WO2005081842A3 - System for delivering conformal radiation therapy while simultaneously imaging soft tissue - Google Patents

System for delivering conformal radiation therapy while simultaneously imaging soft tissue Download PDF

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Publication number
WO2005081842A3
WO2005081842A3 PCT/US2005/004953 US2005004953W WO2005081842A3 WO 2005081842 A3 WO2005081842 A3 WO 2005081842A3 US 2005004953 W US2005004953 W US 2005004953W WO 2005081842 A3 WO2005081842 A3 WO 2005081842A3
Authority
WO
WIPO (PCT)
Prior art keywords
radiation therapy
soft tissue
simultaneously imaging
conformal radiation
imaging soft
Prior art date
Application number
PCT/US2005/004953
Other languages
French (fr)
Other versions
WO2005081842A2 (en
Inventor
James F Dempsey
Original Assignee
Univ Florida
James F Dempsey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida, James F Dempsey filed Critical Univ Florida
Priority to CA2556934A priority Critical patent/CA2556934C/en
Priority to AT05723166T priority patent/ATE503419T1/en
Priority to DE602005027182T priority patent/DE602005027182D1/en
Priority to AU2005216070A priority patent/AU2005216070B2/en
Priority to EP05723166A priority patent/EP1725166B1/en
Priority to JP2006554190A priority patent/JP5110881B2/en
Publication of WO2005081842A2 publication Critical patent/WO2005081842A2/en
Publication of WO2005081842A3 publication Critical patent/WO2005081842A3/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048Monitoring, verifying, controlling systems and methods
    • A61N5/1064Monitoring, verifying, controlling systems and methods for adjusting radiation treatment in response to monitoring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
    • A61B5/0036Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room including treatment, e.g., using an implantable medical device, ablating, ventilating
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/05Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/48Other medical applications
    • A61B5/4836Diagnosis combined with treatment in closed-loop systems or methods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/48Other medical applications
    • A61B5/4848Monitoring or testing the effects of treatment, e.g. of medication
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/103Treatment planning systems
    • A61N5/1039Treatment planning systems using functional images, e.g. PET or MRI
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1042X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy with spatial modulation of the radiation beam within the treatment head
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048Monitoring, verifying, controlling systems and methods
    • A61N5/1049Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1077Beam delivery systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1077Beam delivery systems
    • A61N5/1081Rotating beam systems with a specific mechanical construction, e.g. gantries
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/32Excitation or detection systems, e.g. using radio frequency signals
    • G01R33/34Constructional details, e.g. resonators, specially adapted to MR
    • G01R33/34046Volume type coils, e.g. bird-cage coils; Quadrature bird-cage coils; Circularly polarised coils
    • G01R33/34061Helmholtz coils
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/38Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field
    • G01R33/381Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field using electromagnets
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48NMR imaging systems
    • G01R33/4808Multimodal MR, e.g. MR combined with positron emission tomography [PET], MR combined with ultrasound or MR combined with computed tomography [CT]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/45For evaluating or diagnosing the musculoskeletal system or teeth
    • A61B5/4504Bones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048Monitoring, verifying, controlling systems and methods
    • A61N5/1049Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
    • A61N2005/1055Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam using magnetic resonance imaging [MRI]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/103Treatment planning systems
    • A61N5/1037Treatment planning systems taking into account the movement of the target, e.g. 4D-image based planning
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048Monitoring, verifying, controlling systems and methods
    • A61N5/1064Monitoring, verifying, controlling systems and methods for adjusting radiation treatment in response to monitoring
    • A61N5/1065Beam adjustment
    • A61N5/1067Beam adjustment in real time, i.e. during treatment
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48NMR imaging systems
    • G01R33/4808Multimodal MR, e.g. MR combined with positron emission tomography [PET], MR combined with ultrasound or MR combined with computed tomography [CT]
    • G01R33/4812MR combined with X-ray or computed tomography [CT]

Abstract

A device and a process for performing high temporal- and spatial-resolution MR imaging of the anatomy of a patient during intensity modulated radiation therapy (IMRT) to directly measure and control the highly conformal ionizing radiation dose delivered to the patient for the treatment of diseases caused by proliferative tissue disorders. This invention combines the technologies of open MRI (0015), multileaf-collimator (125) or compensating filter-based IMRT (0020) delivery and cobalt teletherapy into a single co-registered and gantry (025) mounted system.
PCT/US2005/004953 2004-02-20 2005-02-17 System for delivering conformal radiation therapy while simultaneously imaging soft tissue WO2005081842A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA2556934A CA2556934C (en) 2004-02-20 2005-02-17 System for delivering conformal radiation therapy while simultaneously imaging soft tissue
AT05723166T ATE503419T1 (en) 2004-02-20 2005-02-17 SYSTEM FOR ADMINISTERING CONFORMAL RADIATION THERAPY WHILE IMAGING SOFT TISSUE
DE602005027182T DE602005027182D1 (en) 2004-02-20 2005-02-17 SYSTEM FOR THE ADMINISTRATION OF CONFORMAL RADIATION THERAPY UNDER THE SIMULTANEOUS PICTURE OF SOFT TISSUE
AU2005216070A AU2005216070B2 (en) 2004-02-20 2005-02-17 System for delivering conformal radiation therapy while simultaneously imaging soft tissue
EP05723166A EP1725166B1 (en) 2004-02-20 2005-02-17 System for delivering conformal radiation therapy while simultaneously imaging soft tissue
JP2006554190A JP5110881B2 (en) 2004-02-20 2005-02-17 System for delivering conformal radiation therapy while simultaneously imaging soft tissue

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54667004P 2004-02-20 2004-02-20
US60/546,670 2004-02-20

Publications (2)

Publication Number Publication Date
WO2005081842A2 WO2005081842A2 (en) 2005-09-09
WO2005081842A3 true WO2005081842A3 (en) 2006-10-26

Family

ID=34910804

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/004953 WO2005081842A2 (en) 2004-02-20 2005-02-17 System for delivering conformal radiation therapy while simultaneously imaging soft tissue

Country Status (10)

Country Link
US (7) US7907987B2 (en)
EP (2) EP2353504B1 (en)
JP (6) JP5110881B2 (en)
CN (2) CN1946339A (en)
AT (1) ATE503419T1 (en)
AU (1) AU2005216070B2 (en)
CA (3) CA2974143C (en)
DE (1) DE602005027182D1 (en)
HK (1) HK1156828A1 (en)
WO (1) WO2005081842A2 (en)

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