WO2005074546A3 - Modified human growth hormone polypeptides and their uses - Google Patents

Modified human growth hormone polypeptides and their uses Download PDF

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Publication number
WO2005074546A3
WO2005074546A3 PCT/US2005/002724 US2005002724W WO2005074546A3 WO 2005074546 A3 WO2005074546 A3 WO 2005074546A3 US 2005002724 W US2005002724 W US 2005002724W WO 2005074546 A3 WO2005074546 A3 WO 2005074546A3
Authority
WO
WIPO (PCT)
Prior art keywords
growth hormone
human growth
modified human
hormone polypeptides
polypeptides
Prior art date
Application number
PCT/US2005/002724
Other languages
French (fr)
Other versions
WO2005074546A2 (en
Inventor
Ho Sung Cho
Thomas Daniel
Richard Dimarchi
Anna-Maria Hays
Troy Wilson
Bee-Cheng Sim
David Litzinger
Original Assignee
Ambrx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BRPI0507169-0A priority Critical patent/BRPI0507169A/en
Priority to AT05712243T priority patent/ATE546463T1/en
Priority to CA002553035A priority patent/CA2553035A1/en
Priority to NZ548257A priority patent/NZ548257A/en
Application filed by Ambrx Inc filed Critical Ambrx Inc
Priority to EP05712243A priority patent/EP1740608B1/en
Priority to GB0617304A priority patent/GB2426762A/en
Priority to JP2006551499A priority patent/JP4889505B2/en
Priority to MXPA06008506A priority patent/MXPA06008506A/en
Priority to AU2005211385A priority patent/AU2005211385B2/en
Publication of WO2005074546A2 publication Critical patent/WO2005074546A2/en
Priority to IL176595A priority patent/IL176595A/en
Priority to KR1020067016849A priority patent/KR101207123B1/en
Publication of WO2005074546A3 publication Critical patent/WO2005074546A3/en
Priority to HK07105580.8A priority patent/HK1099776A1/en
Priority to AU2009200832A priority patent/AU2009200832B2/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormones [GH] (Somatotropin)
    • C—CHEMISTRY; METALLURGY
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K—PEPTIDES
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    • C07K14/475—Growth factors; Growth regulators
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
    • C08G65/33396—Polymers modified by chemical after-treatment with organic compounds containing nitrogen having oxygen in addition to nitrogen
    • G—PHYSICS
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6875—Nucleoproteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N2500/00—Screening for compounds of potential therapeutic value

Abstract

Modified human growth hormone polypeptides and uses thereof are provided.
PCT/US2005/002724 2004-02-02 2005-01-28 Modified human growth hormone polypeptides and their uses WO2005074546A2 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
GB0617304A GB2426762A (en) 2004-02-02 2005-01-28 Modified human growth hormone polypeptides and their uses
CA002553035A CA2553035A1 (en) 2004-02-02 2005-01-28 Modified human growth hormone polypeptides and their uses
NZ548257A NZ548257A (en) 2004-02-02 2005-01-28 Modified human growth hormone polypeptides and their uses
MXPA06008506A MXPA06008506A (en) 2004-02-02 2005-01-28 Modified human growth hormone polypeptides and their uses.
EP05712243A EP1740608B1 (en) 2004-02-02 2005-01-28 Modified human growth hormone polypeptides and their uses
AT05712243T ATE546463T1 (en) 2004-02-02 2005-01-28 MODIFIED HUMAN GROWTH HORMONE POLYPEPTIDES AND USES THEREOF
JP2006551499A JP4889505B2 (en) 2004-02-02 2005-01-28 Modified human growth hormone polypeptides and uses thereof
BRPI0507169-0A BRPI0507169A (en) 2004-02-02 2005-01-28 modified human growth hormone polypeptides and their uses
AU2005211385A AU2005211385B2 (en) 2004-02-02 2005-01-28 Modified human growth hormone polypeptides and their uses
IL176595A IL176595A (en) 2004-02-02 2006-06-28 Modified human growth hormone polypeptides and their uses
KR1020067016849A KR101207123B1 (en) 2004-02-02 2006-08-22 Modified human growth hormone polypeptides and their uses
HK07105580.8A HK1099776A1 (en) 2004-02-02 2007-05-28 Modified human growth hormone polypeptides and their uses
AU2009200832A AU2009200832B2 (en) 2004-02-02 2009-03-03 Modified human growth hormone polypeptides and their uses

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US54152804P 2004-02-02 2004-02-02
US60/541,528 2004-02-02
US58117504P 2004-06-18 2004-06-18
US58088504P 2004-06-18 2004-06-18
US58131404P 2004-06-18 2004-06-18
US60/581,314 2004-06-18
US60/581,175 2004-06-18
US60/580,885 2004-06-18
US63861604P 2004-12-22 2004-12-22
US60/638,616 2004-12-22

Publications (2)

Publication Number Publication Date
WO2005074546A2 WO2005074546A2 (en) 2005-08-18
WO2005074546A3 true WO2005074546A3 (en) 2007-01-04

Family

ID=34842043

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/US2005/002599 WO2005074524A2 (en) 2004-02-02 2005-01-28 Modified human interferon polypeptides and their uses
PCT/US2005/003537 WO2005074650A2 (en) 2004-02-02 2005-01-28 Modified human four helical bundle polypeptides and their uses
PCT/US2005/002724 WO2005074546A2 (en) 2004-02-02 2005-01-28 Modified human growth hormone polypeptides and their uses

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PCT/US2005/002599 WO2005074524A2 (en) 2004-02-02 2005-01-28 Modified human interferon polypeptides and their uses
PCT/US2005/003537 WO2005074650A2 (en) 2004-02-02 2005-01-28 Modified human four helical bundle polypeptides and their uses

Country Status (16)

Country Link
US (15) US8778880B2 (en)
EP (4) EP1718664A4 (en)
JP (3) JP2007519422A (en)
KR (3) KR20060130182A (en)
CN (1) CN103755800B (en)
AT (1) ATE546463T1 (en)
AU (5) AU2005211362B2 (en)
BR (3) BRPI0507159A (en)
CA (3) CA2553034A1 (en)
GB (3) GB2429207A (en)
HK (1) HK1099776A1 (en)
IL (3) IL176595A (en)
MX (3) MXPA06008506A (en)
NZ (4) NZ548257A (en)
SG (1) SG135176A1 (en)
WO (3) WO2005074524A2 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9175083B2 (en) 2004-06-18 2015-11-03 Ambrx, Inc. Antigen-binding polypeptides and their uses
US9238878B2 (en) 2009-02-17 2016-01-19 Redwood Bioscience, Inc. Aldehyde-tagged protein-based drug carriers and methods of use
US9434778B2 (en) 2014-10-24 2016-09-06 Bristol-Myers Squibb Company Modified FGF-21 polypeptides comprising an internal deletion and uses thereof
US9540438B2 (en) 2011-01-14 2017-01-10 Redwood Bioscience, Inc. Aldehyde-tagged immunoglobulin polypeptides and methods of use thereof
US9567386B2 (en) 2010-08-17 2017-02-14 Ambrx, Inc. Therapeutic uses of modified relaxin polypeptides

Families Citing this family (198)

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