates use of a second flushing syringe (which is often currently factory filled)
- the flushing syringe represents added cost, not only in clinician time, but in terms of required additional syringes.
- Use of multiple syringes also increases risk of medication error (incorrect selection of flushing liquid) and introduction of microorganisms (a function of number of IV line or catheter accesses) .
- Multi-chamber syringes in various forms are well known. Commonly, multi-chamber syringes are offered for use as mixing syringes and for sequential delivery of disparate fluids, maintaining the fluids separate until delivered.
- Mixing syringes most often provide features for mixing contents of the chambers and for delivering the mixed fluids simultaneously.
- This invention is not related to mixing syringes.
- chambers are separated by an intermediate sliding stopper which receives motive force communicated through an intermediate fluid from a primary stopper which is part of a plunger assembly against which an external force is applied.
- each intermediate stopper must provide a fluid tight seal until all fluid from a distal chamber is evacuated from the syringe.
- a first concern arises, for example, when it is recognized that such a syringe may be used to dispense an accurately measured dose of a very expensive medication into an IV apparatus from a distal chamber of a multi-chamber syringe. Then, immediately following dispensing the first medication, a volume of a following solution is dispensed through the IV line to flush the first solution fully.
- a deformable piston, having a hollow center such as the stopper of Vietnameser would not have zero dead space.
- filling procedures for contents of the proximal chamber may permit a quantity of air (or other gas) to be trapped therein. It may be noted that even if such gas is not trapped during filling, free gas may be found in the proximal chamber simply as a result of out-gassing.
- Vietnameser does not teach a way of purging the proximal chamber of gas, making such a system unacceptable for use in directly administering liquid medications to a patient. While other art may provide more effective ways to deal with the dead space issue, there is no known art which teaches a way of delivering only liquid from the proximal or intermediate chambers.
- U.S. Patent 5,236,420 titled BYPASS, PRESSURIZED PISTON FOR CHAMBERS issued August 17, 1993, also to Frederick W. Vietnameser discloses a valved plunger which may be used to evacuate gas from a proximal syringe chamber.
- Other art such as U.S. Patents 6,027,481 issued February 22, 2000 to Laurent Barrelle, et .al. (Barrelle) and 5,851,200 issued December 22, 1998 to Tetsure Higashikawa, et al. (Hagashikawa) disclose multi-chamber syringes with sliding valves.
- Halseth teaches a sequential delivery syringe which utilizes a modification to a discharge opening of a syringe for providing access to a rear chamber of a two chamber syringe.
- the modification comprises affixing a piercing member at the discharge opening.
- the piercing member punctures a ⁇ mid-piston" and a collapsible bag disposed in a rear chamber to provide access to fluid in the bag. Access occurs when the mid-piston is displaced by action of a plunger and stopper piston to cause the mid-piston and bag to contact the piercing member.
- the invention involves a stopper assembly which operates within a standard, substantially constant diameter syringe barrel to separate a distal chamber from a proximal chamber. Before dispensing, the distal chamber contains a first volume of liquid. The proximal chamber contains a disparate second volume of fluid. A closed valve in the stopper assembly keeps the contents of each chamber separate from the other.
- the stopper assembly comprises two elements, a valved stopper and a valve actuator. The valved stopper contains the valve mechanism.
- a plunger associated with the syringe communicates through the second volume of fluid to displace the stopper assembly thereby dispensing liquid from the distal chamber.
- the valve is opened by action of the valve actuator to permit sequential and selective dispensing of liquid contents from the proximal chamber.
- the valve closure mechanism is a slit through the distal face of the valved stopper.
- Selective opening of the valve is based upon a common geometry of all known, currently commercially available standard syringe barrels. All such syringe barrels have a substantially constant diameter hollow barrel abruptly closed at a distally disposed inner surface. Distally, the inner surface comprises an orifice through which fluid is dispensed from the barrel. Generally, a plunger with an associated stopper affixed thereto is provided for displacing fluid through the barrel and orifice. To prevent premature mixing of the disparate solutions in the two chambers, the stopper assembly must open only upon being displaced to the most distal end of the syringe barrel.
- the actuator comprises a member which detects collision between a surface of the distal wall of the valved stopper and the distal inner surface and reacts to open the valve.
- the detecting member is disposed to apply a closing force upon the valve until displaced by the collision.
- the valve actuator must be displaced as the valved stopper is displaced.
- valved stopper and valve actuator comprise an interlocking interface which causes the valve actuator to be displaced as the valved stopper is displaced. Opening a slit valve can be accomplished by outward displacement of a portion of the valved stopper transverse to the split.
- the valve actuator comprises a body part, which is securely affixed, via the interlocking interface, to the valved stopper and an associated collision detecting arm.
- the arm is hingedly affixed to the body part.
- the detecting arm articulates about the hinge to displace a portion of the valved stopper and, thereby, open the slit valve.
- an outwardly distending arm is rigidly affixed to the detecting arm to extend into to contact with a portion of the inner surface of the valved stopper.
- the distending arm Before the collision, the distending arm is in compressive contact with the inner surface of the valved stopper, adding to the forces which act upon the slit to keep it closed.
- the outwardly distending arm As the detecting arm is articulated, the outwardly distending arm is arcuately displaced proximally until compressive forces received from the inner surface of the valved stopper act to retain the slit valve in an open state. In this manner, once opened, the slit valve requires no additional force to stay open and operation of the plunger and associated stopper need no additional force to keep the valve open.
- a slit valve is maintained in a closed position until the valve assembly collides with the inner proximal surface of the end of the syringe barrel and is thereafter effectively opened to permit dispensing of fluid from the proximal chamber.
- gas most commonly air
- the body comprises a gas separator.
- the gas separator is formed in a centrally disposed portion of the body and may be made as a hollow frustoconical shape, being open at the bottom.
- a series of very small, closely spaced holes are dispersed about the conical sides of the separator.
- the top of the frustoconical shape is closed except for a hole which is sufficiently large to permit purging gas from the separator.
- the open bottom of the separator (frustoconical shape) is disposed distally within the valved stopper into contact with the inner surface of the stopper about the slit.
- An outwardly projecting rim about the bottom of the separator provides an interlocking surface for a complimentary groove molded into the valved stopper about the slit. Also, stability of a freely displaced valve assembly within the barrel of a syringe must be considered.
- the body of the actuator is provided with sufficient radially extending appendages to maintain the valved stopper in a stable state such that the plane of the slit is transverse to the plane of the barrel of the syringe throughout displacement of the valve assembly.
- the valve assembly may be made from only two parts.
- the valved stopper may be molded from flexible synthetic resinous material, consistent with material used in plunger stoppers.
- the valve actuator may be injection molded from semi rigid synthetic resinous material from which living hinges may be molded and which is appropriately inert and non-interactive with solutions stored in the proximal chamber.
- a material may be polypropylene.
- the valve assembly • provides a selective partitioning between proximal and distal chambers of a multi-chamber syringe. • may be used in standard (off the shelf) commercial syringes having constant diameter hollow barrels. • provides a closed valve which is opened only upon collision between the valve assembly and inner surface of the distal end of the syringe. • comprises an interlock which effectively latches the valve in an open state as liquid is • dispensed from the proximal chamber.
- valve assembly which partitions a standard commercial syringe to make a multi-chamber syringe. It is a fundamental object to provide a valve assembly for a syringe which keeps two disparate fluids apart until one of the fluids has been dispensed. It is an important object to provide a valve assembly which has a low dead space for liquid dispensed from a distal chamber.
- Figure 1A is a section of the syringe seen in Figure 1 taken along lines 1A-1A (prior art) .
- Figure 2 is a section of a syringe, similar to the section seen in Figure 1A, but with a valve assembly distally disposed relative to a plunger and stopper similar to the plunger and stopper of the syringe of Figure 1.
- Figure 2A is a magnified portion, taken along lines 2A- 2A, of the syringe seen in Figure 2.
- Figure 3 is a perspective of the valve assembly seen in the syringe barrel in Figure 2.
- Figure 4 is an exploded view of the valve assembly seen in Figure 3 showing a valved stopper apart from a valve actuator.
- Figure 5 is a perspective of the valved stopper rotated such that the distal side of a slit valve is seen.
- Figure 6 is a perspective of a valved stopper, which is similar to the valved stopper seen in Figure 5, but rotated such that the proximal side of the valve is seen.
- Figure 7 is a perspective of the valve actuator, rotated such that the distal side of the actuator is seen.
- Figure 8 is a perspective of the valve actuator, seen in Figure 7, but rotated such that the proximal side of the actuator is seen.
- Figure 9 is a lateral side view of a valve assembly having an actuator which is similar to the actuator seen in
- Figures 7 and 8 the actuator being disposed in a section of a valved stopper.
- Figure 9A is a lateral side view of a valve assembly which is similar to the assembly seen in Figure 9, but wherein a valve assembly is differently affixed to the valved stopper.
- Figure 10 is a medial section of a distal portion of a syringe barrel and a valve assembly disposed therein, the valve assembly being oriented transverse to a slit for a valve in the valved stopper portion of the valve assembly.
- Figure 11 is a medial section of a distal portion of a syringe barrel and a valve assembly disposed therein similar to the section seen in Figure 10, but with the valve assembly being rotated to be oriented parallel to a slit for a valve in the valved stopper portion of the valve assembly.
- Figure 12 is a medial section of a distal portion of a syringe barrel and a valve assembly disposed at a distal end of the syringe barrel where the slit valve is open, the valve assembly being oriented transverse to the slit of the valve in the valved stopper portion of the valve assembly.
- Figure 13 is a medial section of the distal portion of syringe barrel and valve assembly seen in Figure 12, but rotated 90 degrees such that an open valve is seen.
- Figure 14 is a perspective of parts of an assembly fixture and parts of a valve assembly arrayed in an assembly sequence.
- Figure 15 is a section of a syringe, similar to the section seen in Figure 2A, but with two valve assemblies distally disposed relative to a plunger and stopper similar to the plunger and stopper of the syringe of Figure 1.
- proximal is used to indicate the segment of a device normally closest to a clinician using the device.
- distal refers to the opposite end.
- Primes of numbers are used to represent parts which are similar, but not identical to other parts having the same numbers.
- fluid is defined to be a substance (either liquid or gas) which tends to flow or to take the shape of its container.
- gas is defined to be a fluid that expands indefinitely and which may be understood in most circumstances within the scope of this document to be consistent with air.
- liquid is a substance which is free flowing like water, but which is neither solid nor gaseous.
- Prior art syringes (as exemplified by syringe 10) in Figures 1 and 1A, are available from a large number of commercial companies worldwide.
- Such syringes typically comprise an elongated hollow syringe barrel 20 which is open at a proximal end 22 to receive a syringe plunger 30 and stopper 40 and closed at a distal end 42 about a fluid transmission orifice 44.
- barrel 20 is of substantially constant diameter (within tolerances allowed by manufacturing methods, such as by injection molding for barrels made from synthetic resinous materials) .
- Stopper 40 is compressible and sufficiently elastic when compressed to provide an efficient wiping action along the length of an internal cylindrical surface 46 of barrel 20.
- a valve assembly 50 is inserted into barrel 20 to divide space within barrel 20 into a proximal chamber 60 and a distal chamber 70.
- each chamber, 60 and 70 may be filled with a bolus of fluid, 72 and 74, respectively. It may be noted that, when chamber 60 is substantially filled with a bolus of fluid (which should be mostly an incompressible liquid) , displacement of stopper 40 results in substantially the same displacement of valve assembly 50.
- fluid 72 disposed in chamber 60 is trapped and may contain a small bubble of gas (likely air) , numbered 76 associated with other liquid 78 also contained therein.
- gas 76 may be inadvertently trapped therein during filling or may be the result of outgassing or other gas producing phenomena following insertion of stopper 40 into barrel 20. In any event, such gas must be seriously considered and dealt with when such a device is used to dispense liquid to a patient to assure gas (air) is not injected into a patient line.
- a valve assembly 50 apart from a barrel 20, is seen in Figure 3. Although more parts may be used in a valve assembly made according to the instant invention, valve assembly 50 comprises just two parts, a valved stopper 80 and a valve actuator 90.
- valved stopper 80 has a hollow cylindrical well 92 into which valve actuator 90 is displaced for use. Additional details of valved stopper 80 and valve actuator 90 are seen in Figure 4. Valved stopper 80 has an outer cylindrical wall 94 which has pattern of annular I grooves, generally numbered 96, to facilitate sealingly wiping of inner surface 46 of barrel 20 as valve assembly 50 is displaced therealong (see Figure 2A) . Within well 92, valved stopper 80 comprises a plurality of grooves disposition and purpose of which are disclosed in more detail hereafter.
- Valve actuator 90 comprises a proximal stabilizing disk 100, a medially disposed stabilizing plate 110, a pair of actuator arms, 120 and 120', a medially disposed support body 130, into which is formed a gas separator vessel 140 and an annular connecting lip 150.
- Valve actuator 90 is displaced into well 92 as indicated by dashed lines 152 and 152".
- Distal end 154 of valve assembly 50 is seen in Figure 5.
- a slit 160 which is medially disposed through a distal wall 162 of valved stopper 80. Slit 160 is formed as a closed valve which remains fluid tight until selectively opened as disclosed in detail hereafter. Greater detail of construction of well 92 is seen in Figure 6.
- Valved stopper 80 has a plurality of grooves and associated slots, each of which serve a specific purpose. However, there are no grooves for rim 172 of disk 100 and outer edges 182 and 182' of plate 110. Such grooves would impede distal displacement of valve actuator 90 within valve stopper 80. Such distal displacement is necessary for valve action, as is disclosed in detail hereafter.
- a groove 190 coincides with protrusions 192 and 192' of arms 120 and 120' (see Figure 4) , respectively.
- Stabilizing disk 100 has outer rim which is disposed within well 92 (see Figure 4) to provide a stabilizing plane for valve assembly 50. Further, disk 100 has a plurality of holes, generally numbered 220, which are sufficiently large to freely pass fluid therethrough. In addition, as seen in Figure 8, disk 100 has a centrally disposed hole 222 which is also sufficiently large to pass all forms of fluid therethrough.
- Stabilizing plate 110 has circularly formed outer edges, 180 and 182'. Edges 180 and 180' are truncated by elongated planar edges 230 and 230' to provide linear access between selected holes (disclosed in detail hereafter) between stabilizing disk 100 and arms 120 and 120', respectively. Need for such access is also disclosed hereafter.
- Each actuator arm 120 and 120' is connected to body 130 through a living hinge 240 and 240', respectively (see Figure 7) . For simplicity, only actuator arm 120 is described hereafter in detail. However, it should be understood that parts associated with actuator arm 120' are simply as mirror images (with referencing numbers being primed) of parts of actuator arm 120.
- protrusion 192 Disposed radially outward from hinge 240 is protrusion 192 (again see Figure 7), which coincides with slot 190, see Figure 6.
- a limb 250 Transversely disposed to protrusion 192 is a limb 250, which provides an extension reaching to extremity 204.
- extremity 204 has an outwardly disposed foot 252.
- Extremity 204 and foot 252 coincide with slot 200, as is better seen in Figure 9.
- foot 252 is optional and may not be used as is seen in Figure 9A.
- gas separator vessel 140 is frustoconically shaped, having a distal mouth 260 encircled by annular lip 150 and a hollow inner chamber 262.
- annular lip 150 is seen to be unitary in form, a plurality of protrusions might be used. However, a single lip is preferred. Note (in Figure 7) that lip 150 has a planar distal face 254 and an outer rim 256 which interfaces with distal wall 162 in annular slotted groove 210 of valved stopper 90 (see Figure 6) to provide a fluid tight seal thereby.
- Vessel 140 has an annular surface which is marked by a plurality of small holes, generally numbered 270. Holes 270 are sized to provide a lower resistant path for liquid into chamber 262 while imparting a much higher resistance to influent flow of gas from the outside of chamber 262 when chamber 262 is filled with liquid.
- chamber 262 when chamber 262 is primed (filled with liquid) , only liquid flows into chamber 262 from proximal chamber 60, thereby effectively separating gas from liquid from an externally disposed fluid and delivering only liquid through mouth 260.
- chamber 262 To assure only liquid is contained within chamber 262, chamber 262 must be primed. Such priming is facilitated by filling proximal chamber 60 from an open stopper 40 end of barrel 20, barrel 20 being maintained in an upright state. Gas contained in chamber 262 is purged through hole 222, see Figure 8. If desired, added energy may be applied to assure purging of chamber 262, such as by application of low frequency vibration or of ultrasound.
- a holding space between stabilizing disk 100, distal wall 162 of valved stopper 80 and side walls of well 92 provides a cavity outside vessel 140 wherein undelivered gas is captured.
- the volume of gas inside chamber 60 should not exceed the holding space.
- Size of holes 270 is critical to vessel 140 operating as a gas separator. Examples of such hole sizes are found in commercial filters made for water sprinkler applications. As examples, a Toro product package provides such a filter in a 570 fixed spray nozzle, model number 53320. Another example is a filter available in a Rainbird National Sales
- Toro and Rainbird filters are manufactured by injection molding, having holes which are usually rectangular in form and which range from 0.5 to 1.0 millimeters on a side. It may be noted that holes 270 in
- FIGs 7 and 8 are seen to be round. However, rectangular holes 270', as seen in Figures 4 and 14, may be preferred as being easier to mold. Shape of holes (such as holes 270 and 270') is somewhat irrelevant, more important is selecting a hole size for each selected shape that properly impedes gas flow from a fluid environment .
- An assembled valve assembly 50 is seen in Figure 9, with valved stopper 80 being seen in cross section. Note correspondence of slot 190 and protrusions 192 and 192', slot 200 and extremities 204 and 204' and slot 210 and lip 150.
- slot 200 has an associated rib 280 which is inwardly disposed to catch upon feet 252 and 252' of extremities 204 and 204', respectively, securely affix extremities 204 and 204' to distal wall 162.
- slot 210 has an associated inwardly disposed rib 290 which catches upon lip 150 to securely affix mouth 260 against distal wall
- valve actuator 90 is securely affixed to valved stopper 80 such that, when valved stopper is displaced by action of fluid and stopper 40, valve actuator 90 is likewise displaced.
- a valve assembly 50' is seen in Figure 9A.
- Valve assembly 50' is like valve assembly 50 except that limbs 250 and 250' terminate in extremities 204 and 204', respectively, which are devoid of feet (such as feet 252 and 252', seen in Figures 7 and 9. Lack of such feet requires that all displacement force upon valve actuator 90 must be derived through forces applied to lip 150 and protrusions 190 and 190'. Note that such forces may not be as effectively applied against protrusions 190 and 190' as they are connected to body 130 through living hinges 240 and 240'.
- valve assembly 50 is seen in two states.
- valve assembly 50 is seen to be proximally displaced from distal end 42 of syringe barrel 20, as seen in Figures 10 and 11.
- Each arm (120 and 120') is angularly disposed to form an acute angle with more proximal portion 300 of inner surface 46 of syringe barrel 20. So disposed, medially directed force resulting from compression of outer cylindrical wall 94 upon protrusions 192 and 192', is placed upon slit 160 through each extremity 204 and 204'.
- protrusions 192 and 192' act as latches.
- articulation of arms 120 and 120' draws against slit 160, parting lips 320 and 320' of slit 160 to allow liquid flow therethrough. Note that when protrusions 192 and 192' are so latched, no additional force may be required to keep lips 320 and 320' apart.
- annular ring 330 which raises the surface of distal face 310 as seen in Figures 5, 10 and 11 may be provided.
- a raised ring such as ring 330, may also provide an earlier point of contact where a first collision occurs between distal face 310 and distal end 42 of syringe barrel 20.
- material for valved stopper 80 may be either the same or similar to material generally used for syringe stoppers. However, consideration should be given to material which deforms to conform to an internal distal surface of a syringe, as seen in Figures 12 and 13.
- holes 220 are circular and bear the numbers 340 and 340'.
- Holes 340 and 340' are aligned with articulating arms 120 and 120', respectively. As is seen in Figure 14, this alignment may be profitably used in a process of assembling valve assembly 50.
- An assembly fixture 400 is seen to comprise an assembly well 410, an assembly piston and associated alignment disk 420 and a pair of alignment rods 430 and 430'.
- Well 410 comprises a depth limiting shelf 440 and a medially and outwardly disposed blade 450.
- valved stopper 80 is displaced into well along lines 460/460' as seen in Figure 14. Alignment rods 430 and 430' are displaced through holes in assembly piston and disk 420 and therefrom through holes 340 and 340', respectively, into contact with arms 120 and 120'. Valve actuator 90 is then displaced into well 92 along lines 470/470'. Valve actuator 90 and valved stopper 80 are then further displaced into assembly well 410 until blade 450 breaches distal wall 162 to form slit 160 (not seen in Figure 14) . Valved stopper 80 is then forced against shelf 440 causing distal wall 162 to be there retained and to be deformed to accept at least installation of lip 150 into slot 210.
- valve assembly 50 is assembled in one continuous motion. Transverse eying of alignment rods 430 and 430' transversely relative to blade 450 assures proper alignment of slit 160 to arms 120 and 120'. It is important that arms 120 and 120' are distally canted to assure proper assembly into valve assembly 50. For a similar reason, installation of valve assembly into a syringe barrel, e.g. barrel 20, must also be made with assurance that arms 120 and 120' will remain so canted. For this reason, a syringe loading fixture which employs an assembly piston and disk 420 and alignment rods 430 and 430' is recommended. However, no other alignment is required when installing valve assembly 50 in a syringe barrel.
- valve assembly 50 may be used in a syringe barrel 20. Placing a second valve assembly 50 distal from a first valve assembly 50 creates an intermediate chamber 60'. By forming stabilizing disk 100 to effectively match convex shape of distal end 42 of syringe 20, collision of the more proximally disposed first valve assembly will operate to open and dispense liquid 78 from chamber 60 upon collision of first valve assembly 50 with disk 100 of the second valve assembly 50. Note that liquid 78' is dispensed from chamber 60' before liquid 78 is dispensed from chamber 60. Also, any gas 76' associated with fluid 72' is trapped in the second valve assembly 50.
Abstract
Description
Claims
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007511414A JP2007535987A (en) | 2004-05-03 | 2005-04-26 | Multi-chamber sequential dose dispensing syringe |
CA2565531A CA2565531C (en) | 2004-05-03 | 2005-04-26 | Multi-chamber, sequential dose dispensing syringe |
AU2005243678A AU2005243678B2 (en) | 2004-05-03 | 2005-04-26 | Multi-chamber sequential dose dispensing syringe |
MXPA06012625A MXPA06012625A (en) | 2004-05-03 | 2005-04-26 | Multi-chamber sequential dose dispensing syringe. |
EP05742063A EP1742686A4 (en) | 2004-05-03 | 2005-04-26 | Multi-chamber sequential dose dispensing syringe |
BRPI0510532-3A BRPI0510532A (en) | 2004-05-03 | 2005-04-26 | combination to provide a multi-chamber syringe for sequential dispensing, and methods for mounting a valve actuator, to use a valve assembly as a chamber divider in a multi-chamber dispensing syringe, and to filter gas from from liquid being distributed to a distribution line |
CN2005800216081A CN1980706B (en) | 2004-05-03 | 2005-04-26 | Multi-chamber sequential dose dispensing syringe |
US11/284,504 US7048720B1 (en) | 2004-05-03 | 2005-11-22 | Multi-chamber, sequential dose dispensing syringe |
US11/359,304 US7101354B2 (en) | 2004-05-03 | 2006-02-21 | Mixing syringe with and without flush |
HK07113514.3A HK1105177A1 (en) | 2004-05-03 | 2007-12-12 | Multi-chamber sequential dose dispensing syringe |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/838,101 | 2004-05-03 | ||
US10/838,101 US6997910B2 (en) | 2004-05-03 | 2004-05-03 | Multi-chamber, sequential dose dispensing syringe |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10838101 A-371-Of-International | 2005-04-26 | ||
US11/284,504 Continuation-In-Part US7048720B1 (en) | 2004-05-03 | 2005-11-22 | Multi-chamber, sequential dose dispensing syringe |
Publications (2)
Publication Number | Publication Date |
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WO2005110516A2 true WO2005110516A2 (en) | 2005-11-24 |
WO2005110516A3 WO2005110516A3 (en) | 2006-05-04 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/US2005/014299 WO2005110516A2 (en) | 2004-05-03 | 2005-04-26 | Multi-chamber sequential dose dispensing syringe |
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EP (1) | EP1742686A4 (en) |
JP (1) | JP2007535987A (en) |
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2004
- 2004-05-03 US US10/838,101 patent/US6997910B2/en not_active Expired - Fee Related
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2005
- 2005-04-26 CA CA2565531A patent/CA2565531C/en not_active Expired - Fee Related
- 2005-04-26 JP JP2007511414A patent/JP2007535987A/en active Pending
- 2005-04-26 AU AU2005243678A patent/AU2005243678B2/en not_active Ceased
- 2005-04-26 MX MXPA06012625A patent/MXPA06012625A/en unknown
- 2005-04-26 WO PCT/US2005/014299 patent/WO2005110516A2/en active Application Filing
- 2005-04-26 CN CNA200910135639XA patent/CN101559247A/en active Pending
- 2005-04-26 EP EP05742063A patent/EP1742686A4/en not_active Withdrawn
- 2005-04-26 BR BRPI0510532-3A patent/BRPI0510532A/en not_active IP Right Cessation
- 2005-04-26 CN CN2005800216081A patent/CN1980706B/en not_active Expired - Fee Related
- 2005-11-22 US US11/284,504 patent/US7048720B1/en not_active Expired - Fee Related
-
2007
- 2007-12-12 HK HK07113514.3A patent/HK1105177A1/en not_active IP Right Cessation
-
2008
- 2008-03-19 US US12/051,717 patent/US20080319400A1/en not_active Abandoned
Non-Patent Citations (1)
Title |
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See references of EP1742686A4 * |
Also Published As
Publication number | Publication date |
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HK1105177A1 (en) | 2008-02-06 |
WO2005110516A3 (en) | 2006-05-04 |
CA2565531A1 (en) | 2005-11-24 |
AU2005243678B2 (en) | 2012-02-16 |
US6997910B2 (en) | 2006-02-14 |
EP1742686A4 (en) | 2012-08-01 |
EP1742686A2 (en) | 2007-01-17 |
BRPI0510532A (en) | 2007-10-30 |
AU2005243678A1 (en) | 2005-11-24 |
US20050245880A1 (en) | 2005-11-03 |
US20060100590A1 (en) | 2006-05-11 |
US7048720B1 (en) | 2006-05-23 |
JP2007535987A (en) | 2007-12-13 |
CN1980706A (en) | 2007-06-13 |
US20080319400A1 (en) | 2008-12-25 |
CA2565531C (en) | 2011-10-11 |
CN1980706B (en) | 2010-06-16 |
MXPA06012625A (en) | 2007-06-19 |
CN101559247A (en) | 2009-10-21 |
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