WO2005110052A3 - The use of inhaled gaseous nitric oxide as a mucolytic agent or expectorant - Google Patents

The use of inhaled gaseous nitric oxide as a mucolytic agent or expectorant Download PDF

Info

Publication number
WO2005110052A3
WO2005110052A3 PCT/US2005/016428 US2005016428W WO2005110052A3 WO 2005110052 A3 WO2005110052 A3 WO 2005110052A3 US 2005016428 W US2005016428 W US 2005016428W WO 2005110052 A3 WO2005110052 A3 WO 2005110052A3
Authority
WO
WIPO (PCT)
Prior art keywords
nitric oxide
expectorant
containing gas
mucolytic agent
gaseous
Prior art date
Application number
PCT/US2005/016428
Other languages
French (fr)
Other versions
WO2005110052A2 (en
Inventor
Bruce Murray
Bryan Perry
Christopher Miller
Doug Hole
Original Assignee
Pulmonox Technologies Corp
Bruce Murray
Bryan Perry
Christopher Miller
Doug Hole
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pulmonox Technologies Corp, Bruce Murray, Bryan Perry, Christopher Miller, Doug Hole filed Critical Pulmonox Technologies Corp
Priority to CA002565230A priority Critical patent/CA2565230A1/en
Priority to AU2005244079A priority patent/AU2005244079A1/en
Publication of WO2005110052A2 publication Critical patent/WO2005110052A2/en
Publication of WO2005110052A3 publication Critical patent/WO2005110052A3/en
Priority to US11/595,108 priority patent/US8518457B2/en
Priority to US14/010,421 priority patent/US20140141098A1/en
Priority to US15/884,621 priority patent/US10987377B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/021—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes operated by electrical means
    • A61M16/022—Control means therefor
    • A61M16/024—Control means therefor including calculation means, e.g. using a processor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/02—Gases
    • A61M2202/0266—Nitrogen (N)
    • A61M2202/0275—Nitric oxide [NO]

Landscapes

  • Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Methods and devices for treating excess mucus accumulation in mammals by administering gaseous inhaled nitric oxide as a mucolytic agent or expectorant are provided. Delivery of gaseous nitric oxide can be made nasally or orally and is preferably substantially coincident with inhalation of the mammal or based on a synchronous parameter of the mammal's respiratory cycle. Varying therapeutic profiles may be used for the delivery of gaseous nitric oxide depending on the severity of the excess mucus accumulation. Parameters for the therapeutic profiles may include flow rate of nitric oxide containing gas, duration of administration of nitric oxide containing gas, number of breaths for which nitric oxide containing gas is to be administered, and concentrations of therapeutic NO delivered to the airways.
PCT/US2005/016428 2004-05-11 2005-05-11 The use of inhaled gaseous nitric oxide as a mucolytic agent or expectorant WO2005110052A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002565230A CA2565230A1 (en) 2004-05-11 2005-05-11 The use of inhaled gaseous nitric oxide as a mucolytic agent or expectorant
AU2005244079A AU2005244079A1 (en) 2004-05-11 2005-05-11 The use of inhaled gaseous nitric oxide as a mucolytic agent or expectorant
US11/595,108 US8518457B2 (en) 2004-05-11 2006-11-10 Use of inhaled gaseous nitric oxide as a mucolytic agent or expectorant
US14/010,421 US20140141098A1 (en) 2004-05-11 2013-08-26 Use of inhaled gaseous nitric oxide as a mucolytic agent or expectorant
US15/884,621 US10987377B2 (en) 2004-05-11 2018-01-31 Use of inhaled gaseous nitric oxide as a mucolytic agent or expectorant

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56988804P 2004-05-11 2004-05-11
US60/569,888 2004-05-11

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/595,108 Continuation-In-Part US8518457B2 (en) 2004-05-11 2006-11-10 Use of inhaled gaseous nitric oxide as a mucolytic agent or expectorant

Publications (2)

Publication Number Publication Date
WO2005110052A2 WO2005110052A2 (en) 2005-11-24
WO2005110052A3 true WO2005110052A3 (en) 2006-03-02

Family

ID=35394611

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/016428 WO2005110052A2 (en) 2004-05-11 2005-05-11 The use of inhaled gaseous nitric oxide as a mucolytic agent or expectorant

Country Status (3)

Country Link
AU (1) AU2005244079A1 (en)
CA (1) CA2565230A1 (en)
WO (1) WO2005110052A2 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7892198B2 (en) 2000-12-26 2011-02-22 Sensormedics Corporation Device and method for treatment of surface infections with nitric oxide
US7955294B2 (en) 2004-05-11 2011-06-07 Sensormedics Corporation Intermittent dosing of nitric oxide gas
US8079998B2 (en) 2006-10-20 2011-12-20 Pulmonox Technologies Corporation Methods and devices for the delivery of therapeutic gases including nitric oxide
US8518457B2 (en) 2004-05-11 2013-08-27 Pulmonox Technologies Corporation Use of inhaled gaseous nitric oxide as a mucolytic agent or expectorant
US8795222B2 (en) 2000-12-26 2014-08-05 Pulmonox Technologies Corp. Device and method for treatment of surface infections with nitric oxide

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110573143A (en) * 2017-04-10 2019-12-13 北卡罗来纳大学查珀尔希尔分校 Compounds, compositions and methods for inhibiting pathogens and/or modifying mucus

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5615669A (en) * 1994-07-22 1997-04-01 Siemens Elema Ab Gas mixture and device for delivering the gas mixture to the lungs of a respiratory subject
US5839433A (en) * 1993-10-12 1998-11-24 Higenbottam; Timothy William Nitric oxide treatment
US6571790B1 (en) * 1997-05-12 2003-06-03 Robert E. Weinstein Method and device for organizing and coordinating the combined use of liquid medications for continuous nebulization for the treatment of respiratory disorders

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5839433A (en) * 1993-10-12 1998-11-24 Higenbottam; Timothy William Nitric oxide treatment
US5615669A (en) * 1994-07-22 1997-04-01 Siemens Elema Ab Gas mixture and device for delivering the gas mixture to the lungs of a respiratory subject
US6571790B1 (en) * 1997-05-12 2003-06-03 Robert E. Weinstein Method and device for organizing and coordinating the combined use of liquid medications for continuous nebulization for the treatment of respiratory disorders

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7892198B2 (en) 2000-12-26 2011-02-22 Sensormedics Corporation Device and method for treatment of surface infections with nitric oxide
US8795222B2 (en) 2000-12-26 2014-08-05 Pulmonox Technologies Corp. Device and method for treatment of surface infections with nitric oxide
US7955294B2 (en) 2004-05-11 2011-06-07 Sensormedics Corporation Intermittent dosing of nitric oxide gas
US8518457B2 (en) 2004-05-11 2013-08-27 Pulmonox Technologies Corporation Use of inhaled gaseous nitric oxide as a mucolytic agent or expectorant
US8079998B2 (en) 2006-10-20 2011-12-20 Pulmonox Technologies Corporation Methods and devices for the delivery of therapeutic gases including nitric oxide

Also Published As

Publication number Publication date
WO2005110052A2 (en) 2005-11-24
AU2005244079A1 (en) 2005-11-24
CA2565230A1 (en) 2005-11-24

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