WO2005098428A3 - Method and system for screening compounds for muscular and/or neurological activity in animals - Google Patents

Method and system for screening compounds for muscular and/or neurological activity in animals Download PDF

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Publication number
WO2005098428A3
WO2005098428A3 PCT/US2005/011603 US2005011603W WO2005098428A3 WO 2005098428 A3 WO2005098428 A3 WO 2005098428A3 US 2005011603 W US2005011603 W US 2005011603W WO 2005098428 A3 WO2005098428 A3 WO 2005098428A3
Authority
WO
WIPO (PCT)
Prior art keywords
activity
agents
convulsive
muscular
animals
Prior art date
Application number
PCT/US2005/011603
Other languages
French (fr)
Other versions
WO2005098428A2 (en
Inventor
Vincent Pierebone
Randall Murphy
Original Assignee
Marinus Pharmaceuticals Inc
John B Pierce Lab
Vincent Pierebone
Randall Murphy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Marinus Pharmaceuticals Inc, John B Pierce Lab, Vincent Pierebone, Randall Murphy filed Critical Marinus Pharmaceuticals Inc
Publication of WO2005098428A2 publication Critical patent/WO2005098428A2/en
Publication of WO2005098428A3 publication Critical patent/WO2005098428A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates

Abstract

Screening methods and instrumentation for candidate pharmacological agents are applied to discover compounds with muscular and/or neurological activity. The method comprises the use of teleost fish, such as the medaka (Oryzias latipes), which may be stimulated with chemical agents or an electric field to produce, for example, seizure activity and/ or convulsive activity. The convulsive behavior may be recorded optically and electrically. Antagonism of the convulsive behavior is produced by application of candidate pharmacological agents to the well containing the fish. The method may include stimulation and antagonism in a plurality of sample wells with a repetitive or simultaneous application of threshold electric fields. The methods and instrumentation can be applied to the study of other serious neurological diseases such as neuropathic pain. In addition the process of assaying the protection of animals to convulsant agents the assay measures pharmacological safety parameters including sedation and cognitive impairment.
PCT/US2005/011603 2004-04-07 2005-04-07 Method and system for screening compounds for muscular and/or neurological activity in animals WO2005098428A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56038004P 2004-04-07 2004-04-07
US60/560,380 2004-04-07

Publications (2)

Publication Number Publication Date
WO2005098428A2 WO2005098428A2 (en) 2005-10-20
WO2005098428A3 true WO2005098428A3 (en) 2006-02-02

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/011603 WO2005098428A2 (en) 2004-04-07 2005-04-07 Method and system for screening compounds for muscular and/or neurological activity in animals

Country Status (2)

Country Link
US (1) US20060018833A1 (en)
WO (1) WO2005098428A2 (en)

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US20060018833A1 (en) 2006-01-26
WO2005098428A2 (en) 2005-10-20

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