WO2005099671A3 - Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles - Google Patents

Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles Download PDF

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Publication number
WO2005099671A3
WO2005099671A3 PCT/EP2005/005551 EP2005005551W WO2005099671A3 WO 2005099671 A3 WO2005099671 A3 WO 2005099671A3 EP 2005005551 W EP2005005551 W EP 2005005551W WO 2005099671 A3 WO2005099671 A3 WO 2005099671A3
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WO
WIPO (PCT)
Prior art keywords
release
triggering
delayed
active principles
controlled release
Prior art date
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PCT/EP2005/005551
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German (de)
French (fr)
Other versions
WO2005099671A2 (en
Inventor
Valerie Legrand
Catherine Castan
Remi Meyrueix
Gerard Soula
Original Assignee
Flamel Tech Sa
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Application filed by Flamel Tech Sa filed Critical Flamel Tech Sa
Priority to JP2007508876A priority Critical patent/JP2007532689A/en
Priority to CA002563689A priority patent/CA2563689A1/en
Priority to EP05742904A priority patent/EP1744729A2/en
Publication of WO2005099671A2 publication Critical patent/WO2005099671A2/en
Publication of WO2005099671A3 publication Critical patent/WO2005099671A3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Abstract

The invention relates to a microparticulate system for the delayed and controlled release of active principles (AP) whose absorption window in vivo is essentially limited to the upper parts of the gastrointestinal tract, this system being intended for oral administration. The object of the invention is to provide a system ensuring that the AP is released with certainty by means of a dual mechanism of 'time-dependent' and 'pH-dependent' release. To achieve this object, the invention proposes a multimicrocapsular oral galenical form which is designed so as to guarantee therapeutic efficacy, and in which the release of the AP is governed by a dual release triggering mechanism that is 'time-triggering' and 'pH-triggering'. This system comprises of microcapsules (200 to 600 µm) comprising a core of AP coated with a film (maximum 40% by weight) comprising a hydrophilic polymer A (Eudragit® L) and a hydrophobic compound B (vegetable wax, melting point = 40-90°C), B/A being between 0.2 and 1.5. These microcapsules have a dissolution behavior in vitro such that, at a constant pH of 1.4, a latency phase of between 1 and 5 hours is observed, followed by a release of the AP, and such that the change from pH 1.4 to pH 6.8 results in a release of the AP without a latency period in vitro.
PCT/EP2005/005551 2004-04-19 2005-04-19 Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles WO2005099671A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2007508876A JP2007532689A (en) 2004-04-19 2005-04-19 Particulate oral galenical formulation for delayed and controlled release of active pharmaceutical ingredients
CA002563689A CA2563689A1 (en) 2004-04-19 2005-04-19 Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
EP05742904A EP1744729A2 (en) 2004-04-19 2005-04-19 Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/826,690 2004-04-19
US10/826,690 US8101209B2 (en) 2001-10-09 2004-04-19 Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles

Publications (2)

Publication Number Publication Date
WO2005099671A2 WO2005099671A2 (en) 2005-10-27
WO2005099671A3 true WO2005099671A3 (en) 2006-06-08

Family

ID=34980132

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/005551 WO2005099671A2 (en) 2004-04-19 2005-04-19 Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles

Country Status (6)

Country Link
US (1) US8101209B2 (en)
EP (1) EP1744729A2 (en)
JP (1) JP2007532689A (en)
CN (1) CN1976682A (en)
CA (1) CA2563689A1 (en)
WO (1) WO2005099671A2 (en)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2359812C (en) * 2000-11-20 2004-02-10 The Procter & Gamble Company Pharmaceutical dosage form with multiple coatings for reduced impact of coating fractures
US8101209B2 (en) 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
IL164221A0 (en) 2002-04-09 2005-12-18 Flamel Tech Sa Oral pharmaceutical formulation in the form of aqueous suspension of microcapsules for modified release of amoxicillim
AU2003246792B2 (en) 2002-04-09 2008-08-28 Flamel Ireland Limited Oral suspension of active principle microcapsules
US6974592B2 (en) * 2002-04-11 2005-12-13 Ocean Nutrition Canada Limited Encapsulated agglomeration of microcapsules and method for the preparation thereof
EP1691789B1 (en) * 2003-11-25 2017-12-20 SmithKline Beecham (Cork) Limited Carvedilol free base, salts, anhydrous forms or solvate thereof, corresponding pharmaceutical compositions, controlled release formulations, and treatment or delivery methods
FR2878159B1 (en) * 2004-11-24 2008-10-17 Flamel Technologies Sa ORAL MEDICATION WITH MODIFIED RELEASE OF AT LEAST ONE ACTIVE PRINCIPLE IN MULTIMICROCAPSULAR FORM
PT1698630E (en) 2005-03-03 2014-09-15 Alfa Wassermann Spa New polymorphous forms of rifaximin, processes for their production and use thereof in the medicinal preparations
ITBO20050123A1 (en) * 2005-03-07 2005-06-06 Alfa Wassermann Spa GASTRORESISTIC PHARMACEUTICAL FORMULATIONS CONTAINING RIFAXIMINA
FR2886150B1 (en) * 2005-05-24 2007-08-24 Flamel Technologies Sa ORAL PHARMACEUTICAL FORM BASED ON AT LEAST ONE ACTIVE INGREDIENT WHOSE SOLUBILITY VARIES IN ACCORDANCE WITH THE CONDITIONS OF GASTRIC PH
WO2006131790A2 (en) * 2005-06-09 2006-12-14 Flamel Technologies Oral ribavirin pharmaceutical composition
US20070166378A1 (en) * 2005-06-09 2007-07-19 Flamel Technologies, Inc. Oral ribavirin pharmaceutical compositions
US8652529B2 (en) 2005-11-10 2014-02-18 Flamel Technologies Anti-misuse microparticulate oral pharmaceutical form
DE102005060393A1 (en) * 2005-12-16 2007-06-21 Add Advanced Drug Delivery Technologies Ltd. Pharmaceutical pellet, useful for the production of tablet, comprises a spherical active agent, preferably metroprololsuccinate, comprising core with smooth surface and a coat on the core, where the active agent release is pH-independent
WO2007096489A1 (en) * 2006-02-17 2007-08-30 Trimaran Limited Novel pharmaceutical compositions for optimizing replacement treatments and broadening the pharmacopeia for the overall treatment of addictions
CN101410109A (en) * 2006-03-24 2009-04-15 万能药生物有限公司 Antibiotic compositions of modified release and process of production thereof
WO2008027557A2 (en) 2006-08-31 2008-03-06 Spherics, Inc. Topiramate compositions and methods of enhancing its bioavailability
ITMI20061692A1 (en) 2006-09-05 2008-03-06 Alfa Wassermann Spa USE OF POLYOLS TO OBTAIN STYLE POLYMORPHIC FORMS OF RIFAXIMINA
CA2618240C (en) 2006-11-17 2015-01-20 Supernus Pharmaceuticals, Inc. Sustained-release formulations of topiramate
CN102218044A (en) * 2006-12-04 2011-10-19 苏佩努斯制药公司 Enhanced immediate release formulations of topiramate
US10166196B2 (en) * 2007-01-10 2019-01-01 Dsm Nutritional Products Ag Vegetarian microcapsules
US20100310475A1 (en) * 2007-06-18 2010-12-09 Dolhay Klinika Egeszsegugyi Kft. Biocide Capsules, Preparation Comprising them and Sanitary Pad Comprising the Preparation
GB0724279D0 (en) * 2007-12-12 2008-01-23 Photocure Asa Use
US20090169622A1 (en) * 2007-12-27 2009-07-02 Roxane Laboratories, Inc. Delayed-release oral pharmaceutical composition for treatment of colonic disorders
PE20120858A1 (en) * 2009-06-11 2012-08-01 Photocure Asa SOLID COMPOSITIONS INCLUDING 5-AMINOLEVULINIC ACID
IT1398550B1 (en) 2010-03-05 2013-03-01 Alfa Wassermann Spa RIFAXIMINA COMPREHENSIVE FORMULATIONS USEFUL TO OBTAIN A PROLONGED EFFECT IN TIME
AU2011224350B2 (en) * 2010-03-09 2015-07-02 Alkermes Pharma Ireland Limited Alcohol resistant enteric pharmaceutical compositions
MX2020011961A (en) 2010-03-24 2022-04-19 Jazz Pharmaceuticals Inc Controlled release dosage forms for high dose, water soluble and hygroscopic drug substances.
US11759441B2 (en) 2011-01-07 2023-09-19 Anji Pharmaceuticals Inc. Biguanide compositions and methods of treating metabolic disorders
ITBO20110461A1 (en) 2011-07-29 2013-01-30 Alfa Wassermann Spa PHARMACEUTICAL COMPOSITIONS INCLUDING RIFAXIMINA, PROCESSES FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF VAGINAL INFECTIONS.
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
JP6285866B2 (en) 2011-11-23 2018-02-28 セラピューティックスエムディー インコーポレーテッドＴｈｅｒａｐｅｕｔｉｃｓｍｄ， Ｉｎｃ． Natural complex hormone replacement preparations and therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
DK3300015T3 (en) 2013-03-12 2019-11-18 Panacea Biomatx Inc SYSTEM FOR MANUFACTURING INDIVIDUAL FORMULATIONS FOR INDIVIDUALS
US10172794B2 (en) 2013-12-13 2019-01-08 Biogen Ma Inc. Controlled release dosage form for once daily administration of dimethyl fumarate
AU2015260837B2 (en) 2014-05-12 2019-02-28 Alfasigma S.P.A. New solvated crystal form of rifaximin, production, compositions and uses thereof
AU2015264003A1 (en) 2014-05-22 2016-11-17 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10398662B1 (en) 2015-02-18 2019-09-03 Jazz Pharma Ireland Limited GHB formulation and method for its manufacture
HUE055974T2 (en) 2015-03-03 2022-01-28 Saniona As Tesofensine and metoprolol combination formulation
EP3288556A4 (en) 2015-04-29 2018-09-19 Dexcel Pharma Technologies Ltd. Orally disintegrating compositions
CN107920997A (en) 2015-06-17 2018-04-17 比奥根Ma公司 Dimethyl fumarate particle and its pharmaceutical composition
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
WO2017173071A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
US11602512B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11504347B1 (en) 2016-07-22 2022-11-22 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602513B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11000498B2 (en) 2016-07-22 2021-05-11 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
UY37341A (en) 2016-07-22 2017-11-30 Flamel Ireland Ltd FORMULATIONS OF GAMMA-MODIFIED RELEASE HYDROXIBUTIRATE WITH IMPROVED PHARMACOCINETICS
IT201600122310A1 (en) 2016-12-01 2018-06-01 Sofar Spa Composition for use in the treatment of bowel disorders
US20180263936A1 (en) 2017-03-17 2018-09-20 Jazz Pharmaceuticals Ireland Limited Gamma-hydroxybutyrate compositions and their use for the treatment of disorders
US20200232961A1 (en) * 2017-09-19 2020-07-23 The Regents Of The University Of Michigan Characterization and application of polymers for in vivo relevant drug absorption characterization in vitro
KR20210094513A (en) 2018-11-19 2021-07-29 재즈 파마슈티칼즈 아일랜드 리미티드 Alcohol-Resistant Drug Formulations
MX2021008208A (en) 2019-01-07 2021-11-17 Saniona As Tesofensine for reduction of body weight in prader-willi patients.
CA3127871A1 (en) 2019-03-01 2020-09-10 Flamel Ireland Limited Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations
CN113197799A (en) * 2020-04-21 2021-08-03 百欧生命标准有限公司 Cosmetic composition for improving skin condition
JP2023523738A (en) 2020-04-22 2023-06-07 サニオナ エー／エス Treatment of hypothalamic obesity
CN112791046B (en) * 2021-01-22 2022-11-01 杭州汉达医药科技有限公司 Medicinal preparation with child safety protection function and use method
US11779557B1 (en) 2022-02-07 2023-10-10 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11583510B1 (en) 2022-02-07 2023-02-21 Flamel Ireland Limited Methods of administering gamma hydroxybutyrate formulations after a high-fat meal
WO2023234935A1 (en) * 2022-05-31 2023-12-07 Venkor Corporation Bonded microparticulates preparation and applications thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0383967A1 (en) * 1989-02-17 1990-08-29 Dojin Iyaku-Kako Co., Ltd. Long acting diclofenac sodium preparation
WO2003030878A2 (en) * 2001-10-09 2003-04-17 Flamel Technologies Galenic microparticulate oral formulation
WO2003084518A2 (en) * 2002-04-09 2003-10-16 Flamel Technologies Oral suspension of active principle microcapsules
WO2004000286A1 (en) * 2002-06-24 2003-12-31 Les Laboratoires Servier Microcapsules for the delayed, controlled release of perindopril

Family Cites Families (271)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1019727A (en) 1971-03-18 1977-10-25 Abbott Laboratories Adenosine-5'-carboxylic acid amides
US4029884A (en) 1971-03-18 1977-06-14 Abbott Laboratories Adenosine-5'-carboxylic acid amides
US3927216A (en) 1971-06-01 1975-12-16 Icn Pharmaceuticals 1,2,4-Triazol E-3-carboxamides for inhibiting virus infections
DE2815926A1 (en) * 1978-04-13 1979-10-18 Boehringer Mannheim Gmbh NEW CARBAZOLYL- (4) -OXY-PROPANOLAMINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
US3864483A (en) * 1972-03-22 1975-02-04 Abbott Lab Adenosine-5{40 -carboxylic acid amides
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US4036227A (en) 1973-04-25 1977-07-19 Alza Corporation Osmotic releasing device having a plurality of release rate patterns
US3914414A (en) 1973-06-14 1975-10-21 Abbott Lab Method of increasing coronary pO{HD 2 {B in mammals
US3914415A (en) 1973-06-14 1975-10-21 Abbott Lab Adenosine-5{40 -carboxylic acid amides
US3892769A (en) 1973-07-20 1975-07-01 Merck & Co Inc Acetaminophen esters of aryl salicylic acids
US3980766A (en) 1973-08-13 1976-09-14 West Laboratories, Inc. Orally administered drug composition for therapy in the treatment of narcotic drug addiction
DE2417465A1 (en) 1974-04-10 1975-10-30 Lester R Wellman Sealed container opening and reclosing system - has locking section joined by fold line to reinforcing anchoring section
US3966917A (en) * 1974-07-30 1976-06-29 Abbott Laboratories Platelet aggregation inhibitors
DE2530563C2 (en) * 1975-07-09 1986-07-24 Bayer Ag, 5090 Leverkusen Analgesic drugs with reduced potential for abuse
US4077407A (en) * 1975-11-24 1978-03-07 Alza Corporation Osmotic devices having composite walls
FR2313915A1 (en) 1976-01-26 1977-01-07 Corneille Gilbert Sustained release vincamine microcapsules - with inert core, vincamine (deriv.) intermediate layer and microporous outer coating
US4111203A (en) 1976-11-22 1978-09-05 Alza Corporation Osmotic system with means for improving delivery kinetics of system
US4218433A (en) 1977-03-03 1980-08-19 Nippon Kayaku Kabushiki Kaisha Constant-rate eluting tablet and method of producing same
GB1598458A (en) 1977-04-01 1981-09-23 Hoechst Uk Ltd Tableting of microcapsules
NO154918C (en) * 1977-08-27 1987-01-14 Bayer Ag ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE DERIVATIVES OF 3,4,5-TRIHYDROXYPIPERIDINE.
SE7804231L (en) 1978-04-14 1979-10-15 Haessle Ab Gastric acid secretion
DE2904310A1 (en) 1979-02-05 1980-08-07 Boehringer Mannheim Gmbh MOLDINGS WITH RETARDED ACTIVE SUBSTANCE RELEASE AND METHOD FOR THE PRODUCTION THEREOF
FR2470599A1 (en) 1979-12-07 1981-06-12 Panoz Donald IMPROVEMENTS IN PROCESSES FOR THE PREPARATION OF GALENIC SHAPES WITH DELAYED ACTION AND PROGRAMMED RELEASE AND GALENIC FORMS OF MEDICAMENTS THUS OBTAINED
US4308251A (en) 1980-01-11 1981-12-29 Boots Pharmaceuticals, Inc. Controlled release formulations of orally-active medicaments
JPS6056122B2 (en) * 1980-05-21 1985-12-09 塩野義製薬株式会社 sustained release formulation
US4321253A (en) * 1980-08-22 1982-03-23 Beatty Morgan L Suspension of microencapsulated bacampicillin acid addition salt for oral, especially pediatric, administration
US4454309A (en) 1980-11-12 1984-06-12 Tyndale Plains-Hunter, Ltd. Polyurethane polyene compositions
JPS57197214A (en) 1981-05-29 1982-12-03 Tanabe Seiyaku Co Ltd Rapid-releasing microcapsule and its preparation
US4434153A (en) * 1982-03-22 1984-02-28 Alza Corporation Drug delivery system comprising a reservoir containing a plurality of tiny pills
US4553973A (en) 1982-07-12 1985-11-19 Alza Corporation Process for preparing osmotic device
US4519801A (en) * 1982-07-12 1985-05-28 Alza Corporation Osmotic device with wall comprising cellulose ether and permeability enhancer
US4507276A (en) 1982-08-20 1985-03-26 Bristol-Myers Company Analgesic capsule
US4461759A (en) 1983-01-03 1984-07-24 Verex Laboratories, Inc. Constant release rate solid oral dosage formulations of veropamil
HU187215B (en) * 1983-01-26 1985-11-28 Egyt Gyogyszervegyeszeti Gyar Method for producing pharmaceutical product of high actor content and prolonged effect
US4612008A (en) 1983-05-11 1986-09-16 Alza Corporation Osmotic device with dual thermodynamic activity
DE3319027A1 (en) * 1983-05-26 1984-11-29 Boehringer Mannheim Gmbh, 6800 Mannheim METHOD FOR PRODUCING OPTICALLY ACTIVE CARBAZOL DERIVATIVES, NEW R- AND S-CARBAZOL DERIVATIVES, AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
US4833905A (en) * 1983-06-03 1989-05-30 Micromatic Textron Inc. Method for splining clutch hubs with close tolerance spline bellmouth and oil seal surface roundness
US4782043A (en) 1983-06-15 1988-11-01 Merck & Co., Inc. Renin inhibitors containing a C-terminal amide cycle
GB8319766D0 (en) * 1983-07-22 1983-08-24 Graham N B Controlled release device
GB8322007D0 (en) 1983-08-16 1983-09-21 Wellcome Found Pharmaceutical delivery system
JPS6051189A (en) * 1983-08-30 1985-03-22 Sankyo Co Ltd Thiazolidine derivative and its preparation
US4610686A (en) 1983-11-02 1986-09-09 Alza Corporation Controlled delivery of haloperidol by an osmotic delivery system
US4777049A (en) 1983-12-01 1988-10-11 Alza Corporation Constant release system with pulsed release
US4894240A (en) * 1983-12-22 1990-01-16 Elan Corporation Plc Controlled absorption diltiazem formulation for once-daily administration
GB8414221D0 (en) * 1984-06-04 1984-07-11 Sterwin Ag Unit dosage form
IL75400A (en) 1984-06-16 1988-10-31 Byk Gulden Lomberg Chem Fab Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same
JPS6150978A (en) 1984-08-16 1986-03-13 Takeda Chem Ind Ltd Pyridine derivative and preparation thereof
AU4640985A (en) 1984-08-31 1986-03-06 Nippon Chemiphar Co. Ltd. Benzimidazole derivatives
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
EP0198769A3 (en) 1985-04-12 1987-09-02 Forest Laboratories, Inc. Floating sustained release therapeutic compositions
US4609374A (en) 1985-04-22 1986-09-02 Alza Corporation Osmotic device comprising means for governing initial time of agent release therefrom
US4624847A (en) 1985-04-22 1986-11-25 Alza Corporation Drug delivery device for programmed delivery of beneficial drug
US4728512A (en) 1985-05-06 1988-03-01 American Home Products Corporation Formulations providing three distinct releases
LU85943A1 (en) 1985-06-12 1987-01-13 Galephar PHARMACEUTICAL TABLETS FOR THE EASY ADMINISTRATION OF PELLETS, THEIR PREPARATION AND THEIR USE
LU86099A1 (en) * 1985-09-30 1987-04-02 Pharlyse EXTENDED RELEASE GALENIC FORMS OF VERAPAMIL, THEIR MANUFACTURE AND THE MEDICINAL PRODUCTS CONTAINING THEM
US4693896A (en) 1985-10-07 1987-09-15 Fmc Corporation Ethylcellulose-coated, gastric-disintegrable aspirin tablet
DE3543999A1 (en) * 1985-12-13 1987-06-19 Bayer Ag HIGH PURITY ACARBOSE
CA1327010C (en) 1986-02-13 1994-02-15 Tadashi Makino Stabilized solid pharmaceutical composition containing antiulcer benzimidazole compound and its production
JPS62195323A (en) 1986-02-24 1987-08-28 Eisai Co Ltd Gastric resident particle
AU591248B2 (en) 1986-03-27 1989-11-30 Kinaform Technology, Inc. Sustained-release pharaceutical preparation
SE8601624D0 (en) 1986-04-11 1986-04-11 Haessle Ab NEW PHARMACEUTICAL PREPARATIONS
US4816262A (en) * 1986-08-28 1989-03-28 Universite De Montreal Controlled release tablet
IT1200217B (en) 1986-09-30 1989-01-05 Valducci Roberto MEMBRANE FOR PHARMACEUTICAL AND INDUSTRIAL USE
IT1197316B (en) 1986-10-01 1988-11-30 Proter Spa GALENIC FORMULATION FOR ORAL USE OF REINA DERIVATIVES SLOWLY RELEASED FOR THERAPEUTIC USE
SE8605515D0 (en) 1986-12-22 1986-12-22 Astra Laekemedel Ab A LIQUID DOSAGE FORM FOR ORAL ADMINISTRATION OF A PHARMACEUTICALLY ACTIVE SUBSTANCE
US5026560A (en) 1987-01-29 1991-06-25 Takeda Chemical Industries, Ltd. Spherical granules having core and their production
EP0281200B1 (en) 1987-03-02 1994-01-19 Yamanouchi Europe B.V. Pharmaceutical composition, pharmaceutical granulate and process for their preparation
GB8705083D0 (en) 1987-03-04 1987-04-08 Euro Celtique Sa Spheroids
US4792448A (en) 1987-06-11 1988-12-20 Pfizer Inc. Generic zero order controlled drug delivery system
US4902513A (en) * 1987-07-31 1990-02-20 Jean Carvais Oral sustained release medicament
US4814183A (en) * 1987-08-31 1989-03-21 Merck & Co., Inc. Device for the controlled release of drugs with Donnan-like modulation by charged insoluble resins
IT1215726B (en) 1988-01-18 1990-02-22 Alfa Wassermann Spa GALENIC FORMULATIONS WITH SCHEDULED SALE.
DE3810757A1 (en) 1988-03-30 1989-10-26 Freudenberg Carl Fa METHOD FOR PRODUCING A MICROPOROESIS FILM
US5268182A (en) 1988-06-24 1993-12-07 Abbott Laboratories Sustained-release drug dosage units of terazosin
FR2634377B1 (en) 1988-06-30 1991-09-27 Cortial NOVEL EXTENDED RELEASE PHARMACEUTICAL FORM BASED ON AN ACTIVE RESIN-PRINCIPLE COMPLEX
US5028434A (en) 1988-07-21 1991-07-02 Alza Corporation Method for administering nilvadipine for treating cardiovascular symptoms
GB8820353D0 (en) * 1988-08-26 1988-09-28 Staniforth J N Controlled release tablet
US5296236A (en) * 1988-09-16 1994-03-22 Recordati S.A., Chemical And Pharmaceutical Company Controlled release therapeutic system for a liquid pharmaceutical formulations
US4999189A (en) * 1988-11-14 1991-03-12 Schering Corporation Sustained release oral suspensions
US5186930A (en) * 1988-11-14 1993-02-16 Schering Corporation Sustained release oral suspensions
IT1227899B (en) 1988-12-23 1991-05-14 Poli Ind Chimica Spa TOTAL OR PARTIAL COATING OF PHARMACEUTICAL ACTIVE SUBSTANCES AND RELATED COMPOSITIONS
CA2007181C (en) 1989-01-06 1998-11-24 Angelo Mario Morella Sustained release pharmaceutical composition
FR2642080B1 (en) * 1989-01-23 1992-10-02 Onera (Off Nat Aerospatiale) POLYSILANES AND THEIR PREPARATION PROCESS
US5026559A (en) 1989-04-03 1991-06-25 Kinaform Technology, Inc. Sustained-release pharmaceutical preparation
US5133974A (en) 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
US5084278A (en) * 1989-06-02 1992-01-28 Nortec Development Associates, Inc. Taste-masked pharmaceutical compositions
AU632602B2 (en) 1989-08-02 1993-01-07 John David Arnold Method and preparation for reducing risk of myocardial infarction
NZ233975A (en) 1989-08-16 1992-06-25 Sterling Drug Inc Aspirin granules coated with a gastroprotectant
IT1256651B (en) 1992-12-11 1995-12-12 Giancarlo Santus PHARMACEUTICAL COMPOSITION WITH CONTROLLED RELEASE IN LIQUID SUSPENSION
US5248516A (en) 1989-12-19 1993-09-28 Fmc Corporation Film-forming composition: method of producing same and use for coating pharmaceuticals and foods and the like
US5206030A (en) * 1990-02-26 1993-04-27 Fmc Corporation Film-forming composition and use for coating pharmaceuticals, foods and the like
IT1246383B (en) * 1990-04-17 1994-11-18 Eurand Int METHOD FOR MASKING THE TASTE OF DRUGS
EP0477135A1 (en) 1990-09-07 1992-03-25 Warner-Lambert Company Chewable spheroidal coated microcapsules and methods for preparing same
US5431922A (en) 1991-03-05 1995-07-11 Bristol-Myers Squibb Company Method for administration of buspirone
GB9104854D0 (en) 1991-03-07 1991-04-17 Reckitt & Colmann Prod Ltd Sustained release compositions
FI922107A0 (en) 1991-05-10 1992-05-08 Faulding F H & Co Ltd MICROCAPSULAR COMPOSITION OCH FOERFARANDE.
US5286497A (en) * 1991-05-20 1994-02-15 Carderm Capital L.P. Diltiazem formulation
IT1250421B (en) 1991-05-30 1995-04-07 Recordati Chem Pharm CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION WITH BIO-ADHESIVE PROPERTIES.
US5464632C1 (en) 1991-07-22 2001-02-20 Prographarm Lab Rapidly disintegratable multiparticular tablet
FR2679451B1 (en) 1991-07-22 1994-09-09 Prographarm Laboratoires MULTIPARTICLE TABLET WITH RAPID DELIVERY.
ATE154241T1 (en) 1991-10-01 1997-06-15 Takeda Chemical Industries Ltd MICROPARTICLE SUMMARY FOR EXTENDED RELEASE AND PRODUCTION THE SAME
US5656295A (en) 1991-11-27 1997-08-12 Euro-Celtique, S.A. Controlled release oxycodone compositions
US5409709A (en) * 1991-11-29 1995-04-25 Lion Corporation Antipyretic analgesic preparation containing ibuprofen
US5571533A (en) 1992-02-07 1996-11-05 Recordati, S.A., Chemical And Pharmaceutical Company Controlled-release mucoadhesive pharmaceutical composition for the oral administration of furosemide
IL103224A (en) 1992-09-18 1998-08-16 Teva Pharma Stabilized pharmaceutical compositions containing derivatives of vitamins d2 and d3
US5405863A (en) * 1992-12-01 1995-04-11 Smithkline Beecham Corporation Antioxidant cardioprotective use of, and method of treatment using, hydroxycarbazole compounds
US5594016A (en) * 1992-12-28 1997-01-14 Mitsubishi Chemical Corporation Naphthalene derivatives
US5512593A (en) * 1993-03-02 1996-04-30 John S. Nagle Composition and method of treating depression using natoxone or naltrexone in combination with a serotonin reuptake inhibitor
US5308862A (en) 1993-03-05 1994-05-03 Boehringer Mannheim Pharmaceuticals Corporation - Smithkline Beecham Corp., Ltd. Partnership No. 1 Use of, and method of treatment using, carbazolyl-(4)-oxypropanolamine compounds for inhibition of smooth muscle cell proliferation
FR2704146B1 (en) * 1993-04-19 1995-07-13 Cripdom Microcapsules of acetylsalicylic acid with controlled release.
EP0647448A1 (en) 1993-10-07 1995-04-12 Euroceltique S.A. Orally administrable opioid formulations having extended duration of effect
US5500227A (en) * 1993-11-23 1996-03-19 Euro-Celtique, S.A. Immediate release tablet cores of insoluble drugs having sustained-release coating
US5393772A (en) * 1993-11-24 1995-02-28 Boehringer Mannheim Pharmaceuticals Corporation Use of, and method of treatment using, hydroxycarbazole compounds for inhibition of smooth muscle migration and proliferation
GB9401894D0 (en) 1994-02-01 1994-03-30 Rhone Poulenc Rorer Ltd New compositions of matter
KR100232297B1 (en) * 1994-05-06 1999-12-01 디. 제이. 우드 Controlled-release dosage forms of azithromycin
SE9402422D0 (en) 1994-07-08 1994-07-08 Astra Ab New beads for controlled release and a pharmaceutical preparation containing the same
DE4432757A1 (en) 1994-09-14 1996-03-21 Boehringer Mannheim Gmbh Pharmaceutical preparation containing metformin and process for its preparation
FR2725623A1 (en) 1994-10-18 1996-04-19 Flamel Tech Sa MEDICINAL AND / OR NUTRITION MICROCAPSULES FOR PER OS ADMINISTRATION
US5858398A (en) * 1994-11-03 1999-01-12 Isomed Inc. Microparticular pharmaceutical compositions
US5834024A (en) * 1995-01-05 1998-11-10 Fh Faulding & Co. Limited Controlled absorption diltiazem pharmaceutical formulation
US5760069A (en) 1995-02-08 1998-06-02 Boehringer Mannheim Pharmaceuticals Corporation-Smithkline Beecham Corporation Limited Partnership #1 Method of treatment for decreasing mortality resulting from congestive heart failure
US20010011099A1 (en) 1995-05-30 2001-08-02 Smithkline Beecham Corporation Antioxidant neuroprotective use of, and method of treatment using, hydroxycarbazole compounds
US5674529A (en) 1995-06-06 1997-10-07 Church & Dwight Co., Inc. Alkalinizing potassium salt controlled release preparations
US5643915A (en) 1995-06-06 1997-07-01 Andrulis Pharmaceuticals Corp. Treatment of ischemia/reperfusion injury with thalidomide alone or in combination with other therapies
US5945124A (en) 1995-07-05 1999-08-31 Byk Gulden Chemische Fabrik Gmbh Oral pharmaceutical composition with delayed release of active ingredient for pantoprazole
EP0866713B1 (en) * 1995-11-13 2006-08-02 North-West University Administration media for analgesic, anti-inflammatory and anti-pyretic drugs containing nitrous oxide and pharmaceutical compositions containing such media and drugs
IT1276130B1 (en) 1995-11-14 1997-10-27 Gentili Ist Spa GLIBENCLAMIDE-METFORMIN ASSOCIATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN IT AND THEIR USE IN THE TREATMENT OF TYPE DIABETES MELLITUS
US6245351B1 (en) 1996-03-07 2001-06-12 Takeda Chemical Industries, Ltd. Controlled-release composition
US20030064108A1 (en) * 1996-04-23 2003-04-03 Stefan Lukas Taste masked pharmaceutical compositions
CZ59199A3 (en) 1996-08-23 1999-08-11 Boehringer Mannheim Pharmaceuticals Corporation-Smithkline Beecham Corporation Limited Partnership No. 1 INHIBITION METHOD OF FaS EXPRESSION
FR2752732B1 (en) * 1996-08-28 1998-11-20 Pf Medicament EXTENDED RELEASE GALENIC FORM OF MILNACIPRAN
US5780055A (en) 1996-09-06 1998-07-14 University Of Maryland, Baltimore Cushioning beads and tablet comprising the same capable of forming a suspension
DE19637082A1 (en) * 1996-09-12 1998-03-19 Boehringer Mannheim Gmbh Rapidly disintegrating pellets
KR20000048967A (en) * 1996-10-09 2000-07-25 제이 베리 부조가니 Method for inhibiting stress-activated protein kinases
CA2275475A1 (en) 1996-12-19 1998-06-25 Hiroshi Kikuchi Pharmaceutical composition for oral administration
FR2759083B1 (en) 1997-02-06 1999-04-30 Dev Des Utilisations Du Collag COLLAGENIC MATERIAL USEFUL IN PARTICULAR FOR THE PREVENTION OF POST-OPERATIVE ADHESIONS
DE69826113T2 (en) * 1997-03-11 2005-01-20 Arakis Ltd., Saffron Walden R AND S-ENANTIOMER SEPARATED DOSAGE FORMS
US6162463A (en) 1997-05-01 2000-12-19 Dov Pharmaceutical Inc Extended release formulation of diltiazem hydrochloride
US6043252A (en) * 1997-05-05 2000-03-28 Icos Corporation Carboline derivatives
US6730326B2 (en) * 1997-07-22 2004-05-04 Roche Diagnostics Gmbh Thermodynamically stable modification of 1-(4-carbazolyl-oxy-3[2-(2-methoxyphenoxy)-ethylamino]-2-propanol process for its preparation and pharmaceutical compositions containing it
US6019735A (en) * 1997-08-28 2000-02-01 Visco Technologies, Inc. Viscosity measuring apparatus and method of use
US6322525B1 (en) 1997-08-28 2001-11-27 Visco Technologies, Inc. Method of analyzing data from a circulating blood viscometer for determining absolute and effective blood viscosity
US6428488B1 (en) 1997-08-28 2002-08-06 Kenneth Kensey Dual riser/dual capillary viscometer for newtonian and non-newtonian fluids
GT199800126A (en) 1997-08-29 2000-01-29 COMBINATION THERAPY.
JP2002522354A (en) 1997-09-19 2002-07-23 シャイア ラボラトリーズ，インコーポレイテッド Solid solution beadlets
US6472373B1 (en) 1997-09-21 2002-10-29 Schering Corporation Combination therapy for eradicating detectable HCV-RNA in antiviral treatment naive patients having chronic hepatitis C infection
ZA989365B (en) * 1997-10-15 1999-04-15 Boehringer Mannheim Pharm Corp Preparation for treating alzheimer's disease
US20020054911A1 (en) 2000-05-11 2002-05-09 Boehringer Mannheim Pharmaceutical Corporation-Sm Ithkline Beckman Corporation, Limited Partnershi Novel oral dosage form for carvedilol
US6558699B2 (en) * 1997-11-17 2003-05-06 Smithkline Beecham Corporation High drug load immediate and modified release oral dosage formulations and processes for their manufacture
FR2771291B1 (en) 1997-11-21 2000-02-25 Ethypharm Lab Prod Ethiques SPHEROIDS, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS
US6541479B1 (en) 1997-12-02 2003-04-01 Massachusetts College Of Pharmacy Calcium channel blockers
UA53774C2 (en) 1997-12-22 2003-02-17 Еро-Селтік, С.А. Method of reducing abuse potential of an oral dosage form of opioid analgesic
BR9908911A (en) 1998-03-19 2001-10-02 Bristol Myers Squibb Co Biphasic system and distribution process by controlled release of high solubility pharmaceutical substances
BR9908616A (en) 1998-03-20 2000-10-31 Kowa Co Gastric and / or duodenal adhesive pharmaceutical composition.
US6184220B1 (en) * 1998-03-27 2001-02-06 Boehringer Ingelheim Pharma Kg Oral suspension of pharmaceutical substance
US5945123A (en) 1998-04-02 1999-08-31 K-V Pharmaceutical Company Maximizing effectiveness of substances used to improve health and well being
ATE246502T1 (en) 1998-04-09 2003-08-15 Roche Diagnostics Gmbh MEDICINAL FORMS CONTAINING CARVEDILOL
US6852337B2 (en) * 1998-04-09 2005-02-08 Roche Diagnostics Gmbh Carvedilol-galenics
EP0968714A1 (en) 1998-07-02 2000-01-05 Roche Diagnostics GmbH Process to prepare fast dissolving pharmaceutical compositions containing hardly soluble agents
ES2206868T3 (en) 1998-07-15 2004-05-16 Merck Sante TABLETS THAT UNDERSTAND A COMBINATION OF METFORMIN GLIBENCLAMIDE.
US6664284B2 (en) 1998-07-23 2003-12-16 Roche Diagnostics Gmbh Stabilized carvedilol injection solution
WO2000006128A1 (en) 1998-07-28 2000-02-10 Tanabe Seiyaku Co., Ltd. Preparation capable of releasing drug at target site in intestine
US6099862A (en) 1998-08-31 2000-08-08 Andrx Corporation Oral dosage form for the controlled release of a biguanide and sulfonylurea
US6303607B1 (en) * 1998-09-10 2001-10-16 Cv Therapeutics, Inc. Method for administering a sustained release ranolanolazine formulation
AU1025899A (en) 1998-09-16 2000-04-03 Icos Corporation Carboline derivatives as cgmp phosphodiesterase inhibitors
JP2000128774A (en) * 1998-10-26 2000-05-09 Tanabe Seiyaku Co Ltd Production of globular, fine grain including medicine
US6096341A (en) * 1998-10-30 2000-08-01 Pharma Pass Llc Delayed release tablet of bupropion hydrochloride
NZ511442A (en) * 1998-11-02 2003-02-28 Elan Corp Plc Multiparticulate modified release composition for multiple dosing of ADD patients with methylphenidate HCl
PE20001302A1 (en) 1998-11-27 2000-11-30 Hoffmann La Roche PREPARATIONS OF A PHARMACEUTICAL COMBINATION CONTAINING CARVEDILOL AND HYDROCHLOROTHIAZIDE
US6419960B1 (en) 1998-12-17 2002-07-16 Euro-Celtique S.A. Controlled release formulations having rapid onset and rapid decline of effective plasma drug concentrations
US20030035840A1 (en) * 2001-02-08 2003-02-20 Boyong Li Controlled release oral dosage form
US7374779B2 (en) * 1999-02-26 2008-05-20 Lipocine, Inc. Pharmaceutical formulations and systems for improved absorption and multistage release of active agents
US6395300B1 (en) * 1999-05-27 2002-05-28 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
US7576131B2 (en) 1999-06-04 2009-08-18 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia
US6309663B1 (en) 1999-08-17 2001-10-30 Lipocine Inc. Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents
US20030118641A1 (en) 2000-07-27 2003-06-26 Roxane Laboratories, Inc. Abuse-resistant sustained-release opioid formulation
US6428809B1 (en) 1999-08-18 2002-08-06 Microdose Technologies, Inc. Metering and packaging of controlled release medication
US6432989B1 (en) 1999-08-27 2002-08-13 Pfizer Inc Use of CRF antagonists to treat circadian rhythm disorders
HUP0203623A2 (en) * 1999-08-31 2003-02-28 Grünenthal GmbH Delayed-action form of administration containing tramadol saccharinate and its use
ES2168043B1 (en) 1999-09-13 2003-04-01 Esteve Labor Dr PHARMACEUTICAL FORM ORAL SOLID MODIFIED RELEASE CONTAINING A COMPOSITE OF BENCIMIDAZOL LABIL IN THE MIDDLE ACID.
US6264983B1 (en) 1999-09-16 2001-07-24 Rhodia, Inc. Directly compressible, ultra fine acetaminophen compositions and process for producing same
US6458387B1 (en) * 1999-10-18 2002-10-01 Epic Therapeutics, Inc. Sustained release microspheres
US6484565B2 (en) 1999-11-12 2002-11-26 Drexel University Single riser/single capillary viscometer using mass detection or column height detection
WO2001035958A1 (en) * 1999-11-15 2001-05-25 Smithkline Beecham Corporation Carvedilol methanesulfonate
EP1106210A3 (en) * 1999-12-07 2003-12-03 Pfizer Products Inc. Combination of aldose reductase inhibitors and antihypertensive agents for the treatment of diabetic complications
US6248359B1 (en) 2000-01-05 2001-06-19 Laboratorios Phoenix U.S.A., Inc. Multi-tablet oxybutynin system for treating incontinence
US6491949B2 (en) 2000-01-14 2002-12-10 Osmotica Corp. Osmotic device within an osmotic device
SI2517710T1 (en) * 2000-02-08 2015-07-31 Euro-Celtique S.A. Tamper-resistant oral opioid agonist formulations
US6627223B2 (en) 2000-02-11 2003-09-30 Eurand Pharmaceuticals Ltd. Timed pulsatile drug delivery systems
US6761904B2 (en) 2000-03-31 2004-07-13 Nycomed Austria Gmbh Pharmaceutical kit comprising midodrine as active drug substance
AU2001263813A1 (en) * 2000-04-03 2001-10-15 F.Hoffmann-La Roche Ag Concentrated solutions of carvedilol
US20010036959A1 (en) 2000-04-03 2001-11-01 Gabel Rolf Dieter Carvedilol-hydrophilic solutions
US6534651B2 (en) 2000-04-06 2003-03-18 Inotek Pharmaceuticals Corp. 7-Substituted isoindolinone inhibitors of inflammation and reperfusion injury and methods of use thereof
AU5066101A (en) * 2000-04-13 2001-10-30 Synthon B.V. Modified release formulations containing a hypnotic agent
US6815542B2 (en) 2000-06-16 2004-11-09 Ribapharm, Inc. Nucleoside compounds and uses thereof
KR20080015888A (en) * 2000-06-28 2008-02-20 테바 파마슈티컬 인더스트리즈 리미티드 Carvedilol
FR2811571B1 (en) 2000-07-11 2002-10-11 Flamel Tech Sa ORAL PHARMACEUTICAL COMPOSITION FOR CONTROLLED RELEASE AND SUSTAINED ABSORPTION OF AN ACTIVE INGREDIENT
IT1318625B1 (en) * 2000-07-14 2003-08-27 Roberto Valducci ORAL SOLID PHARMACEUTICAL FORMULATIONS WITH MULTI-PHASE RELEASE - EMPLOYEE.
US20020099013A1 (en) 2000-11-14 2002-07-25 Thomas Piccariello Active agent delivery systems and methods for protecting and administering active agents
IL138156A0 (en) * 2000-08-29 2001-10-31 Eshpar Jonathan Articulated structure
AU2001290239A1 (en) * 2000-09-19 2002-04-02 Daiichi Pharmaceutical Co., Ltd. Medicinal composition
US6541014B2 (en) 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
US7074417B2 (en) 2000-10-13 2006-07-11 Advancis Pharmaceutical Corporation Multiple-delayed release anti-viral product, use and formulation thereof
US6499158B1 (en) * 2000-10-30 2002-12-31 Steris, Inc. Surgical table top and accessory clamp used thereon
FR2816840B1 (en) 2000-11-17 2004-04-09 Flamel Tech Sa MEDICINE BASED ON SUSTAINED RELEASE ANTI-HYPERCLYCEMIA MICROCAPSULES AND METHOD FOR PREPARING THE SAME
US6495154B1 (en) 2000-11-21 2002-12-17 Vivus Inc. On demand administration of clomipramine and salts thereof to treat premature ejaculation
AU2002254036A1 (en) 2001-03-05 2002-09-19 Ortho-Mcneil Pharmaceutical, Inc. Taste masked pharmaceutical compositions
FR2821745B1 (en) 2001-03-09 2004-07-02 Ethypharm Lab Prod Ethiques GRANULES AND GRANULES COATED WITH MASK TASTE
WO2002078692A1 (en) * 2001-04-02 2002-10-10 Smithkline Beecham Corporation Method of treatment
BR0102252B1 (en) 2001-04-10 2013-10-22 Angiotensin II AT1 Receptor Antagonist Controlled Release System, Pharmaceutical Composition and Use
JP2004530676A (en) 2001-04-18 2004-10-07 ノストラム・ファーマスーティカルズ・インコーポレイテッド Novel coatings for sustained release pharmaceutical compositions
IN191028B (en) * 2001-05-17 2003-09-13 Sun Pharmaceutical Ind Ltd
FR2825023B1 (en) 2001-05-23 2005-04-15 Flamel Tech Sa ANTIDIABETIC ORAL PHARMACEUTICAL FORM "ONE TAKEN PER DAY" INCLUDING BIGUANIDE AND AT LEAST ONE OTHER ACTIVE INGREDIENT
US20040219208A1 (en) 2001-08-03 2004-11-04 Ryu Kawamura Sustained-release medicines
US7332182B2 (en) * 2001-08-06 2008-02-19 Purdue Pharma L.P. Pharmaceutical formulation containing opioid agonist, opioid antagonist and irritant
US7842307B2 (en) * 2001-08-06 2010-11-30 Purdue Pharma L.P. Pharmaceutical formulation containing opioid agonist, opioid antagonist and gelling agent
EP1418886A1 (en) 2001-08-10 2004-05-19 Beiersdorf AG Cosmetic cleansing formulations, based on a combination of sodium laureth sulphate and alkyl polyamphopolycarboxy glycinates
US20030030878A1 (en) * 2001-08-13 2003-02-13 Jyh-Ming Jong Optical receiver for receiving a plurality of input signals
US20030083286A1 (en) * 2001-08-22 2003-05-01 Ching-Leou Teng Bioadhesive compositions and methods for enhanced intestinal drug absorption
US20030099711A1 (en) * 2001-08-29 2003-05-29 David Meadows Sustained release preparations
US20030050620A1 (en) * 2001-09-07 2003-03-13 Isa Odidi Combinatorial type controlled release drug delivery device
US20030059397A1 (en) 2001-09-17 2003-03-27 Lyn Hughes Dosage forms
WO2003028649A2 (en) 2001-10-02 2003-04-10 Smithkline Beecham Corporation Novel composition of carvedilol
US8101209B2 (en) 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
US20040019096A1 (en) * 2001-10-23 2004-01-29 Vlassios Andronis Novel formulations of carvedilol
US20030104052A1 (en) 2001-10-25 2003-06-05 Bret Berner Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract
US20040126428A1 (en) 2001-11-02 2004-07-01 Lyn Hughes Pharmaceutical formulation including a resinate and an aversive agent
US6710184B2 (en) 2002-01-15 2004-03-23 Teva Pharmaceutical Industries Ltd. Crystalline solids of carvedilol and processes for their preparation
FR2837100B1 (en) 2002-03-18 2004-07-23 Flamel Tech Sa MODIFIED RELEASE MICROCAPSULE-BASED TABLETS
EP1490029A4 (en) * 2002-03-22 2006-02-22 Ranbaxy Lab Ltd Controlled release drug delivery system of pravastatin
IL164221A0 (en) * 2002-04-09 2005-12-18 Flamel Tech Sa Oral pharmaceutical formulation in the form of aqueous suspension of microcapsules for modified release of amoxicillim
US20050106249A1 (en) * 2002-04-29 2005-05-19 Stephen Hwang Once-a-day, oral, controlled-release, oxycodone dosage forms
WO2003092622A2 (en) * 2002-04-30 2003-11-13 Sb Pharmco Puerto Rico Inc. Carvedilol monocitrate monohydrate
MXPA04012021A (en) 2002-05-31 2005-08-16 Johnson & Johnson Dosage forms and compositions for osmotic delivery of variable dosages of oxycodone.
EP1539140A4 (en) 2002-06-27 2005-12-07 Sb Pharmco Inc Carvedilol hydobromide
WO2004002419A2 (en) 2002-06-27 2004-01-08 Sb Pharmco Puerto Rico Inc. Carvedilol phosphate salts and/or solvates thereof, correspondinq compositions, and/or methods of treatment
US7399488B2 (en) 2002-07-05 2008-07-15 Collegium Pharmaceutical, Inc. Abuse-deterrent pharmaceutical compositions of opiods and other drugs
US20040152756A1 (en) 2002-07-15 2004-08-05 Wei Chen Carvedilol polymorph
US20060013877A1 (en) 2002-07-22 2006-01-19 Nanohybrid Co., Ltd. Hybrid of itraconazole, cyclosporine or carvedilol with a layered silicate and a process for preparing the same
FR2842736B1 (en) 2002-07-26 2005-07-22 Flamel Tech Sa ORAL PHARMACEUTICAL FORMULATION IN THE FORM OF A PLURALITY OF MICROCAPSULES FOR PROLONGED RELEASE OF LOW SOLUBLE ACTIVE (S) PRINCIPLE (S)
FR2842735B1 (en) 2002-07-26 2006-01-06 Flamel Tech Sa MODIFIED RELEASE MICROCAPSULES OF LOW SOLUBLE ACTIVE PRINCIPLES FOR PER OS ADMINISTRATION
EP1530458A1 (en) 2002-08-14 2005-05-18 Ranbaxy Laboratories, Ltd. Extended release matrix tablets
CA2498410A1 (en) 2002-09-13 2004-03-25 Cydex, Inc. Capsules containing aqueous fill compositions stabilized with derivatized cyclodextrin
US7538094B2 (en) * 2002-09-19 2009-05-26 Three Rivers Pharmacueticals, Llc Composition containing ribavirin and use thereof
MY148805A (en) * 2002-10-16 2013-05-31 Takeda Pharmaceutical Controlled release preparation
SE0203065D0 (en) 2002-10-16 2002-10-16 Diabact Ab Gastric acid secretion inhibiting composition
DE10250084A1 (en) 2002-10-25 2004-05-06 Grünenthal GmbH Dosage form protected against abuse
US20040151772A1 (en) 2002-11-08 2004-08-05 Egalet A/S Controlled release carvedilol compositions
TWI332507B (en) * 2002-11-19 2010-11-01 Hoffmann La Roche Antiviral nucleoside derivatives
US20040110781A1 (en) 2002-12-05 2004-06-10 Harmon Troy M. Pharmaceutical compositions containing indistinguishable drug components
JP2004188307A (en) 2002-12-11 2004-07-08 Japan Atom Energy Res Inst Method of synthesizing zirconium-deposited fibrous adsorbing material having phosphate group and method of removing arsenic by using the same
CN1726012A (en) 2002-12-11 2006-01-25 辉瑞产品公司 Controlled-release of an active substance into a high fat environment
US20060210620A1 (en) 2003-01-21 2006-09-21 Kumra Pannanchukunnath M Co-precipitated amorphous losartan and dosage forms comprising the same
CA2520321A1 (en) 2003-04-04 2004-10-14 Pharmacia Corporation Oral extended release compressed tablets of multiparticulates
MY135852A (en) 2003-04-21 2008-07-31 Euro Celtique Sa Pharmaceutical products
KR20120104199A (en) 2003-08-06 2012-09-20 그뤼넨탈 게엠베하 Dosage form that is safeguarded from abuse
DE10336400A1 (en) * 2003-08-06 2005-03-24 Grünenthal GmbH Anti-abuse dosage form
WO2005016370A1 (en) 2003-08-13 2005-02-24 Howard J. Smith & Associates Pty Ltd Method of treating viral infections
EP1691789B1 (en) 2003-11-25 2017-12-20 SmithKline Beecham (Cork) Limited Carvedilol free base, salts, anhydrous forms or solvate thereof, corresponding pharmaceutical compositions, controlled release formulations, and treatment or delivery methods
JP2007512372A (en) 2003-11-25 2007-05-17 エスビー・ファルムコ・プエルト・リコ・インコーポレイテッド Carvedilol salts, corresponding compositions, delivery and / or treatment methods
US20050169994A1 (en) 2003-11-25 2005-08-04 Burke Matthew D. Carvedilol free base, salts, anhydrous forms or solvates thereof, corresponding pharmaceutical compositions, controlled release formulations, and treatment or delivery methods
TWI350762B (en) 2004-02-12 2011-10-21 Euro Celtique Sa Particulates
PT1765292T (en) 2004-06-12 2017-12-29 Collegium Pharmaceutical Inc Abuse-deterrent drug formulations
CA2581764A1 (en) * 2004-09-27 2006-04-06 Sigmoid Biotechnologies Limited Minicapsule formulations
FR2878161B1 (en) 2004-11-23 2008-10-31 Flamel Technologies Sa ORAL MEDICINE FORM, SOLID AND DESIGNED TO AVOID MEASUREMENT
FR2878158B1 (en) 2004-11-24 2009-01-16 Flamel Technologies Sa ORAL PHARMACEUTICAL FORM, SOLID MICROPARTICULAR DESIGNED TO PREVENT MEASUREMENT
FR2881652B1 (en) * 2005-02-08 2007-05-25 Flamel Technologies Sa MICROPARTICULAR ORAL PHARMACEUTICAL FORM ANTI-MEASURING
FR2889810A1 (en) 2005-05-24 2007-02-23 Flamel Technologies Sa ORAL MEDICINAL FORM, MICROPARTICULAR, ANTI-MEASUREMENT
US20070166378A1 (en) 2005-06-09 2007-07-19 Flamel Technologies, Inc. Oral ribavirin pharmaceutical compositions
WO2006133733A1 (en) 2005-06-13 2006-12-21 Flamel Technologies Oral dosage form comprising an antimisuse system
FR2892937B1 (en) 2005-11-10 2013-04-05 Flamel Tech Sa MICROPARTICULAR ORAL PHARMACEUTICAL FORM ANTI-MEASURING

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0383967A1 (en) * 1989-02-17 1990-08-29 Dojin Iyaku-Kako Co., Ltd. Long acting diclofenac sodium preparation
WO2003030878A2 (en) * 2001-10-09 2003-04-17 Flamel Technologies Galenic microparticulate oral formulation
WO2003084518A2 (en) * 2002-04-09 2003-10-16 Flamel Technologies Oral suspension of active principle microcapsules
WO2004000286A1 (en) * 2002-06-24 2003-12-31 Les Laboratoires Servier Microcapsules for the delayed, controlled release of perindopril

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