WO2005074797A1 - Combined mr-optical coil for prostate-, cervix- and rectum cancer imaging diagnostics - Google Patents

Combined mr-optical coil for prostate-, cervix- and rectum cancer imaging diagnostics Download PDF

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Publication number
WO2005074797A1
WO2005074797A1 PCT/US2005/002864 US2005002864W WO2005074797A1 WO 2005074797 A1 WO2005074797 A1 WO 2005074797A1 US 2005002864 W US2005002864 W US 2005002864W WO 2005074797 A1 WO2005074797 A1 WO 2005074797A1
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WO
WIPO (PCT)
Prior art keywords
optical
anatomical
imaging unit
combined
magnetic resonance
Prior art date
Application number
PCT/US2005/002864
Other languages
French (fr)
Inventor
Wilhelm Durr
Ralph Gareus
Arne Hengerer
Ralph Weissleder
Bogdan Von Rueckmann
Original Assignee
Siemens Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/048,312 external-priority patent/US7894876B2/en
Application filed by Siemens Aktiengesellschaft filed Critical Siemens Aktiengesellschaft
Priority to JP2006551520A priority Critical patent/JP2007519493A/en
Publication of WO2005074797A1 publication Critical patent/WO2005074797A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163—Optical arrangements
    • A61B1/00174—Optical arrangements characterised by the viewing angles
    • A61B1/00183—Optical arrangements characterised by the viewing angles for variable viewing angles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/415—Evaluating particular organs or parts of the immune or lymphatic systems the glands, e.g. tonsils, adenoids or thymus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/418—Evaluating particular organs or parts of the immune or lymphatic systems lymph vessels, ducts or nodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/285—Invasive instruments, e.g. catheters or biopsy needles, specially adapted for tracking, guiding or visualization by NMR
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/043—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances for fluorescence imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission

Definitions

  • the present invention relates generally to the field of medical imaging, and, more particularly, to combined magnetic resonance-optical coil for prostate, cervix and rectum imaging.
  • MR magnetic resonance
  • CT computer tomography
  • US ultrasound
  • nuclear medicine e.g., Positron Emission Tomography
  • PET Positron Emission Tomography
  • SPECT Single Photon Emission Computed Tomography
  • a more accurate diagnosis can be provided by combining the different imaging techniques.
  • anatomical information e.g., bones and organs
  • optical information from an optical imaging technique.
  • the different imaging techniques are typically combined during postprocessing. Post-processing is generally time-consuming. Further, accurate combinations of anatomical and optical modalities are generally only possible with rigid structures, such as the brain. However, even the brain has minor movement, which can potentially render the combinations inaccurate.
  • an apparatus for providing anatomical and optical diagnostic imaging includes an anatomical imaging unit for inserting into a body cavity, wherein the anatomical imaging unit acquires anatomical images of the body cavity; and an optical imaging unit operatively connected to the anatomical imaging unit, wherein the optical imaging unit acquires optical information of the body cavity.
  • an apparatus for providing anatomical and optical diagnostic imaging is provided.
  • the apparatus includes a sheath encompassing a magnetic resonance coil. Optical compounds are integrated into the coil to facilitate the detection of fluorescence, preferably near infra red fluorescence.
  • a method is provided. The method includes inserting a combined anatomical-optical device into a body cavity; and receiving a combined image from the combined anatomical- optical device, wherein the combined image displays anatomical imaging- based information and optical imaging-based information
  • Figure 1 depicts a combined MR-Optical device, in accordance with one exemplary embodiment of the present invention.
  • DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS Illustrative embodiments of the invention are described below. In the interest of clarity, not all features of an actual implementation are described in this specification. It will of course be appreciated that in the development of any such actual embodiment, numerous implementation-specific decisions must be made to achieve the developers' specific goals, such as compliance with system-related and business-related constraints, which will vary from one implementation to another.
  • a system combining anatomical imaging technologies (e.g., MR) with optical imaging technologies.
  • the system can be used for a variety of applications, including, but not limited to, (1) cancer diagnosis and staging; (2) image guidance; and (3) radiation therapy planning.
  • Image guidance may include guiding a biopsy.
  • a prostatectomy potentially has severe side effects, such as impotence and incontinence.
  • a histologically-confirmed diagnosis such as one provided from a biopsy, may prevent unnecessary prostatectomy.
  • Image guidance may also include guiding minimal invasive therapy.
  • the present invention may be used to plan radiation therapy, for example, by detecting, and thus sparing, healthy tissue from radiation exposure.
  • MR-Optical combined magnetic resonance-optical
  • An optical probe is integrated into a magnetic resonance (“MR") coil for enriching magnetic resonance-based images with optical-based information.
  • the combined MR-Optical device may be inserted into a body cavity and a combined image displaying anatomical imaging-based information and optical imaging-based information is received.
  • the combined image may be used for any of a variety of practical applications, as contemplated by those skilled in the art, such as diagnostics (e.g., cancer diagnostics), application guiding and therapy planning.
  • the Optical-MR device 100 includes an optical probe 105, an MR coil 110, a sheath 115, and a handheld component 120.
  • the optical probe 105 may be a trans-rectal optical transducer.
  • the optical probe 105 may be pushed and/or pulled relative to the MR coil.
  • the optical probe 105 may also rotate independently of the MR coil 110.
  • the handheld component 120 allows a user to easily grip and handle the MR-Optical device 100.
  • Optical compounds could be integrated into the coil.
  • the optics facilitate the detection of fluorescence, preferably near infra red fluorescence.
  • the measured fluorescence could be due to auto-fluorescence or an applied fluorescence probe (contract agent), which could be specific for the cancer type under investigation.
  • the device could be used to detect activatable probes (smart probes).
  • the sheath 115 comprises a rigid housing, preferably transluminescent and filled with a coupling liquid (not shown).
  • the coupling liquid preferably has the same optical index as the surrounding material to prevent bending of illumination light beams (described in greater detail below).
  • the MR-Optical device 100 includes an optical wire 125 operatively connected to an optical device 130.
  • the MR-Optical device 100 further includes an MR wire 135 operatively connected to an amplifier 140.
  • the optical wire could be lead through the center of MR coil 110 to the terminal detector/illuminator lead (optical probe 105).
  • the optical wire 125 and the MR wire 135 may be parallel.
  • the optical wire connects the head with an external light source and detector 130.
  • the amplifier 140 may be a component of a magnetic resonance tomography ("MRT") unit, as known to those skilled in the art.
  • MRT magnetic resonance tomography
  • the Optical wire and the MR wire may include more than one wire, as contemplated by those skilled in the art.
  • the MR coil 110 is preferably constructed to be translucent (e.g., the spacing between the wires may be made out of a translucent plastic, the coil wires are constructed to be stable without a matrix support).
  • the sheath 115 may be replaced with a light transparent balloon (not shown).
  • the balloon may comprise a foldable investigation head with a liquid pump that fuels rotation.
  • the sheath 115 and the balloon encompass the assembly of MR coil 110.
  • the sheath 115 and the balloon may fix the MR- Optical device 100 to the body cavity.
  • the balloon may be inflated.
  • the balloon is preferably inflated with a coupling liquid, but, in an alternate embodiment, may be inflated with air.
  • the MR coil 110 may be a flexible coil, such as the MRInnervu ® commercially distributed by MEDRAD ® Incorporated.
  • the sheath 115 and the balloon may be any of a variety of shapes (e.g. toric) as contemplated by those skilled in the art.
  • the sheath 115 and the balloon are preferably shaped such that the MR-Optical device 110 can easily penetrate the particular body cavity being examined.
  • the optics can cover a 360 degree view or any limited angle.
  • the lead might be revolved from outside (independently of the the MR coil).
  • the optical lead can be push/pulled relatively to the MR coil.
  • the balloon may not cover the optical lead. Illumination and light detection is not restricted by the balloon or by the coil.
  • the balloon might be toric or two balloons might be used. Illumination and fluorescent light could be guided by two separate wires. Alternative modulation techniques could be used to distinguish between illumination and fluorescent light.
  • a particular design might operate in a CW (continues Wave) mode.
  • Other designs might apply TD (time domain) measurements, OCT (optical tomography) or 2-Photone measurements.
  • Tomographic methods might be applied to increase signal-to- noise or increase tissue penetration.
  • For the design of the optics three general embodiments of the optics are possible.
  • Light wire feeds a circular diffuser or discrete microscopic lenses assembled in a circle.
  • the optical head is moved along the MR axis to get a good coverage of the cavity.
  • There is a rotating mirror at the end of the light wire which projects the illumination light circularly on the cavity wall (e.g. rectum epithelia) and captures fluorescent light.
  • the mirror is connected to a cardan shaft and motor that is located outside of the magnetic field.
  • the optical head is moved along the MR axis to get a good coverage of the cavity.
  • DMA Digital Mirror Array
  • the following light sources are possible; broadband light source (e.e. xenonlamp or mercury lamp), LED or LED array, or a laser.
  • the detector could be a CCD camera or a CMOS. All materials for the optics are nonconductive. If this is not feasible, conductive material has to be as small and thin as possible to keep HP coupling minimal.
  • the intra-rectal measurements obtained from the MR-Optical device 100 are preferably combined with an external phased array coils (not shown) for increasing signal-to-noise and increasing the area of the body cavity being examined.
  • the external phased array coils are a typical component of a standard MRT unit. In one embodiment, the external phased array coils may be body arrays, providing ventral and dorsal receiver channels.
  • the body arrays expand the viewable area in the body cavity, which provides information of lymph nodes for, for example, staging.
  • the MR-Optical device 100 may also be combined with monocrystaline iron oxide nanoparticles ("MION"), which is an MR contrast agent.
  • MION monocrystaline iron oxide nanoparticles
  • the MION may be dually labeled with a fluorescence dye, which is an optical contrast agent.
  • the MR data set i.e., the image obtained from the MRT unit using the present invention

Abstract

We present, in exemplay embodiments of the present invention, a system combining anatomical imaging technologies (e.g., MR) with optical imaging technologies. The system can be used for a variety of applications, including, but not limited to, (1) cancer diagnosis and staging ; (2) image guidance ; and (3) radiation therapy planning. Image guidance may include guiding a biopsy. For example, a prostatectomy potentially has severe side effects, such as impotence and incontinence. Thus, a histologically-confirmed diagnosis, such as one provided from a biopsy, may prevent unnecessary prostatectomy. Image guidance may also include guiding minimal invasive therapy such as brachytherapy focused ultrasound. The present invention may be used to plan radiation therapy, for example, by detecting, and thus sparing, healthy tissue from radiation exposure.

Description

COMBINED MR-OPTICAL COIL FOR PROSTATE-, CERVIX- AND RECTUM CANCER IMAGING DIAGNOSTICS
CROSS-REFERENCE TO RELATED APPLICATIONS This application claims priority to U.S. Provisional Application No. 60/541 ,102, which was filed on February 2, 2004, and which is fully incorporated herein by reference. This application is related to US Patent Application No. not assigned (Provisional Serial No. 60/541 ,022), entitled "Combined MR-Ultrasound (US) Coil for Prostate-, Cevix-, and Rectum Cancer Imaging Diagnostics" filed on January 27, 2005 and US Patent Application No. not assigned (Provisional Serial No. 60/541 ,020), entitled "Combined Intra-Rectal Optical-MR and Intra- Rectal Optical-US Device for Prostate-, Cevix-, Rectum Imaging Diagnostics" filed on January 27, 2005 both of which are fully incorporated herein by reference.
BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates generally to the field of medical imaging, and, more particularly, to combined magnetic resonance-optical coil for prostate, cervix and rectum imaging.
2. Description of the Related Art Various diagnostic imaging methods are currently used for the diagnosis of prostate, cervix and rectum cancers. Modern diagnostic imaging techniques include magnetic resonance ("MR"), computer tomography ("CT"), ultrasound ("US") and nuclear medicine (e.g., Positron Emission Tomography ("PET"), Single Photon Emission Computed Tomography ("SPECT")). A more accurate diagnosis can be provided by combining the different imaging techniques. In particular, anatomical information (e.g., bones and organs) from an anatomical imaging technique may be enriched with optical information from an optical imaging technique. The different imaging techniques are typically combined during postprocessing. Post-processing is generally time-consuming. Further, accurate combinations of anatomical and optical modalities are generally only possible with rigid structures, such as the brain. However, even the brain has minor movement, which can potentially render the combinations inaccurate.
SUMMARY OF THE INVENTION In one aspect of the present invention, an apparatus for providing anatomical and optical diagnostic imaging is provided. The apparatus includes an anatomical imaging unit for inserting into a body cavity, wherein the anatomical imaging unit acquires anatomical images of the body cavity; and an optical imaging unit operatively connected to the anatomical imaging unit, wherein the optical imaging unit acquires optical information of the body cavity. In another aspect of the present invention, an apparatus for providing anatomical and optical diagnostic imaging is provided. The apparatus includes a sheath encompassing a magnetic resonance coil. Optical compounds are integrated into the coil to facilitate the detection of fluorescence, preferably near infra red fluorescence. In yet another aspect of the present invention, a method is provided. The method includes inserting a combined anatomical-optical device into a body cavity; and receiving a combined image from the combined anatomical- optical device, wherein the combined image displays anatomical imaging- based information and optical imaging-based information
BRIEF DESCRIPTION OF THE DRAWINGS The invention may be understood by reference to the following description taken in conjunction with the accompanying drawings, in which like reference numerals identify like elements, and in which: Figure 1 depicts a combined MR-Optical device, in accordance with one exemplary embodiment of the present invention. DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS Illustrative embodiments of the invention are described below. In the interest of clarity, not all features of an actual implementation are described in this specification. It will of course be appreciated that in the development of any such actual embodiment, numerous implementation-specific decisions must be made to achieve the developers' specific goals, such as compliance with system-related and business-related constraints, which will vary from one implementation to another. Moreover, it will be appreciated that such a development effort might be complex and time-consuming, but would nevertheless be a routine undertaking for those of ordinary skill in the art having the benefit of this disclosure. While the invention is susceptible to various modifications and alternative forms, specific embodiments thereof have been shown by way of example in the drawings and are herein described in detail. It should be understood, however, that the description herein of specific embodiments is not intended to limit the invention to the particular forms disclosed, but on the contrary, the intention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the invention as defined by the appended claims. It is to be understood that the systems and methods described herein may be implemented in various forms of hardware, software, firmware, special purpose processors, or a combination thereof. We present, in exemplary embodiments of the present invention, a system combining anatomical imaging technologies (e.g., MR) with optical imaging technologies. The system can be used for a variety of applications, including, but not limited to, (1) cancer diagnosis and staging; (2) image guidance; and (3) radiation therapy planning. Image guidance may include guiding a biopsy. For example, a prostatectomy potentially has severe side effects, such as impotence and incontinence. Thus, a histologically-confirmed diagnosis, such as one provided from a biopsy, may prevent unnecessary prostatectomy. Image guidance may also include guiding minimal invasive therapy. The present invention may be used to plan radiation therapy, for example, by detecting, and thus sparing, healthy tissue from radiation exposure. We propose a combined magnetic resonance-optical ("MR-Optical") imaging device which is inserted into an accessible body cavity, such as the rectum or the vagina. An optical probe is integrated into a magnetic resonance ("MR") coil for enriching magnetic resonance-based images with optical-based information. The combined MR-Optical device may be inserted into a body cavity and a combined image displaying anatomical imaging-based information and optical imaging-based information is received. The combined image may be used for any of a variety of practical applications, as contemplated by those skilled in the art, such as diagnostics (e.g., cancer diagnostics), application guiding and therapy planning. Referring now to Figure 1 , an exploded view of a MR-Optical device 100 with combined MR imaging and optical imaging functionality is shown, in accordance with one exemplary embodiment of the present invention. The Optical-MR device 100 includes an optical probe 105, an MR coil 110, a sheath 115, and a handheld component 120. The optical probe 105 may be a trans-rectal optical transducer. The optical probe 105 may be pushed and/or pulled relative to the MR coil. The optical probe 105 may also rotate independently of the MR coil 110. The handheld component 120 allows a user to easily grip and handle the MR-Optical device 100. Optical compounds could be integrated into the coil. The optics facilitate the detection of fluorescence, preferably near infra red fluorescence. The measured fluorescence could be due to auto-fluorescence or an applied fluorescence probe (contract agent), which could be specific for the cancer type under investigation. The device could be used to detect activatable probes (smart probes). The sheath 115 comprises a rigid housing, preferably transluminescent and filled with a coupling liquid (not shown). The coupling liquid preferably has the same optical index as the surrounding material to prevent bending of illumination light beams (described in greater detail below). The MR-Optical device 100 includes an optical wire 125 operatively connected to an optical device 130. The MR-Optical device 100 further includes an MR wire 135 operatively connected to an amplifier 140. The optical wire could be lead through the center of MR coil 110 to the terminal detector/illuminator lead (optical probe 105). The optical wire 125 and the MR wire 135 may be parallel. The optical wire connects the head with an external light source and detector 130. It should be appreciated that, although not shown for the sake of simplicity, the amplifier 140 may be a component of a magnetic resonance tomography ("MRT") unit, as known to those skilled in the art. It should further be appreciated that although only one wire is shown, the Optical wire and the MR wire may include more than one wire, as contemplated by those skilled in the art. The MR coil 110 is preferably constructed to be translucent (e.g., the spacing between the wires may be made out of a translucent plastic, the coil wires are constructed to be stable without a matrix support). In an alternate embodiment, the sheath 115 may be replaced with a light transparent balloon (not shown). The balloon may comprise a foldable investigation head with a liquid pump that fuels rotation. The sheath 115 and the balloon encompass the assembly of MR coil 110. The sheath 115 and the balloon may fix the MR- Optical device 100 to the body cavity. For example, when the MR-Optical device 100 is inserted in the body cavity, the balloon may be inflated. The balloon is preferably inflated with a coupling liquid, but, in an alternate embodiment, may be inflated with air. If a transparent balloon is used, the MR coil 110 (e.g., RF coil, bird cage) may be a flexible coil, such as the MRInnervu® commercially distributed by MEDRAD® Incorporated. Furthermore, the sheath 115 and the balloon may be any of a variety of shapes (e.g. toric) as contemplated by those skilled in the art. The sheath 115 and the balloon are preferably shaped such that the MR-Optical device 110 can easily penetrate the particular body cavity being examined. Although only one balloon is described here, it should be appreciated that more than one (e.g., two) balloons may be used, as contemplated by those skilled in the art. The optics can cover a 360 degree view or any limited angle. In the later case, the lead might be revolved from outside (independently of the the MR coil). In both designs the optical lead can be push/pulled relatively to the MR coil. The balloon may not cover the optical lead. Illumination and light detection is not restricted by the balloon or by the coil. The balloon might be toric or two balloons might be used. Illumination and fluorescent light could be guided by two separate wires. Alternative modulation techniques could be used to distinguish between illumination and fluorescent light. A particular design might operate in a CW (continues Wave) mode. Other designs might apply TD (time domain) measurements, OCT (optical tomography) or 2-Photone measurements. Tomographic methods might be applied to increase signal-to- noise or increase tissue penetration. For the design of the optics, three general embodiments of the optics are possible.
1. Light wire (single fiber or fiber bundle) feeds a circular diffuser or discrete microscopic lenses assembled in a circle. The optical head is moved along the MR axis to get a good coverage of the cavity. 2. There is a rotating mirror at the end of the light wire, which projects the illumination light circularly on the cavity wall (e.g. rectum epithelia) and captures fluorescent light. The mirror is connected to a cardan shaft and motor that is located outside of the magnetic field. The optical head is moved along the MR axis to get a good coverage of the cavity. 3. There is a DMA (Digital Mirror Array), which projects the light in two or three dimension.
The following light sources are possible; broadband light source (e.e. xenonlamp or mercury lamp), LED or LED array, or a laser. The detector could be a CCD camera or a CMOS. All materials for the optics are nonconductive. If this is not feasible, conductive material has to be as small and thin as possible to keep HP coupling minimal. The intra-rectal measurements obtained from the MR-Optical device 100 are preferably combined with an external phased array coils (not shown) for increasing signal-to-noise and increasing the area of the body cavity being examined. The external phased array coils are a typical component of a standard MRT unit. In one embodiment, the external phased array coils may be body arrays, providing ventral and dorsal receiver channels. The body arrays expand the viewable area in the body cavity, which provides information of lymph nodes for, for example, staging. The MR-Optical device 100 may also be combined with monocrystaline iron oxide nanoparticles ("MION"), which is an MR contrast agent. The MION may be dually labeled with a fluorescence dye, which is an optical contrast agent. Further, the MR data set (i.e., the image obtained from the MRT unit using the present invention) may be used for segmentation and subsequence modeling of NIRF absorption and auto-florescence for increasing the NIRF image quality. The particular embodiments disclosed above are illustrative only, as the invention may be modified and practiced in different but equivalent manners apparent to those skilled in the art having the benefit of the teachings herein. Furthermore, no limitations are intended to the details of construction or design herein shown, other than as described in the claims below. It is therefore evident that the particular embodiments disclosed above may be altered or modified and all such variations are considered within the scope and spirit of the invention. Accordingly, the protection sought herein is as set forth in the claims below.

Claims

WHAT IS CLAIMED IS:
1. An apparatus for providing anatomical and optical diagnostic imaging, comprising: an anatomical imaging unit for inserting into a body cavity, wherein the anatomical imaging unit acquires anatomical images of the body cavity; and an optical imaging unit operatively connected to the anatomical imaging unit, wherein the optical imaging unit acquires optical information of the body cavity.
2. The apparatus of claim 1 , wherein the anatomical imaging unit comprises a magnetic resonance component.
3. The apparatus of claim 1 , wherein the optical imaging unit comprises an optical component.
4. The apparatus of claim 1 , wherein the optical imaging unit moves relative to the anatomical imaging unit.
5. The apparatus of claim 1 , wherein the optical imaging unit rotates independent of the anatomical imaging unit.
6. The apparatus of claim 1 , wherein movement of the optical imaging unit is reproducible.
7. The apparatus of claim 1 , further comprising a handheld component operatively connected to the anatomical imaging unit and the optical imaging unit.
8. An apparatus for providing anatomical and optical diagnostic imaging, comprising: a sheath encompassing a magnetic resonance coil; and an optical probe operatively connected to one end of the sheath.
9. The apparatus of claim 8, further comprising a handheld component operatively connected to the other end of the sheath.
10. The apparatus of claim 8, wherein the magnetic resonance coil is a flexible coil.
11. The apparatus of claim 8, wherein the sheath comprises one of a rigid housing and at least one balloon.
12. The apparatus of claim 8, wherein the optical probe moves relative to the magnetic resonance coil.
13. The apparatus of claim 8, wherein the optical probe revolves independently of the MR coil.
14. The apparatus of claim 8, wherein the magnetic resonance coil is operatively connected to a magnetic resonance amplifier.
15. The apparatus of claim 8, wherein the optical probe is operatively connected to an optical device.
16. The apparatus of claim 8, further comprising a phased array of coils for increasing signal-to-noise ratio and increasing the region of investigation.
17. A method, comprising: inserting a combined anatomical-optical device into a body cavity; and receiving a combined image from the combined anatomical-optical device, wherein the combined image displays anatomical imaging-based information and optical imaging-based information.
18. The method of claim 17, wherein the step of inserting a combined anatomical-optical device comprises inserting a combined MR-Optical device.
19. The method of claim 17, the step of inserting a combined anatomical-optical device into a body cavity comprises inserting a combined anatomical-optical device into a rectum.
20. The method of claim 17, further comprising analyzing the combined image for one of diagnostics, application guiding and therapy planning
PCT/US2005/002864 2004-02-02 2005-02-02 Combined mr-optical coil for prostate-, cervix- and rectum cancer imaging diagnostics WO2005074797A1 (en)

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US54110204P 2004-02-02 2004-02-02
US60/541,102 2004-02-02
US11/048,312 US7894876B2 (en) 2004-02-02 2005-02-01 Combined MR-optical coil for prostate, cervix and rectum cancer imaging diagnostics
US11/048,312 2005-02-01

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DE102007045988A1 (en) 2007-09-26 2008-10-23 Siemens Ag Spectroscopy unit for characterization of e.g. tumor, has light inlet/outlet controlling light from inspection device into examination object, where inspection device is marked in subranges with magnet resonance visible substances
JP2010502332A (en) * 2006-09-06 2010-01-28 ドイチェス クレブスフォルシュングスツェントルム シュティフトゥング デス エッフェントリッヒェンレヒツ Dual-modality imaging
JP2010509976A (en) * 2006-11-21 2010-04-02 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ System, method, computer readable medium and use for imaging tissue in anatomical structures
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