WO2005066204A3 - Neutralizing epitope-based growth enhancing vaccine - Google Patents

Neutralizing epitope-based growth enhancing vaccine Download PDF

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Publication number
WO2005066204A3
WO2005066204A3 PCT/US2004/043125 US2004043125W WO2005066204A3 WO 2005066204 A3 WO2005066204 A3 WO 2005066204A3 US 2004043125 W US2004043125 W US 2004043125W WO 2005066204 A3 WO2005066204 A3 WO 2005066204A3
Authority
WO
WIPO (PCT)
Prior art keywords
neutralizing epitope
growth enhancing
gdf8
based growth
new
Prior art date
Application number
PCT/US2004/043125
Other languages
French (fr)
Other versions
WO2005066204A2 (en
Inventor
David E Junker
Mark D Cochran
Original Assignee
Schering Plough Ltd
David E Junker
Mark D Cochran
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34748944&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2005066204(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to EP04815235A priority Critical patent/EP1699820A2/en
Priority to BRPI0418317-7A priority patent/BRPI0418317A/en
Priority to CA002551877A priority patent/CA2551877A1/en
Priority to MXPA06007514A priority patent/MXPA06007514A/en
Priority to JP2006547309A priority patent/JP2007535912A/en
Application filed by Schering Plough Ltd, David E Junker, Mark D Cochran filed Critical Schering Plough Ltd
Priority to AU2004312411A priority patent/AU2004312411B8/en
Priority to NZ547593A priority patent/NZ547593A/en
Publication of WO2005066204A2 publication Critical patent/WO2005066204A2/en
Publication of WO2005066204A3 publication Critical patent/WO2005066204A3/en
Priority to IL176494A priority patent/IL176494A0/en
Priority to NO20063478A priority patent/NO20063478L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/06—Anabolic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Abstract

The invention provides new, specific antigenic peptides from the protein GDF8. The invention also provides fusion proteins comprising the new peptides, immunogens and vaccines based on the new peptides and/or fusion proteins, antibodies that specifically bind to the new peptides of GDF8, and methods of treating animals in order to modulate the activity of GDF8, employing vaccines or antibodies according to the invention.
PCT/US2004/043125 2003-12-31 2004-12-21 Neutralizing epitope-based growth enhancing vaccine WO2005066204A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
NZ547593A NZ547593A (en) 2003-12-31 2004-12-21 Neutralizing epitope-based growth enhancing vaccine
BRPI0418317-7A BRPI0418317A (en) 2003-12-31 2004-12-21 neutralization epitope-based growth enhancement vaccine
CA002551877A CA2551877A1 (en) 2003-12-31 2004-12-21 Neutralizing epitope-based growth enhancing vaccine
MXPA06007514A MXPA06007514A (en) 2003-12-31 2004-12-21 Neutralizing epitope-based growth enhancing vaccine.
JP2006547309A JP2007535912A (en) 2003-12-31 2004-12-21 Neutralizing epitope-based growth-enhancing vaccine
EP04815235A EP1699820A2 (en) 2003-12-31 2004-12-21 Neutralizing epitope-based growth enhancing vaccine
AU2004312411A AU2004312411B8 (en) 2003-12-31 2004-12-21 Neutralizing epitope-based growth enhancing vaccine
IL176494A IL176494A0 (en) 2003-12-31 2006-06-22 Neutralizing epitope-based growth enhancing vaccine
NO20063478A NO20063478L (en) 2003-12-31 2006-07-28 Neutralizing epitope-based growth-promoting vaccine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53371903P 2003-12-31 2003-12-31
US60/533,719 2003-12-31

Publications (2)

Publication Number Publication Date
WO2005066204A2 WO2005066204A2 (en) 2005-07-21
WO2005066204A3 true WO2005066204A3 (en) 2005-08-11

Family

ID=34748944

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/043125 WO2005066204A2 (en) 2003-12-31 2004-12-21 Neutralizing epitope-based growth enhancing vaccine

Country Status (21)

Country Link
US (3) US7371726B2 (en)
EP (1) EP1699820A2 (en)
JP (2) JP2007535912A (en)
KR (1) KR20060120229A (en)
CN (1) CN1902221A (en)
AR (1) AR047345A1 (en)
AU (1) AU2004312411B8 (en)
BR (1) BRPI0418317A (en)
CA (1) CA2551877A1 (en)
EC (1) ECSP066683A (en)
IL (1) IL176494A0 (en)
MX (1) MXPA06007514A (en)
NO (1) NO20063478L (en)
NZ (1) NZ547593A (en)
PE (1) PE20051050A1 (en)
RU (1) RU2422460C2 (en)
SG (1) SG153874A1 (en)
TW (1) TWI357906B (en)
UA (1) UA93855C2 (en)
WO (1) WO2005066204A2 (en)
ZA (1) ZA200605227B (en)

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US8426194B2 (en) * 2003-01-21 2013-04-23 Ptc Therapeutics, Inc. Methods and agents for screening for compounds capable of modulating VEGF expression
CN1902221A (en) * 2003-12-31 2007-01-24 先灵-普劳有限公司 Neutralizing epitope-based growth enhancing vaccine
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WO2006073827A2 (en) * 2004-12-30 2006-07-13 Schering-Plough Ltd. Neutralizing epitope-based growth enhancing vaccine
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UA92504C2 (en) * 2005-10-12 2010-11-10 Эли Лилли Энд Компани Anti-myostatin monoclonal antibody
IN2014DN10515A (en) 2006-03-31 2015-08-21 Chugai Pharmaceutical Co Ltd
AU2013231037B2 (en) * 2006-08-03 2016-05-12 Myostin Therapeutics Pty Ltd Myostatin antagonists
AU2007279456A1 (en) * 2006-08-03 2008-02-07 Myostin Therapeutics Pty Ltd Myostatin antagonists
CA2661836A1 (en) * 2006-09-05 2008-03-13 Eli Lilly And Company Anti-myostatin antibodies
US8283115B1 (en) 2007-06-20 2012-10-09 Ptc Therapeutics, Inc. Methods of screening for compounds for treating muscular dystrophy using UTRN mRNA translation regulation
US8283116B1 (en) 2007-06-22 2012-10-09 Ptc Therapeutics, Inc. Methods of screening for compounds for treating spinal muscular atrophy using SMN mRNA translation regulation
CA2700701C (en) 2007-09-26 2020-12-29 Chugai Seiyaku Kabushiki Kaisha Method of modifying isoelectric point of antibody via amino acid substitution in cdr
SG189775A1 (en) 2008-04-11 2013-05-31 Chugai Pharmaceutical Co Ltd Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
JO3340B1 (en) 2010-05-26 2019-03-13 Regeneron Pharma Antibodies to human gdf8
TW201210612A (en) * 2010-06-03 2012-03-16 Glaxo Group Ltd Humanised antigen binding proteins
AU2011292197B2 (en) 2010-08-16 2015-05-28 Amgen Inc. Antibodies that bind myostatin, compositions and methods
CN103328632A (en) 2010-11-30 2013-09-25 中外制药株式会社 Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly
DK2780368T3 (en) 2011-11-14 2018-02-05 Regeneron Pharma COMPOSITIONS AND PROCEDURES FOR INCREASING MUSCLE MASS AND MUSCLE STRENGTH BY SPECIFIC ANTAGONIZATION OF GDF8 AND / OR ACTIVIN A
WO2014030750A1 (en) 2012-08-24 2014-02-27 中外製薬株式会社 MOUSE FcγRII-SPECIFIC Fc ANTIBODY
WO2014163101A1 (en) 2013-04-02 2014-10-09 中外製薬株式会社 Fc region variant
EP2981822B1 (en) 2013-05-06 2020-09-02 Scholar Rock, Inc. Compositions and methods for growth factor modulation
TWI655207B (en) 2013-07-30 2019-04-01 再生元醫藥公司 Anti-activin A antibody and use thereof
US10307480B2 (en) 2014-11-06 2019-06-04 Scholar Rock, Inc. Anti-pro/latent-myostatin antibodies and uses thereof
CR20170326A (en) 2014-12-19 2017-08-22 Chugai Pharmaceutical Co Ltd ANTIMIOSTATINE ANTIBODIES, POLYPEPTIDES CONTAINING VARIANTS FC REGIONS, AND METHODS OF USE
WO2016125495A1 (en) 2015-02-05 2016-08-11 Chugai Seiyaku Kabushiki Kaisha Antibodies comprising an ion concentration dependent antigen-binding domain, fc region variants, il-8-binding antibodies, and uses therof
WO2016168613A1 (en) 2015-04-15 2016-10-20 Regeneron Pharmaceuticals, Inc. Methods of increasing strength and functionality with gdf8 inhibitors
CA3036652A1 (en) * 2015-09-15 2017-03-23 Scholar Rock, Inc. Anti-pro/latent-myostatin antibodies and uses thereof
WO2017110981A1 (en) 2015-12-25 2017-06-29 Chugai Seiyaku Kabushiki Kaisha Anti-myostatin antibodies and methods of use
WO2017120523A2 (en) 2016-01-08 2017-07-13 Scholar Rock, Inc. Anti-pro/latent myostatin antibodies and methods of use thereof
EP4218804A3 (en) 2016-06-13 2023-09-13 Scholar Rock, Inc. Use of myostatin inhibitors and combination therapies
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Also Published As

Publication number Publication date
AR047345A1 (en) 2006-01-18
ECSP066683A (en) 2006-10-25
JP2011083290A (en) 2011-04-28
US7892561B2 (en) 2011-02-22
JP2007535912A (en) 2007-12-13
US20080227156A1 (en) 2008-09-18
US7585648B2 (en) 2009-09-08
US7371726B2 (en) 2008-05-13
MXPA06007514A (en) 2006-08-31
PE20051050A1 (en) 2005-12-12
AU2004312411B8 (en) 2011-11-24
IL176494A0 (en) 2006-10-05
NO20063478L (en) 2006-08-28
US20090311282A1 (en) 2009-12-17
UA93855C2 (en) 2011-03-25
NZ547593A (en) 2009-09-25
EP1699820A2 (en) 2006-09-13
KR20060120229A (en) 2006-11-24
SG153874A1 (en) 2009-07-29
TWI357906B (en) 2012-02-11
TW200526683A (en) 2005-08-16
CN1902221A (en) 2007-01-24
AU2004312411A1 (en) 2005-07-21
RU2422460C2 (en) 2011-06-27
RU2006127314A (en) 2008-02-10
WO2005066204A2 (en) 2005-07-21
ZA200605227B (en) 2007-03-28
BRPI0418317A (en) 2007-05-02
CA2551877A1 (en) 2005-07-21
US20050143306A1 (en) 2005-06-30
AU2004312411B2 (en) 2011-11-03

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