WO2005095590A3 - Sperm suspensions for sorting into x or y chromosome-bearing enriched populations - Google Patents

Sperm suspensions for sorting into x or y chromosome-bearing enriched populations Download PDF

Info

Publication number
WO2005095590A3
WO2005095590A3 PCT/US2005/010481 US2005010481W WO2005095590A3 WO 2005095590 A3 WO2005095590 A3 WO 2005095590A3 US 2005010481 W US2005010481 W US 2005010481W WO 2005095590 A3 WO2005095590 A3 WO 2005095590A3
Authority
WO
WIPO (PCT)
Prior art keywords
sorting
sperm
chromosome
enriched populations
suspensions
Prior art date
Application number
PCT/US2005/010481
Other languages
French (fr)
Other versions
WO2005095590A2 (en
Inventor
Cindy L Ludwig
Kathleen S Crowley
Charles N Graves
Original Assignee
Monsanto Technology Llc
Cindy L Ludwig
Kathleen S Crowley
Charles N Graves
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Technology Llc, Cindy L Ludwig, Kathleen S Crowley, Charles N Graves filed Critical Monsanto Technology Llc
Priority to CA2561661A priority Critical patent/CA2561661C/en
Priority to BRPI0509488-7A priority patent/BRPI0509488A/en
Priority to AU2005228893A priority patent/AU2005228893B2/en
Priority to EP05731409A priority patent/EP1730266A2/en
Priority to CN2005800173705A priority patent/CN101014700B/en
Priority to NZ550196A priority patent/NZ550196A/en
Priority to MXPA06011344A priority patent/MXPA06011344A/en
Priority to JP2007506461A priority patent/JP2007531523A/en
Publication of WO2005095590A2 publication Critical patent/WO2005095590A2/en
Publication of WO2005095590A3 publication Critical patent/WO2005095590A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/52—Sperm; Prostate; Seminal fluid; Leydig cells of testes
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0608—Germ cells
    • C12N5/061—Sperm cells, spermatogonia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0608—Germ cells
    • C12N5/0611—Primordial germ cells, e.g. embryonic germ cells [EG]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis

Abstract

Sperm cell suspensions comprising a motility inhibitor are disclosed. The cells contained in such suspensions tend to have a greater capacity for enduring the various process steps typically associated with the sorting of sperm cells into gender enriched populations, thereby resulting in post-sort compositions with an increased number of viable or motile sperm. Processes for forming such cell suspensions, as well as processes for staining sperm cells, are also disclosed.
PCT/US2005/010481 2004-03-29 2005-03-29 Sperm suspensions for sorting into x or y chromosome-bearing enriched populations WO2005095590A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CA2561661A CA2561661C (en) 2004-03-29 2005-03-29 Sperm suspensions for sorting into x or y chromosome-bearing enriched populations
BRPI0509488-7A BRPI0509488A (en) 2004-03-29 2005-03-29 sperm suspensions for selection of enriched populations carrying x or y chromosome
AU2005228893A AU2005228893B2 (en) 2004-03-29 2005-03-29 Sperm suspensions for sorting into X or Y chromosome-bearing enriched populations
EP05731409A EP1730266A2 (en) 2004-03-29 2005-03-29 Sperm suspensions for sorting into x or y chromosome-bearing enriched populations
CN2005800173705A CN101014700B (en) 2004-03-29 2005-03-29 Sperm suspensions for sorting into x or y chromosome-bearing enriched populations
NZ550196A NZ550196A (en) 2004-03-29 2005-03-29 Method for sorting sperm cells into X or Y chromosome-bearing enriched populations comprising a composition which inhibits motility and a DNA-selective dye
MXPA06011344A MXPA06011344A (en) 2004-03-29 2005-03-29 Sperm suspensions for sorting into x or y chromosome-bearing enriched populations.
JP2007506461A JP2007531523A (en) 2004-03-29 2005-03-29 Sperm suspension for sorting into X or Y chromosome-bearing enriched populations

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US55740704P 2004-03-29 2004-03-29
US60/557,407 2004-03-29
US61417804P 2004-09-29 2004-09-29
US60/614,178 2004-09-29
US61844004P 2004-10-13 2004-10-13
US60/618,440 2004-10-13

Publications (2)

Publication Number Publication Date
WO2005095590A2 WO2005095590A2 (en) 2005-10-13
WO2005095590A3 true WO2005095590A3 (en) 2005-12-08

Family

ID=34964337

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2005/010481 WO2005095590A2 (en) 2004-03-29 2005-03-29 Sperm suspensions for sorting into x or y chromosome-bearing enriched populations
PCT/US2005/010599 WO2005094852A2 (en) 2004-03-29 2005-03-29 Sperm suspensions for use in insemination

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2005/010599 WO2005094852A2 (en) 2004-03-29 2005-03-29 Sperm suspensions for use in insemination

Country Status (16)

Country Link
US (2) US7892725B2 (en)
EP (5) EP1729789A2 (en)
JP (4) JP2007531523A (en)
CN (2) CN104974983A (en)
AR (2) AR048515A1 (en)
AU (2) AU2005228893B2 (en)
BR (2) BRPI0509488A (en)
CA (3) CA2972254A1 (en)
DK (2) DK2801363T3 (en)
ES (1) ES2397678T3 (en)
HK (2) HK1173745A1 (en)
MX (2) MXPA06011344A (en)
NZ (2) NZ550196A (en)
PL (1) PL2151243T3 (en)
PT (1) PT2151243E (en)
WO (2) WO2005095590A2 (en)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2279574C (en) 1997-01-31 2007-07-24 The Horticulture & Food Research Institute Of New Zealand Ltd. Optical apparatus
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
ES2296398T3 (en) 1998-07-30 2008-04-16 Xy, Inc. NON-SURGICAL ARTIFICIAL EQUINE INSEMINATION SYSTEM.
US7208265B1 (en) 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
EP2258169B1 (en) 2000-05-09 2019-07-10 Xy, Llc Method for isolating X-chromosome bearing and Y-chromosome bearing populations of spermatozoa
CA2468772C (en) 2000-11-29 2013-10-29 George E. Seidel System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
NZ538462A (en) 2002-08-01 2008-06-30 Xy Inc Low pressure sperm cell separation system
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
US7855078B2 (en) 2002-08-15 2010-12-21 Xy, Llc High resolution flow cytometer
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
EP2308416B1 (en) 2003-03-28 2015-01-07 Inguran, LLC Apparatus and methods for providing sex-sorted animal sperm
AU2004242121B2 (en) * 2003-05-15 2010-06-24 Xy, Llc. Efficient haploid cell sorting for flow cytometer systems
US7892725B2 (en) 2004-03-29 2011-02-22 Inguran, Llc Process for storing a sperm dispersion
AR049732A1 (en) 2004-07-22 2006-08-30 Monsanto Co PROCESS TO ENRICH A Sperm Cell Population
DE102005044530B4 (en) * 2004-09-16 2010-02-18 Masterrind Gmbh Method for the sex-specific selection of mammalian spermatozoa
US9433484B2 (en) * 2007-07-27 2016-09-06 Brad K. Stroud Artificial breeding techniques for bovines including semen diluents and AI apparatus
US8415094B2 (en) * 2007-12-21 2013-04-09 Jaffar Ali bin M. Abdullah Protein-free gamete and embryo handling and culture media products
CN101554152B (en) * 2009-05-21 2012-05-09 西北农林科技大学 Frozen semen diluent and preparation method thereof
NZ600737A (en) * 2009-11-24 2013-05-31 Biassex Pty Ltd Method for influencing sex selection in artificial insemination and apparatus for same
US11622844B2 (en) 2010-08-10 2023-04-11 Maximate, Llc Method, apparatus and kit for artificial insemination of bovine
USRE48283E1 (en) 2010-08-10 2020-10-27 Brad Stroud Method and apparatus to reduce the number of sperm used in artificial insemination of cattle
US10610343B2 (en) 2013-07-03 2020-04-07 Brad K. Stroud Method, apparatus and kit for artificial insemination of bovine
US9340762B2 (en) 2010-08-20 2016-05-17 Yu Sun Method for automated sperm manipulation and device for holding sperm and oocytes
NZ764002A (en) 2011-06-01 2022-12-23 Inguran Llc Compositions and methods for improving the quality of processed sperm
US9781919B2 (en) 2011-06-01 2017-10-10 Inguran, Llc Compositions and methods for improving the quality of processed sperm
WO2014153188A2 (en) 2013-03-14 2014-09-25 Life Technologies Corporation High efficiency, small volume nucleic acid synthesis
LT2768607T (en) 2011-09-26 2021-12-27 Thermo Fisher Scientific Geneart Gmbh Multiwell plate for high efficiency, small volume nucleic acid synthesis
EP2825635B1 (en) 2012-03-14 2020-04-15 Membrane Protective Technologies, Inc. System and substances for cryopreservation of viable cells
EP2834357B1 (en) 2012-04-04 2017-12-27 Life Technologies Corporation Tal-effector assembly platform, customized services, kits and assays
US9888990B2 (en) 2012-06-06 2018-02-13 Inguran, Llc Methods for use of sex sorted semen to improve genetic management in swine
US9433195B2 (en) 2012-06-06 2016-09-06 Inguran, Llc Methods for increasing genetic progress in a line or breed of swine using sex-selected sperm cells
WO2014032017A1 (en) 2012-08-23 2014-02-27 Carrell Douglas T Sperm separation devices and associated methods
TR201909835T4 (en) * 2012-10-05 2019-07-22 Inguran Llc Methods of treating sperm for sex selection.
US10620213B2 (en) 2012-10-05 2020-04-14 Inguran, Llc High pressure sperm sorting and flow cytometer methods
US20160017394A1 (en) 2014-07-15 2016-01-21 Life Technologies Corporation Compositions and methods for nucleic acid assembly
CA2965138A1 (en) * 2014-10-20 2016-04-28 University Of Utah Research Foundation Tissue sample processing system and associated methods
CA3210347A1 (en) 2014-11-20 2016-05-26 Inguran, Llc Low sugar sperm media and compositions
CN107532129B (en) 2014-12-09 2022-09-13 生命技术公司 Efficient small volume nucleic acid synthesis
WO2017007925A1 (en) 2015-07-07 2017-01-12 Thermo Fisher Scientific Geneart Gmbh Enzymatic synthesis of nucleic acid sequences
EP3763818A1 (en) 2015-10-06 2021-01-13 Pierce Biotechnology, Inc. Devices and methods for producing proteins
PT110231B (en) * 2017-08-02 2021-02-22 Universidade Do Porto MTOR POTENTIATORS AND THEIR USES TO IMPROVE THE QUALITY AND FUNCTION OF SPERM DURING STORAGE
EP3814494B1 (en) 2018-06-29 2023-11-01 Thermo Fisher Scientific GENEART GmbH High throughput assembly of nucleic acid molecules
US10470798B1 (en) 2018-11-30 2019-11-12 Ohana Biosciences, Inc. Methods for promoting fertilization
GB201905303D0 (en) 2019-04-15 2019-05-29 Thermo Fisher Scient Geneart Gmbh Multiplex assembly of nucleic acid molecules
US20240025939A1 (en) 2020-03-06 2024-01-25 Life Technologies Corporation High sequence fidelity nucleic acid synthesis and assembly
DE102021002257A1 (en) 2021-04-29 2022-11-03 Forschungsverbund Berlin E.V. Composition for preserving mammalian sperm and use of the composition

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3005756A (en) * 1958-11-14 1961-10-24 Noland L Van Demark Diluter containing carbon dioxide for preserving semen
US3791384A (en) * 1971-07-15 1974-02-12 Schaumann H Artificial insemination of sows
US4267268A (en) * 1979-03-12 1981-05-12 Nelson Jr Robert A Spermatozoa extenders
WO2001051612A1 (en) * 2000-01-14 2001-07-19 Istituto Sperimentale Italiano 'lazzaro Spallanzani' Process for the production of non-human embryos of high-genetic value and of predetermined sex
WO2002041906A2 (en) * 2000-11-22 2002-05-30 Pharmacia Corporation Methods and apparatus for producing gender enriched sperm
WO2004087177A1 (en) * 2003-03-28 2004-10-14 Monsanto Technology Llc Process for the staining of sperm

Family Cites Families (629)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3005759A (en) * 1959-04-24 1961-10-24 American Zinc Inst Zinc electroplating
US3299354A (en) 1962-07-05 1967-01-17 Coulter Electronics Aperture tube structure for particle study apparatus
US3499435A (en) 1967-06-02 1970-03-10 Paul E Rockwell Esophageal probe for use in monitoring
US3547526A (en) 1967-10-26 1970-12-15 Kollsman Instr Corp Optical beam cross-section converter
US3810010A (en) 1968-11-02 1974-05-07 Telefunken Patent Particle analysis method and apparatus wherein liquid containing particles is sucked into a constricted flow path
US3829216A (en) 1968-11-26 1974-08-13 M Persidsky Optical system and method for counting sperm cells
DE1815352C3 (en) 1968-12-18 1975-03-20 Wolfgang Prof. Dr. Dittrich Automatic measuring and counting device for the particles of a dispersion
US3894529A (en) 1969-04-10 1975-07-15 Bio Controls Inc Method and means for controlling the sex of mammalian offspring and product therefor
US4327177A (en) 1969-04-10 1982-04-27 Wallace Shrimpton Method and means for controlling the sex of mammalian offspring and product therefor
US4474875A (en) * 1969-04-10 1984-10-02 Wallace Shrimpton Method and means for controlling the sex of mammalian offspring and product therefor
DE1919628C3 (en) 1969-04-18 1975-04-10 Wolfgang Prof. Dr. Dittrich Arrangement for the automatic counting and / or classification of particles dispersed in a flowable medium
US3687806A (en) 1969-11-04 1972-08-29 Bio Controls Inc Method for controlling sex of mammalian offspring
US3788744A (en) 1970-01-14 1974-01-29 Bio Physics Systems Inc Method and apparatus for photoanalysis
US3661460A (en) 1970-08-28 1972-05-09 Technicon Instr Method and apparatus for optical analysis of the contents of a sheathed stream
US3816249A (en) 1970-11-23 1974-06-11 B Bhattacharya Universal medium and method for extending the useful life of semen in vitro
US3644128A (en) 1970-12-28 1972-02-22 Stuart Lipner Method of preparing comminuted meat products
US3756459A (en) 1971-01-12 1973-09-04 Damon Corp Method and apparatus for metering fluid utilizing pressure differentials
US3833796A (en) 1971-10-13 1974-09-03 Georgia Tech Res Inst Method and apparatus for chromosome digitizing
BE793185A (en) 1971-12-23 1973-04-16 Atomic Energy Commission APPARATUS FOR QUICKLY ANALYZING AND SORTING PARTICLES SUCH AS BIOLOGICAL CELLS
US3826364A (en) 1972-05-22 1974-07-30 Univ Leland Stanford Junior Particle sorting method and apparatus
US3761941A (en) 1972-10-13 1973-09-25 Mead Corp Phase control for a drop generating and charging system
CA1029833A (en) 1973-02-23 1978-04-18 Hildegarde Goehde Apparatus for the automatic counting and measuring of suspended particles
US3791517A (en) 1973-03-05 1974-02-12 Bio Physics Systems Inc Digital fluidic amplifier particle sorter
US4009260A (en) 1973-04-19 1977-02-22 Schering Aktiengesellschaft Fractionation of sperm
USRE29141E (en) 1973-06-14 1977-02-22 Coulter Electronics, Inc. Apparatus for orienting generally flat particles for sensing
US3893766A (en) 1973-06-14 1975-07-08 Coulter Electronics Apparatus for orienting generally flat particles for slit-scan photometry
US3947093A (en) 1973-06-28 1976-03-30 Canon Kabushiki Kaisha Optical device for producing a minute light beam
US3944917A (en) 1973-08-13 1976-03-16 Coulter Electronics, Inc. Electrical sensing circuitry for particle analyzing device
US3909744A (en) 1973-09-24 1975-09-30 United Technologies Corp Unstable resonator system producing a high irradiance beam in the far field
US3906929A (en) 1973-11-23 1975-09-23 Lynn Lawrence Augspurger Processes for reproduction of cellular bodies
FR2254639B1 (en) 1973-12-18 1978-06-02 Agronomique Inst Nat Rech
US4070617A (en) 1974-05-08 1978-01-24 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Device for controlling the particle flow in an apparatus for measuring the properties of particles suspended in liquid
US3973196A (en) 1974-05-24 1976-08-03 Coulter Electronics, Inc. Method and apparatus for ejecting a metered amount of particulate sample
US3963606A (en) 1974-06-03 1976-06-15 Coulter Electronics, Inc. Semi-automatic adjusting delay for an electronic particle separator
US3877430A (en) 1974-07-17 1975-04-15 Horst K Wieder Artificial insemination apparatus
US4083957A (en) 1974-07-26 1978-04-11 Lang John L Process for the alteration of the sex-ratio of mammals
US4006360A (en) 1974-08-21 1977-02-01 Block Engineering, Inc. Method of discriminating between dyed particles and background fluorescence of the dye
US3976197A (en) 1974-11-22 1976-08-24 Bhattacharya Bhairab C Thermal convection counter streaming sedimentation method and apparatus for controlling the sex of mammalian offspring
US4092229A (en) 1975-12-17 1978-05-30 Bhattacharya Bhairab C Thermal convection counter streaming sedimentation and forced convection galvanization method for controlling the sex of mammalian offspring
US4014611A (en) 1975-04-30 1977-03-29 Coulter Electronics, Inc. Aperture module for use in particle testing apparatus
DE2521236C3 (en) 1975-05-10 1978-12-14 Hildegard Dr. 4400 Muenster Goehde Geb. Kuhl Device for counting and measuring particles suspended in a liquid
US3960449A (en) 1975-06-05 1976-06-01 The Board Of Trustees Of Leland Stanford Junior University Measurement of angular dependence of scattered light in a flowing stream
US4058732A (en) 1975-06-30 1977-11-15 Analytical Radiation Corporation Method and apparatus for improved analytical fluorescent spectroscopy
US4007087A (en) 1975-10-17 1977-02-08 Gametrics Limited Sperm fractionation and storage
AU2154077A (en) 1976-01-27 1978-07-27 Univ Edinburgh Control of sex ratio in mammalian offspring
US4162282A (en) 1976-04-22 1979-07-24 Coulter Electronics, Inc. Method for producing uniform particles
US4302166A (en) 1976-04-22 1981-11-24 Coulter Electronics, Inc. Droplet forming apparatus for use in producing uniform particles
JPS5319891A (en) 1976-06-10 1978-02-23 Coulter Electronics Method and apparatus for folling drop formation and separation
GB1583150A (en) 1976-08-02 1981-01-21 Milk Marketing Board Apparatus for collecting eggs
US4110604A (en) 1976-11-04 1978-08-29 Becton, Dickinson And Company Particle density measuring system
DE2709399C3 (en) 1977-03-04 1980-07-24 Goehde, Wolfgang, Dr., 4400 Muenster Device for measuring cell properties
DE2716095A1 (en) 1977-04-12 1978-10-19 Zoeld Tibor Dr Phys GAS CONTROLLED PROCESS FOR SORTING PARTICLES SUSPENDED IN AN ELECTROLYTE AND DEVICE FOR CARRYING OUT THE PROCESS
US4448767A (en) 1977-10-11 1984-05-15 Sumar Corporation Preparation of monospecific male-specific antibody and the use thereof for increasing the percentage of mammalian offspring of either sex
US4191749A (en) 1977-10-11 1980-03-04 Bryant Bernard J Method and material for increasing the percentage of mammalian offspring of either sex
US4189236A (en) 1978-03-20 1980-02-19 Coulter Electronics, Inc. Ellipsoid-conic radiation collector and method
US4179218A (en) 1978-05-15 1979-12-18 The Boeing Company Particle size analyzer
US4251733A (en) * 1978-06-29 1981-02-17 Hirleman Jr Edwin D Technique for simultaneous particle size and velocity measurement
DE2832091A1 (en) 1978-07-21 1980-01-31 Eidenschink Henning OPTICAL METHOD FOR DETERMINING THE PARTICLE SIZE OF COLLOIDAL SOLUTIONS AND MEASURING DEVICE FOR IMPLEMENTING THE METHOD
US4276139A (en) 1978-08-16 1981-06-30 Lawson Rommon L Process for magnetic separation and collection of viable female and male spermatozoa
US4225405A (en) 1978-08-16 1980-09-30 Lawson Rommom L Process for separation and collection of viable female and male spermatozoa
US4230558A (en) 1978-10-02 1980-10-28 Coulter Electronics, Inc. Single drop separator
US4341471A (en) 1979-01-02 1982-07-27 Coulter Electronics, Inc. Apparatus and method for measuring the distribution of radiant energy produced in particle investigating systems
US4274408A (en) 1979-03-26 1981-06-23 Beatrice Nimrod Method for guide-wire placement and novel syringe therefor
US4200802A (en) 1979-03-28 1980-04-29 The United States Of America As Represented By The United States Department Of Energy Parabolic cell analyzer
US4408877A (en) 1979-04-10 1983-10-11 Ernst Leitz Wetzlar Gmbh Device for hydrodynamic focussing of a particle-suspension in a liquid flow cytophotometer
NO144002C (en) 1979-04-10 1981-05-27 Norsk Hydro S Inst For Kreftfo DEVICE FOR USE IN LIQUID PHOTOMETRY
US4255021A (en) 1979-04-20 1981-03-10 The United States Of America As Represented By The United States Department Of Energy Optical device with conical input and output prism faces
US4263508A (en) 1979-04-20 1981-04-21 Research Corporation Pulse edge measurement for determining particle dimensional characteristics
US4318481A (en) 1979-08-20 1982-03-09 Ortho Diagnostics, Inc. Method for automatically setting the correct phase of the charge pulses in an electrostatic flow sorter
US4317520A (en) 1979-08-20 1982-03-02 Ortho Diagnostics, Inc. Servo system to control the spatial position of droplet formation of a fluid jet in a cell sorting apparatus
US4325483A (en) 1979-08-20 1982-04-20 Ortho Diagnostics, Inc. Method for detecting and controlling flow rates of the droplet forming stream of an electrostatic particle sorting apparatus
US4318480A (en) 1979-08-20 1982-03-09 Ortho Diagnostics, Inc. Method and apparatus for positioning the point of droplet formation in the jetting fluid of an electrostatic sorting device
US4318482A (en) 1979-08-20 1982-03-09 Ortho Diagnostics, Inc. Method for measuring the velocity of a perturbed jetting fluid in an electrostatic particle sorting system
DE2943116C2 (en) 1979-10-25 1986-06-19 Gesellschaft für Strahlen- und Umweltforschung mbH, 8000 München Device for flow cytometric reaction and / or diffusion measurement
US4284355A (en) 1979-10-29 1981-08-18 Ortho Diagnostics, Inc. Automated method for cell volume determination
US4400764A (en) 1980-02-05 1983-08-23 The Boeing Company Low backscatter illumination system
US4367043A (en) 1980-05-05 1983-01-04 Leland Stanford Junior University Method and means for delivering liquid samples to a sample scanning device
US4362246A (en) 1980-07-14 1982-12-07 Adair Edwin Lloyd Method of treating collected mammal semen and separating sperm into X Y components
US4348107A (en) 1980-07-18 1982-09-07 Coulter Electronics, Inc. Orifice inside optical element
EP0046345A3 (en) 1980-08-15 1982-03-03 Ortho Diagnostic Systems Inc. Controlled hydrodynamic flow in flow cytometry systems
US4350410A (en) 1980-10-08 1982-09-21 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Multiprism collimator
US4691829A (en) 1980-11-03 1987-09-08 Coulter Corporation Method of and apparatus for detecting change in the breakoff point in a droplet generation system
US4487320A (en) 1980-11-03 1984-12-11 Coulter Corporation Method of and apparatus for detecting change in the breakoff point in a droplet generation system
US4395676A (en) 1980-11-24 1983-07-26 Coulter Electronics, Inc. Focused aperture module
US4361400A (en) 1980-11-26 1982-11-30 The United States Of America As Represented By The United States Department Of Energy Fluidic assembly for an ultra-high-speed chromosome flow sorter
US4680258A (en) 1981-03-24 1987-07-14 Sloan-Kettering Institute For Cancer Research Process for sex determination in man by use of monoclonal antibodies to the H-Y antigen
US4818103A (en) 1981-05-15 1989-04-04 Ratcom Flow cytometry
US4673288A (en) 1981-05-15 1987-06-16 Ratcom, Inc. Flow cytometry
EP0068404B1 (en) 1981-06-24 1985-10-02 Becton Dickinson and Company Analyzer for simultaneously determining volume and light emission characteristics of particles
US4339434A (en) 1981-08-17 1982-07-13 Gametrics Limited Method of increasing the incidence of female offspring
US4395397A (en) 1981-09-17 1983-07-26 Sidney Farber Cancer Institute, Inc. Apparatus and method for killing unwanted cells
US4422761A (en) 1981-09-28 1983-12-27 Frommer Joseph C Photo-electric particle sensing system
US4515274A (en) 1981-12-02 1985-05-07 Coulter Corporation Particle analyzing and sorting apparatus
JPS59500340A (en) 1982-03-08 1984-03-01 モトロ−ラ・インコ−ポレ−テツド integrated circuit lead frame
US4511661A (en) 1982-03-19 1985-04-16 University Patents, Inc. ATCC HB8116 And its monoclonal anti-H-Y antibody, Hyclonalan
US4498766A (en) 1982-03-25 1985-02-12 Becton, Dickinson And Company Light beam focal spot elongation in flow cytometry devices
DE3315194A1 (en) 1982-04-29 1983-11-03 International Remote Imaging Systems Inc., 91311 Chatsworth, Calif. METHOD FOR SEPARATING PARTICLES FLOWING IN A FLUID SAMPLE
DE3315195A1 (en) 1982-04-29 1983-11-03 International Remote Imaging Systems Inc., 91311 Chatsworth, Calif. METHOD FOR ALIGNING PARTICLES IN A FLUID SAMPLE
US4629687A (en) 1982-07-29 1986-12-16 Board Of Trustees Of Michigan State University Positive selection sorting of cells
GB2125181B (en) 1982-08-11 1986-01-29 Coulter Electronics Flow cells for particle study
US4559309A (en) 1982-09-01 1985-12-17 Memorial Sloan Kettering Cancer Center Flow cytometry-fluorescence measurements for characterizing sperm
EP0120854A4 (en) 1982-10-05 1985-06-10 Genetic Engineering Inc Method of treating collected mammal semen and separating sperm into x and y components.
US4501366A (en) 1982-12-14 1985-02-26 Adolph Coors Company Photomultiplier tube assembly
DE3372137D1 (en) 1982-12-21 1987-07-23 Crosfield Electronics Ltd Light beam-splitter
US4492436A (en) 1983-01-03 1985-01-08 At&T Bell Laboratories Polarization independent beam splitter
JPS59143146A (en) 1983-02-07 1984-08-16 Nippon Kogaku Kk <Nikon> Mirror condenser type illuminating optical system
CA1206559A (en) 1983-03-04 1986-06-24 Robert E. Auer Method of and apparatus for detecting change in the breakoff point of a droplet generation system
IT1197570B (en) 1983-02-11 1988-12-06 Serono Ist Farm MIXTURES OF FSH AND LH FROM PORCINE HYPOPHYSIS IN DEFINED RATIO
CH651930A5 (en) 1983-03-24 1985-10-15 Coulter Corp Apparatus for analysis and sorting of particles
JPS59174742A (en) 1983-03-25 1984-10-03 Agency Of Ind Science & Technol Method and apparatus for dividing and sorting fine particle
GB2145112B (en) 1983-04-27 1987-02-18 Milk Marketing Board Sorting living spermatozoa
US4523809A (en) 1983-08-04 1985-06-18 The United States Of America As Represented By The Secretary Of The Air Force Method and apparatus for generating a structured light beam array
NZ207393A (en) 1983-08-05 1987-03-31 Neal Lloyd First Staining dna in living cells
US4538733A (en) 1983-10-14 1985-09-03 Becton, Dickinson And Company Particle sorter with neutralized collection wells and method of using same
US4780406A (en) 1983-10-18 1988-10-25 The Regents Of The University Of California Flow cytometric measurement of total DNA and incorporated halodeoxyuridine
US4585736A (en) 1983-10-18 1986-04-29 The United States Of America As Represented By The United States Department Of Energy Flow cytometric measurement of total DNA and incorporated halodeoxyuridine
US4735504A (en) 1983-10-31 1988-04-05 Technicon Instruments Corporation Method and apparatus for determining the volume & index of refraction of particles
CA1228748A (en) 1983-12-24 1987-11-03 Hans Oetliker Method and apparatus for guiding and collecting light in photometry or the like
US4573796A (en) 1984-01-06 1986-03-04 The United States Of America As Represented By The United States Department Of Energy Apparatus for eliminating background interference in fluorescence measurements
US4631483A (en) 1984-02-01 1986-12-23 Coulter Electronics, Inc. Particle analyzing apparatus and method of moving particles in suspension through such apparatus
US4714680B1 (en) 1984-02-06 1995-06-27 Univ Johns Hopkins Human stem cells
US4965204A (en) 1984-02-06 1990-10-23 The Johns Hopkins University Human stem cells and monoclonal antibodies
EP0172242A1 (en) 1984-02-29 1986-02-26 Research Corporation Flow cytometers
US4545677A (en) 1984-03-05 1985-10-08 Becton, Dickinson And Company Prismatic beam expander for light beam shaping in a flow cytometry apparatus
US4600302A (en) 1984-03-26 1986-07-15 Becton, Dickinson And Company Flow cytometry apparatus with uniform incoherent light excitation
DE3412620A1 (en) 1984-04-04 1985-10-17 Basf Ag, 6700 Ludwigshafen LASER OPTICAL ARRANGEMENT FOR MEASURING THE DEGREE OF DISPERSION IN FLOWING SYSTEMS
US4609286A (en) 1984-04-16 1986-09-02 Becton, Dickinson And Company Dispersion prism for separation of wavelengths of spectrally rich light in a flow cytometry apparatus
US4605558A (en) 1984-04-20 1986-08-12 Wallace Shrimpton Process for cell separation
US4660971A (en) 1984-05-03 1987-04-28 Becton, Dickinson And Company Optical features of flow cytometry apparatus
FR2563726B1 (en) 1984-05-04 1986-10-10 Robert Cassou ARTIFICIAL INSEMINATION APPARATUS, PARTICULARLY CARNIVORES
FR2566543B1 (en) 1984-06-20 1988-02-26 Commissariat Energie Atomique HIGH COLLECTION AND CYTOFLUORIMETER OPTICAL DEVICE USING THE SAME
EP0171676B1 (en) 1984-07-31 1990-11-07 Hitachi, Ltd. Free-flow electrophoretic separation method and apparatus therefor
US4661913A (en) 1984-09-11 1987-04-28 Becton, Dickinson And Company Apparatus and method for the detection and classification of articles using flow cytometry techniques
ATE48477T1 (en) 1984-09-11 1989-12-15 Partec Ag METHOD AND DEVICE FOR SORTING MICROSCOPIC PARTICLES.
US4598408A (en) 1984-10-22 1986-07-01 Trw Inc. High extraction efficiency cylindrical ring resonator
JPS61139747A (en) 1984-12-12 1986-06-27 Canon Inc Particle analyser
JPS61159135A (en) 1984-12-31 1986-07-18 Canon Inc Particle analyzing device
US4702598A (en) 1985-02-25 1987-10-27 Research Corporation Flow cytometer
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
CA1250808A (en) 1985-04-29 1989-03-07 David W. Dresser Semen sexing
US4662742A (en) 1985-05-10 1987-05-05 Becton, Dickinson And Company Scatter/fluorescene beam splitter in a flow cytometry apparatus
USRE34782E (en) 1985-07-01 1994-11-08 Diatron Corporation Fluorometer
US4877965A (en) 1985-07-01 1989-10-31 Diatron Corporation Fluorometer
US4744090A (en) 1985-07-08 1988-05-10 Trw Inc. High-extraction efficiency annular resonator
NO156916C (en) 1985-07-10 1987-12-16 Harald B Steen FLOW CLEANING FOR FLUID FLOW PHOTOMETER.
NO156917C (en) 1985-07-16 1987-12-16 Harald B Steen DEVICE FOR MEASUREMENT OF BIOLOGICAL CELLS LIGHT DISTRIBUTION IN LIQUID CURRENT PHOTOMETERS.
US4989977A (en) 1985-07-29 1991-02-05 Becton, Dickinson And Company Flow cytometry apparatus with improved light beam adjustment
US4794086A (en) 1985-11-25 1988-12-27 Liquid Air Corporation Method for measurement of impurities in liquids
US4770992A (en) 1985-11-27 1988-09-13 Den Engh Gerrit J Van Detection of specific DNA sequences by flow cytometry
US4999283A (en) 1986-01-10 1991-03-12 University Of Kentucky Research Foundation Method for x and y spermatozoa separation
US5447841A (en) 1986-01-16 1995-09-05 The Regents Of The Univ. Of California Methods for chromosome-specific staining
US5756696A (en) 1986-01-16 1998-05-26 Regents Of The University Of California Compositions for chromosome-specific staining
US4710635A (en) 1986-04-14 1987-12-01 Becton, Dickinson And Company Dual laser excitation from single laser source
NL8601000A (en) 1986-04-21 1987-11-16 Jan Greve T H Twente Afdeling THE USE OF POLARIZED LIGHT IN FLOW CYTOMETRY.
JPS62274238A (en) 1986-05-22 1987-11-28 ベクトン・デイツキンソン・アンド・カンパニ− Gel for optical bonding used for flow sight metry device
US4790653A (en) 1986-05-22 1988-12-13 Becton Dickinson And Company Housing for a flow cytometry apparatus with particle unclogging feature
US4786165A (en) 1986-07-10 1988-11-22 Toa Medical Electronics Co., Ltd. Flow cytometry and apparatus therefor
US4867908A (en) 1986-08-29 1989-09-19 Becton, Dickinson And Company Method and materials for calibrating flow cytometers and other analysis instruments
US4704891A (en) 1986-08-29 1987-11-10 Becton, Dickinson And Company Method and materials for calibrating flow cytometers and other analysis instruments
FR2609885B1 (en) 1987-01-22 1989-04-14 Cassou Robert INSTRUMENT FOR ARTIFICIAL INSEMINATION, TRANSFER OF EMBRYOS OR COLLECTION OF FOLLICULAR LIQUIDS FROM MAMMALS
US4780451B1 (en) 1987-01-23 1995-04-04 Asua International Inc Composition and method for producing superovulation in cattle
US5162306A (en) 1987-01-23 1992-11-10 Donaldson Lloyd E Composition and method for producing superovulation in mammals
ATE91789T1 (en) 1987-02-17 1993-08-15 Ratcom Inc FLOW CYTOMETRY.
US4764013A (en) 1987-03-23 1988-08-16 The United States Of America As Represented By The United States Department Of Energy Interferometric apparatus and method for detection and characterization of particles using light scattered therefrom
US4765737A (en) 1987-03-30 1988-08-23 Cornell Research Foundation Cell size measurements using light in flow cytometry and cell sorting
US5021244A (en) 1988-12-06 1991-06-04 Cytogam, Inc. Sex-associated membrane antibodies and their use for increasing the probability that offspring will be of a desired sex
US5346990A (en) 1987-04-08 1994-09-13 Cytogam, Inc. Sex-associated membrane proteins and methods for increasing the probability that offspring will be of a desired sex
US4983038A (en) 1987-04-08 1991-01-08 Hitachi, Ltd. Sheath flow type flow-cell device
JPS63262565A (en) 1987-04-20 1988-10-28 Hitachi Ltd Flow cell
EP0289677A3 (en) 1987-04-27 1989-05-10 Fritz K. Preikschat Apparatus and method for particle analysis
ATE110467T1 (en) 1987-04-27 1994-09-15 Preikschat F K DEVICE AND METHOD FOR THE STUDY OF PARTICLES.
FR2614626B1 (en) 1987-04-30 1989-07-21 Ranoux Claude CONTAINER FOR FERTILIZATION OF OVOCYTES AND REPLACEMENT OF EMBRYOS IN HUMANS AND ANIMALS
JP2642632B2 (en) 1987-07-03 1997-08-20 株式会社日立製作所 Particle measuring device and particle measuring method
GB8716285D0 (en) 1987-07-10 1987-08-19 Medical Res Council Light collecting device
US4979093A (en) 1987-07-16 1990-12-18 Cavro Scientific Instruments XYZ positioner
US4987539A (en) 1987-08-05 1991-01-22 Stanford University Apparatus and method for multidimensional characterization of objects in real time
US4796788A (en) 1987-08-26 1989-01-10 Liqui-Box Corporation Bag-in-box packaging and dispensing of substances which will not readily flow by gravity
US4758729A (en) 1987-08-28 1988-07-19 Spectra-Physics, Inc. Apparatus and method for measuring the included angle of a reflective cone
DE3832901A1 (en) 1987-10-02 1989-04-20 Hitachi Ltd PARTICLE MEASURING DEVICE
US4793705A (en) 1987-10-07 1988-12-27 The United States Of America As Represented By The United States Department Of Energy Single molecule tracking
US4831385A (en) 1987-10-14 1989-05-16 Burlington Industries, Inc. Vacuum tray fluid-jet start-up system
US4980277A (en) 1987-10-16 1990-12-25 Cultor Ltd. Cryoprotectant solution and method
US5712807A (en) 1987-10-21 1998-01-27 Bangham; James Andrew Pulse analyzing method and apparatus
US5789155A (en) 1987-10-30 1998-08-04 California Institute Of Technology Process for identifying nucleic acids and triple helices formed thereby
US4845025A (en) 1987-11-10 1989-07-04 Coulter Corporation Biological sample mixing apparatus and method
GB8726304D0 (en) 1987-11-10 1987-12-16 Secr Defence Particle asymmetry analyser
EP0316173A1 (en) 1987-11-10 1989-05-17 The Secretary of State for Defence in Her Britannic Majesty's Government of the United Kingdom of Great Britain and Particle monitoring system
GB8726305D0 (en) 1987-11-10 1987-12-16 Secr Defence Portable particle analysers
US5040890A (en) 1987-11-25 1991-08-20 Becton, Dickinson And Company Sheathed particle flow controlled by differential pressure
US4887721A (en) 1987-11-30 1989-12-19 The United States Of America As Represented By The United States Department Of Energy Laser particle sorter
US4988619A (en) 1987-11-30 1991-01-29 United States Department Of Energy Flow cytometry apparatus
US4936465A (en) 1987-12-07 1990-06-26 Zoeld Tibor Method and apparatus for fast, reliable, and environmentally safe dispensing of fluids, gases and individual particles of a suspension through pressure control at well defined parts of a closed flow-through system
US5219729A (en) 1988-02-25 1993-06-15 Serono Laboratories, Inc. Fertility assay
US5622820A (en) 1988-03-10 1997-04-22 City Of Hope Method for amplification and detection of RNA and DNA sequences
US4836038A (en) 1988-03-18 1989-06-06 Aim Instruments Ltd. Automated sampler-injector apparatus and method for sampling a quantity of sample and testing portions of said quantity
US5057413A (en) 1988-06-13 1991-10-15 Becton, Dickinson And Company Method for discriminating between intact and damaged cells in a sample
US5070080A (en) 1988-08-10 1991-12-03 Fahim Mostafa S Method of inhibiting generation, maturation, motility and viability of sperm with minerals in bioavailable form
JPH0718785B2 (en) 1988-09-19 1995-03-06 株式会社日立製作所 Flow cell device
JP2635125B2 (en) 1988-09-30 1997-07-30 東亜医用電子株式会社 Particle analysis apparatus and method for determining nuclear leaf index
JP2635126B2 (en) 1988-09-30 1997-07-30 東亜医用電子株式会社 Particle analysis apparatus and method for determining nuclear leaf index
JPH02168160A (en) 1988-12-22 1990-06-28 Omron Tateisi Electron Co Cell selecting apparatus
US5726009A (en) 1989-03-20 1998-03-10 Anticancer, Inc. Native-state method and system for determining viability and proliferative capacity of tissues in vitro
JPH02289808A (en) 1989-04-28 1990-11-29 Olympus Optical Co Ltd Lighting optical system
US4981580A (en) 1989-05-01 1991-01-01 Coulter Corporation Coincidence arbitration in a flow cytomery sorting system
AU623016B2 (en) * 1989-05-10 1992-04-30 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Method to preselect the sex of offspring
EP0475936B1 (en) 1989-05-12 1995-09-13 Cytogam, Inc. Sex-associated membrane proteins and methods for increasing the probability that offspring will be of a desired sex
US4942305A (en) 1989-05-12 1990-07-17 Pacific Scientific Company Integrating sphere aerosol particle detector
US5055393A (en) 1989-06-13 1991-10-08 Salk Institute Biotechnology/Industrial Associates, Inc. Prenatal sex determination of bovine cells using male-specific oligonucleotides
US4954715A (en) 1989-06-26 1990-09-04 Zoeld Tibor Method and apparatus for an optimized multiparameter flow-through particle and cell analyzer
JPH0353164A (en) 1989-07-20 1991-03-07 Canon Inc Sample supply device and sample measuring instrument using the same
US5098657A (en) 1989-08-07 1992-03-24 Tsi Incorporated Apparatus for measuring impurity concentrations in a liquid
US5030002A (en) 1989-08-11 1991-07-09 Becton, Dickinson And Company Method and apparatus for sorting particles with a moving catcher tube
US5005981A (en) 1989-09-08 1991-04-09 Becton, Dickinson And Company Apparatus for method for causing vortices in a test tube
US5215376A (en) 1989-09-08 1993-06-01 Becton, Dickinson And Company Method for causing vortices in a test tube
EP0418026B1 (en) 1989-09-13 1994-11-30 Kabushiki Kaisha Tiyoda Seisakusho Apparatus for pretreating cells for flow cytometry
JP2808321B2 (en) 1989-09-19 1998-10-08 東亜医用電子株式会社 Cell analysis method and device
US5072382A (en) 1989-10-02 1991-12-10 Kamentsky Louis A Methods and apparatus for measuring multiple optical properties of biological specimens
US5275787A (en) 1989-10-04 1994-01-04 Canon Kabushiki Kaisha Apparatus for separating or measuring particles to be examined in a sample fluid
DE69025256T2 (en) 1989-10-11 1996-06-27 Canon Kk Apparatus and method for separating particles from liquid suspended particles in connection with their properties
JPH03140840A (en) 1989-10-26 1991-06-14 Hitachi Ltd Flow cytoanalyser
FR2653885B1 (en) 1989-10-27 1994-01-14 Abx APPARATUS FOR COUNTING AND DETERMINING AT LEAST ONE LEUKOCYTAIC SUB-POPULATION.
US5034613A (en) 1989-11-14 1991-07-23 Cornell Research Foundation, Inc. Two-photon laser microscopy
US5101978A (en) 1989-11-27 1992-04-07 The United States Of America As Represented By The Secretary Of The Army Fluidic sorting device for two or more materials suspended in a fluid
AU647741B2 (en) 1989-12-01 1994-03-31 Regents Of The University Of California, The Methods and compositions for chromosome-specific staining
US5274240A (en) 1990-01-12 1993-12-28 The Regents Of The University Of California Capillary array confocal fluorescence scanner and method
DE69118429T2 (en) 1990-01-26 1996-09-12 Canon Kk Method of measuring a species using fluorescent light
JP3049254B2 (en) 1990-02-08 2000-06-05 シスメックス株式会社 Optical particle analyzer with two types of light sources
IL93634A0 (en) 1990-03-05 1990-12-23 Galai Lab Ltd Particle size analyzer
US5153117A (en) 1990-03-27 1992-10-06 Genetype A.G. Fetal cell recovery method
US5492534A (en) 1990-04-02 1996-02-20 Pharmetrix Corporation Controlled release portable pump
US5150313A (en) 1990-04-12 1992-09-22 Regents Of The University Of California Parallel pulse processing and data acquisition for high speed, low error flow cytometry
US5076472A (en) 1990-06-13 1991-12-31 Becton, Dickinson And Company Cleaning cycle for flow cytometers
US5087295A (en) 1990-06-13 1992-02-11 Becton Dickinson And Company Cleaning cycle for flow cytometers
JPH0716392B2 (en) 1990-06-20 1995-03-01 株式会社ピーシーシーテクノロジー Cell fusion and fused cell sorting system
JPH0710226B2 (en) 1990-06-20 1995-02-08 株式会社ピーシーシーテクノロジー Protoplast stirring device, cell fusion device and flow cytometer device including the same
US5160974A (en) 1990-06-25 1992-11-03 Flow Science, Inc. Closed sample cell for use in flow cytometry
JPH04126065A (en) 1990-06-25 1992-04-27 Saburo Okonogi Device for molding food raw material into bar-like shape
US5559032A (en) 1990-06-29 1996-09-24 Pomeroy; Patrick C. Method and apparatus for post-transfer assaying of material on solid support
US5366888A (en) 1990-07-09 1994-11-22 Amrad Corporation Limited Enhanced maintenance of pregnancy using leukaemia inhibitory factor in embryo culturing
JP2939647B2 (en) 1990-07-24 1999-08-25 シスメックス株式会社 Automatic focus adjustment method for flow imaging cytometer
IE76732B1 (en) 1990-08-07 1997-11-05 Becton Dickinson Co One step test for absolute counts
US5259593A (en) 1990-08-30 1993-11-09 University Of Southern California Apparatus for droplet stream manufacturing
JPH04115136A (en) 1990-09-05 1992-04-16 Hitachi Ltd Particle measuring apparatus
US5132548A (en) 1990-09-14 1992-07-21 High Yield Technology High sensitivity, large detection area particle sensor for vacuum applications
JPH04126080A (en) 1990-09-14 1992-04-27 Juzo Udaka Production of heat-resistant xylose isomerase
JP2957246B2 (en) 1990-09-14 1999-10-04 大和化成株式会社 Microbial carboxypeptidase B-like enzyme
JPH04126064A (en) 1990-09-14 1992-04-27 Nitto Shokai:Kk Method for preparing doubly covered bean jam food
US5204884A (en) 1991-03-18 1993-04-20 University Of Rochester System for high-speed measurement and sorting of particles
US5273527A (en) 1992-05-12 1993-12-28 Ovamed Corporation Delivery catheter
US5663048A (en) 1990-10-04 1997-09-02 University Of Calgary Y-chromosome specific polynucleotide probes for prenatal sexing
US5840482A (en) 1990-10-10 1998-11-24 The Regents Of The University Of California Y chromosome specific nucleic acid probe and method for determining the Y chromosome in situ
WO1992008120A1 (en) 1990-10-29 1992-05-14 Macquarie University Pulsed laser flow cytometry
US5116125A (en) 1990-10-31 1992-05-26 Biophos Medical Ab Fertility analyzer
WO1992008122A1 (en) 1990-10-31 1992-05-14 Biophos Medical Ab Fertility analyzer
JP2874746B2 (en) 1990-11-22 1999-03-24 シスメックス株式会社 Flow cell mechanism in flow imaging cytometer
US5991028A (en) 1991-02-22 1999-11-23 Applied Spectral Imaging Ltd. Spectral bio-imaging methods for cell classification
JPH0734012B2 (en) 1991-02-27 1995-04-12 東亜医用電子株式会社 Flow image cytometer
JP3121849B2 (en) 1991-02-27 2001-01-09 シスメックス株式会社 Flow image cytometer
US5144224A (en) 1991-04-01 1992-09-01 Larsen Lawrence E Millimeter wave flow cytometer
US5199576A (en) 1991-04-05 1993-04-06 University Of Rochester System for flexibly sorting particles
EP0515211A3 (en) 1991-05-23 1993-04-07 Becton Dickinson And Company Apparatus and method for phase resolved fluorescence lifetimes of independent and varying amplitude pulses
DE9107792U1 (en) 1991-06-25 1991-09-12 Labotect-Labor-Technik, Goettingen, Gmbh, 3406 Bovenden, De
FR2678506B1 (en) 1991-07-01 2000-03-10 Claude Ranoux SPONTANEOUS FERTILIZATION PROCESS.
US5548661A (en) 1991-07-12 1996-08-20 Price; Jeffrey H. Operator independent image cytometer
US5412466A (en) 1991-07-26 1995-05-02 Toa Medical Electronics Co., Ltd. Apparatus for forming flattened sample flow for analyzing particles
EP0529666B1 (en) 1991-08-30 2000-04-12 Omron Corporation Cell analyzing apparatus
US5488469A (en) 1991-08-30 1996-01-30 Omron Corporation Cell analyzing apparatus
US5548395A (en) 1991-09-20 1996-08-20 Toa Medical Electronics Co., Ltd. Particle analyzer
US5578449A (en) 1991-10-03 1996-11-26 Hilding Ohlsson, S.A. Procedure for the sex determination of embryos in mammals especially applied to bovine embryos
JP3212647B2 (en) 1991-10-24 2001-09-25 シスメックス株式会社 Imaging flow cytometer
US5919621A (en) 1991-10-24 1999-07-06 Brown; David B. Methods for diagnosing human male infertility
IT1253226B (en) 1991-10-24 1995-07-11 Piero Serra CATHETER FOR THE INTRODUCTION OR ASPIRATION OF LIQUIDS OF DIFFERENT NATURES IN ANIMALS PARTICULARLY FOR GYNECOLOGICAL TREATMENTS IN CATTLE, EQUINE AND SIMILAR
US5866344A (en) 1991-11-15 1999-02-02 Board Of Regents, The University Of Texas System Antibody selection methods using cell surface expressed libraries
US5370842A (en) 1991-11-29 1994-12-06 Canon Kabushiki Kaisha Sample measuring device and sample measuring system
JP2593021B2 (en) 1991-12-13 1997-03-19 伊藤ハム株式会社 How to identify bovine embryo sex
JP3130628B2 (en) 1992-01-30 2001-01-31 シスメックス株式会社 Particle determination device
US5400179A (en) 1992-02-18 1995-03-21 Asahi Kogaku Kogyo Kabushiki Kaisha Optical multilayer thin film and beam splitter
DE69321748T2 (en) 1992-02-20 1999-06-17 Canon Kk Method and measuring apparatus for handling particles
GB2278679B (en) 1992-02-21 1995-09-06 Secr Defence Analysis of particle characteristics
US5558998A (en) 1992-02-25 1996-09-24 The Regents Of The Univ. Of California DNA fragment sizing and sorting by laser-induced fluorescence
US6120735A (en) 1992-02-26 2000-09-19 The Ohio States University Fractional cell sorter
JPH084601B2 (en) * 1992-04-10 1996-01-24 岡山県 Sperm freezing method and sperm freezing device
US5298967A (en) 1992-06-02 1994-03-29 Pacific Scientific Company Measurement of concentrations of dissolved solvent
JP3145486B2 (en) 1992-06-12 2001-03-12 シスメックス株式会社 Imaging flow cytometer
GB2284909B (en) 1992-07-13 1996-11-13 Pall Corp Automated system and method for processing biological fluid
JP3215175B2 (en) 1992-08-10 2001-10-02 シスメックス株式会社 Particle analyzer
US5315122A (en) 1992-08-25 1994-05-24 Becton, Dickinson And Company Apparatus and method for fluorescent lifetime measurement
PT662124E (en) 1992-09-03 2002-10-31 Univ California HIGH-SPEED CITOMETRIC FLUX SEPARATION OF MAMIFERO VIABLE CELLS
US5466572A (en) 1992-09-03 1995-11-14 Systemix, Inc. High speed flow cytometric separation of viable cells
US5736410A (en) 1992-09-14 1998-04-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US5275933A (en) 1992-09-25 1994-01-04 The Board Of Trustees Of The Leland Stanford Junior University Triple gradient process for recovering nucleated fetal cells from maternal blood
US5371585A (en) 1992-11-10 1994-12-06 Pacific Scientific Company Particle detecting instrument with sapphire detecting cell defining a rectangular flow path
US5359907A (en) 1992-11-12 1994-11-01 Horiba Instruments, Inc. Method and apparatus for dry particle analysis
US5395588A (en) 1992-12-14 1995-03-07 Becton Dickinson And Company Control of flow cytometer having vacuum fluidics
GB2290668B (en) 1993-01-16 1997-07-23 James Andrew Bangham Signal processing system
JP2525713B2 (en) 1993-01-19 1996-08-21 農林水産省畜産試験場長 Culture and transport method of bovine embryo using low molecular weight thiol compound
US5467189A (en) 1993-01-22 1995-11-14 Venturedyne, Ltd. Improved particle sensor and method for assaying a particle
JP3052665B2 (en) 1993-01-26 2000-06-19 株式会社日立製作所 Flow cell device
CA2113957A1 (en) 1993-01-29 1994-07-30 University Of Guelph Nucleotide sequences for bovine sex determination
EP0682671A4 (en) 1993-02-01 1998-01-14 Seq Ltd Methods and apparatus for dna sequencing.
US5453575A (en) 1993-02-01 1995-09-26 Endosonics Corporation Apparatus and method for detecting blood flow in intravascular ultrasonic imaging
US5367474A (en) 1993-02-08 1994-11-22 Coulter Corporation Flow cytometer
US5547849A (en) 1993-02-17 1996-08-20 Biometric Imaging, Inc. Apparatus and method for volumetric capillary cytometry
US5556764A (en) 1993-02-17 1996-09-17 Biometric Imaging, Inc. Method and apparatus for cell counting and cell classification
US5563059A (en) 1993-02-23 1996-10-08 Genentech, Inc. Use of human inhibin and human activin to increase the number of mature primate oocytes
EP0648348B1 (en) 1993-03-01 1999-04-28 General Signal Corporation Variable annular illuminator for photolithographic projection imager.
NO930980L (en) 1993-03-18 1994-09-19 Flowtech As Optical configuration for fluid flow cytophotometer
US5658751A (en) 1993-04-13 1997-08-19 Molecular Probes, Inc. Substituted unsymmetrical cyanine dyes with selected permeability
US5494795A (en) 1993-05-05 1996-02-27 The United States Of America As Represented By The Secretary Of The Navy Specific oligonucleotide primers for detection of pathogenic campylobacter bacteria by polymerase chain reaction
EP0627643B1 (en) 1993-06-03 1999-05-06 Hamamatsu Photonics K.K. Laser scanning optical system using axicon
US5439578A (en) 1993-06-03 1995-08-08 The Governors Of The University Of Alberta Multiple capillary biochemical analyzer
BR9405395A (en) 1993-06-04 1999-09-08 Kwahak Internacional Co Ltda Device for artificial insemination and embryo transfer.
NO932088L (en) 1993-06-08 1995-01-05 Oddbjoern Gjelsnes Device for use in liquid flow cytometry
US5483469A (en) 1993-08-02 1996-01-09 The Regents Of The University Of California Multiple sort flow cytometer
US5464581A (en) 1993-08-02 1995-11-07 The Regents Of The University Of California Flow cytometer
US6328071B1 (en) 1993-08-06 2001-12-11 Cary Austin Well pressure tank
US5596401A (en) 1993-09-16 1997-01-21 Toa Medical Electronics Co., Ltd. Particle analyzing apparatus using a coherence lowering device
US5503994A (en) 1993-10-08 1996-04-02 The Board Of Trustees Of The Leland Stanford Junior University System for sample detection with compensation for difference in sensitivity to detection of components moving at different velocities
US5480774A (en) 1993-10-14 1996-01-02 A/F Protein, Inc. Determination of genomic sex in salmonids
JP3290786B2 (en) 1993-11-26 2002-06-10 シスメックス株式会社 Particle analyzer
GB9324938D0 (en) 1993-12-04 1994-01-26 Atomic Energy Authority Uk Aerosol generator
FI96452C (en) 1994-01-26 1996-06-25 Pekka Haenninen Method for excitation of dyes
CA2159817C (en) 1994-02-28 2000-09-12 Dae Kee Kim Pyrimidine acyclonucleoside derivatives
AU696154B2 (en) 1994-03-25 1998-09-03 Daiso Co., Ltd. Epimerase
US5475487A (en) 1994-04-20 1995-12-12 The Regents Of The University Of California Aqueous carrier waveguide in a flow cytometer
DE4414940C2 (en) 1994-04-28 1998-07-02 Pekka Haenninen Luminescence scanning microscope with two photons excitation
US5595866A (en) 1994-05-27 1997-01-21 Methodist Hospital Of Indiana, Inc. Step-wise method to remove cryoprotectant from sperm
DE4419894A1 (en) 1994-06-07 1995-12-14 Gip Medizin Technik Gmbh Endoscopic puncture needle with elastic catheter
EP0687956B2 (en) 1994-06-17 2005-11-23 Carl Zeiss SMT AG Illumination device
US5891734A (en) 1994-08-01 1999-04-06 Abbott Laboratories Method for performing automated analysis
US5601234A (en) 1994-08-01 1997-02-11 Abbott Laboratories Fluid nozzle and method of introducing a fluid
JP3375203B2 (en) 1994-08-08 2003-02-10 シスメックス株式会社 Cell analyzer
FR2723735B1 (en) 1994-08-18 1996-10-31 Abx Sa AUTOMATIC CONNECTION BOX FOR DISPENSING REAGENTS IN AN APPARATUS IN PARTICULAR A HEMATOLOGICAL ANALYZER.
US5790692A (en) 1994-09-07 1998-08-04 Jeffrey H. Price Method and means of least squares designed filters for image segmentation in scanning cytometry
US20020186874A1 (en) 1994-09-07 2002-12-12 Jeffrey H. Price Method and means for image segmentation in fluorescence scanning cytometry
US5700692A (en) 1994-09-27 1997-12-23 Becton Dickinson And Company Flow sorter with video-regulated droplet spacing
US5934885A (en) 1994-10-07 1999-08-10 Bayer Corporation Reagent pump assembly
IL115327A (en) 1994-10-07 2000-08-13 Bayer Ag Diaphragm pump
US5602349A (en) 1994-10-14 1997-02-11 The University Of Washington Sample introduction system for a flow cytometer
US5643796A (en) 1994-10-14 1997-07-01 University Of Washington System for sensing droplet formation time delay in a flow cytometer
US5602039A (en) 1994-10-14 1997-02-11 The University Of Washington Flow cytometer jet monitor system
US6861265B1 (en) 1994-10-14 2005-03-01 University Of Washington Flow cytometer droplet formation system
WO1996012171A2 (en) 1994-10-14 1996-04-25 University Of Washington High speed flow cytometer droplet formation system
JP3347495B2 (en) 1994-11-14 2002-11-20 シスメックス株式会社 Particle analyzer
US5495719A (en) 1994-11-14 1996-03-05 Gray, Jr.; Carl O. Method of preserving spermatozoa
US5514537A (en) 1994-11-28 1996-05-07 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Process and apparatus for sorting spermatozoa
WO1996018205A1 (en) 1994-12-08 1996-06-13 Molecular Dynamics, Inc. Fluorescence imaging system employing a macro scanning objective
US5632754A (en) 1994-12-23 1997-05-27 Devices For Vascular Intervention Universal catheter with interchangeable work element
DE69533469T2 (en) 1994-12-26 2005-09-22 Sysmex Corp. flow cytometer
US5835262A (en) 1994-12-28 1998-11-10 Research Development Corporation Of Japan Multi-wavelength optical microscope
FI98765C (en) 1995-01-16 1997-08-11 Erkki Soini Flow cytometric method and apparatus
US5793485A (en) 1995-03-20 1998-08-11 Sandia Corporation Resonant-cavity apparatus for cytometry or particle analysis
US5608519A (en) 1995-03-20 1997-03-04 Gourley; Paul L. Laser apparatus and method for microscopic and spectroscopic analysis and processing of biological cells
US5620842A (en) 1995-03-29 1997-04-15 Becton Dickinson And Company Determination of the number of fluorescent molecules on calibration beads for flow cytometry
US5786560A (en) 1995-03-31 1998-07-28 Panasonic Technologies, Inc. 3-dimensional micromachining with femtosecond laser pulses
US5699152A (en) * 1995-04-03 1997-12-16 Alltrista Corporation Electro-optical inspection system and method
US5682038A (en) 1995-04-06 1997-10-28 Becton Dickinson And Company Fluorescent-particle analyzer with timing alignment for analog pulse subtraction of fluorescent pulses arising from different excitation locations
US5528045A (en) 1995-04-06 1996-06-18 Becton Dickinson And Company Particle analyzer with spatially split wavelength filter
US5641457A (en) 1995-04-25 1997-06-24 Systemix Sterile flow cytometer and sorter with mechanical isolation between flow chamber and sterile enclosure
US5687727A (en) 1995-05-01 1997-11-18 Danforth Biomedical Incorporated Catheter adaptor with slitting blade and improved manual control and method of use
EP0957797A4 (en) 1995-05-09 2001-05-16 Univ Missouri A system for introducing a fluid into the uterus of an animal
FR2734637B1 (en) 1995-05-24 1997-08-14 Abx Sa DEVICE FOR OPTICAL INSPECTION OF A FLUID, PARTICULARLY FOR HEMATOLOGICAL ANALYSIS
US5798276A (en) 1995-06-07 1998-08-25 Molecular Probes, Inc. Reactive derivatives of sulforhodamine 101 with enhanced hydrolytic stability
US5650847A (en) 1995-06-14 1997-07-22 Erkki Soini Method and device for determination of parameters of individual microparticles
US6454945B1 (en) 1995-06-16 2002-09-24 University Of Washington Microfabricated devices and methods
US5716852A (en) 1996-03-29 1998-02-10 University Of Washington Microfabricated diffusion-based chemical sensor
US5589457A (en) 1995-07-03 1996-12-31 Ausa International, Inc. Process for the synchronization of ovulation
US6411835B1 (en) 1997-01-13 2002-06-25 Medispectra, Inc. Spectral volume microprobe arrays
JPH11511252A (en) 1995-08-11 1999-09-28 ユニバーシティ・オブ・グエルフ Methods for identifying sex-specific and species-specific molecules, molecules identified using the methods, and uses of the molecules
CA2231114A1 (en) 1995-09-06 1997-03-13 The Research Foundation Of State University Of New York Two-photon upconverting dyes and applications
DE19533092A1 (en) 1995-09-07 1997-03-13 Basf Ag Device for parallelized two-photon fluorescence correlation spectroscopy (TPA-FCS) and its use for drug screening
US6329158B1 (en) 1995-09-15 2001-12-11 Becton Dickinson And Company Use of dimly fluorescing nucleic acid dyes in the identification of nucleated cells
US6040139A (en) * 1995-09-19 2000-03-21 Bova; G. Steven Laser cell purification system
US5726751A (en) 1995-09-27 1998-03-10 University Of Washington Silicon microchannel optical flow cytometer
US5780230A (en) 1995-10-06 1998-07-14 Coriell Institute For Medical Research Compositions and methods for human sperm activation and quantitative assessment of human sperm genome replication
US5736330A (en) 1995-10-11 1998-04-07 Luminex Corporation Method and compositions for flow cytometric determination of DNA sequences
CA2235069C (en) 1995-10-19 2010-12-14 Advanced Reproduction Technologies, Inc. Methods and compositions to improve germ cell and embryo survival and function
US6117068A (en) 1995-10-19 2000-09-12 Elite Genetics, Inc Artificial insemination system
ATE231682T1 (en) 1995-11-09 2003-02-15 Medical Res Council USE OF CYB MEDIA FOR TRANSPORTING AND STORING SPERM
DE19549015C1 (en) 1995-12-28 1997-04-03 Siemens Ag Method of monitoring precise location at which fluid stream breaks up into droplets
JP3584108B2 (en) 1996-01-08 2004-11-04 キヤノン株式会社 Lens barrel
US6641708B1 (en) 1996-01-31 2003-11-04 Board Of Regents, The University Of Texas System Method and apparatus for fractionation using conventional dielectrophoresis and field flow fractionation
WO1997029354A1 (en) 1996-02-05 1997-08-14 Bayer Aktiengesellschaft Process and device for sorting and for extraction of biological objects arranged on planar means, such as biological cells or cell organelles, histological sections, chromosome particles etc. using laser beams
BR9600722A (en) 1996-02-14 1997-12-30 Jorge Antonio Rodrigues Claro Infusion pump for contained in flexible plastic bags
WO1997030338A1 (en) 1996-02-16 1997-08-21 Inphocyte, Inc. System and method for rapid analysis of cells using spectral cytometry
JP3127111B2 (en) 1996-02-22 2001-01-22 株式会社日立製作所 Flow type particle image analysis method and apparatus
US6090947A (en) * 1996-02-26 2000-07-18 California Institute Of Technology Method for the synthesis of pyrrole and imidazole carboxamides on a solid support
US6143901A (en) * 1996-07-31 2000-11-07 Genesoft, Inc. Complex formation between dsDNA and pyrrole imidazole polyamides
US5895922A (en) 1996-03-19 1999-04-20 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence Fluorescent biological particle detection system
US5701012A (en) 1996-03-19 1997-12-23 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence Fluorescent biological particle detection system
US5747349A (en) 1996-03-20 1998-05-05 University Of Washington Fluorescent reporter beads for fluid analysis
JP3590470B2 (en) * 1996-03-27 2004-11-17 アルプス電気株式会社 Cleaning water generation method and cleaning method, and cleaning water generation device and cleaning device
JP3640461B2 (en) 1996-04-03 2005-04-20 シスメックス株式会社 Particle analyzer
US5707808A (en) 1996-04-15 1998-01-13 The Regents Of The University Of California Optical selection and collection of DNA fragments
IL126544A (en) 1996-04-25 2004-08-31 Genicon Sciences Inc Analyte assay using scattered-light detectable particles
AU3121297A (en) 1996-05-15 1997-12-05 International Remote Imaging Systems Inc. Selectiely emphasizing particles of interest from a fluid sample for analysis
JP2963393B2 (en) 1996-06-14 1999-10-18 浜松ホトニクス株式会社 Voltage divider circuit for photomultiplier tube
US5846737A (en) 1996-07-26 1998-12-08 Molecular Probes, Inc. Conjugates of sulforhodamine fluorophores with enhanced fluorescence
US5909278A (en) 1996-07-29 1999-06-01 The Regents Of The University Of California Time-resolved fluorescence decay measurements for flowing particles
ES2328423T3 (en) 1996-07-30 2009-11-12 Siemens Healthcare Diagnostics Inc. OPTICAL SYSTEM FOR AN ANALYTIC HEMATOLOGY INSTRUMENT.
EP0822401A3 (en) 1996-07-30 1999-05-06 Bayer Corporation Hydraulic system for a hematology analytical instrument
US6042249A (en) 1996-07-30 2000-03-28 Bayer Corporation Illuminator optical assembly for an analytical instrument and methods of alignment and manufacture
US5719667A (en) 1996-07-30 1998-02-17 Bayer Corporation Apparatus for filtering a laser beam in an analytical instrument
US6074827A (en) 1996-07-30 2000-06-13 Aclara Biosciences, Inc. Microfluidic method for nucleic acid purification and processing
US5872627A (en) 1996-07-30 1999-02-16 Bayer Corporation Method and apparatus for detecting scattered light in an analytical instrument
US5883378A (en) 1996-07-30 1999-03-16 Bayer Corporation Apparatus and methods for transmitting electrical signals indicative of optical interactions between a light beam and a flowing suspension of particles
US5745308A (en) 1996-07-30 1998-04-28 Bayer Corporation Methods and apparatus for an optical illuminator assembly and its alignment
US5844685A (en) 1996-07-30 1998-12-01 Bayer Corporation Reference laser beam sampling apparatus
US5998140A (en) * 1996-07-31 1999-12-07 The Scripps Research Institute Complex formation between dsDNA and oligomer of cyclic heterocycles
US5804436A (en) 1996-08-02 1998-09-08 Axiom Biotechnologies, Inc. Apparatus and method for real-time measurement of cellular response
CA2261148A1 (en) 1996-08-07 1998-02-12 Robert Slovak Additive dispensing apparatus
EP0925494B1 (en) 1996-09-04 2001-12-19 Scandinavian Micro Biodevices A/S A micro flow system for particle separation and analysis
DE69729307D1 (en) 1996-09-06 2004-07-01 Medarex Inc CYANIDINE COMPOSITIONS AND THEIR THERAPEUTIC AND DIAGNOSTIC USES
US5873254A (en) 1996-09-06 1999-02-23 Interface Multigrad Technology Device and methods for multigradient directional cooling and warming of biological samples
US6221654B1 (en) 1996-09-25 2001-04-24 California Institute Of Technology Method and apparatus for analysis and sorting of polynucleotides based on size
US5759767A (en) 1996-10-11 1998-06-02 Joseph R. Lakowicz Two-photon and multi-photon measurement of analytes in animal and human tissues and fluids
US6002471A (en) 1996-11-04 1999-12-14 California Institute Of Technology High resolution scanning raman microscope
US5799830A (en) 1996-11-08 1998-09-01 Carroll; David C. Pressure vessel access port
US5696157A (en) 1996-11-15 1997-12-09 Molecular Probes, Inc. Sulfonated derivatives of 7-aminocoumarin
CA2279574C (en) 1997-01-31 2007-07-24 The Horticulture & Food Research Institute Of New Zealand Ltd. Optical apparatus
US5874266A (en) 1997-03-27 1999-02-23 Palsson; Bernhard O. Targeted system for removing tumor cells from cell populations
US6534308B1 (en) 1997-03-27 2003-03-18 Oncosis, Llc Method and apparatus for selectively targeting specific cells within a mixed cell population
US6753161B2 (en) 1997-03-27 2004-06-22 Oncosis Llc Optoinjection methods
GB9707096D0 (en) 1997-04-08 1997-05-28 Smithkline Beecham Plc Novel device
JP2968231B2 (en) * 1997-04-11 1999-10-25 株式会社荏原製作所 Air conditioning system
US6050935A (en) 1997-05-09 2000-04-18 Biofertec Container assembly for intravaginal fertilization and culture and embryo transfer and method of intravaginal fertilization and culture employing such a container
US6133995A (en) 1997-05-09 2000-10-17 Sysmex Corporation Particle measuring apparatus
JP4754661B2 (en) 1997-06-09 2011-08-24 ミリポア・コーポレイション Method and apparatus for detecting microparticles in a fluid sample
AU8148898A (en) 1997-06-23 1999-01-04 Luminex Corporation Interlaced lasers for multiple fluorescence measurement
ATE326228T1 (en) 1997-07-01 2006-06-15 Vicam Lp METHOD FOR SEX DETERMINATION OF MAMMAL OFFSPRING
US6111398A (en) 1997-07-03 2000-08-29 Coulter International Corp. Method and apparatus for sensing and characterizing particles
BR9704313A (en) 1997-07-08 1999-04-06 Alves Elias Walter Use of chicken egg ig-y associated with monoclonal antibodies against sex specific antigens in bovine sperm immunosexation
US5899848A (en) 1997-07-14 1999-05-04 Haubrich; Mark A. Device and process for artificial insemination of animals
US5876942A (en) 1997-07-24 1999-03-02 National Science Council Of Republic Of China Process for sexing cow embryos
US5985216A (en) 1997-07-24 1999-11-16 The United States Of America, As Represented By The Secretary Of Agriculture Flow cytometry nozzle for high efficiency cell sorting
US5985538A (en) 1997-08-01 1999-11-16 Saint Barnabas Medical Center Cryopreservation and cell culture medium comprising less than 50 mM sodium ions and greater than 100 mM choline salt
US6003678A (en) 1997-08-21 1999-12-21 University Of Washington Particle separating apparatus and method
US5819948A (en) 1997-08-21 1998-10-13 Van Den Engh; Gerrit J. Particle separating apparatus and method
US5880474A (en) 1997-08-29 1999-03-09 Becton Dickinson And Company Multi-illumination-source flow particle analyzer with inter-location emissions crosstalk cancelation
WO1999015010A1 (en) 1997-09-22 1999-04-01 University Of Guelph Reduction of sperm sensitivity to chilling
US6540895B1 (en) 1997-09-23 2003-04-01 California Institute Of Technology Microfabricated cell sorter for chemical and biological materials
US6322901B1 (en) 1997-11-13 2001-11-27 Massachusetts Institute Of Technology Highly luminescent color-selective nano-crystalline materials
AU754775B2 (en) 1997-11-19 2002-11-21 University Of Washington High throughput optical scanner
US6086574A (en) 1997-11-21 2000-07-11 Hyclone Laboratories, Inc. Fluid delivery systems with diptube connector
US5895764A (en) 1997-11-24 1999-04-20 University Of New Mexico Controlled sheath flow injection cytometry
US6207392B1 (en) * 1997-11-25 2001-03-27 The Regents Of The University Of California Semiconductor nanocrystal probes for biological applications and process for making and using such probes
US5990479A (en) 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
EP1040340A4 (en) 1997-12-12 2008-01-09 Chemunex S A Digital flow cytometer
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
US6071689A (en) 1997-12-31 2000-06-06 Xy, Inc. System for improving yield of sexed embryos in mammals
WO1999038883A1 (en) 1998-02-03 1999-08-05 Xy, Inc. Specific oligonucleotide primers for detection of bovine male chromosome presence by polymerase chain reaction and method
US6746873B1 (en) 1998-02-20 2004-06-08 Xy, Inc. Vibratory system for a sorting flow cytometer
CA2321075C (en) 1998-02-20 2009-10-06 Cytomation, Inc. A vibratory system for a sorting flow cytometer
US6154276A (en) 1998-02-23 2000-11-28 The Regents Of The University Of California Waveguide detection of right-angle-scattered light in flow cytometry
US6211477B1 (en) 1998-02-26 2001-04-03 Becton Dickinson And Company Electrostatic deceleration system for flow cytometer
US6248590B1 (en) 1998-02-27 2001-06-19 Cytomation, Inc. Method and apparatus for flow cytometry
US6042025A (en) * 1998-03-13 2000-03-28 Smith Et Al. Two hole dispenser with baffles
US6371331B1 (en) 1998-03-16 2002-04-16 Partec Partikelzahlgerate Gmbh Electronic apparatus for dispensing precise small quantities of fluid
JP3594794B2 (en) 1998-03-24 2004-12-02 独立行政法人 科学技術振興機構 Nanosecond time-gated spectroscopic diagnostic equipment
US6642018B1 (en) 1998-03-27 2003-11-04 Oncosis Llc Method for inducing a response in one or more targeted cells
EP1068509A4 (en) 1998-03-30 2005-05-25 Bioshaf Flow cytometer for analysis of general diagnostic factors in cells and body fluids
US6175409B1 (en) 1999-04-02 2001-01-16 Symyx Technologies, Inc. Flow-injection analysis and variable-flow light-scattering methods and apparatus for characterizing polymers
JP3350442B2 (en) 1998-04-09 2002-11-25 科学技術振興事業団 Microscope system
WO1999057955A1 (en) 1998-05-14 1999-11-18 Luminex Corporation Zero dead time architecture and method for flow cytometer
EP1046032A4 (en) 1998-05-18 2002-05-29 Univ Washington Liquid analysis cartridge
CA2333201A1 (en) 1998-05-22 1999-12-02 California Institute Of Technology Microfabricated cell sorter
US6079836A (en) 1998-07-20 2000-06-27 Coulter International Corp. Flow cytometer droplet break-off location adjustment mechanism
ES2296398T3 (en) 1998-07-30 2008-04-16 Xy, Inc. NON-SURGICAL ARTIFICIAL EQUINE INSEMINATION SYSTEM.
US6729369B2 (en) 1998-07-31 2004-05-04 Chata Biosystems, Inc. Vessel for containing/transporting a fluent substance
US20040107150A1 (en) 1998-07-31 2004-06-03 Chata Biosystems, Inc. Of Colorado Apparatus and method with vessel for containing/transporting a fluent substance
DE29813921U1 (en) 1998-08-04 1998-10-08 Kisfeld Alfons Device for inseminating animals, especially sows
US6309815B1 (en) * 1998-08-07 2001-10-30 University Of Kansas Medical Center Composition and method for preparation, storage and activation of large populations of immotile sperm
WO2000009113A1 (en) 1998-08-17 2000-02-24 Trout William E Use of zeranol to modulate reproductive cycles
ATE376175T1 (en) 1998-08-21 2007-11-15 Union Biometrica Inc INSTRUMENT FOR ANALYZING AND SELECTIVE DISTRIBUTION OF OBJECT SAMPLES
US6326144B1 (en) 1998-09-18 2001-12-04 Massachusetts Institute Of Technology Biological applications of quantum dots
US6495333B1 (en) 1998-09-22 2002-12-17 Becton Dickinson And Company Flow cytometric, whole blood dendritic cell immune function assay
US6208411B1 (en) 1998-09-28 2001-03-27 Kla-Tencor Corporation Massively parallel inspection and imaging system
US6707555B1 (en) 1998-10-15 2004-03-16 Sysmex Corporation Optical information measuring apparatus
US6423505B1 (en) 1998-12-03 2002-07-23 Becton Dickinson And Company Methods and reagents for quantitation of HLA-DR and CD11b expression on peripheral blood cells
US7116407B2 (en) 1998-12-15 2006-10-03 Union Biometrica, Inc. System for axial pattern analysis of multicellular organisms
US6128133A (en) 1998-12-22 2000-10-03 Lucent Technologies Inc. Optical beamsplitter
JP2000206032A (en) 1999-01-06 2000-07-28 Bayer Corp Counting method for variable-ratio-volume particles and method for decision of characteristic of sample
US6256096B1 (en) 1999-01-11 2001-07-03 Softray Flow cytometry apparatus and method
US20010006416A1 (en) 1999-01-11 2001-07-05 Johnson Paul E. Ribbon flow cytometry apparatus and methods
US6150119A (en) 1999-01-19 2000-11-21 Caliper Technologies Corp. Optimized high-throughput analytical system
US6473176B2 (en) 1999-01-25 2002-10-29 Amnis Corporation Imaging and analyzing parameters of small moving objects such as cells
US6671044B2 (en) 1999-01-25 2003-12-30 Amnis Corporation Imaging and analyzing parameters of small moving objects such as cells in broad flat flow
US6580504B1 (en) 1999-01-25 2003-06-17 Amnis Corporation Multipass cavity for illumination and excitation of moving objects
US6119465A (en) 1999-02-10 2000-09-19 Mullens; Patrick L. Shipping container for storing materials at cryogenic temperatures
FR2789778B1 (en) 1999-02-12 2001-09-14 France Telecom METHOD FOR ASSOCIATING ROUTING REFERENCES WITH DATA PACKETS BY MEANS OF A SORTED MEMORY, AND PACKET ROUTER APPLYING THIS METHOD
US6323632B1 (en) 1999-08-13 2001-11-27 Coulter International Corp. Solid state RF oscillator-detector for flow cytometer
JP2000239101A (en) * 1999-02-18 2000-09-05 Japan Science & Technology Corp Refrigeration of rat sperm
CH690557A5 (en) 1999-03-01 2000-10-13 Arson Ag Illuminator.
US6097485A (en) 1999-03-08 2000-08-01 Integrated Waveguides, Inc. Microchip optical transport technology for use in a personal flow cytometer
FR2791645B1 (en) 1999-04-02 2001-06-15 Valois Sa FLUID PRODUCT SAMPLE FOR PRESS
US6193647B1 (en) 1999-04-08 2001-02-27 The Board Of Trustees Of The University Of Illinois Microfluidic embryo and/or oocyte handling device and method
US6793387B1 (en) 1999-05-08 2004-09-21 Chata Biosystems, Inc. Apparatus for automatic preparation of a mixture and method
FR2793495B1 (en) 1999-05-14 2001-08-10 Imv Technologies THINNER FOR CRYOPRESERVATION OF CATTLE SPERMATOZOIDS
FR2793708B1 (en) 1999-05-21 2001-08-03 Valois Sa FLUID PRODUCT DISPENSING DEVICE
US6372506B1 (en) 1999-07-02 2002-04-16 Becton, Dickinson And Company Apparatus and method for verifying drop delay in a flow cytometer
JP3361778B2 (en) * 1999-07-09 2003-01-07 社団法人家畜改良事業団 Injector for sperm for artificial insemination or fertilized egg transplantation of livestock and method of operating the same
IT1307787B1 (en) 1999-07-26 2001-11-19 Univ Firenze PROCESS TO INCREASE THE MOTILITY OF SPERMATOZOI AND SPERMATOZOIA SUPERIOR MOTILITY SO OBTAINED.
DE19935766A1 (en) 1999-07-29 2001-02-01 Friedrich Schiller Uni Jena Bu Process for the optical excitation of fluorophore-labeled DNA and RNA
US6664550B2 (en) 1999-08-30 2003-12-16 Sandia National Laboratories Apparatus to collect, classify, concentrate, and characterize gas-borne particles
US6495366B1 (en) 1999-09-03 2002-12-17 Therakos, Inc. Uninterrupted flow pump apparatus and method
US6813017B1 (en) 1999-10-20 2004-11-02 Becton, Dickinson And Company Apparatus and method employing incoherent light emitting semiconductor devices as particle detection light sources in a flow cytometer
WO2001028700A1 (en) 1999-10-21 2001-04-26 Cytomation, Inc. Transiently dynamic flow cytometer analysis system
US6472153B1 (en) 1999-10-26 2002-10-29 Epoch Biosciences, Inc. Hybridization-triggered fluorescent detection of nucleic acids
US7208265B1 (en) * 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
JP5087192B2 (en) 1999-11-30 2012-11-28 インテレクソン コーポレイション Method and apparatus for selectively aiming a specific cell in a cell group
US6263745B1 (en) * 1999-12-03 2001-07-24 Xy, Inc. Flow cytometer nozzle and flow cytometer sample handling methods
US6558911B1 (en) 1999-12-10 2003-05-06 Oregon Health Sciences University Sperm quality assay
US6726619B2 (en) 2000-01-03 2004-04-27 Iberica De Reproduccion Asistida, S.L. Artificial insemination device for pigs
PT1118268E (en) 2000-01-14 2002-09-30 Exelixis Deutschland Gmbh METHOD FOR THE CRIOPRESERVATION OF PEEZ-ZEBRA SPERM
US6465169B2 (en) 2000-01-14 2002-10-15 Artemis Pharmaceuticals Gmbh Method for cryoconservation of Zebrafish sperm
EP1257664A4 (en) 2000-01-28 2006-04-05 Althea Technologies Inc Methods for analysis of gene expression
US6587203B2 (en) 2000-02-17 2003-07-01 Cornell Research Foundation, Inc. Sort stream stabilizer for flow cytometer
US6618143B2 (en) 2000-02-18 2003-09-09 Idexx Laboratories, Inc. High numerical aperture flow cytometer and method of using same
US6646742B1 (en) 2000-02-19 2003-11-11 Mwi, Inc. Optical device and method for multi-angle laser light scatter
GB2360360B (en) 2000-03-14 2002-03-20 Univ Bristol A method of sorting cells
JP3587755B2 (en) 2000-03-14 2004-11-10 シスメックス株式会社 Particle measuring apparatus and method
US6482652B2 (en) 2000-03-23 2002-11-19 The Board Of Trustees Of The Leland Stanford Junior University Biological particle sorter
CZ20023261A3 (en) 2000-03-30 2003-02-12 Iowa State University Research Foundation Genetic markers for enhanced properties of animal meat
US6970246B2 (en) 2000-04-11 2005-11-29 Chemometec A/S Method and apparatus for detecting fluorescence of a sample
EP1147774A1 (en) 2000-04-20 2001-10-24 Stichting Dienst Landbouwkundig Onderzoek Method for improving the quality of sperm for artificial insemination of animals
EP2258169B1 (en) 2000-05-09 2019-07-10 Xy, Llc Method for isolating X-chromosome bearing and Y-chromosome bearing populations of spermatozoa
AU2001274864A1 (en) 2000-05-19 2001-12-03 Cytomation, Inc. A rapid multi-material sample input system
JP2001328901A (en) * 2000-05-19 2001-11-27 Seatsuku Yoshitomi Kk Kit for cryopreservation of mouse sperm
US6590911B1 (en) 2000-06-02 2003-07-08 Coherent, Inc. Passively modelocked harmonic-generating laser
US6700130B2 (en) 2001-06-29 2004-03-02 Honeywell International Inc. Optical detection system for flow cytometry
US6784981B1 (en) * 2000-06-02 2004-08-31 Idexx Laboratories, Inc. Flow cytometry-based hematology system
US7351376B1 (en) 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
US6503698B1 (en) 2000-06-16 2003-01-07 The United States Of America As Represented By The Secretary Of Agriculture Cryopreservation of swine embryos
EP1294293A4 (en) 2000-06-12 2009-11-04 Xy Inc Integrated herd management system utilizing isolated populations of x-chromosome bearing and y-chromosome bearing spermatozoa
DE10031028B4 (en) 2000-06-26 2008-09-04 Gnothis Holding Sa Method for the selection of particles
GB0016920D0 (en) 2000-07-10 2000-08-30 Univ Cambridge Tech Decondensation of DNA
CN1450857A (en) 2000-08-10 2003-10-22 Gtc生物治疗学公司 Cryopreservation of sperm
US20040005582A1 (en) 2000-08-10 2004-01-08 Nanobiodynamics, Incorporated Biospecific desorption microflow systems and methods for studying biospecific interactions and their modulators
FR2813283B1 (en) 2000-08-25 2003-02-14 Valois Sa INTEGRATED PUMP DISPENSER
EP1190684A1 (en) 2000-09-05 2002-03-27 Universiteit Gent Device and method for artificial insemination of bovines and other animals
US20020028434A1 (en) 2000-09-06 2002-03-07 Guava Technologies, Inc. Particle or cell analyzer and method
AU2001288980B2 (en) 2000-09-08 2005-12-01 Pig Improvement Company Uk Limited Novel PRKAG3 alleles and use of the same as genetic markers for reproductive and meat quality traits
WO2002023163A1 (en) 2000-09-15 2002-03-21 California Institute Of Technology Microfabricated crossflow devices and methods
GB0023041D0 (en) 2000-09-20 2000-11-01 Univ Manchester Identification apparatus
CN1325909C (en) 2000-09-27 2007-07-11 清华大学 Apparatus for particle operation and guide and use method thereof
WO2002026114A2 (en) 2000-09-27 2002-04-04 Bitensky Mark W Cellular diagnostic arrays, methods of using and processes for producing same
BR0005045A (en) 2000-09-28 2002-05-14 Marcos Fernando De Resende Mat Sperm sexing method using the classic complement system pathway, eliminating the alternative pathway by inactivating protein "b"
AU2002211389A1 (en) 2000-10-03 2002-04-15 California Institute Of Technology Microfluidic devices and methods of use
US20040031071A1 (en) 2000-10-05 2004-02-12 Xy, Inc. System of hysteroscopic insemination of mares
JP2004510423A (en) * 2000-10-05 2004-04-08 エックスワイ，インコーポレイテッド Female hysteroscope insemination system
WO2002031467A1 (en) 2000-10-12 2002-04-18 Amnis Corporation Multipass cavity for illumination and excitation of moving objects
JP2004537712A (en) 2000-10-18 2004-12-16 バーチャル・アレイズ・インコーポレーテッド Multiple cell analysis system
AU2002239480B2 (en) 2000-10-23 2005-06-02 Medical Instill Technologies, Inc. Fluid dispenser with bladder inside rigid vial
US20040034879A1 (en) 2000-11-09 2004-02-19 Steve Rothstein Mammalian sex selection using genetic modification
SE0004777D0 (en) 2000-12-22 2000-12-22 Amersham Pharm Biotech Ab Separation of X and Y sperm cells
US7713687B2 (en) * 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
US6849423B2 (en) 2000-11-29 2005-02-01 Picoliter Inc Focused acoustics for detection and sorting of fluid volumes
CA2468772C (en) 2000-11-29 2013-10-29 George E. Seidel System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
US20020064809A1 (en) 2000-11-29 2002-05-30 Mutz Mitchell W. Focused acoustic ejection cell sorting system and method
US20020064808A1 (en) 2000-11-29 2002-05-30 Mutz Mitchell W. Focused acoustic energy for ejecting cells from a fluid
CA2430336A1 (en) 2000-11-30 2002-06-06 The Netherlands Cancer Institute Membrane molecule indicator compositions and methods
US6576291B2 (en) 2000-12-08 2003-06-10 Massachusetts Institute Of Technology Preparation of nanocrystallites
WO2002057775A1 (en) 2000-12-15 2002-07-25 Cytomation, Inc. Electrical conductive containment system
US6577387B2 (en) 2000-12-29 2003-06-10 Johnson & Johnson Vision Care, Inc. Inspection of ophthalmic lenses using absorption
CA2436958A1 (en) 2001-01-29 2002-08-08 Universite De Geneve Pyrimidine acyclonucleoside derivatives, preparation method and use thereof
US6673095B2 (en) 2001-02-12 2004-01-06 Wound Healing Of Oklahoma, Inc. Apparatus and method for delivery of laser light
US7029916B2 (en) 2001-02-21 2006-04-18 Maxcyte, Inc. Apparatus and method for flow electroporation of biological samples
WO2002077011A2 (en) 2001-03-12 2002-10-03 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Oxidation-reduction sensitive green fluorescent protein variants
US6706163B2 (en) 2001-03-21 2004-03-16 Michael Seul On-chip analysis of particles and fractionation of particle mixtures using light-controlled electrokinetic assembly of particles near surfaces
US20050081256A1 (en) 2001-03-22 2005-04-14 Forsberg Erik J. Sex- specific selection of sperm from transgenic animals
EP1565747B1 (en) 2001-03-29 2013-11-27 Cellect Technologies Corp. Method and system for separating and sorting particles
EP1245944B1 (en) 2001-03-29 2007-02-14 Sysmex Corporation Flow cytometer
CN100406470C (en) * 2001-03-30 2008-07-30 科学和工业研究委员会 Protein for causing sperm not wandering prepared from india worm lizard body cavity liquid
DE60227649D1 (en) 2001-04-03 2008-08-28 Micronics Inc ISOLATED FOCUSING CYTOMETER
JP2002311027A (en) 2001-04-09 2002-10-23 Hitachi Software Eng Co Ltd Beads, manufacturing method of beads, flow cytometer, and program
US6416190B1 (en) * 2001-04-27 2002-07-09 University Of Chicago Apparatus for using optical tweezers to manipulate materials
US20020186375A1 (en) 2001-05-01 2002-12-12 Asbury Charles L. Device and methods for detecting samples in a flow cytometer independent of variations in fluorescence polarization
WO2002092161A1 (en) 2001-05-10 2002-11-21 Biophan, Llc Miniaturized particle analyzer
WO2002092247A1 (en) 2001-05-17 2002-11-21 Cytomation, Inc. Flow cytometer with active automated optical alignment system
US7345758B2 (en) 2001-05-17 2008-03-18 Cytopeia Apparatus for analyzing and sorting biological particles
US20020182590A1 (en) 2001-05-25 2002-12-05 Vanderbilt University Determining protein function in cell culture using RNA interference
US20030048433A1 (en) 2001-06-01 2003-03-13 Jean-Marie Desjonqueres Cytometer signal processing system and method
FR2825987B1 (en) 2001-06-19 2003-12-12 Valois Sa FLUID PRODUCT DISPENSER
US7105355B2 (en) 2001-07-18 2006-09-12 The Regents Of The University Of Michigan Flow cytometers and detection system of lesser size
US7704728B2 (en) 2001-07-18 2010-04-27 The University Of Michigan Microfluidic gravity pump with constant flow rate
FR2828281B1 (en) 2001-08-02 2004-12-31 Biocytex DEVICE FOR ANALYZING A SAMPLE IN PARTICULAR BY FLOW CYTOMETRY
WO2003020877A2 (en) 2001-09-01 2003-03-13 Pharmacia Corporation Staining and sorting genomes and chromosomes using sequence-specific polyamides
DE10151216A1 (en) 2001-10-16 2003-04-24 Zeiss Carl Jena Gmbh Method for the optical detection of characteristic quantities of an illuminated sample
US20030078703A1 (en) 2001-10-19 2003-04-24 Surromed, Inc. Cytometry analysis system and method using database-driven network of cytometers
US6838289B2 (en) 2001-11-14 2005-01-04 Beckman Coulter, Inc. Analyte detection system
US6831279B2 (en) 2001-11-27 2004-12-14 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence Laser diode-excited biological particle detection system
KR20040070258A (en) 2001-12-18 2004-08-06 톰슨 라이센싱 에스.에이. Internally generated close captioning/tele-texting for set-up menus of network capable signal processing apparatus
WO2003056330A2 (en) 2001-12-31 2003-07-10 Institut für Physikalische Hochtechnologie e.V. Cell sorting system for the size-based sorting or separation of cells suspended in a flowing fluid
WO2003056335A2 (en) 2001-12-31 2003-07-10 Institut für Physikalische Hochtechnologie e.V. Micro-recess array for size-dependent sorting or separation of cells suspended in a flowing medium and method for analysing the functional activity of individual cells
WO2003062796A1 (en) 2002-01-22 2003-07-31 Dakocytomation Denmark A/S Environmental containment system for a flow cytometer
US6698627B2 (en) 2002-02-19 2004-03-02 Valois S.A.S. Fluid dispenser
US6849394B2 (en) 2002-02-21 2005-02-01 Minitube Of America Compositions comprising reproductive cell media and methods for using such compositions
WO2003072765A1 (en) 2002-02-27 2003-09-04 The Regents Of The University Of Michigan Process for sorting motile particles from lesser-motile particles and apparatus suitable therefor
US7223371B2 (en) 2002-03-14 2007-05-29 Micronics, Inc. Microfluidic channel network device
US20030175980A1 (en) 2002-03-14 2003-09-18 Hayenga Jon W. Ribbon flow cytometry and cell sorting
JP2004000144A (en) 2002-03-29 2004-01-08 Aisin Seiki Co Ltd Cell separating and sorting apparatus and substrate for cell alignment
US7312085B2 (en) * 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
MXPA04012850A (en) 2002-06-28 2005-02-24 Monsanto Technology Llc Swine genetics business system.
WO2004006916A1 (en) 2002-07-10 2004-01-22 Applied Research Systems Ars Holding Nv Use of compounds for increasing spermatozoa motility
BR0312843A (en) 2002-07-22 2005-05-10 Xy Inc System to process sperm cells
ES2451765T3 (en) 2002-07-31 2014-03-28 Premium Genetics (Uk) Limited Material classification system and procedure using laser holographic guidance
NZ538462A (en) 2002-08-01 2008-06-30 Xy Inc Low pressure sperm cell separation system
US7855078B2 (en) 2002-08-15 2010-12-21 Xy, Llc High resolution flow cytometer
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
JP3983151B2 (en) 2002-09-25 2007-09-26 ダイワ精工株式会社 Fishing spinning reel
US20040061853A1 (en) 2002-09-27 2004-04-01 Blasenheim Barry J. Prism-based flow cytometry excitation optics
US7201875B2 (en) 2002-09-27 2007-04-10 Becton Dickinson And Company Fixed mounted sorting cuvette with user replaceable nozzle
US6941005B2 (en) 2002-11-01 2005-09-06 Coulter International Corp. Monitoring and control of droplet sorting
CA2506935A1 (en) 2002-11-20 2004-06-03 University Of Virginia Patent Foundation Isolation of sperm cells from other biological materials using microfabricated devices and related methods thereof
AU2003297304A1 (en) 2002-12-19 2004-07-22 Monsanto Technology Llc Method and means for early detection of pregnancy in animals by combination testing
EP2308416B1 (en) 2003-03-28 2015-01-07 Inguran, LLC Apparatus and methods for providing sex-sorted animal sperm
AU2004242121B2 (en) 2003-05-15 2010-06-24 Xy, Llc. Efficient haploid cell sorting for flow cytometer systems
US20050011582A1 (en) 2003-06-06 2005-01-20 Haug Jeffrey S. Fluid delivery system for a flow cytometer
US7460223B2 (en) * 2003-09-19 2008-12-02 Applied Biosystems Inc. Inverted orientation for a microplate
US7998700B2 (en) 2004-03-29 2011-08-16 Inguran, Llc Use of a composition which regulates oxidation/reduction reactions intracellularly and/or extracellulary in a staining or sorting process
US7892725B2 (en) 2004-03-29 2011-02-22 Inguran, Llc Process for storing a sperm dispersion
AR049732A1 (en) 2004-07-22 2006-08-30 Monsanto Co PROCESS TO ENRICH A Sperm Cell Population
WO2006015056A2 (en) 2004-07-27 2006-02-09 Dakocytomation Denmarks A/S Enhancing flow cytometry discrimination with geometric transformation
US20060118167A1 (en) 2004-12-03 2006-06-08 Xy, Inc. Pressure regulated continuously variable volume container for fluid delivery
US20060147894A1 (en) 2004-12-30 2006-07-06 Vicam, L.P. Jacketed vessel for holding semen for sex biasing mammals through artificial insemination and systems and methods for enhancing the probability of sex biasing using the same
US7591064B2 (en) 2005-07-20 2009-09-22 Hitachi Global Storage Technologies Netherlands B.V. Method of fabrication for tape medium read head with unitary formation of multiple elements
US7618770B2 (en) 2005-07-29 2009-11-17 Xy, Inc. Methods and apparatus for reducing protein content in sperm cell extenders
WO2007047811A2 (en) * 2005-10-19 2007-04-26 Scott Josephson Improved reproductive management

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3005756A (en) * 1958-11-14 1961-10-24 Noland L Van Demark Diluter containing carbon dioxide for preserving semen
US3791384A (en) * 1971-07-15 1974-02-12 Schaumann H Artificial insemination of sows
US4267268A (en) * 1979-03-12 1981-05-12 Nelson Jr Robert A Spermatozoa extenders
WO2001051612A1 (en) * 2000-01-14 2001-07-19 Istituto Sperimentale Italiano 'lazzaro Spallanzani' Process for the production of non-human embryos of high-genetic value and of predetermined sex
WO2002041906A2 (en) * 2000-11-22 2002-05-30 Pharmacia Corporation Methods and apparatus for producing gender enriched sperm
WO2004087177A1 (en) * 2003-03-28 2004-10-14 Monsanto Technology Llc Process for the staining of sperm

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BENCIC D C ET AL: "Carbon dioxide reversibly inhibits sperm motility and fertilizing ability in steelhead (Oncorhynchus mykiss)", FISH PHYSIOLOGY AND BIOCHEMISTRY, vol. 23, no. 4, November 2000 (2000-11-01), pages 275 - 281, XP002346197, ISSN: 0920-1742 *
BOATMAN D E ET AL: "BICARBONATE CARBON DIOXIDE REGULATION OF SPERM CAPACITATION HYPERACTIVATED MOTILITY AND ACROSOME REACTIONS", BIOLOGY OF REPRODUCTION, vol. 44, no. 5, 1991, pages 806 - 813, XP002346196, ISSN: 0006-3363 *
BRUEMMER J E ET AL: "EFFECT OF PYRUVATE ON THE FUNCTION OF STALLION SPERMATOZOA STORED FOR UP TO 48 HOURS", JOURNAL OF ANIMAL SCIENCE, NEW YORK, NY, US, vol. 80, no. 1, January 2002 (2002-01-01), pages 12 - 18, XP001206850, ISSN: 0021-8812 *
GARCIA M A ET AL: "DEVELOPMENT OF A BUFFER SYSTEM FOR DIALYSIS OF BOVINE SPERMATOZOA BEFORE FREEZING III. EFFECT OF DIFFERENT INORGANIC AND ORGANIC SALTS ON FRESH AND FROZEN-THAWED SEMEN", THERIOGENOLOGY, LOS ALTOS, CA, US, vol. 31, no. 5, 1989, pages 1039 - 1048, XP002337532, ISSN: 0093-691X *

Also Published As

Publication number Publication date
PT2151243E (en) 2013-01-25
NZ550198A (en) 2009-12-24
ES2397678T3 (en) 2013-03-08
CN104974983A (en) 2015-10-14
AR049259A1 (en) 2006-07-12
WO2005094852A3 (en) 2006-02-02
US7892725B2 (en) 2011-02-22
HK1203831A1 (en) 2015-11-06
CN102586179B (en) 2015-04-08
JP2007531523A (en) 2007-11-08
US20050214733A1 (en) 2005-09-29
EP1730266A2 (en) 2006-12-13
CA2561519A1 (en) 2005-10-13
CA2561519C (en) 2017-08-22
WO2005094852A2 (en) 2005-10-13
EP2151243B1 (en) 2012-10-24
CN102586179A (en) 2012-07-18
CA2561661A1 (en) 2005-10-13
US7838210B2 (en) 2010-11-23
BRPI0509485A (en) 2007-09-11
DK2801363T3 (en) 2018-05-28
BRPI0509488A (en) 2007-09-11
AU2005229073B2 (en) 2010-08-19
JP2009082143A (en) 2009-04-23
CA2561661C (en) 2015-11-24
MXPA06011344A (en) 2006-12-15
EP2801363A1 (en) 2014-11-12
DK2151243T3 (en) 2013-01-28
WO2005095590A2 (en) 2005-10-13
JP2009100752A (en) 2009-05-14
EP1729789A2 (en) 2006-12-13
AU2005229073A1 (en) 2005-10-13
AU2005228893B2 (en) 2010-08-19
PL2151243T3 (en) 2013-03-29
US20050244805A1 (en) 2005-11-03
CA2972254A1 (en) 2005-10-13
NZ550196A (en) 2010-11-26
HK1173745A1 (en) 2013-05-24
JP2007537727A (en) 2007-12-27
AU2005228893A1 (en) 2005-10-13
AR048515A1 (en) 2006-05-03
EP2260854A1 (en) 2010-12-15
EP2151243A2 (en) 2010-02-10
MXPA06011345A (en) 2006-12-15
EP2151243A3 (en) 2010-03-03
EP2801363B1 (en) 2018-02-21

Similar Documents

Publication Publication Date Title
WO2005095590A3 (en) Sperm suspensions for sorting into x or y chromosome-bearing enriched populations
WO2007079183A3 (en) Placental stem cell populations
AR111785A2 (en) IN VITRO METHOD OF PRODUCTION OF Erythrocytes
WO2007051038A3 (en) Pdx1-expressing dorsal and ventral foregut endoderm
WO2005021728A3 (en) Enriched pancreatic stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for these populations
WO2006030442A3 (en) Methods of ex vivo progenitor and stem cell expansion by co-culture with mesenchymal cells
WO2006012597A3 (en) Process for enriching a population of sperm cells
WO2008118392A3 (en) Synthetic cell platforms and methods of use thereof
WO2009034927A1 (en) Cell culture instrument and cell culture method using the same
WO2006017134A3 (en) Preprimitive streak and mesendoderm cells
WO2007102162A3 (en) Regulating stem cells
WO2007002762A3 (en) Components of cell culture media produced from plant cells
WO2009135905A3 (en) Mesenchymal stem cells and bone-forming cells
AU2019268061A1 (en) Placental stem cell populations
WO2009133351A3 (en) Production of biofuel from plant tissue culture sources
WO2010111659A8 (en) Tumor-initiating cells and methods for using same
WO2006138720A3 (en) Isolation of multi-lineage stem cells
WO2008144580A3 (en) Primate stem cells produced by somatic cell nuclear transfer
WO2009155041A3 (en) Method to modulate hematopoietic stem cell growth
DE69824605D1 (en) IMPROVED PLANT TRANSFORMED BY AGROBACTERIES
WO2019217493A3 (en) Cell populations and gene expression associated with in vitro beta cell differentiation
EP2341147A3 (en) Preprimitive streak and mesendoderm cells
WO2006047426A3 (en) Compositions, methods and systems for preparation of a stem cell-enriched cell population
WO2005033275A3 (en) Methods for altering hematopoietic progenitor cell adhesion, differentiation, and migration
WO2004072220A3 (en) Process of sex selection of mammal spermatozoa and method to control quality of frozen sexed semen doses

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DPEN Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed from 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2005228893

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 550196

Country of ref document: NZ

Ref document number: 2561661

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: PA/a/2006/011344

Country of ref document: MX

Ref document number: 2007506461

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWW Wipo information: withdrawn in national office

Country of ref document: DE

WWE Wipo information: entry into national phase

Ref document number: 2005731409

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2005228893

Country of ref document: AU

Date of ref document: 20050329

Kind code of ref document: A

WWP Wipo information: published in national office

Ref document number: 2005228893

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 200580017370.5

Country of ref document: CN

WWP Wipo information: published in national office

Ref document number: 2005731409

Country of ref document: EP

ENP Entry into the national phase

Ref document number: PI0509488

Country of ref document: BR