WO2005087811A3 - Estrogen receptors and methods of use - Google Patents
Estrogen receptors and methods of use Download PDFInfo
- Publication number
- WO2005087811A3 WO2005087811A3 PCT/US2005/007857 US2005007857W WO2005087811A3 WO 2005087811 A3 WO2005087811 A3 WO 2005087811A3 US 2005007857 W US2005007857 W US 2005007857W WO 2005087811 A3 WO2005087811 A3 WO 2005087811A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methods
- polypeptides
- estrogen receptors
- antibodies
- seq
- Prior art date
Links
- 102000015694 estrogen receptors Human genes 0.000 title 1
- 108010038795 estrogen receptors Proteins 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 5
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/743—Steroid hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Reproductive Health (AREA)
- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Gynecology & Obstetrics (AREA)
- Neurology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
Abstract
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007502975A JP5307393B2 (en) | 2004-03-10 | 2005-03-10 | Estrogen receptor and method of use |
CN2005800074678A CN1930188B (en) | 2004-03-10 | 2005-03-10 | Estrogen receptors and methods of use |
AU2005222395A AU2005222395B2 (en) | 2004-03-10 | 2005-03-10 | Estrogen receptors and methods of use |
EP05725183.7A EP1730195B1 (en) | 2004-03-10 | 2005-03-10 | Estrogen receptors and methods of use |
US10/591,199 US7745230B2 (en) | 2004-03-10 | 2005-03-10 | Estrogen receptors and methods of use |
CA2559144A CA2559144C (en) | 2004-03-10 | 2005-03-10 | Estrogen receptor alpha splice variant er-.alpha.36 |
KR1020067020936A KR20070033965A (en) | 2004-03-10 | 2005-03-10 | Estrogen Receptor and How to Use |
ES05725183.7T ES2533002T3 (en) | 2004-03-10 | 2005-03-10 | Estrogen receptors and methods of use |
HK07109926.3A HK1104563A1 (en) | 2004-03-10 | 2007-09-12 | Estrogen receptors and methods of use |
US12/825,057 US8013127B2 (en) | 2004-03-10 | 2010-06-28 | Antibody that binds to ER-α36 |
US13/177,523 US8263738B2 (en) | 2004-03-10 | 2011-07-06 | Estrogen receptors and methods of use |
US13/568,145 US8617833B2 (en) | 2004-03-10 | 2012-08-07 | Estrogen receptors and methods of use |
US13/568,144 US8551776B2 (en) | 2004-03-10 | 2012-08-07 | Estrogen receptors and methods of use |
US13/568,141 US8512952B2 (en) | 2004-03-10 | 2012-08-07 | Estrogen receptors and methods of use |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55206704P | 2004-03-10 | 2004-03-10 | |
US60/552,067 | 2004-03-10 | ||
US64346905P | 2005-01-13 | 2005-01-13 | |
US60/643,469 | 2005-01-13 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/591,199 A-371-Of-International US7745230B2 (en) | 2004-03-10 | 2005-03-10 | Estrogen receptors and methods of use |
US12/825,057 Continuation US8013127B2 (en) | 2004-03-10 | 2010-06-28 | Antibody that binds to ER-α36 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2005087811A2 WO2005087811A2 (en) | 2005-09-22 |
WO2005087811A3 true WO2005087811A3 (en) | 2006-03-30 |
Family
ID=34976296
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2005/007857 WO2005087811A2 (en) | 2004-03-10 | 2005-03-10 | Estrogen receptors and methods of use |
Country Status (10)
Country | Link |
---|---|
US (6) | US7745230B2 (en) |
EP (1) | EP1730195B1 (en) |
JP (2) | JP5307393B2 (en) |
KR (1) | KR20070033965A (en) |
CN (2) | CN102504025B (en) |
AU (1) | AU2005222395B2 (en) |
CA (1) | CA2559144C (en) |
ES (1) | ES2533002T3 (en) |
HK (1) | HK1104563A1 (en) |
WO (1) | WO2005087811A2 (en) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2559144C (en) | 2004-03-10 | 2014-01-21 | Creighton University | Estrogen receptor alpha splice variant er-.alpha.36 |
JP5265556B2 (en) * | 2006-10-25 | 2013-08-14 | シェノゲン・ファーマ・グループ・リミテッド | Compounds and methods for treating estrogen receptor related diseases |
HU0700534D0 (en) | 2006-11-24 | 2007-10-29 | Mezoegazdasagi Biotechnologiai | Transgenic animal with enhanced immune response and method for the preparation thereof |
CN102307595A (en) * | 2009-02-10 | 2012-01-04 | 盛诺基医药科技有限公司 | Antibodies and methods for treating estrogen receptor-associated diseases |
US20110311517A1 (en) * | 2009-02-10 | 2011-12-22 | Shenogen Pharma Group, Ltd. | Antibodies and methods for treating estrogen receptor-associated diseases |
US8815779B2 (en) * | 2009-09-16 | 2014-08-26 | SwitchGear Genomics, Inc. | Transcription biomarkers of biological responses and methods |
US8841269B2 (en) * | 2010-02-23 | 2014-09-23 | Creighton University | Polynucleotides for use in treating and diagnosing cancers |
EP2627671A1 (en) * | 2010-10-15 | 2013-08-21 | Université Libre de Bruxelles | Estrogen receptor alpha polypeptide sequence, diagnostic and therapeutic applications thereof |
CA2849301C (en) * | 2011-09-22 | 2019-07-30 | Expression Pathology, Inc. | Multiplex mrm assay for evaluation of cancer |
US10031139B2 (en) | 2012-03-30 | 2018-07-24 | Konica Minolta, Inc. | Method for detecting biological material |
CN105263962B (en) * | 2013-03-19 | 2019-12-31 | 北京盛诺基医药科技股份有限公司 | Antibodies and methods for treating estrogen receptor-related diseases |
EP2976362B1 (en) | 2013-03-19 | 2019-10-23 | Beijing Shenogen Pharma Group Ltd. | Antibodies and methods for treating estrogen receptor-associated diseases |
WO2015010596A1 (en) * | 2013-07-22 | 2015-01-29 | 北京盛诺基医药科技有限公司 | Prognosis diagnosis method of breast cancer |
AU2015334842B2 (en) * | 2014-10-24 | 2022-02-17 | Koninklijke Philips N.V. | Medical prognosis and prediction of treatment response using multiple cellular signaling pathway activities |
GB201505305D0 (en) * | 2015-03-27 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel Peptides and combination of peptides for use in immunotherapy against various tumors |
KR101763580B1 (en) | 2015-09-15 | 2017-08-01 | 숙명여자대학교산학협력단 | Method for screening agent for Estrogen receptor mediated diseases using Human glutathione S-transferase P1-1 |
CN107987164B (en) * | 2017-12-18 | 2021-02-19 | 青岛珅奥基生物工程有限公司 | Estrogen receptor ER-alpha 36 antigen polypeptide and monoclonal antibody thereof |
CN108191976A (en) * | 2017-12-18 | 2018-06-22 | 青岛珅奥基生物工程有限公司 | A kind of anti-36 monoclonal antibodies of ER- α |
CN114874326B (en) * | 2022-06-21 | 2023-01-17 | 图凌(杭州)生物医药有限公司 | Monoclonal antibody for detecting estrogen receptor alpha, and preparation method and application thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2001000823A1 (en) * | 1999-06-29 | 2001-01-04 | European Molecular Biology Laboratory | NOVEL ISOFORMS OF THE HUMAN ESTROGEN RECEPTOR-$g(a) |
WO2001062969A2 (en) * | 2000-02-22 | 2001-08-30 | Pe Corporation (Ny) | Estrogen receptor alpha variants and methods of detection thereof |
WO2002097044A2 (en) * | 2001-05-25 | 2002-12-05 | Thomas Jefferson University | Alternative splice forms of proteins as basis for multiple therapeutic modalities |
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US4036945A (en) | 1976-05-03 | 1977-07-19 | The Massachusetts General Hospital | Composition and method for determining the size and location of myocardial infarcts |
US4331647A (en) | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
US4784949A (en) | 1984-04-19 | 1988-11-15 | Cetus Corporation | Universal dominant selectable marker cassette |
DE3583940D1 (en) | 1984-10-02 | 1991-10-02 | Harry M Meade | PRODUCTION OF STREPTAVIDINE-LIKE POLYPEPTIDES. |
US5560922A (en) | 1986-05-30 | 1996-10-01 | Rutgers, The State University Of New Jersey | Transdermal absorption dosage unit using a polyacrylate adhesive polymer and process |
US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US5788983A (en) | 1989-04-03 | 1998-08-04 | Rutgers, The State University Of New Jersey | Transdermal controlled delivery of pharmaceuticals at variable dosage rates and processes |
US5312752A (en) | 1989-07-31 | 1994-05-17 | Trustees Of Boston University | Specific antibodies against the DNA-binding domain of and immunoassays to determine the presence and functional status of estrogen receptor proteins |
US5053133A (en) | 1990-02-09 | 1991-10-01 | Elias Klein | Affinity separation with activated polyamide microporous membranes |
US5595887A (en) | 1990-07-16 | 1997-01-21 | Bionebraska, Inc. | Purification directed cloning of peptides using carbonic anhydrase as the affinity binding segment |
DE69406664T2 (en) * | 1993-06-18 | 1998-06-04 | Biotie Therapies Oy | COMPOSITIONS AND DIAGNOSTIC METHODS USING MONOCLONAL ANTIBODY AGAINST CD44V6 |
AU731387B2 (en) | 1996-03-20 | 2001-03-29 | Scripps Research Institute, The | Azatide peptidomimetics |
US6306434B1 (en) | 1997-02-12 | 2001-10-23 | Chong Kun Dang Corp. | Pharmaceutical composition comprising cyclosporin solid-state microemulsion |
GB9716790D0 (en) | 1997-08-07 | 1997-10-15 | Creative Peptides Sweden Ab | Recombinant DNA molecules comprising multimeric copies of a gene sequence and expression thereof |
US6365146B1 (en) | 1999-04-23 | 2002-04-02 | Rutgers, The State University Of New Jersey | Polymer encapsulation of hydrophobic materials |
WO2000064946A2 (en) | 1999-04-28 | 2000-11-02 | Board Of Regents, The University Of Texas System | Compositions and methods for cancer treatment by selectively inhibiting vegf |
ATE375516T1 (en) | 2000-06-12 | 2007-10-15 | Fujirebio Kk | IMMUNE TEST FOR MEASUREMENT OF THE HUMAN C-PEPTIDE AND REAGENT KIT FOR THIS |
WO2002102977A2 (en) | 2001-06-15 | 2002-12-27 | Wyeth | Characterization of a membrane estrogen receptor |
US20060240016A1 (en) * | 2001-12-18 | 2006-10-26 | Luc Aguilar | Activity of THAP-family chemokine-binding domains |
US20070015271A1 (en) * | 2002-04-04 | 2007-01-18 | Rosen Craig A | Human secreted proteins |
US20060173162A1 (en) * | 2002-08-15 | 2006-08-03 | Rene Djurup | Bactericidak anti-apoptotic, pro-inflammatory and anti-inflammatory peptides of heparin-binding protein (hbp) |
US20030044412A1 (en) | 2002-08-26 | 2003-03-06 | Pietras Richard J. | Membrane estrogen receptor-directed therapy in breast cancer |
CA2559144C (en) | 2004-03-10 | 2014-01-21 | Creighton University | Estrogen receptor alpha splice variant er-.alpha.36 |
US20110311517A1 (en) * | 2009-02-10 | 2011-12-22 | Shenogen Pharma Group, Ltd. | Antibodies and methods for treating estrogen receptor-associated diseases |
US8841269B2 (en) * | 2010-02-23 | 2014-09-23 | Creighton University | Polynucleotides for use in treating and diagnosing cancers |
-
2005
- 2005-03-10 CA CA2559144A patent/CA2559144C/en active Active
- 2005-03-10 ES ES05725183.7T patent/ES2533002T3/en active Active
- 2005-03-10 CN CN201110351822.0A patent/CN102504025B/en active Active
- 2005-03-10 US US10/591,199 patent/US7745230B2/en active Active
- 2005-03-10 WO PCT/US2005/007857 patent/WO2005087811A2/en active Application Filing
- 2005-03-10 JP JP2007502975A patent/JP5307393B2/en not_active Expired - Fee Related
- 2005-03-10 EP EP05725183.7A patent/EP1730195B1/en active Active
- 2005-03-10 KR KR1020067020936A patent/KR20070033965A/en not_active Application Discontinuation
- 2005-03-10 AU AU2005222395A patent/AU2005222395B2/en active Active
- 2005-03-10 CN CN2005800074678A patent/CN1930188B/en active Active
-
2007
- 2007-09-12 HK HK07109926.3A patent/HK1104563A1/en unknown
-
2010
- 2010-06-28 US US12/825,057 patent/US8013127B2/en not_active Expired - Fee Related
-
2011
- 2011-07-06 US US13/177,523 patent/US8263738B2/en active Active
-
2012
- 2012-08-07 US US13/568,144 patent/US8551776B2/en active Active
- 2012-08-07 US US13/568,141 patent/US8512952B2/en active Active
- 2012-08-07 US US13/568,145 patent/US8617833B2/en active Active
-
2013
- 2013-03-05 JP JP2013043135A patent/JP5873034B2/en active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001000823A1 (en) * | 1999-06-29 | 2001-01-04 | European Molecular Biology Laboratory | NOVEL ISOFORMS OF THE HUMAN ESTROGEN RECEPTOR-$g(a) |
WO2001062969A2 (en) * | 2000-02-22 | 2001-08-30 | Pe Corporation (Ny) | Estrogen receptor alpha variants and methods of detection thereof |
WO2002097044A2 (en) * | 2001-05-25 | 2002-12-05 | Thomas Jefferson University | Alternative splice forms of proteins as basis for multiple therapeutic modalities |
Non-Patent Citations (2)
Title |
---|
DATABASE EMBL-SVA [online] 28 August 2003 (2003-08-28), "Homo sapiens mRNA; cDNA DKFZp686N23123 (from clone DKFZp686N23123)", XP002354993, retrieved from EBI accession no. EM_PRO:BX640939 Database accession no. BX640939.1 * |
JAZAERI O ET AL: "EXPRESSION OF ESTROGEN RECEPTOR ALPHA MRNA AND PROTEIN VARIANTS IN HUMAN ENDOMETRIAL CARCINOMA", GYNECOLOGIC ONCOLOGY, ACADEMIC PRESS, LONDON, GB, vol. 74, no. 1, 1999, pages 38 - 47, XP001011870, ISSN: 0090-8258 * |
Also Published As
Publication number | Publication date |
---|---|
US20130011847A1 (en) | 2013-01-10 |
CN1930188A (en) | 2007-03-14 |
JP2013153751A (en) | 2013-08-15 |
CN102504025A (en) | 2012-06-20 |
US8551776B2 (en) | 2013-10-08 |
US8263738B2 (en) | 2012-09-11 |
US20070258895A1 (en) | 2007-11-08 |
CA2559144A1 (en) | 2005-09-22 |
US8617833B2 (en) | 2013-12-31 |
US8013127B2 (en) | 2011-09-06 |
CN102504025B (en) | 2015-10-21 |
JP5873034B2 (en) | 2016-03-01 |
US20100285018A1 (en) | 2010-11-11 |
JP2007528406A (en) | 2007-10-11 |
US7745230B2 (en) | 2010-06-29 |
AU2005222395A1 (en) | 2005-09-22 |
CN1930188B (en) | 2012-01-11 |
US20120322149A1 (en) | 2012-12-20 |
KR20070033965A (en) | 2007-03-27 |
JP5307393B2 (en) | 2013-10-02 |
HK1104563A1 (en) | 2008-01-18 |
CA2559144C (en) | 2014-01-21 |
EP1730195B1 (en) | 2015-01-14 |
AU2005222395B2 (en) | 2012-02-16 |
US20120321634A1 (en) | 2012-12-20 |
ES2533002T3 (en) | 2015-04-06 |
US20120016109A1 (en) | 2012-01-19 |
US8512952B2 (en) | 2013-08-20 |
EP1730195A2 (en) | 2006-12-13 |
WO2005087811A2 (en) | 2005-09-22 |
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