WO2005065241A3 - Smmr (small molecule metabolite reporters) for use as in vivo glucose biosensors - Google Patents

Smmr (small molecule metabolite reporters) for use as in vivo glucose biosensors Download PDF

Info

Publication number
WO2005065241A3
WO2005065241A3 PCT/US2004/043087 US2004043087W WO2005065241A3 WO 2005065241 A3 WO2005065241 A3 WO 2005065241A3 US 2004043087 W US2004043087 W US 2004043087W WO 2005065241 A3 WO2005065241 A3 WO 2005065241A3
Authority
WO
WIPO (PCT)
Prior art keywords
small molecule
smmr
molecule metabolite
vivo glucose
glucose biosensors
Prior art date
Application number
PCT/US2004/043087
Other languages
French (fr)
Other versions
WO2005065241A2 (en
Inventor
Emile M Bellott
Dongsheng Bu
James J Childs
Christopher R Lambert
Hubert A Nienaber
Shirley J Shi
Zhaolin Wang
Jerome J Workman Jr
Alex R Zelenchuk
Original Assignee
Argose Inc
Emile M Bellott
Dongsheng Bu
James J Childs
Christopher R Lambert
Hubert A Nienaber
Shirley J Shi
Zhaolin Wang
Jerome J Workman Jr
Alex R Zelenchuk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Argose Inc, Emile M Bellott, Dongsheng Bu, James J Childs, Christopher R Lambert, Hubert A Nienaber, Shirley J Shi, Zhaolin Wang, Jerome J Workman Jr, Alex R Zelenchuk filed Critical Argose Inc
Priority to US10/584,821 priority Critical patent/US8029765B2/en
Publication of WO2005065241A2 publication Critical patent/WO2005065241A2/en
Publication of WO2005065241A3 publication Critical patent/WO2005065241A3/en
Priority to US11/475,784 priority patent/US8008088B2/en
Priority to US13/215,061 priority patent/US8466286B2/en
Priority to US13/919,923 priority patent/US20140127137A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]
    • Y10T436/144444—Glucose

Abstract

Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
PCT/US2004/043087 2003-12-24 2004-12-23 Smmr (small molecule metabolite reporters) for use as in vivo glucose biosensors WO2005065241A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US10/584,821 US8029765B2 (en) 2003-12-24 2004-12-23 SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors
US11/475,784 US8008088B2 (en) 2003-12-24 2006-06-26 SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors
US13/215,061 US8466286B2 (en) 2003-12-24 2011-08-22 SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors
US13/919,923 US20140127137A1 (en) 2003-12-24 2013-06-17 Smmr (small molecule metabolite reporters) for use as in vivo glucose biosensors

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US53266703P 2003-12-24 2003-12-24
US60/532,667 2003-12-24
US57117004P 2004-05-14 2004-05-14
US60/571,170 2004-05-14

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US10/584,821 A-371-Of-International US8029765B2 (en) 2003-12-24 2004-12-23 SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors
US11/475,784 Continuation US8008088B2 (en) 2003-12-24 2006-06-26 SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors
US13/215,061 Continuation US8466286B2 (en) 2003-12-24 2011-08-22 SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors

Publications (2)

Publication Number Publication Date
WO2005065241A2 WO2005065241A2 (en) 2005-07-21
WO2005065241A3 true WO2005065241A3 (en) 2006-05-04

Family

ID=34752980

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/043087 WO2005065241A2 (en) 2003-12-24 2004-12-23 Smmr (small molecule metabolite reporters) for use as in vivo glucose biosensors

Country Status (2)

Country Link
US (4) US8029765B2 (en)
WO (1) WO2005065241A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8838195B2 (en) 2007-02-06 2014-09-16 Medtronic Minimed, Inc. Optical systems and methods for ratiometric measurement of blood glucose concentration
US8979790B2 (en) 2007-11-21 2015-03-17 Medtronic Minimed, Inc. Use of an equilibrium sensor to monitor glucose concentration
US8983565B2 (en) 2007-02-06 2015-03-17 Medtronic Minimed, Inc. Optical determination of pH and glucose

Families Citing this family (290)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9702434A (en) 1991-03-07 1998-05-31 Masimo Corp Signal processing apparatus.
US5638818A (en) 1991-03-21 1997-06-17 Masimo Corporation Low noise optical probe
EP1905352B1 (en) 1994-10-07 2014-07-16 Masimo Corporation Signal processing method
US8019400B2 (en) 1994-10-07 2011-09-13 Masimo Corporation Signal processing apparatus
US5758644A (en) 1995-06-07 1998-06-02 Masimo Corporation Manual and automatic probe calibration
US6002952A (en) 1997-04-14 1999-12-14 Masimo Corporation Signal processing apparatus and method
US6229856B1 (en) 1997-04-14 2001-05-08 Masimo Corporation Method and apparatus for demodulating signals in a pulse oximetry system
AU4214199A (en) 1998-06-03 1999-12-20 Masimo Corporation Stereo pulse oximeter
US7245953B1 (en) 1999-04-12 2007-07-17 Masimo Corporation Reusable pulse oximeter probe and disposable bandage apparatii
US6721585B1 (en) 1998-10-15 2004-04-13 Sensidyne, Inc. Universal modular pulse oximeter probe for use with reusable and disposable patient attachment devices
US6463311B1 (en) 1998-12-30 2002-10-08 Masimo Corporation Plethysmograph pulse recognition processor
US6684090B2 (en) 1999-01-07 2004-01-27 Masimo Corporation Pulse oximetry data confidence indicator
US6360114B1 (en) 1999-03-25 2002-03-19 Masimo Corporation Pulse oximeter probe-off detector
US6377829B1 (en) 1999-12-09 2002-04-23 Masimo Corporation Resposable pulse oximetry sensor
WO2002015781A1 (en) 2000-08-18 2002-02-28 Masimo Corporation Dual-mode pulse oximeter
US6850787B2 (en) 2001-06-29 2005-02-01 Masimo Laboratories, Inc. Signal component processor
US6697658B2 (en) 2001-07-02 2004-02-24 Masimo Corporation Low power pulse oximeter
US7355512B1 (en) 2002-01-24 2008-04-08 Masimo Corporation Parallel alarm processor
US6850788B2 (en) 2002-03-25 2005-02-01 Masimo Corporation Physiological measurement communications adapter
US6970792B1 (en) 2002-12-04 2005-11-29 Masimo Laboratories, Inc. Systems and methods for determining blood oxygen saturation values using complex number encoding
US7919713B2 (en) 2007-04-16 2011-04-05 Masimo Corporation Low noise oximetry cable including conductive cords
US6920345B2 (en) 2003-01-24 2005-07-19 Masimo Corporation Optical sensor including disposable and reusable elements
US7003338B2 (en) 2003-07-08 2006-02-21 Masimo Corporation Method and apparatus for reducing coupling between signals
US7500950B2 (en) 2003-07-25 2009-03-10 Masimo Corporation Multipurpose sensor port
US7483729B2 (en) 2003-11-05 2009-01-27 Masimo Corporation Pulse oximeter access apparatus and method
WO2005065241A2 (en) * 2003-12-24 2005-07-21 Argose, Inc. Smmr (small molecule metabolite reporters) for use as in vivo glucose biosensors
US7438683B2 (en) 2004-03-04 2008-10-21 Masimo Corporation Application identification sensor
WO2005087097A1 (en) 2004-03-08 2005-09-22 Masimo Corporation Physiological parameter system
CA2464029A1 (en) 2004-04-08 2005-10-08 Valery Telfort Non-invasive ventilation monitor
US7254429B2 (en) 2004-08-11 2007-08-07 Glucolight Corporation Method and apparatus for monitoring glucose levels in a biological tissue
US8036727B2 (en) 2004-08-11 2011-10-11 Glt Acquisition Corp. Methods for noninvasively measuring analyte levels in a subject
WO2006094107A1 (en) 2005-03-01 2006-09-08 Masimo Laboratories, Inc. Physiological parameter confidence measure
EP1874178A4 (en) 2005-04-13 2009-12-09 Glucolight Corp Method for data reduction and calibration of an oct-based blood glucose monitor
US20070036682A1 (en) * 2005-08-15 2007-02-15 Honeywell International Inc. Microoptic glucose detector
US7962188B2 (en) 2005-10-14 2011-06-14 Masimo Corporation Robust alarm system
EP2374407B1 (en) 2005-11-29 2021-05-05 Masimo Corporation Optical sensor including disposable and reusable elements
US8182443B1 (en) 2006-01-17 2012-05-22 Masimo Corporation Drug administration controller
US8219172B2 (en) 2006-03-17 2012-07-10 Glt Acquisition Corp. System and method for creating a stable optical interface
US7941199B2 (en) 2006-05-15 2011-05-10 Masimo Laboratories, Inc. Sepsis monitor
US8998809B2 (en) 2006-05-15 2015-04-07 Cercacor Laboratories, Inc. Systems and methods for calibrating minimally invasive and non-invasive physiological sensor devices
US9176141B2 (en) 2006-05-15 2015-11-03 Cercacor Laboratories, Inc. Physiological monitor calibration system
US20070276211A1 (en) * 2006-05-26 2007-11-29 Jose Mir Compact minimally invasive biomedical monitor
WO2007140478A2 (en) 2006-05-31 2007-12-06 Masimo Corporation Respiratory monitoring
US10188348B2 (en) 2006-06-05 2019-01-29 Masimo Corporation Parameter upgrade system
US20100100005A1 (en) * 2006-07-11 2010-04-22 Infotonics Technology Center, Inc. Minimally invasive allergy testing system with coated allergens
US8457707B2 (en) 2006-09-20 2013-06-04 Masimo Corporation Congenital heart disease monitor
US9161696B2 (en) 2006-09-22 2015-10-20 Masimo Corporation Modular patient monitor
US8840549B2 (en) 2006-09-22 2014-09-23 Masimo Corporation Modular patient monitor
US7880626B2 (en) 2006-10-12 2011-02-01 Masimo Corporation System and method for monitoring the life of a physiological sensor
EP2073692B1 (en) 2006-10-12 2017-07-26 Masimo Corporation Perfusion index smoothing
US9861305B1 (en) 2006-10-12 2018-01-09 Masimo Corporation Method and apparatus for calibration to reduce coupling between signals in a measurement system
US8265723B1 (en) 2006-10-12 2012-09-11 Cercacor Laboratories, Inc. Oximeter probe off indicator defining probe off space
US9192329B2 (en) 2006-10-12 2015-11-24 Masimo Corporation Variable mode pulse indicator
US8255026B1 (en) 2006-10-12 2012-08-28 Masimo Corporation, Inc. Patient monitor capable of monitoring the quality of attached probes and accessories
US8600467B2 (en) 2006-11-29 2013-12-03 Cercacor Laboratories, Inc. Optical sensor including disposable and reusable elements
EP2096994B1 (en) 2006-12-09 2018-10-03 Masimo Corporation Plethysmograph variability determination
US8852094B2 (en) 2006-12-22 2014-10-07 Masimo Corporation Physiological parameter system
US8652060B2 (en) 2007-01-20 2014-02-18 Masimo Corporation Perfusion trend indicator
US8781544B2 (en) 2007-03-27 2014-07-15 Cercacor Laboratories, Inc. Multiple wavelength optical sensor
US8374665B2 (en) 2007-04-21 2013-02-12 Cercacor Laboratories, Inc. Tissue profile wellness monitor
WO2008157325A2 (en) * 2007-06-15 2008-12-24 Charles Stark Draper Laboratory, Inc. Devices, systems, and methods for measuring glucose
US8764671B2 (en) 2007-06-28 2014-07-01 Masimo Corporation Disposable active pulse sensor
US8981100B2 (en) 2007-07-27 2015-03-17 Life Technologies Corporation Use of novel coumarins as glutathione and thiol labels
US8328720B2 (en) * 2007-08-10 2012-12-11 Infotonics Technology Center, Inc. MEMS interstitial prothrombin time test
US8048040B2 (en) 2007-09-13 2011-11-01 Masimo Corporation Fluid titration system
US8310336B2 (en) 2008-10-10 2012-11-13 Masimo Corporation Systems and methods for storing, analyzing, retrieving and displaying streaming medical data
EP2227843B1 (en) 2007-10-12 2019-03-06 Masimo Corporation Connector assembly
US20090247984A1 (en) * 2007-10-24 2009-10-01 Masimo Laboratories, Inc. Use of microneedles for small molecule metabolite reporter delivery
EP2232243B1 (en) * 2007-12-20 2015-12-16 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO Real-time method for the detection of viable micro-organisms
US8571617B2 (en) 2008-03-04 2013-10-29 Glt Acquisition Corp. Flowometry in optical coherence tomography for analyte level estimation
JP5575752B2 (en) 2008-05-02 2014-08-20 マシモ コーポレイション Monitor configuration system
EP2312995B1 (en) 2008-05-05 2017-06-28 Masimo Corporation Pulse oximetry system with electrical decoupling circuitry
US8181531B2 (en) * 2008-06-27 2012-05-22 Edwin Carlen Accessible stress-based electrostatic monitoring of chemical reactions and binding
US8577431B2 (en) 2008-07-03 2013-11-05 Cercacor Laboratories, Inc. Noise shielding for a noninvasive device
US8203438B2 (en) 2008-07-29 2012-06-19 Masimo Corporation Alarm suspend system
US8203704B2 (en) 2008-08-04 2012-06-19 Cercacor Laboratories, Inc. Multi-stream sensor for noninvasive measurement of blood constituents
US9011670B2 (en) * 2008-08-14 2015-04-21 The Charles Stark Draper Laboratory, Inc. Three-dimensional metal ion sensor arrays on printed circuit boards
WO2010031070A2 (en) 2008-09-15 2010-03-18 Masimo Corporation Patient monitor including multi-parameter graphical display
SE532941C2 (en) 2008-09-15 2010-05-18 Phasein Ab Gas sampling line for breathing gases
DE102008049675A1 (en) 2008-09-30 2010-04-01 Markus Dr. Heinrich Process for the preparation of 3-aminobiphenyls
US8346330B2 (en) 2008-10-13 2013-01-01 Masimo Corporation Reflection-detector sensor position indicator
US8401602B2 (en) 2008-10-13 2013-03-19 Masimo Corporation Secondary-emitter sensor position indicator
PL3112358T3 (en) * 2008-12-10 2020-11-16 Wista Laboratories Ltd. 3,6-disubstituted xanthylium salts
US8771204B2 (en) 2008-12-30 2014-07-08 Masimo Corporation Acoustic sensor assembly
US8588880B2 (en) 2009-02-16 2013-11-19 Masimo Corporation Ear sensor
US10032002B2 (en) 2009-03-04 2018-07-24 Masimo Corporation Medical monitoring system
US9323894B2 (en) 2011-08-19 2016-04-26 Masimo Corporation Health care sanitation monitoring system
US10007758B2 (en) 2009-03-04 2018-06-26 Masimo Corporation Medical monitoring system
US9218454B2 (en) 2009-03-04 2015-12-22 Masimo Corporation Medical monitoring system
US8388353B2 (en) 2009-03-11 2013-03-05 Cercacor Laboratories, Inc. Magnetic connector
US8989831B2 (en) 2009-05-19 2015-03-24 Masimo Corporation Disposable components for reusable physiological sensor
US8571619B2 (en) 2009-05-20 2013-10-29 Masimo Corporation Hemoglobin display and patient treatment
US8471713B2 (en) 2009-07-24 2013-06-25 Cercacor Laboratories, Inc. Interference detector for patient monitor
US8473020B2 (en) 2009-07-29 2013-06-25 Cercacor Laboratories, Inc. Non-invasive physiological sensor cover
US8688183B2 (en) 2009-09-03 2014-04-01 Ceracor Laboratories, Inc. Emitter driver for noninvasive patient monitor
US9579039B2 (en) 2011-01-10 2017-02-28 Masimo Corporation Non-invasive intravascular volume index monitor
US20110137297A1 (en) 2009-09-17 2011-06-09 Kiani Massi Joe E Pharmacological management system
DE112010003689T5 (en) 2009-09-17 2013-01-17 Marcelo Lamego Improved analyte monitoring using one or more accelerometers
US20110082711A1 (en) 2009-10-06 2011-04-07 Masimo Laboratories, Inc. Personal digital assistant or organizer for monitoring glucose levels
US8741591B2 (en) 2009-10-09 2014-06-03 The Research Foundation For The State University Of New York pH-insensitive glucose indicator protein
US9066680B1 (en) 2009-10-15 2015-06-30 Masimo Corporation System for determining confidence in respiratory rate measurements
EP3735899B1 (en) 2009-10-15 2023-11-29 Masimo Corporation Acoustic respiratory monitoring sensor having multiple sensing elements
WO2011047216A2 (en) 2009-10-15 2011-04-21 Masimo Corporation Physiological acoustic monitoring system
US8790268B2 (en) 2009-10-15 2014-07-29 Masimo Corporation Bidirectional physiological information display
US8821415B2 (en) 2009-10-15 2014-09-02 Masimo Corporation Physiological acoustic monitoring system
US9724016B1 (en) 2009-10-16 2017-08-08 Masimo Corp. Respiration processor
US9839381B1 (en) 2009-11-24 2017-12-12 Cercacor Laboratories, Inc. Physiological measurement system with automatic wavelength adjustment
DE112010004682T5 (en) 2009-12-04 2013-03-28 Masimo Corporation Calibration for multi-level physiological monitors
WO2011084713A1 (en) * 2009-12-17 2011-07-14 Glumetrics, Inc. Glucose sensor and controller with user selectable output
US9153112B1 (en) 2009-12-21 2015-10-06 Masimo Corporation Modular patient monitor
WO2011091059A1 (en) 2010-01-19 2011-07-28 Masimo Corporation Wellness analysis system
GB2490832B (en) 2010-03-01 2016-09-21 Masimo Corp Adaptive alarm system
WO2011112524A1 (en) 2010-03-08 2011-09-15 Masimo Corporation Reprocessing of a physiological sensor
US9307928B1 (en) 2010-03-30 2016-04-12 Masimo Corporation Plethysmographic respiration processor
US9138180B1 (en) 2010-05-03 2015-09-22 Masimo Corporation Sensor adapter cable
US8666468B1 (en) 2010-05-06 2014-03-04 Masimo Corporation Patient monitor for determining microcirculation state
US10010272B2 (en) 2010-05-27 2018-07-03 Profusa, Inc. Tissue-integrating electronic apparatus
US9326712B1 (en) 2010-06-02 2016-05-03 Masimo Corporation Opticoustic sensor
US8740792B1 (en) 2010-07-12 2014-06-03 Masimo Corporation Patient monitor capable of accounting for environmental conditions
US9408542B1 (en) 2010-07-22 2016-08-09 Masimo Corporation Non-invasive blood pressure measurement system
WO2012027613A1 (en) 2010-08-26 2012-03-01 Masimo Corporation Blood pressure measurement system
US20120076736A1 (en) * 2010-09-17 2012-03-29 Rochester Institute Of Technology Host supported genetic biosensors
JP5710767B2 (en) 2010-09-28 2015-04-30 マシモ コーポレイション Depth of consciousness monitor including oximeter
US9775545B2 (en) 2010-09-28 2017-10-03 Masimo Corporation Magnetic electrical connector for patient monitors
CN103260501B (en) 2010-10-06 2015-09-02 普罗弗萨股份有限公司 Tissue integration sensor
US9211095B1 (en) 2010-10-13 2015-12-15 Masimo Corporation Physiological measurement logic engine
US8723677B1 (en) 2010-10-20 2014-05-13 Masimo Corporation Patient safety system with automatically adjusting bed
US20120226117A1 (en) 2010-12-01 2012-09-06 Lamego Marcelo M Handheld processing device including medical applications for minimally and non invasive glucose measurements
EP2673721A1 (en) 2011-02-13 2013-12-18 Masimo Corporation Medical characterization system
DE102011012343A1 (en) * 2011-02-24 2012-08-30 TriOpto Tec GmbH Phenalen-1-one derivatives, process for the preparation and use thereof
US9066666B2 (en) 2011-02-25 2015-06-30 Cercacor Laboratories, Inc. Patient monitor for monitoring microcirculation
JP5751667B2 (en) * 2011-03-22 2015-07-22 国立大学法人広島大学 Moisture detection method
US10244981B2 (en) 2011-03-30 2019-04-02 SensiVida Medical Technologies, Inc. Skin test image analysis apparatuses and methods thereof
US8830449B1 (en) 2011-04-18 2014-09-09 Cercacor Laboratories, Inc. Blood analysis system
US9095316B2 (en) 2011-04-20 2015-08-04 Masimo Corporation System for generating alarms based on alarm patterns
US9622692B2 (en) 2011-05-16 2017-04-18 Masimo Corporation Personal health device
US9986919B2 (en) 2011-06-21 2018-06-05 Masimo Corporation Patient monitoring system
US9532722B2 (en) 2011-06-21 2017-01-03 Masimo Corporation Patient monitoring system
US9245668B1 (en) 2011-06-29 2016-01-26 Cercacor Laboratories, Inc. Low noise cable providing communication between electronic sensor components and patient monitor
US11439329B2 (en) 2011-07-13 2022-09-13 Masimo Corporation Multiple measurement mode in a physiological sensor
US9192351B1 (en) 2011-07-22 2015-11-24 Masimo Corporation Acoustic respiratory monitoring sensor with probe-off detection
US8755872B1 (en) 2011-07-28 2014-06-17 Masimo Corporation Patient monitoring system for indicating an abnormal condition
US9782077B2 (en) 2011-08-17 2017-10-10 Masimo Corporation Modulated physiological sensor
US9808188B1 (en) 2011-10-13 2017-11-07 Masimo Corporation Robust fractional saturation determination
EP2766834B1 (en) 2011-10-13 2022-04-20 Masimo Corporation Medical monitoring hub
US9943269B2 (en) 2011-10-13 2018-04-17 Masimo Corporation System for displaying medical monitoring data
WO2013056141A1 (en) 2011-10-13 2013-04-18 Masimo Corporation Physiological acoustic monitoring system
US9778079B1 (en) 2011-10-27 2017-10-03 Masimo Corporation Physiological monitor gauge panel
US9445759B1 (en) 2011-12-22 2016-09-20 Cercacor Laboratories, Inc. Blood glucose calibration system
US11172890B2 (en) 2012-01-04 2021-11-16 Masimo Corporation Automated condition screening and detection
US9392945B2 (en) 2012-01-04 2016-07-19 Masimo Corporation Automated CCHD screening and detection
US10149616B2 (en) 2012-02-09 2018-12-11 Masimo Corporation Wireless patient monitoring device
US9480435B2 (en) 2012-02-09 2016-11-01 Masimo Corporation Configurable patient monitoring system
US10307111B2 (en) 2012-02-09 2019-06-04 Masimo Corporation Patient position detection system
EP2845086B1 (en) 2012-03-25 2021-12-22 Masimo Corporation Physiological monitor touchscreen interface
EP4268712A3 (en) 2012-04-17 2024-01-17 Masimo Corporation Hypersaturation index
WO2013184965A1 (en) 2012-06-07 2013-12-12 Masimo Corporation Depth of consciousness monitor
US9697928B2 (en) 2012-08-01 2017-07-04 Masimo Corporation Automated assembly sensor cable
US10827961B1 (en) 2012-08-29 2020-11-10 Masimo Corporation Physiological measurement calibration
US9955937B2 (en) 2012-09-20 2018-05-01 Masimo Corporation Acoustic patient sensor coupler
US9877650B2 (en) 2012-09-20 2018-01-30 Masimo Corporation Physiological monitor with mobile computing device connectivity
US9749232B2 (en) 2012-09-20 2017-08-29 Masimo Corporation Intelligent medical network edge router
US9717458B2 (en) 2012-10-20 2017-08-01 Masimo Corporation Magnetic-flap optical sensor
US9560996B2 (en) 2012-10-30 2017-02-07 Masimo Corporation Universal medical system
US9787568B2 (en) 2012-11-05 2017-10-10 Cercacor Laboratories, Inc. Physiological test credit method
US9750461B1 (en) 2013-01-02 2017-09-05 Masimo Corporation Acoustic respiratory monitoring sensor with probe-off detection
US9724025B1 (en) 2013-01-16 2017-08-08 Masimo Corporation Active-pulse blood analysis system
US9750442B2 (en) 2013-03-09 2017-09-05 Masimo Corporation Physiological status monitor
US10441181B1 (en) 2013-03-13 2019-10-15 Masimo Corporation Acoustic pulse and respiration monitoring system
US9965946B2 (en) 2013-03-13 2018-05-08 Masimo Corporation Systems and methods for monitoring a patient health network
US9474474B2 (en) 2013-03-14 2016-10-25 Masimo Corporation Patient monitor as a minimally invasive glucometer
US9986952B2 (en) 2013-03-14 2018-06-05 Masimo Corporation Heart sound simulator
US9936917B2 (en) 2013-03-14 2018-04-10 Masimo Laboratories, Inc. Patient monitor placement indicator
EP3488871B1 (en) * 2013-03-14 2020-09-02 Profusa, Inc. Oxygen sensors
CA2904031A1 (en) 2013-03-14 2014-10-02 Profusa, Inc. Method and device for correcting optical signals
US10456038B2 (en) 2013-03-15 2019-10-29 Cercacor Laboratories, Inc. Cloud-based physiological monitoring system
US9380981B2 (en) 2013-03-15 2016-07-05 Covidien Lp Photoacoustic monitoring technique with noise reduction
JP2014215416A (en) * 2013-04-25 2014-11-17 Jsr株式会社 Coloring composition, colored cured film and display element
US9891079B2 (en) 2013-07-17 2018-02-13 Masimo Corporation Pulser with double-bearing position encoder for non-invasive physiological monitoring
WO2015020911A2 (en) 2013-08-05 2015-02-12 Cercacor Laboratories, Inc. Blood pressure monitor with valve-chamber assembly
WO2015038683A2 (en) 2013-09-12 2015-03-19 Cercacor Laboratories, Inc. Medical device management system
US10010276B2 (en) 2013-10-07 2018-07-03 Masimo Corporation Regional oximetry user interface
US11147518B1 (en) 2013-10-07 2021-10-19 Masimo Corporation Regional oximetry signal processor
US10832818B2 (en) 2013-10-11 2020-11-10 Masimo Corporation Alarm notification system
US10828007B1 (en) 2013-10-11 2020-11-10 Masimo Corporation Acoustic sensor with attachment portion
US10279247B2 (en) 2013-12-13 2019-05-07 Masimo Corporation Avatar-incentive healthcare therapy
US10086138B1 (en) 2014-01-28 2018-10-02 Masimo Corporation Autonomous drug delivery system
US11259745B2 (en) 2014-01-28 2022-03-01 Masimo Corporation Autonomous drug delivery system
US10532174B2 (en) 2014-02-21 2020-01-14 Masimo Corporation Assistive capnography device
EP3140277A1 (en) * 2014-05-07 2017-03-15 Danmarks Tekniske Universitet Method for the preparation of intermediates for carboxy-fluoresceins and novel carboxy-fluorescein
US9924897B1 (en) 2014-06-12 2018-03-27 Masimo Corporation Heated reprocessing of physiological sensors
US10123729B2 (en) 2014-06-13 2018-11-13 Nanthealth, Inc. Alarm fatigue management systems and methods
US10231670B2 (en) 2014-06-19 2019-03-19 Masimo Corporation Proximity sensor in pulse oximeter
US10111591B2 (en) 2014-08-26 2018-10-30 Nanthealth, Inc. Real-time monitoring systems and methods in a healthcare environment
WO2016036985A1 (en) 2014-09-04 2016-03-10 Masimo Corportion Total hemoglobin index system
US10383520B2 (en) 2014-09-18 2019-08-20 Masimo Semiconductor, Inc. Enhanced visible near-infrared photodiode and non-invasive physiological sensor
WO2016057553A1 (en) 2014-10-07 2016-04-14 Masimo Corporation Modular physiological sensors
CN105884686B (en) * 2015-01-22 2020-06-09 中国药科大学 10-substituted acridine-3 (10) -ketone compound, preparation method and application thereof
KR102575058B1 (en) 2015-01-23 2023-09-05 마시모 스웨덴 에이비 Nasal/Oral Cannula Systems and Manufacturing
BR112017016302B1 (en) 2015-02-06 2022-12-06 Masimo Corporation PHYSIOLOGICAL SENSOR MANUFACTURING METHOD WITH EFFICIENT FLEXIBLE CIRCUIT
USD755392S1 (en) 2015-02-06 2016-05-03 Masimo Corporation Pulse oximetry sensor
US10568553B2 (en) 2015-02-06 2020-02-25 Masimo Corporation Soft boot pulse oximetry sensor
KR20230164226A (en) 2015-02-06 2023-12-01 마시모 코오퍼레이션 Connector assembly with pogo pins for use with medical sensors
US10524738B2 (en) 2015-05-04 2020-01-07 Cercacor Laboratories, Inc. Noninvasive sensor system with visual infographic display
WO2016191307A1 (en) 2015-05-22 2016-12-01 Cercacor Laboratories, Inc. Non-invasive optical physiological differential pathlength sensor
US10448871B2 (en) 2015-07-02 2019-10-22 Masimo Corporation Advanced pulse oximetry sensor
AU2016304884B2 (en) 2015-08-11 2021-01-28 Masimo Corporation Medical monitoring analysis and replay including indicia responsive to light attenuated by body tissue
US10736518B2 (en) 2015-08-31 2020-08-11 Masimo Corporation Systems and methods to monitor repositioning of a patient
US11504066B1 (en) 2015-09-04 2022-11-22 Cercacor Laboratories, Inc. Low-noise sensor system
US11679579B2 (en) 2015-12-17 2023-06-20 Masimo Corporation Varnish-coated release liner
EP3408774B1 (en) * 2016-01-29 2023-09-27 University of Virginia Patent Foundation d/b/a University of Virginia Licensing & Ventures Group Method, system, and computer readable medium for virtualization of a continuous glucose monitoring trace
US10993662B2 (en) 2016-03-04 2021-05-04 Masimo Corporation Nose sensor
US10537285B2 (en) 2016-03-04 2020-01-21 Masimo Corporation Nose sensor
US11191484B2 (en) 2016-04-29 2021-12-07 Masimo Corporation Optical sensor tape
US10608817B2 (en) 2016-07-06 2020-03-31 Masimo Corporation Secure and zero knowledge data sharing for cloud applications
US10617302B2 (en) 2016-07-07 2020-04-14 Masimo Corporation Wearable pulse oximeter and respiration monitor
WO2018071715A1 (en) 2016-10-13 2018-04-19 Masimo Corporation Systems and methods for patient fall detection
US11504058B1 (en) 2016-12-02 2022-11-22 Masimo Corporation Multi-site noninvasive measurement of a physiological parameter
WO2018119204A1 (en) 2016-12-21 2018-06-28 Profusa, Inc. Polymerizable near-ir dyes
US11331018B2 (en) 2016-12-22 2022-05-17 Profusa, Inc. System and single-channel biosensor for and method of determining analyte value
WO2018119239A1 (en) 2016-12-22 2018-06-28 Cercacor Laboratories, Inc Methods and devices for detecting intensity of light with translucent detector
US10721785B2 (en) 2017-01-18 2020-07-21 Masimo Corporation Patient-worn wireless physiological sensor with pairing functionality
US10388120B2 (en) 2017-02-24 2019-08-20 Masimo Corporation Localized projection of audible noises in medical settings
US10327713B2 (en) 2017-02-24 2019-06-25 Masimo Corporation Modular multi-parameter patient monitoring device
US11086609B2 (en) 2017-02-24 2021-08-10 Masimo Corporation Medical monitoring hub
WO2018156648A1 (en) 2017-02-24 2018-08-30 Masimo Corporation Managing dynamic licenses for physiological parameters in a patient monitoring environment
KR102567007B1 (en) 2017-02-24 2023-08-16 마시모 코오퍼레이션 Medical monitoring data display system
WO2018156809A1 (en) 2017-02-24 2018-08-30 Masimo Corporation Augmented reality system for displaying patient data
CN110891486A (en) 2017-03-10 2020-03-17 梅西莫股份有限公司 Pneumonia screening instrument
CN106967102B (en) * 2017-03-20 2019-03-15 济南大学 A kind of enhanced fluorescence probe of hydrogen peroxide based on Rhodamine Derivatives
WO2018194992A1 (en) 2017-04-18 2018-10-25 Masimo Corporation Nose sensor
US10918281B2 (en) 2017-04-26 2021-02-16 Masimo Corporation Medical monitoring device having multiple configurations
USD835282S1 (en) 2017-04-28 2018-12-04 Masimo Corporation Medical monitoring device
JP7278220B2 (en) 2017-04-28 2023-05-19 マシモ・コーポレイション Spot check measurement system
USD835284S1 (en) 2017-04-28 2018-12-04 Masimo Corporation Medical monitoring device
USD835285S1 (en) 2017-04-28 2018-12-04 Masimo Corporation Medical monitoring device
USD835283S1 (en) 2017-04-28 2018-12-04 Masimo Corporation Medical monitoring device
CN117373636A (en) 2017-05-08 2024-01-09 梅西莫股份有限公司 System for pairing a medical system with a network controller using an adapter
US11026604B2 (en) 2017-07-13 2021-06-08 Cercacor Laboratories, Inc. Medical monitoring device for harmonizing physiological measurements
USD890708S1 (en) 2017-08-15 2020-07-21 Masimo Corporation Connector
US10637181B2 (en) 2017-08-15 2020-04-28 Masimo Corporation Water resistant connector for noninvasive patient monitor
USD906970S1 (en) 2017-08-15 2021-01-05 Masimo Corporation Connector
CN111212599A (en) 2017-10-19 2020-05-29 迈心诺公司 Display arrangement for medical monitoring system
EP3703566B1 (en) 2017-10-31 2023-07-26 Masimo Corporation System for displaying oxygen state indications
USD925597S1 (en) 2017-10-31 2021-07-20 Masimo Corporation Display screen or portion thereof with graphical user interface
WO2019194875A2 (en) 2017-12-28 2019-10-10 Profusa, Inc. Oxidase-based sensors and methods of using
US11766198B2 (en) 2018-02-02 2023-09-26 Cercacor Laboratories, Inc. Limb-worn patient monitoring device
EP3782165A1 (en) 2018-04-19 2021-02-24 Masimo Corporation Mobile patient alarm display
US11883129B2 (en) 2018-04-24 2024-01-30 Cercacor Laboratories, Inc. Easy insert finger sensor for transmission based spectroscopy sensor
US11627919B2 (en) 2018-06-06 2023-04-18 Masimo Corporation Opioid overdose monitoring
US10779098B2 (en) 2018-07-10 2020-09-15 Masimo Corporation Patient monitor alarm speaker analyzer
US11872156B2 (en) 2018-08-22 2024-01-16 Masimo Corporation Core body temperature measurement
US11406286B2 (en) 2018-10-11 2022-08-09 Masimo Corporation Patient monitoring device with improved user interface
USD917564S1 (en) 2018-10-11 2021-04-27 Masimo Corporation Display screen or portion thereof with graphical user interface
USD998630S1 (en) 2018-10-11 2023-09-12 Masimo Corporation Display screen or portion thereof with a graphical user interface
US11389093B2 (en) 2018-10-11 2022-07-19 Masimo Corporation Low noise oximetry cable
BR112021006841A2 (en) 2018-10-11 2021-07-13 Masimo Corporation non-invasive physiological sensor assembly and method of fabricating a connector assembly for a non-invasive sensor assembly
USD998631S1 (en) 2018-10-11 2023-09-12 Masimo Corporation Display screen or portion thereof with a graphical user interface
USD917550S1 (en) 2018-10-11 2021-04-27 Masimo Corporation Display screen or portion thereof with a graphical user interface
USD999246S1 (en) 2018-10-11 2023-09-19 Masimo Corporation Display screen or portion thereof with a graphical user interface
USD916135S1 (en) 2018-10-11 2021-04-13 Masimo Corporation Display screen or portion thereof with a graphical user interface
MX2021004064A (en) 2018-10-12 2021-06-23 Masimo Corp System for transmission of sensor data using dual communication protocol.
USD897098S1 (en) 2018-10-12 2020-09-29 Masimo Corporation Card holder set
US11464410B2 (en) 2018-10-12 2022-10-11 Masimo Corporation Medical systems and methods
US11684296B2 (en) 2018-12-21 2023-06-27 Cercacor Laboratories, Inc. Noninvasive physiological sensor
JP7168169B2 (en) 2019-02-14 2022-11-09 ユニチカ株式会社 Particle detection material and particle detection method using the material
US20200329993A1 (en) 2019-04-17 2020-10-22 Masimo Corporation Electrocardiogram device
WO2021030416A1 (en) * 2019-08-12 2021-02-18 Efferent Labs, Inc. Wearable devices for monitoring physiological changes and methods of use
USD919094S1 (en) 2019-08-16 2021-05-11 Masimo Corporation Blood pressure device
USD985498S1 (en) 2019-08-16 2023-05-09 Masimo Corporation Connector
USD919100S1 (en) 2019-08-16 2021-05-11 Masimo Corporation Holder for a patient monitor
USD917704S1 (en) 2019-08-16 2021-04-27 Masimo Corporation Patient monitor
USD921202S1 (en) 2019-08-16 2021-06-01 Masimo Corporation Holder for a blood pressure device
US11832940B2 (en) 2019-08-27 2023-12-05 Cercacor Laboratories, Inc. Non-invasive medical monitoring device for blood analyte measurements
KR20220083771A (en) 2019-10-18 2022-06-20 마시모 코오퍼레이션 Display layouts and interactive objects for patient monitoring
USD927699S1 (en) 2019-10-18 2021-08-10 Masimo Corporation Electrode pad
BR112022007593A2 (en) 2019-10-25 2022-08-23 Cercacor Lab Inc INDICATOR COMPOUNDS, DEVICES INCLUDING INDICATOR COMPOUNDS AND MANUFACTURING AND USE METHODS
US11879960B2 (en) 2020-02-13 2024-01-23 Masimo Corporation System and method for monitoring clinical activities
US11721105B2 (en) 2020-02-13 2023-08-08 Masimo Corporation System and method for monitoring clinical activities
US20210290080A1 (en) 2020-03-20 2021-09-23 Masimo Corporation Remote patient management and monitoring systems and methods
USD933232S1 (en) 2020-05-11 2021-10-12 Masimo Corporation Blood pressure monitor
USD979516S1 (en) 2020-05-11 2023-02-28 Masimo Corporation Connector
USD980091S1 (en) 2020-07-27 2023-03-07 Masimo Corporation Wearable temperature measurement device
USD974193S1 (en) 2020-07-27 2023-01-03 Masimo Corporation Wearable temperature measurement device
USD946597S1 (en) 2020-09-30 2022-03-22 Masimo Corporation Display screen or portion thereof with graphical user interface
USD946596S1 (en) 2020-09-30 2022-03-22 Masimo Corporation Display screen or portion thereof with graphical user interface
USD946598S1 (en) 2020-09-30 2022-03-22 Masimo Corporation Display screen or portion thereof with graphical user interface
USD997365S1 (en) 2021-06-24 2023-08-29 Masimo Corporation Physiological nose sensor
USD1000975S1 (en) 2021-09-22 2023-10-10 Masimo Corporation Wearable temperature measurement device
CN114195811B (en) * 2021-12-29 2023-07-04 湖南师范大学 Synthesis of difunctional fluorescent probe and application of difunctional fluorescent probe in simultaneous distinguishing detection of hydrogen peroxide and HClO

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5208332A (en) * 1991-04-05 1993-05-04 The United States Of America As Represented By The United States Department Of Energy Optical probe for the cytochrome P-450 cholesterol side chain cleavage enzyme
US6150097A (en) * 1996-04-12 2000-11-21 The Public Health Research Institute Of The City Of New York, Inc. Nucleic acid detection probes having non-FRET fluorescence quenching and kits and assays including such probes
US6399392B1 (en) * 1999-04-23 2002-06-04 Molecular Probes, Inc. Xanthene dyes and their application as luminescence quenching compounds

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USH227H (en) 1986-08-29 1987-03-03 The United States Of America As Represented By The Secretary Of The Army Colored smoke-producing composition
US4810636A (en) 1986-12-09 1989-03-07 Miles Inc. Chromogenic acridinone enzyme substrates
US5512246A (en) 1989-09-21 1996-04-30 Anthony P. Russell Method and means for detecting polyhydroxyl compounds
US6040194A (en) 1989-12-14 2000-03-21 Sensor Technologies, Inc. Methods and device for detecting and quantifying substances in body fluids
WO1992019957A2 (en) 1991-05-03 1992-11-12 University Of Maryland At Baltimore Method for optically measuring chemical analytes
US5451343A (en) 1991-05-20 1995-09-19 Spectra Group Limited, Inc. Fluorone and pyronin y derivatives
ATE180018T1 (en) 1991-08-23 1999-05-15 Molecular Probes Inc USE OF HALOALKYL DERIVATIVES OF REPORTER MOLECULES FOR ANALYZING METABOLIC ACTIVITY IN CELLS
GB2284809B (en) 1993-11-07 1998-04-29 Japan Res Dev Corp A fluorescent phenylboronic acid suitable for use in the detection of saccharides
US5605152A (en) 1994-07-18 1997-02-25 Minimed Inc. Optical glucose sensor
US5972199A (en) 1995-10-11 1999-10-26 E. Heller & Company Electrochemical analyte sensors using thermostable peroxidase
US6002954A (en) 1995-11-22 1999-12-14 The Regents Of The University Of California Detection of biological molecules using boronate-based chemical amplification and optical sensors
AU1058297A (en) 1995-11-22 1997-06-11 Minimed, Inc. Detection of biological molecules using chemical amplification and optical sensors
US6766183B2 (en) 1995-11-22 2004-07-20 Medtronic Minimed, Inc. Long wave fluorophore sensor compounds and other fluorescent sensor compounds in polymers
US6162931A (en) 1996-04-12 2000-12-19 Molecular Probes, Inc. Fluorinated xanthene derivatives
WO1998022820A1 (en) 1996-11-21 1998-05-28 Lawrence Livermore National Laboratory Detection of biological molecules using boronate-based chemical amplification and optical sensors
US5954643A (en) 1997-06-09 1999-09-21 Minimid Inc. Insertion set for a transcutaneous sensor
US6130101A (en) 1997-09-23 2000-10-10 Molecular Probes, Inc. Sulfonated xanthene derivatives
US5936087A (en) 1997-11-25 1999-08-10 The Perkin-Elmer Corporation Dibenzorhodamine dyes
US6210910B1 (en) 1998-03-02 2001-04-03 Trustees Of Tufts College Optical fiber biosensor array comprising cell populations confined to microcavities
CA2322858C (en) 1998-03-11 2009-06-02 Sensors For Medicine And Science, Inc. Detection of analytes by fluorescent lanthanide chelates
US6485703B1 (en) 1998-07-31 2002-11-26 The Texas A&M University System Compositions and methods for analyte detection
US6558320B1 (en) 2000-01-20 2003-05-06 Medtronic Minimed, Inc. Handheld personal data assistant (PDA) with a medical device and method of using the same
US6304766B1 (en) 1998-08-26 2001-10-16 Sensors For Medicine And Science Optical-based sensing devices, especially for in-situ sensing in humans
AU770909B2 (en) 1998-08-26 2004-03-04 Sensors For Medicine And Science, Inc. Optical-based sensing devices
US6806089B1 (en) 1998-09-08 2004-10-19 University Of Maryland, Baltimore Low frequency modulation sensors using nanosecond fluorophores
WO2000014515A1 (en) 1998-09-08 2000-03-16 University Of Maryland At Baltimore Low frequency modulation sensors using nanosecond fluorophores
US6360888B1 (en) 1999-02-25 2002-03-26 Minimed Inc. Glucose sensor package system
US6368274B1 (en) 1999-07-01 2002-04-09 Medtronic Minimed, Inc. Reusable analyte sensor site and method of using the same
US7247138B2 (en) 1999-07-01 2007-07-24 Medtronic Minimed, Inc. Reusable analyte sensor site and method of using the same
US6682938B1 (en) 1999-09-15 2004-01-27 The Regents Of The University Of California Glucose sensing molecules having selected fluorescent properties
US6673625B2 (en) 1999-09-15 2004-01-06 The Regents Of The University Of California Saccharide sensing molecules having enhanced fluorescent properties
US7003336B2 (en) 2000-02-10 2006-02-21 Medtronic Minimed, Inc. Analyte sensor method of making the same
US6484045B1 (en) 2000-02-10 2002-11-19 Medtronic Minimed, Inc. Analyte sensor and method of making the same
WO2001075450A2 (en) 2000-04-04 2001-10-11 The Regents Of The University Of California Fluorescent lifetime assays for non-invasive quantification of analytes
US6400974B1 (en) 2000-06-29 2002-06-04 Sensors For Medicine And Science, Inc. Implanted sensor processing system and method for processing implanted sensor output
CN101845116B (en) 2000-08-04 2013-04-24 传感技术股份有限公司 Detection of analytes in aqueous environments
KR20030068136A (en) 2000-10-13 2003-08-19 알자 코포레이션 Apparatus and method for piercing skin with microprotrusions
US6800451B2 (en) 2001-01-05 2004-10-05 Sensors For Medicine And Science, Inc. Detection of glucose in solutions also containing an alpha-hydroxy acid or a beta-diketone
WO2002066986A2 (en) 2001-02-15 2002-08-29 Medtronic Minimed, Inc. Polymers functionalized with fluorescent boronate motifs
US7018840B2 (en) 2001-04-17 2006-03-28 Massachusetts Institute Of Technology Fluorescent metal sensors, and methods of making and using the same
EP1386140A1 (en) 2001-05-04 2004-02-04 Sensors for Medicine and Science, Inc. Electro-optical sensing device with reference channel
US7045361B2 (en) 2001-09-12 2006-05-16 Medtronic Minimed, Inc. Analyte sensing via acridine-based boronate biosensors
TWI293363B (en) 2001-12-11 2008-02-11 Sensors For Med & Science Inc High performance fluorescent optical sensor
US7500949B2 (en) 2002-03-01 2009-03-10 Medtronic Minimed, Inc. Multilumen catheter
SG187267A1 (en) 2003-04-15 2013-02-28 Senseonics Inc Printed circuit device with integrated antenna and implantable sensor processing system with integrated printed circuit board antenna
WO2005065241A2 (en) * 2003-12-24 2005-07-21 Argose, Inc. Smmr (small molecule metabolite reporters) for use as in vivo glucose biosensors
US7384397B2 (en) 2003-12-30 2008-06-10 Medtronic Minimed, Inc. System and method for sensor recalibration
US7713745B2 (en) 2004-04-13 2010-05-11 Sensors For Medicine And Science, Inc. Non-covalent immobilization of indicator molecules
US20070014726A1 (en) 2005-07-18 2007-01-18 Sensors For Medicine And Science Oxidation-resistant indicator macromolecule
US20070052910A1 (en) * 2005-09-08 2007-03-08 De-Jiun Li Liquid crystal display panel
WO2008066921A2 (en) 2006-11-30 2008-06-05 Sensors For Medicine And Science, Inc. Oxidation resistant indicator molecules
US7506617B2 (en) * 2007-03-09 2009-03-24 Lochinvar Corporation Control system for modulating water heater

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5208332A (en) * 1991-04-05 1993-05-04 The United States Of America As Represented By The United States Department Of Energy Optical probe for the cytochrome P-450 cholesterol side chain cleavage enzyme
US6150097A (en) * 1996-04-12 2000-11-21 The Public Health Research Institute Of The City Of New York, Inc. Nucleic acid detection probes having non-FRET fluorescence quenching and kits and assays including such probes
US6399392B1 (en) * 1999-04-23 2002-06-04 Molecular Probes, Inc. Xanthene dyes and their application as luminescence quenching compounds

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8838195B2 (en) 2007-02-06 2014-09-16 Medtronic Minimed, Inc. Optical systems and methods for ratiometric measurement of blood glucose concentration
US8983565B2 (en) 2007-02-06 2015-03-17 Medtronic Minimed, Inc. Optical determination of pH and glucose
US8979790B2 (en) 2007-11-21 2015-03-17 Medtronic Minimed, Inc. Use of an equilibrium sensor to monitor glucose concentration

Also Published As

Publication number Publication date
WO2005065241A2 (en) 2005-07-21
US20140127137A1 (en) 2014-05-08
US8008088B2 (en) 2011-08-30
US20120052018A1 (en) 2012-03-01
US8466286B2 (en) 2013-06-18
US8029765B2 (en) 2011-10-04
US20090004108A1 (en) 2009-01-01
US20070110672A1 (en) 2007-05-17

Similar Documents

Publication Publication Date Title
WO2005065241A3 (en) Smmr (small molecule metabolite reporters) for use as in vivo glucose biosensors
WO2005014035A3 (en) Use of galactose oxidase for selective chemical conjugation of protractor molecules to proteins of therapeutic interest
WO2008014280A3 (en) Flourescent dyes for use in glucose sensing
ATE330038T1 (en) NUCLEIC ACID BIOSENSOR
WO2007067743A3 (en) Optical determination of glucose utilizing boronic acid adducts-ii
AU2013207599A1 (en) Process for determining one or more analytes in samples of biological origin having complex composition, and use thereof
EP1936378A4 (en) Nanoparticle biosensor, method of preparing same and uses thereof
WO2005000091A3 (en) Method and apparatus for detecting ischemia
ZA200305860B (en) Composition for heart disease, method to prepare same and uses thereof.
WO2005114190A3 (en) Methods of identifying biomarkers
WO2001066553A3 (en) Novel aryl fructose-1,6-bisphosphatase inhibitors
WO2006127694A3 (en) Analyte sensor
DE502004002801D1 (en) DRILLING TREATMENT AGENT, CONTAINING ETHERCARBOXYLIC ACIDS
WO2006010153A3 (en) Lipid-amino acid conjugates and methods of use
WO2008008797A3 (en) Luminescent 1-hydroxy-2-pyridinone chelates of lanthanides
AU2002303444A1 (en) Detection of microsatellite instability and its use in diagnosis of tumors
ATE388944T1 (en) INDANESIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICAL AGENTS, INTERMEDIATE PRODUCTS AND PROCESSES FOR PRODUCTION
EP2020445A4 (en) Detection of inflammatory disease and composition for prevention or treatment of inflammatory disease
WO2007149105A3 (en) Fluorescein based sensors for tracking nitric oxide in live cells
WO2008112898A3 (en) Genetic alterations on chromosome 12 and methods of use thereof for the diagnosis and treatment of type 1 diabetes
WO2007084112A3 (en) Apparatus for performing twin entangled co-incident photon enhanced raman spectroscopy
WO2006112818A3 (en) 3' modified oligonucleotides containing pseudoisocytosine nucleobase derivatives and applications thereof as primers or probes
WO2008005942A3 (en) Activatable probes and methods of use
WO2004072295A3 (en) Strokes shift emission spectroscopy for detection of disease and physiological state of specimen
WO2006117237A3 (en) Regeneration system, its production and use

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 11475784

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: DE

WWW Wipo information: withdrawn in national office

Country of ref document: DE

32PN Ep: public notification in the ep bulletin as address of the adressee cannot be established

Free format text: DEEMED TO BE WITHDRAWN SINCE FEES HAVE NOT BEEN PAID

122 Ep: pct application non-entry in european phase
WWP Wipo information: published in national office

Ref document number: 11475784

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 10584821

Country of ref document: US