WO2005074681A3 - Apparatus and method for determining effects of a substance on an organ - Google Patents

Apparatus and method for determining effects of a substance on an organ Download PDF

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Publication number
WO2005074681A3
WO2005074681A3 PCT/US2005/003008 US2005003008W WO2005074681A3 WO 2005074681 A3 WO2005074681 A3 WO 2005074681A3 US 2005003008 W US2005003008 W US 2005003008W WO 2005074681 A3 WO2005074681 A3 WO 2005074681A3
Authority
WO
WIPO (PCT)
Prior art keywords
organ
substance
hypothermic
transport
storage
Prior art date
Application number
PCT/US2005/003008
Other languages
French (fr)
Other versions
WO2005074681A2 (en
Inventor
John Brassil
Douglas Schein
Christopher G Curtis
Original Assignee
Organ Recovery Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organ Recovery Systems Inc filed Critical Organ Recovery Systems Inc
Priority to DE602005009322T priority Critical patent/DE602005009322D1/en
Priority to JP2006552193A priority patent/JP5329760B2/en
Priority to CA2554872A priority patent/CA2554872C/en
Priority to EP05712444A priority patent/EP1711816B1/en
Publication of WO2005074681A2 publication Critical patent/WO2005074681A2/en
Publication of WO2005074681A3 publication Critical patent/WO2005074681A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0236—Mechanical aspects
    • A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
    • A01N1/0247—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components for perfusion, i.e. for circulating fluid through organs, blood vessels or other living parts

Abstract

An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. During the period in which the organ is preserved and/or maintained, various drug research and development may be performed on and/or with the organ. The organ may be perfused with a fluid containing a substance such as a test substance to obtain data regarding the organ, the substance and an interaction of the substance and the organ. The data may then be used to ultimately provide information regarding the drugs efficacy in support of regulatory filings for new drugs.
PCT/US2005/003008 2004-02-02 2005-01-27 Apparatus and method for determining effects of a substance on an organ WO2005074681A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DE602005009322T DE602005009322D1 (en) 2004-02-02 2005-01-27 METHOD FOR DETERMINING THE EFFECTS OF A SUBSTANCE ON AN ORGAN
JP2006552193A JP5329760B2 (en) 2004-02-02 2005-01-27 Apparatus and method for determining the effect of a substance on an organ
CA2554872A CA2554872C (en) 2004-02-02 2005-01-27 Apparatus and method for determining effects of a substance on an organ
EP05712444A EP1711816B1 (en) 2004-02-02 2005-01-27 Method for determining effects of a substance on an organ

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/768,167 2004-02-02
US10/768,167 US7749693B2 (en) 1998-09-29 2004-02-02 Method of determining that an organ is not suitable for transplantation and using it for testing substances

Publications (2)

Publication Number Publication Date
WO2005074681A2 WO2005074681A2 (en) 2005-08-18
WO2005074681A3 true WO2005074681A3 (en) 2005-11-24

Family

ID=34837790

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/003008 WO2005074681A2 (en) 2004-02-02 2005-01-27 Apparatus and method for determining effects of a substance on an organ

Country Status (9)

Country Link
US (1) US7749693B2 (en)
EP (1) EP1711816B1 (en)
JP (1) JP5329760B2 (en)
CN (1) CN1985170A (en)
AT (1) ATE406576T1 (en)
CA (1) CA2554872C (en)
DE (1) DE602005009322D1 (en)
ES (1) ES2314627T3 (en)
WO (1) WO2005074681A2 (en)

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