WO2005068464A3 - Process for preparing tadalafil and its intermediates - Google Patents

Process for preparing tadalafil and its intermediates Download PDF

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Publication number
WO2005068464A3
WO2005068464A3 PCT/IN2004/000389 IN2004000389W WO2005068464A3 WO 2005068464 A3 WO2005068464 A3 WO 2005068464A3 IN 2004000389 W IN2004000389 W IN 2004000389W WO 2005068464 A3 WO2005068464 A3 WO 2005068464A3
Authority
WO
WIPO (PCT)
Prior art keywords
intermediates
tadalafil
preparing tadalafil
preparing
processes
Prior art date
Application number
PCT/IN2004/000389
Other languages
French (fr)
Other versions
WO2005068464A2 (en
Inventor
Braj Bhushan Lohray
Vidya Bhushan Lohray
Sunil Indulal Patel
Original Assignee
Cadila Healthcare Ltd
Braj Bhushan Lohray
Vidya Bhushan Lohray
Sunil Indulal Patel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadila Healthcare Ltd, Braj Bhushan Lohray, Vidya Bhushan Lohray, Sunil Indulal Patel filed Critical Cadila Healthcare Ltd
Publication of WO2005068464A2 publication Critical patent/WO2005068464A2/en
Publication of WO2005068464A3 publication Critical patent/WO2005068464A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Processes for preparing Tadalafil and its intermediates are claimed, as is a novel form of Tadalafil.
PCT/IN2004/000389 2003-12-15 2004-12-14 Process for preparing tadalafil and its intermediates WO2005068464A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1270/MUM/2003 2003-12-15
IN1270MU2003 2003-12-15

Publications (2)

Publication Number Publication Date
WO2005068464A2 WO2005068464A2 (en) 2005-07-28
WO2005068464A3 true WO2005068464A3 (en) 2005-12-08

Family

ID=34779411

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2004/000389 WO2005068464A2 (en) 2003-12-15 2004-12-14 Process for preparing tadalafil and its intermediates

Country Status (1)

Country Link
WO (1) WO2005068464A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006049986A1 (en) * 2004-10-28 2006-05-11 Dr. Reddy's Laboratories Ltd. Polymorphic forms of tadalafil
EP1851222A1 (en) * 2005-02-25 2007-11-07 Teva Pharmaceutical Industries Ltd Process of synthesizing tadalafil
KR20070099035A (en) 2005-02-25 2007-10-08 테바 파마슈티컬 인더스트리즈 리미티드 Tadalafil having a large particle size and a process for preparation thereof
WO2007052283A1 (en) * 2005-10-31 2007-05-10 Alembic Limited An improved process for preparing tadalafil and its intermediate
US8445698B2 (en) 2007-06-29 2013-05-21 Ranbaxy Laboratories Limited Process for the preparation of an intermediate of tadalafil
EP2107059A1 (en) 2008-03-31 2009-10-07 LEK Pharmaceuticals D.D. Conversion of tryptophan into ß-carboline derivatives
WO2009144734A1 (en) * 2008-05-28 2009-12-03 Hetero Research Foundation Process for preparation of tadalafil
PL385356A1 (en) 2008-06-03 2009-12-07 Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna Method of tadalaphil production
US8829023B2 (en) 2011-02-10 2014-09-09 Interquim, S.A. Process for obtaining compounds derived from tetrahydro-β-carboline
CN105106216A (en) * 2015-09-11 2015-12-02 青岛蓝盛洋医药生物科技有限责任公司 Drug tadalafil composition capsules for treating impotence of males
CN105272981A (en) * 2015-11-19 2016-01-27 中国药科大学 New Tadalafil crystal form
CN105384740A (en) * 2015-12-18 2016-03-09 海南通用康力制药有限公司 Tadanafil preparation intermediate high purity crystal and preparation method thereof
CN105481860B (en) * 2015-12-31 2018-03-02 山西普德药业有限公司 A kind of process for refining of Tadalafei I type crystal
CN107759592A (en) * 2017-11-01 2018-03-06 吉林医药学院 The preparation of tadalafil intermediate
RU2692764C1 (en) 2019-04-26 2019-06-27 Общество с ограниченной ответственностью "Балтфарма" Method of producing tadalafil
CN115184531A (en) * 2021-04-07 2022-10-14 浙江康恩贝制药股份有限公司 Method for simultaneously determining contents of 3 impurities in tadalafil

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995019978A1 (en) * 1994-01-21 1995-07-27 Laboratoires Glaxo Wellcome S.A. Tetracyclic derivatives, process of preparation and use
WO1996038131A1 (en) * 1995-06-02 1996-12-05 Glaxo Group Limited Method of producing a solid dispersion of a poorly water soluble drug
US6140329A (en) * 1995-07-14 2000-10-31 Icos Corporation Use of cGMP-phosphodiesterase inhibitors in methods and compositions to treat impotence

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995019978A1 (en) * 1994-01-21 1995-07-27 Laboratoires Glaxo Wellcome S.A. Tetracyclic derivatives, process of preparation and use
WO1996038131A1 (en) * 1995-06-02 1996-12-05 Glaxo Group Limited Method of producing a solid dispersion of a poorly water soluble drug
US6140329A (en) * 1995-07-14 2000-10-31 Icos Corporation Use of cGMP-phosphodiesterase inhibitors in methods and compositions to treat impotence

Also Published As

Publication number Publication date
WO2005068464A2 (en) 2005-07-28

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