WO2005094210A3 - Multi-action anthelmintic formulations - Google Patents

Multi-action anthelmintic formulations Download PDF

Info

Publication number
WO2005094210A3
WO2005094210A3 PCT/US2004/025001 US2004025001W WO2005094210A3 WO 2005094210 A3 WO2005094210 A3 WO 2005094210A3 US 2004025001 W US2004025001 W US 2004025001W WO 2005094210 A3 WO2005094210 A3 WO 2005094210A3
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical formulation
action
mammals
provides
helminthiasis
Prior art date
Application number
PCT/US2004/025001
Other languages
French (fr)
Other versions
WO2005094210A2 (en
Inventor
Albert Ahn
Ian Cottrell
Original Assignee
Hartz Mountain Corp
Chanelle Pharmaceuticals Mfg L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hartz Mountain Corp, Chanelle Pharmaceuticals Mfg L filed Critical Hartz Mountain Corp
Publication of WO2005094210A2 publication Critical patent/WO2005094210A2/en
Publication of WO2005094210A3 publication Critical patent/WO2005094210A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention provides a method for preparing a pharmaceutical formulation containing ivermectin and a method and composition that can contain ivermectin plus tetrahydropyrimidines. An examples of a tetrahydropyrimidine includes pyrantel. A pharmaceutical formulation is provided for use in the treatment of helminthiasis of mammals, and particularly tapeworm, hookworm, roundworm and heartworm of domestic animals and farm animals. The present invention also provides a method of treating helminthiasis in mammals, which method comprises administering to the mammal in need thereof an anthelmintically effective amount of a pharmaceutical formulation of the invention.
PCT/US2004/025001 2004-03-12 2004-08-03 Multi-action anthelmintic formulations WO2005094210A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55268204P 2004-03-12 2004-03-12
US60/552,682 2004-03-12

Publications (2)

Publication Number Publication Date
WO2005094210A2 WO2005094210A2 (en) 2005-10-13
WO2005094210A3 true WO2005094210A3 (en) 2006-03-30

Family

ID=35064207

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/025001 WO2005094210A2 (en) 2004-03-12 2004-08-03 Multi-action anthelmintic formulations

Country Status (2)

Country Link
US (1) US7582612B2 (en)
WO (1) WO2005094210A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100024075A1 (en) * 2005-11-23 2010-01-28 Aroian Raffi V Method for Controlling Plant-Parasitic Nematode Infections in Plants
US7955632B2 (en) 2005-12-07 2011-06-07 Bayer B.V. Process for manufacturing chewable dosage forms for drug delivery and products thereof
US20070128251A1 (en) 2005-12-07 2007-06-07 Piedmont Pharmaceuticals, Inc. Process for manufacturing chewable dosage forms for drug delivery and products thereof
NZ552290A (en) * 2006-12-21 2009-05-31 Bomac Research Ltd Tablet fomulation
AU2008360070B2 (en) * 2008-07-29 2015-04-30 Bomac Research Limited Tablet manufacturing method
US8809268B2 (en) 2008-10-29 2014-08-19 The Regents Of The University Of California Combination therapy to combat helminth resistance
TW201041510A (en) * 2009-04-30 2010-12-01 Dow Agrosciences Llc Pesticide compositions exhibiting enhanced activity
TW201041507A (en) 2009-04-30 2010-12-01 Dow Agrosciences Llc Pesticide compositions exhibiting enhanced activity and methods for preparing same
TW201041508A (en) * 2009-04-30 2010-12-01 Dow Agrosciences Llc Pesticide compositions exhibiting enhanced activity
TW201041509A (en) 2009-04-30 2010-12-01 Dow Agrosciences Llc Pesticide compositions exhibiting enhanced activity
GB2475701B (en) * 2009-11-26 2011-10-19 Michael Hilary Burke A process for the preparation of an orally administered anthelmintic unit dose tablet
CN104586803B (en) * 2015-02-12 2019-11-22 浙江华海药业股份有限公司 A kind of preparation method of the net microcrystalline cellulose compositions of En Gelie
WO2019005700A1 (en) 2017-06-26 2019-01-03 Merial, Inc. Dual active parasiticidal granule compositions, methods and uses thereof
CN108489196B (en) * 2018-03-30 2019-03-05 内蒙古拜克生物有限公司 A kind of avermectin crystal drying means

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4597969A (en) * 1982-04-05 1986-07-01 Merck Sharp & Dohme Stabilization of unstable drugs or food supplements
US20010044464A1 (en) * 1998-10-19 2001-11-22 Agro-Kanesho Co., Ltd. Hydrazine oxoacetamide derivative and insecticide
US6492340B2 (en) * 2000-02-16 2002-12-10 Phoenix Scientific, Inc. Parasiticidal formulation and a method of making this formulation

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE793358A (en) * 1971-12-27 1973-06-27 Hoechst Ag NEW 2-CARBALCOXY-AMINO-BENZIMIDAZOLE DERIVATIVES PRESENTING ANTHELMINTIC ACTIVITY AND THEIR PREPARATION PROCESS
IN142490B (en) * 1974-05-15 1977-07-16 Bayer Ag
DE2841668A1 (en) * 1978-09-25 1980-04-10 Bayer Ag MEDICATED ANIMAL FEED BASED ON LIVER FLOUR
JPS57139012A (en) 1981-02-23 1982-08-27 Sankyo Co Ltd Anthelmintic composition
US4447414A (en) * 1982-12-21 1984-05-08 Cutter Laboratories, Inc. Carnivore anthelmintics
US4717566A (en) * 1984-03-19 1988-01-05 Alza Corporation Dosage system and method of using same
DE3411627A1 (en) * 1984-03-29 1985-10-03 Bayer Ag, 5090 Leverkusen STABILIZED ANTHELMINTIC FORMULATIONS
DE3634755A1 (en) * 1986-10-11 1988-04-14 Bayer Ag DERMAL TREATMENT OF CAT WORM DISEASES WITH PRAZIQUANTEL
DE3705227A1 (en) * 1987-02-19 1988-09-01 Bayer Ag ANTHELMINTHIC ACTIVE COMBINATIONS
DE3921399A1 (en) * 1989-06-29 1991-01-10 Gruenzweig & Hartmann METHOD AND DEVICE FOR THE PRODUCTION OF MINERAL WOOL FABRICS FROM PARTICULAR STONE WOOL
GB9024924D0 (en) * 1990-11-16 1991-01-02 Beecham Group Plc Novel compositions
NZ247278A (en) 1991-02-12 1995-03-28 Ancare Distributors Veterinary anthelmintic drench comprising a suspension of praziquantel in a liquid carrier
DE4208254A1 (en) * 1992-03-14 1993-09-16 Hoechst Ag SUBSTITUTED PYRIMIDINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A PEST CONTROL AND FUNGICIDE
BR9406627A (en) * 1993-05-26 1996-02-06 Commw Scient Ind Res Org Antiparasitic compositions
US5538989A (en) * 1993-11-10 1996-07-23 Hoechst-Roussel Agri-Vet Company Fenbendazole formulations
US5550153A (en) * 1994-11-14 1996-08-27 Kerz; Phillip D. Method for treating heartworm-infected canines
AUPM969994A0 (en) 1994-11-28 1994-12-22 Virbac S.A. Equine anthelmintic formulations
PT810823E (en) * 1995-02-24 2001-09-28 Novartis Ag COMPOSITION FOR CONTROL OF PARASITES
US5861142A (en) * 1996-03-25 1999-01-19 Schick; Mary Pichler Method for promoting hair, nail, and skin keratinization
AUPN933396A0 (en) * 1996-04-17 1996-05-09 Pfizer Pty Limited Non-aqueuos oral-drench compositions containing avermectin compounds
US6214367B1 (en) * 1996-06-05 2001-04-10 Ashmont Holdings Limited Injectable compositions
DE19628776A1 (en) * 1996-07-17 1998-01-22 Bayer Ag Oral granules of hexahydropyrazine derivatives
US5834260A (en) * 1996-08-30 1998-11-10 Merck & Co., Inc. Antiparasitic agents
DE19638045A1 (en) 1996-09-18 1998-03-19 Bayer Ag Injection formulations of avermectins and milbemycins
DE19654079A1 (en) * 1996-12-23 1998-06-25 Bayer Ag Endo-ecto-parasiticidal agents
ZA9711534B (en) 1996-12-24 1998-06-24 Rhone Poulenc Agrochimie Pesticidal 1-arylpyrazoles.
DE19725450A1 (en) * 1997-06-16 1998-12-17 Hoechst Schering Agrevo Gmbh 4-Haloalkyl-3-heterocyclylpyridines and 4-haloalkyl-5-heterocyclylpyrimidines, processes for their preparation, compositions containing them and their use as pesticides
US20040018241A1 (en) * 1997-09-26 2004-01-29 Noven Pharmaceuticals, Inc. Bioadhesive compositions and methods for topical administration of active agents
DE69833000T2 (en) * 1997-09-26 2006-09-07 Noven Pharmaceuticals, Inc., Miami BIO-ADHESIVE COMPOSITIONS
US6524602B1 (en) 1998-10-13 2003-02-25 Craig G. Burkhart Polymer delivery system in treatments for parasitic skin diseases
CO5210925A1 (en) * 1998-11-17 2002-10-30 Novartis Ag TETRASUSTITUID DIAMINUM NITROGUANIDINE DERIVATIVES
US6265384B1 (en) 1999-01-26 2001-07-24 Dale L. Pearlman Methods and kits for removing, treating, or preventing lice with driable pediculostatic agents
US6605595B1 (en) * 1999-02-09 2003-08-12 The Kitasato Institute Avermectin derivatives
CH693625A5 (en) 1999-02-18 2003-11-28 Inpharma Sa Pharmaceutical compositions containing compounds of promoter activity of absorption of active ingredients.
US7374779B2 (en) * 1999-02-26 2008-05-20 Lipocine, Inc. Pharmaceutical formulations and systems for improved absorption and multistage release of active agents
US6383471B1 (en) * 1999-04-06 2002-05-07 Lipocine, Inc. Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents
AU781682B2 (en) * 2000-03-20 2005-06-09 Zoetis Services Llc Sustained-release compositions for parenteral administration
US6207179B1 (en) * 2000-05-18 2001-03-27 Phoenix Scientific, Inc. Parasiticidal formulation for animals and a method of making this formulation
DE10031044A1 (en) * 2000-06-26 2002-01-03 Bayer Ag Endoparasiticidal agents for voluntary oral ingestion by animals
US6524455B1 (en) * 2000-10-04 2003-02-25 Eni Technology, Inc. Sputtering apparatus using passive arc control system and method
US20030064941A1 (en) 2001-05-21 2003-04-03 Pfizer Inc. Avermectin and praziquantel combination therapy
US6627613B2 (en) * 2001-07-23 2003-09-30 Michael A. Strobel Application of water and organic solvent soluble ivermectin for topical and oral use
US6872708B2 (en) * 2001-09-10 2005-03-29 Mitsukazu Matsumoto Local injection prescription
DE10146873A1 (en) * 2001-09-24 2003-04-17 Bayer Cropscience Gmbh Heterocyclic amides and imine derivatives, processes for their preparation, compositions containing them and their use as pesticides
DE10148290A1 (en) * 2001-09-29 2003-04-17 Bayer Cropscience Gmbh Heterocyclic amides, processes for their preparation, compositions containing them and their use
US20040224012A1 (en) * 2001-10-05 2004-11-11 Pichit Suvanprakorn Topical application and methods for administration of active agents using liposome macro-beads
AU2002337815A1 (en) 2001-10-05 2003-04-22 Suwalee Chandrkrachang Active agents using liposome beads
ES2439725T3 (en) * 2001-10-05 2014-01-24 Rubicon Scientific Llc Feed for animals that include active ingredients
US6887900B2 (en) * 2002-03-04 2005-05-03 Divergence, Inc. Nematicidal compositions and methods
US7001889B2 (en) * 2002-06-21 2006-02-21 Merial Limited Anthelmintic oral homogeneous veterinary pastes
DE10228680A1 (en) * 2002-06-27 2004-01-22 Holden Development Limited, Tortola Basis for transdermal formulations (PTF)
US6764999B2 (en) * 2002-07-11 2004-07-20 Stephen E. Bachman Nasal delivery of parasiticides
AU2003267999B2 (en) * 2002-07-19 2010-03-11 Abbvie Biotechnology Ltd Treatment of TNFalpha related disorders
US20040037869A1 (en) * 2002-08-16 2004-02-26 Douglas Cleverly Non-animal product containing veterinary formulations
US20040180034A1 (en) * 2003-03-10 2004-09-16 Lyn Hughes Anthelmintic resinates and a method for their preparation
US20040234579A1 (en) * 2003-05-22 2004-11-25 Mark D. Finke, Inc. Dietary supplements and methods of preparing and administering dietary supplements
US7396819B2 (en) * 2003-08-08 2008-07-08 Virbac Corporation Anthelmintic formulations
US7671034B2 (en) * 2003-12-19 2010-03-02 Merial Limited Stabilized formulation of ivermectin feed premix with an extended shelf life

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4597969A (en) * 1982-04-05 1986-07-01 Merck Sharp & Dohme Stabilization of unstable drugs or food supplements
US20010044464A1 (en) * 1998-10-19 2001-11-22 Agro-Kanesho Co., Ltd. Hydrazine oxoacetamide derivative and insecticide
US6492340B2 (en) * 2000-02-16 2002-12-10 Phoenix Scientific, Inc. Parasiticidal formulation and a method of making this formulation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HARDER A. ET AL: "Cyclooctadepsipeptides-an anthelmintically active class of compounds exhibiting a novel mode of action", INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, vol. 22, no. 3, September 2003 (2003-09-01), pages 318 - 331, XP002995541 *

Also Published As

Publication number Publication date
US20050203034A1 (en) 2005-09-15
WO2005094210A2 (en) 2005-10-13
US7582612B2 (en) 2009-09-01

Similar Documents

Publication Publication Date Title
WO2005094210A3 (en) Multi-action anthelmintic formulations
JO3147B1 (en) Substituted 2,3-dihydroimidazo[ 1,2- c] quinazoline Derivatives Useful for Treating Hyper-Proliferative Disorders And Diseases Associated with Angiogenesis
WO2008092006A3 (en) Antimicrobial compositions
WO2006055352A3 (en) Methods of treating cancer with lipid-based platinum compound formulations administered intraperitoneally
MY147393A (en) Administration of dipeptidyl peptidase inhibitors
BR0312573A (en) Phenyl- [4- (3-phenyl-1h-pyrazol-4-yl) -pyrimidin-2-yl] -amine derivatives
WO2006010589A3 (en) Post foaming gel mousse
TW200615266A (en) Organic compounds
BRPI0513811A (en) imidazo [4,5-d] pyrimidines, their uses and processes of preparation
NO20054208L (en) Nitrogen-substituted hexahydropyrazino [1,2-a] pyrimidine-4,7-dione derivatives, methods of preparation and use thereof as medicaments
NO20084703L (en) Triazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases
WO2007087068A3 (en) Inhibitors of tyrosine kinases and uses thereof
TNSN07341A1 (en) Pharmaceutical composition comprising an omega-carboxyaryl substituted diphenyl urea for the treatment of cancer
BRPI0508579A (en) compound, pharmaceutical composition, and use of a compound
WO2005094554A3 (en) Therapeutic agents, methods, and treatments
MX2010002392A (en) Improved brimonidine compositions for treating erythema.
NO20055766L (en) Positive modulators of nicotine acetylcholine receptors
BRPI0415953B8 (en) controlled release dosage formulation and set of controlled release dosage forms
NO20064811L (en) 4- (5-Aminomethyl-2-fluoro-phenyl) -piperidin-1-yl] - (4-bromo-3-methyl-5-propoxy-thiophen-2-yl) -methanone hydrochloride as an inhibitor of mast cell tryptase
WO2006116733A3 (en) Protein kinase inhibitors
WO2009091550A3 (en) Sulfone substituted 2,3-dihydroimidazo [1,2-c] quinazoline derivatives useful for treating hyper-proliferative disorders and diseases with angiogenesis
WO2007012947A3 (en) Method of treating ischemia-reperfusion injury
UY30158A1 (en) USE OF BENZO-HETEROARIL SULFAMIDA DERIVATIVES FOR PAIN TREATMENT
WO2007056236A3 (en) Methods of treating cancer with lipid-based platinum compound formulations administered intravenously
NO20051023L (en) Oral administration of calcitonin

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)
NENP Non-entry into the national phase

Ref country code: DE

WWW Wipo information: withdrawn in national office

Country of ref document: DE

122 Ep: pct application non-entry in european phase