WO2005077320A3 - Method of increasing working time ttcp - Google Patents

Method of increasing working time ttcp Download PDF

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Publication number
WO2005077320A3
WO2005077320A3 PCT/US2005/004025 US2005004025W WO2005077320A3 WO 2005077320 A3 WO2005077320 A3 WO 2005077320A3 US 2005004025 W US2005004025 W US 2005004025W WO 2005077320 A3 WO2005077320 A3 WO 2005077320A3
Authority
WO
WIPO (PCT)
Prior art keywords
ttcp
calcium phosphate
working time
increasing working
whiskers
Prior art date
Application number
PCT/US2005/004025
Other languages
French (fr)
Other versions
WO2005077320A2 (en
Inventor
Jiin-Huey Chern Lin
Chien-Ping Ju
Wen-Cheng Chen
Kuan-Liang Lin
I-Chang Wang
Original Assignee
Calcitec Inc
Jiin-Huey Chern Lin
Chien-Ping Ju
Wen-Cheng Chen
Kuan-Liang Lin
I-Chang Wang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/773,701 external-priority patent/US7169373B2/en
Application filed by Calcitec Inc, Jiin-Huey Chern Lin, Chien-Ping Ju, Wen-Cheng Chen, Kuan-Liang Lin, I-Chang Wang filed Critical Calcitec Inc
Priority to CA002555240A priority Critical patent/CA2555240A1/en
Priority to EP05713163A priority patent/EP1711155A2/en
Publication of WO2005077320A2 publication Critical patent/WO2005077320A2/en
Publication of WO2005077320A3 publication Critical patent/WO2005077320A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B28/00—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements
    • C04B28/34—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing cold phosphate binders
    • C04B28/344—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing cold phosphate binders the phosphate binder being present in the starting composition solely as one or more phosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
    • A61K6/864—Phosphate cements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B12/00—Cements not provided for in groups C04B7/00 - C04B11/00
    • C04B12/02—Phosphate cements
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B28/00—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements
    • C04B28/34—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing cold phosphate binders
    • C04B28/346—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing cold phosphate binders the phosphate binder being present in the starting composition as a mixture of free acid and one or more phosphates
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2111/00—Mortars, concrete or artificial stone or mixtures to prepare them, characterised by specific function, property or use
    • C04B2111/00034—Physico-chemical characteristics of the mixtures
    • C04B2111/00086—Mixtures with prolonged pot-life
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2111/00—Mortars, concrete or artificial stone or mixtures to prepare them, characterised by specific function, property or use
    • C04B2111/00474—Uses not provided for elsewhere in C04B2111/00
    • C04B2111/00836—Uses not provided for elsewhere in C04B2111/00 for medical or dental applications

Abstract

A tetracalcium phosphate (TTCP) particle for use in preparing a fast-setting, bioresorbable calcium phosphate cement is disclosed. The TTCP particle has a basic calcium phosphate whiskers on a surface thereof; the basic calcium phosphate whiskers having a Ca/P molar ratio greater than 1.33, and having a length up to about 5000 nm and a width up to about 500 nm. The basic calcium phosphate whiskers are substantially free of a hydroxyapatite phase and mainly composed of TTCP phase.
PCT/US2005/004025 2004-02-06 2005-02-07 Method of increasing working time ttcp WO2005077320A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002555240A CA2555240A1 (en) 2004-02-06 2005-02-07 Method of increasing working time ttcp
EP05713163A EP1711155A2 (en) 2004-02-06 2005-02-07 Method of increasing working time ttcp

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10/773,701 US7169373B2 (en) 1999-07-14 2004-02-06 Tetracalcium phosphate (TTCP) having calcium phosphate whisker on surface and process for preparing the same
US10/773,701 2004-02-06
US10/940,922 US7270705B2 (en) 1999-07-14 2004-09-14 Method of increasing working time of tetracalcium phosphate cement paste
US10/940,922 2004-09-14

Publications (2)

Publication Number Publication Date
WO2005077320A2 WO2005077320A2 (en) 2005-08-25
WO2005077320A3 true WO2005077320A3 (en) 2005-09-22

Family

ID=34864645

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/004025 WO2005077320A2 (en) 2004-02-06 2005-02-07 Method of increasing working time ttcp

Country Status (4)

Country Link
US (1) US7270705B2 (en)
EP (1) EP1711155A2 (en)
CA (1) CA2555240A1 (en)
WO (1) WO2005077320A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6840995B2 (en) * 1999-07-14 2005-01-11 Calcitec, Inc. Process for producing fast-setting, bioresorbable calcium phosphate cements
US7094282B2 (en) * 2000-07-13 2006-08-22 Calcitec, Inc. Calcium phosphate cement, use and preparation thereof
US6960249B2 (en) * 1999-07-14 2005-11-01 Calcitec, Inc. Tetracalcium phosphate (TTCP) having calcium phosphate whisker on surface
US7156915B2 (en) * 2000-07-13 2007-01-02 Calcitec, Inc. Tetracalcium phosphate (TTCP) with surface whiskers and method of making same
US7204876B2 (en) * 2000-07-13 2007-04-17 Calcitec, Inc. Calcium phosphate cements made from (TTCP) with surface whiskers and process for preparing same
US20030216777A1 (en) * 2002-05-16 2003-11-20 Yin-Chun Tien Method of enhancing healing of interfacial gap between bone and tendon or ligament
US7163651B2 (en) * 2004-02-19 2007-01-16 Calcitec, Inc. Method for making a porous calcium phosphate article
US6994726B2 (en) * 2004-05-25 2006-02-07 Calcitec, Inc. Dual function prosthetic bone implant and method for preparing the same
EP1686934B1 (en) * 2003-11-07 2020-03-18 Vivex Biologics Group, Inc. Injectable bone substitute
EP1753748B1 (en) 2004-05-12 2009-07-29 Pfizer Products Inc. Proline derivatives and their use as dipeptidyl peptidase iv inhibitors
CN102307941A (en) * 2008-11-12 2012-01-04 好迈迪克奥斯迪里科斯公司 Tetra calcium phosphate based organophosphorus compositions and methods
US9265857B2 (en) 2010-05-11 2016-02-23 Howmedica Osteonics Corp. Organophosphorous, multivalent metal compounds, and polymer adhesive interpenetrating network compositions and methods
MY169686A (en) 2011-01-27 2019-05-13 Sirim Berhad A method of converting limestone into tri-calcium phosphate and tetra-calcium phosphate powder simultaneously
US8765189B2 (en) 2011-05-13 2014-07-01 Howmedica Osteonic Corp. Organophosphorous and multivalent metal compound compositions and methods
US10620065B2 (en) * 2016-12-01 2020-04-14 Ut-Battelle, Llc Cement having stress-indicating properties

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1172076A2 (en) * 2000-07-13 2002-01-16 Jiin-Huey Chern Lin Calcium phosphate cement, use and preparation thereof
US6379453B1 (en) * 1999-07-14 2002-04-30 Jiin-Huey Chern Process for producing fast-setting, bioresorbable calcium phosphate cements
US20030121450A1 (en) * 1999-07-14 2003-07-03 Jiin-Huey Chern Lin Process for producing fast-setting, bioresorbable calcium phosphate cements
US6648960B1 (en) * 2002-06-26 2003-11-18 Cana Lab Corporation Method of shortening a working and setting time of a calcium phosphate cement (CPC) paste

Family Cites Families (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US569729A (en) * 1896-10-20 Draw-bar attachment for street-cars
US3679360A (en) 1970-06-26 1972-07-25 Nasa Process for the preparation of brushite crystals
JPS577856A (en) 1980-06-13 1982-01-16 Mitsubishi Mining & Cement Co Manufacture of calcium phosphate porous body
US4553272A (en) 1981-02-26 1985-11-19 University Of Pittsburgh Regeneration of living tissues by growth of isolated cells in porous implant and product thereof
US4518430A (en) 1982-04-29 1985-05-21 American Dental Association Health Foundation Dental resptorative cement pastes
USRE33221E (en) 1982-04-29 1990-05-22 American Dental Association Health Foundation Dental restorative cement pastes
USRE33161E (en) 1982-04-29 1990-02-06 American Dental Association Health Foundation Combinations of sparingly soluble calcium phosphates in slurries and pastes as mineralizers and cements
GB2132991B (en) 1982-12-14 1987-03-18 Mitsui Toatsu Chemicals Process for preparing apatite
US4612053A (en) 1983-10-06 1986-09-16 American Dental Association Health Foundation Combinations of sparingly soluble calcium phosphates in slurries and pastes as mineralizers and cements
DE3479402D1 (en) 1984-06-12 1989-09-21 Oscobal Ag Method of producing a bone replacement material
JPS62182146A (en) 1985-10-11 1987-08-10 三井東圧化学株式会社 Hardenable material
JP2572606B2 (en) 1987-09-14 1997-01-16 旭光学工業株式会社 Manufacturing method of superficially porous calcium phosphate ceramics
US5180426A (en) 1987-12-28 1993-01-19 Asahi Kogaku Kogyo K.K. Composition for forming calcium phosphate type setting material and process for producing setting material
US4880610A (en) 1988-04-20 1989-11-14 Norian Corporation In situ calcium phosphate minerals--method and composition
US5053212A (en) 1988-04-20 1991-10-01 Norian Corporation Intimate mixture of calcium and phosphate sources as precursor to hydroxyapatite
US6005162A (en) 1988-04-20 1999-12-21 Norian Corporation Methods of repairing bone
JPH0645487B2 (en) 1989-05-19 1994-06-15 徳山曹達株式会社 Curing material
US5152791A (en) 1989-12-07 1992-10-06 Olympus Optical Co., Ltd. Prosthetic artificial bone having ceramic layers of different porosity
US5164187A (en) 1990-04-05 1992-11-17 Norian Corporation Hydroxyapatite prosthesis coatings
GB2246770B (en) 1990-07-27 1995-03-29 Osaka Cement Tetracalcium phosphate-based hardening materials
US5149368A (en) 1991-01-10 1992-09-22 Liu Sung Tsuen Resorbable bioactive calcium phosphate cement
US5262166A (en) 1991-04-17 1993-11-16 Lty Medical Inc Resorbable bioactive phosphate containing cements
DE4121043A1 (en) 1991-06-26 1993-01-07 Merck Patent Gmbh BONE REPLACEMENT MATERIAL WITH FGF
DE69205736T2 (en) 1991-06-26 1996-06-13 Nitta Gelatin Kk Hardenable calcium phosphate-containing material for repairing living hard tissues.
US5782971B1 (en) 1991-06-28 1999-09-21 Norian Corp Calcium phosphate cements comprising amorophous calcium phosphate
US5338356A (en) 1991-10-29 1994-08-16 Mitsubishi Materials Corporation Calcium phosphate granular cement and method for producing same
US5605713A (en) 1991-11-22 1997-02-25 Boltong; Maria G. Process for the preparation of calcium phosphate cements and its application as bio-materials
US5218035A (en) 1992-02-03 1993-06-08 Liu Sung Tsuen Phosphate-containing surgical cements
US6013853A (en) 1992-02-14 2000-01-11 The University Of Texas System Continuous release polymeric implant carrier
JP3012095B2 (en) 1992-10-08 2000-02-21 京セラ株式会社 Porous bioprosthesis member and processing method for imparting elasticity thereto
US5522893A (en) 1993-03-12 1996-06-04 American Dental Association Health Foundation Calcium phosphate hydroxyapatite precursor and methods for making and using the same
US5476647A (en) 1993-09-13 1995-12-19 American Dental Association Health Foundation Complex calcium and fluoride containing mouth rinses, dentifrices, and chewable tablets
US5525148A (en) 1993-09-24 1996-06-11 American Dental Association Health Foundation Self-setting calcium phosphate cements and methods for preparing and using them
US5503164A (en) 1994-01-28 1996-04-02 Osteogenics, Inc. Device and method for repair of craniomaxillofacial bone defects including burr holes
DE4404018A1 (en) 1994-02-09 1995-08-10 Merck Patent Gmbh Protected release dosage forms containing clindamycin palmitate
US5496399A (en) 1994-08-23 1996-03-05 Norian Corporation Storage stable calcium phosphate cements
EP0734735B1 (en) 1994-10-13 2002-01-16 Kuraray Co., Ltd. Hard-tissue repair composition based on dimethacrylate monomers and supply unit therefor
WO1996020693A1 (en) 1995-01-06 1996-07-11 American Dental Association Health Foundation Control of calcium fluoride formation in mouth rinses, dentifrices and gels
US5560713A (en) * 1995-01-24 1996-10-01 Mcneilus Truck And Manufacturing, Inc. Ejector wear shoe
US5550172A (en) 1995-02-07 1996-08-27 Ethicon, Inc. Utilization of biocompatible adhesive/sealant materials for securing surgical devices
US6117456A (en) 1995-05-19 2000-09-12 Etex Corporation Methods and products related to the physical conversion of reactive amorphous calcium phosphate
US6027742A (en) 1995-05-19 2000-02-22 Etex Corporation Bioresorbable ceramic composites
US6132463A (en) 1995-05-19 2000-10-17 Etex Corporation Cell seeding of ceramic compositions
US5676976A (en) 1995-05-19 1997-10-14 Etex Corporation Synthesis of reactive amorphous calcium phosphates
US6149688A (en) 1995-06-07 2000-11-21 Surgical Dynamics, Inc. Artificial bone graft implant
US5702449A (en) 1995-06-07 1997-12-30 Danek Medical, Inc. Reinforced porous spinal implants
JPH0956805A (en) 1995-08-24 1997-03-04 Millennium Biologics Inc Improved sintering method for thin film manufacturing of calcium phosphate material
NZ315995A (en) 1995-09-01 1999-09-29 Millenium Biologix Inc Artificial sintered composition comprising stabilised calcium phosphate phases capable of supporting bone cell activity
EP0906128A1 (en) 1996-05-28 1999-04-07 1218122 Ontario Inc. Resorbable implant biomaterial made of condensed calcium phosphate particles
FR2749756B1 (en) 1996-06-14 1998-09-11 Bioland PROCESS FOR THE PREPARATION OF AN IMPLANTABLE COMPOSITE MATERIAL, MATERIAL OBTAINED, IMPLANT COMPRISING SUCH MATERIAL, AND IMPLEMENTATION KIT
US6953594B2 (en) 1996-10-10 2005-10-11 Etex Corporation Method of preparing a poorly crystalline calcium phosphate and methods of its use
CN1244815A (en) 1996-12-13 2000-02-16 诺瑞安有限公司 Preparation, storage and administration of cements
US5939039A (en) 1997-01-16 1999-08-17 Orthovita, Inc. Methods for production of calcium phosphate
US6013591A (en) 1997-01-16 2000-01-11 Massachusetts Institute Of Technology Nanocrystalline apatites and composites, prostheses incorporating them, and method for their production
US5993535A (en) 1997-08-28 1999-11-30 Ngk Spark Plug Co., Ltd. Calcium phosphate cement and calcium phosphate cement composition
US5899939A (en) 1998-01-21 1999-05-04 Osteotech, Inc. Bone-derived implant for load-supporting applications
US6123731A (en) 1998-02-06 2000-09-26 Osteotech, Inc. Osteoimplant and method for its manufacture
US5958430A (en) 1998-02-20 1999-09-28 Battelle Memorial Institute Thin film composition with biological substance and method of making
US6139585A (en) 1998-03-11 2000-10-31 Depuy Orthopaedics, Inc. Bioactive ceramic coating and method
US6696073B2 (en) 1999-02-23 2004-02-24 Osteotech, Inc. Shaped load-bearing osteoimplant and methods of making same
US6294187B1 (en) 1999-02-23 2001-09-25 Osteotech, Inc. Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same
JP3400740B2 (en) 1999-04-13 2003-04-28 東芝セラミックス株式会社 Calcium phosphate porous sintered body and method for producing the same
SE515695C2 (en) 1999-05-31 2001-09-24 Nobel Biocare Ab Implant with coating of bone growth stimulant for bone application and procedure in such implant
US6277149B1 (en) 1999-06-08 2001-08-21 Osteotech, Inc. Ramp-shaped intervertebral implant
US7094282B2 (en) * 2000-07-13 2006-08-22 Calcitec, Inc. Calcium phosphate cement, use and preparation thereof
US7169373B2 (en) * 1999-07-14 2007-01-30 Calcitec, Inc. Tetracalcium phosphate (TTCP) having calcium phosphate whisker on surface and process for preparing the same
US6960249B2 (en) * 1999-07-14 2005-11-01 Calcitec, Inc. Tetracalcium phosphate (TTCP) having calcium phosphate whisker on surface
US6458162B1 (en) 1999-08-13 2002-10-01 Vita Special Purpose Corporation Composite shaped bodies and methods for their production and use
US6162258A (en) 1999-08-25 2000-12-19 Osteotech, Inc. Lyophilized monolithic bone implant and method for treating bone
JP4172883B2 (en) 1999-09-08 2008-10-29 Ｈｏｙａ株式会社 Drug sustained release carrier and method for producing drug sustained release carrier
AU2001231264A1 (en) * 2000-01-31 2001-08-07 Advanced Research And Technology Institute, Inc. Composite biomaterial including anisometric calcium phosphate reinforcement particles and related methods
EP1153621A1 (en) 2000-05-12 2001-11-14 MERCK PATENT GmbH Biocements based on a mixture of TCP-PHA with improved compressive strength
US6533821B1 (en) 2000-06-22 2003-03-18 Thomas Lally Bio-adhesive composition, method for adhering objects to bone
US6325804B1 (en) * 2000-06-28 2001-12-04 Ethicon, Inc. Method for fixing a graft in a bone tunnel
AU7015301A (en) 2000-07-03 2002-01-14 Osteotech Inc Osteogenic implants derived from bone
US6332779B1 (en) 2000-07-03 2001-12-25 Osteotech, Inc. Method of hard tissue repair
CA2425612A1 (en) 2000-10-16 2002-04-25 Brian R. Genge Biocompatible cement containing reactive calcium phosphate nanoparticles and methods for making and using such cement
US6547866B1 (en) 2000-10-30 2003-04-15 Howmedica Osteonics Corp. Porous calcium phosphate cement
JP4070951B2 (en) * 2000-12-07 2008-04-02 ペンタックス株式会社 Method for producing porous calcium phosphate ceramic sintered body
US6752831B2 (en) 2000-12-08 2004-06-22 Osteotech, Inc. Biocompatible osteogenic band for repair of spinal disorders
US6793725B2 (en) 2001-01-24 2004-09-21 Ada Foundation Premixed calcium phosphate cement pastes
US20030055512A1 (en) * 2001-05-21 2003-03-20 Genin Francois Y. Calcium based neutral and bioresorbable bone graft
US6616742B2 (en) 2001-08-30 2003-09-09 Cana Lab Corporation Process for preparing a paste from calcium phosphate cement
US6478825B1 (en) 2001-11-28 2002-11-12 Osteotech, Inc. Implant, method of making same and use of the implant for the treatment of bone defects
US7045105B2 (en) * 2001-12-21 2006-05-16 Lagow Richard J Calcium phosphate bone replacement materials and methods of use thereof
US6955716B2 (en) 2002-03-01 2005-10-18 American Dental Association Foundation Self-hardening calcium phosphate materials with high resistance to fracture, controlled strength histories and tailored macropore formation rates
US20040137032A1 (en) * 2002-03-15 2004-07-15 Wang Francis W. Combinations of calcium phosphates, bone growth factors, and pore-forming additives as osteoconductive and osteoinductive composite bone grafts
US20030216777A1 (en) * 2002-05-16 2003-11-20 Yin-Chun Tien Method of enhancing healing of interfacial gap between bone and tendon or ligament
DE60300666T2 (en) * 2002-07-11 2006-04-27 Biomet Deutschland Gmbh Process for the preparation of porous calcium phosphate chips and granules from gelatine processing
CA2438742C (en) 2002-08-27 2011-08-09 Merck Patent Gesellschaft Mit Beschraenkter Haftung A new calcium phosphate cement composition and a method for the preparation thereof
US20040180091A1 (en) * 2003-03-13 2004-09-16 Chang-Yi Lin Carbonated hydroxyapatite-based microspherical composites for biomedical uses
US7306610B2 (en) * 2003-03-21 2007-12-11 Cana Lab Corporation Method and device for forming a hardened cement in a bone cavity
US20050008759A1 (en) * 2003-07-11 2005-01-13 Li Nie Grain protein-based formulations and methods of using same
US7163651B2 (en) * 2004-02-19 2007-01-16 Calcitec, Inc. Method for making a porous calcium phosphate article
EP1686934B1 (en) * 2003-11-07 2020-03-18 Vivex Biologics Group, Inc. Injectable bone substitute

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6379453B1 (en) * 1999-07-14 2002-04-30 Jiin-Huey Chern Process for producing fast-setting, bioresorbable calcium phosphate cements
US20030121450A1 (en) * 1999-07-14 2003-07-03 Jiin-Huey Chern Lin Process for producing fast-setting, bioresorbable calcium phosphate cements
EP1172076A2 (en) * 2000-07-13 2002-01-16 Jiin-Huey Chern Lin Calcium phosphate cement, use and preparation thereof
US6648960B1 (en) * 2002-06-26 2003-11-18 Cana Lab Corporation Method of shortening a working and setting time of a calcium phosphate cement (CPC) paste

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GBURECK, UWE; BARRALAET JAKE E;HOFMANN MICHAEL, THULL ROGER: "Mechanical Activation of Tetracalcium Phosphate", JOURNAL OF THE AMERICAN CERAMICS SOCIETY, vol. 87, no. 2, February 2004 (2004-02-01), pages 311 - 313, XP002336551 *

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Publication number Publication date
EP1711155A2 (en) 2006-10-18
CA2555240A1 (en) 2005-08-25
US20050069479A1 (en) 2005-03-31
US7270705B2 (en) 2007-09-18
WO2005077320A2 (en) 2005-08-25

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